Chemical Approaches to Controlling Cell Fate

Principles of Developmental Genetics: Second Edition

Volumn , Issue , 2015, Pages 59-76

  Zhang, Mingliang ^a   Li, Ke ^a   Xie, Min ^a   Ding, Sheng ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cell fate; Differentiation; Reprogramming; Self renewal; Small molecule; Stem cell

Indexed keywords

EID: 84943382401     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-405945-0.00004-1     Document Type: Chapter

References (69)

1. Boitano A.E., Wang J., Romeo R., Bouchez L.C., Parker A.E., Sutton S.E., Walker J.R., Flaveny C.A., Perdew G.H., Denison M.S., et al. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science 2010, 329:1345-1348.
2. Borowiak M., Maehr R., Chen S., Chen A.E., Tang W., Fox J.L., Schreiber S.L., Melton D.A. Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell 2009, 4:348-358.
3. Brons I.G., Smithers L.E., Trotter M.W., Rugg-Gunn P., Sun B., Chuva de Sousa Lopes S.M., Howlett S.K., Clarkson A., Ahrlund-Richter L., Pedersen R.A., et al. Derivation of pluripotent epiblast stem cells from mammalian embryos. Nature 2007, 448:191-195.
4. Broxmeyer H.E., Orschell C.M., Clapp D.W., Hangoc G., Cooper S., Plett P.A., Liles W.C., Li X., Graham-Evans B., Campbell T.B., et al. Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist. J. Exp. Med. 2005, 201:1307-1318.
5. Chambers I., Smith A. Self-renewal of teratocarcinoma and embryonic stem cells. Oncogene 2004, 23:7150-7160.
6. Chambers S.M., Fasano C.A., Papapetrou E.P., Tomishima M., Sadelain M., Studer L. Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Nat. Biotechnol. 2009, 27:275-280.
7. Chan K.K., Zhang J., Chia N.Y., Chan Y.S., Sim H.S., Tan K.S., Oh S.K., Ng H.H., Choo A.B. KLF4 and PBX1 directly regulate NANOG expression in human embryonic stem cells. Stem Cells 2009, 27:2114-2125.
8. Chen S., Borowiak M., Fox J.L., Maehr R., Osafune K., Davidow L., Lam K., Peng L.F., Schreiber S.L., Rubin L.L., et al. A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat. Chem. Biol. 2009, 5:258-265.
9. Chen S., Do J.T., Zhang Q., Yao S., Yan F., Peters E.C., Scholer H.R., Schultz P.G., Ding S. Self-renewal of embryonic stem cells by a small molecule. Proc. Natl. Acad. Sci. USA 2006, 103:17266-17271.
10. Chen S., Takanashi S., Zhang Q., Xiong W., Zhu S., Peters E.C., Ding S., Schultz P.G. Reversine increases the plasticity of lineage-committed mammalian cells. Proc. Natl. Acad. Sci. USA 2007, 104:10482-10487.
11. Chen S., Zhang Q., Wu X., Schultz P.G., Ding S. Dedifferentiation of lineage-committed cells by a small molecule. J. Am. Chem. Soc. 2004, 126:410-411.
12. Clark A.T., Rodriguez R.T., Bodnar M.S., Abeyta M.J., Cedars M.I., Turek P.J., Firpo M.T., Reijo Pera R.A. Human STELLAR, NANOG, and GDF3 genes are expressed in pluripotent cells and map to chromosome 12p13, a hotspot for teratocarcinoma. Stem Cells 2004, 22:169-179.
13. D'Amour K.A., Bang A.G., Eliazer S., Kelly O.G., Agulnick A.D., Smart N.G., Moorman M.A., Kroon E., Carpenter M.K., Baetge E.E. Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat. Biotechnol. 2006, 24:1392-1401.
14. Efe J.A., Hilcove S., Kim J., Zhou H., Ouyang K., Wang G., Chen J., Ding S. Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy. Nat. Cell Biol. 2011, 13:215-222.
15. Esteban M.A., Wang T., Qin B., Yang J., Qin D., Cai J., Li W., Weng Z., Chen J., Ni S., et al. Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell 2010, 6:71-79.
16. Evans M.J., Kaufman M.H. Establishment in culture of pluripotential cells from mouse embryos. Nature 1981, 292:154-156.
17. Filby C.E., Williamson R., van Kooy P., Pebay A., Dottori M., Elwood N.J., Zaibak F. Stimulation of Activin A/Nodal signaling is insufficient to induce definitive endoderm formation of cord blood-derived unrestricted somatic stem cells. Stem Cell Res. Ther. 2011, 2:16.
18. Hanna J., Cheng A.W., Saha K., Kim J., Lengner C.J., Soldner F., Cassady J.P., Muffat J., Carey B.W., Jaenisch R. Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs. Proc. Natl. Acad. Sci. USA 2010, 107:9222-9227.
19. Hoggatt J., Mohammad K.S., Singh P., Hoggatt A.F., Chitteti B.R., Speth J.M., Hu P., Poteat B.A., Stilger K.N., Ferraro F., et al. Differential stem- and progenitor-cell trafficking by prostaglandin E2. Nature 2013, 495:365-369.
20. Huang Y., Osorno R., Tsakiridis A., Wilson V. In vivo differentiation potential of epiblast stem cells revealed by chimeric embryo formation. Cell Rep. 2012, 2:1571-1578.
21. Huangfu D., Osafune K., Maehr R., Guo W., Eijkelenboom A., Chen S., Muhlestein W., Melton D.A. Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat. Biotechnol. 2008, 26:1269-1275.
22. Ichida J.K., Blanchard J., Lam K., Son E.Y., Chung J.E., Egli D., Loh K.M., Carter A.C., Di Giorgio F.P., Koszka K., et al. A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog. Cell Stem Cell 2009, 5:491-503.
23. James D., Levine A.J., Besser D., Hemmati-Brivanlou A. TGFbeta/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells. Development 2005, 132:1273-1282.
24. Kawamura T., Suzuki J., Wang Y.V., Menendez S., Morera L.B., Raya A., Wahl G.M., Izpisua Belmonte J.C. Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature 2009, 460:1140-1144.
25. Kim J., Efe J.A., Zhu S., Talantova M., Yuan X., Wang S., Lipton S.A., Zhang K., Ding S. Direct reprogramming of mouse fibroblasts to neural progenitors. Proc. Natl. Acad. Sci. USA 2011, 108:7838-7843.
26. Kroon E., Martinson L.A., Kadoya K., Bang A.G., Kelly O.G., Eliazer S., Young H., Richardson M., Smart N.G., Cunningham J., et al. Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. Nat. Biotechnol. 2008, 26:443-452.
27. Kurian L., Sancho-Martinez I., Nivet E., Aguirre A., Moon K., Pendaries C., Volle-Challier C., Bono F., Herbert J.M., Pulecio J., et al. Conversion of human fibroblasts to angioblast-like progenitor cells. Nat. Methods 2012, 10:77-83.
28. Larochelle A., Krouse A., Metzger M., Orlic D., Donahue R.E., Fricker S., Bridger G., Dunbar C.E., Hematti P. AMD3100 mobilizes hematopoietic stem cells with long-term repopulating capacity in nonhuman primates. Blood 2006, 107:3772-3778.
29. Li H., Zhou H., Wang D., Qiu J., Zhou Y., Li X., Rosenfeld M.G., Ding S., Fu X.D. Versatile pathway-centric approach based on high-throughput sequencing to anticancer drug discovery. Proc. Natl. Acad. Sci. USA 2012, 109:4609-4614.
30. Li W., Wei W., Zhu S., Zhu J., Shi Y., Lin T., Hao E., Hayek A., Deng H., Ding S. Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors. Cell Stem Cell 2009, 4:16-19.
31. Li W., Zhou H., Abujarour R., Zhu S., Young Joo J., Lin T., Hao E., Scholer H.R., Hayek A., Ding S. Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2. Stem Cells 2009, 27:2992-3000.
32. Lin T., Ambasudhan R., Yuan X., Li W., Hilcove S., Abujarour R., Lin X., Hahm H.S., Hao E., Hayek A., et al. A chemical platform for improved induction of human iPSCs. Nat. Methods 2009, 6:805-808.
33. Liskovykh M.A., Chuikin I.A., Ranjan A., Popova E., Tolkunova E.N., Chechik L.L., Malinin A., Morozova A.V., Mosienko V., Bader M., et al. Genetic manipulation and studying of differentiation properties of rat induced pluripotent stem cells. Tsitologiia 2011, 53:946-951.
34. Lu J., Liu H., Huang C.T., Chen H., Du Z., Liu Y., Sherafat M.A., Zhang S.C. Generation of integration-free and region-specific neural progenitors from primate fibroblasts. Cell Rep. 2013, 3:1580-1591.
35. Lyssiotis C.A., Foreman R.K., Staerk J., Garcia M., Mathur D., Markoulaki S., Hanna J., Lairson L.L., Charette B.D., Bouchez L.C., et al. Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4. Proc. Natl. Acad. Sci. USA 2009, 106:8912-8917.
36. Margariti A., Winkler B., Karamariti E., Zampetaki A., Tsai T.N., Baban D., Ragoussis J., Huang Y., Han J.D., Zeng L., et al. Direct reprogramming of fibroblasts into endothelial cells capable of angiogenesis and reendothelialization in tissue-engineered vessels. Proc. Natl. Acad. Sci. USA 2012, 109:13793-13798.
37. Nichols J., Smith A. Naive and primed pluripotent states. Cell Stem Cell 2009, 4:487-492.
38. Niwa H., Burdon T., Chambers I., Smith A. Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3. Genes Dev. 1998, 12:2048-2060.
39. Park I.H., Zhao R., West J.A., Yabuuchi A., Huo H., Ince T.A., Lerou P.H., Lensch M.W., Daley G.Q. Reprogramming of human somatic cells to pluripotency with defined factors. Nature 2008, 451:141-146.
40. Ramirez P., Rettig M.P., Uy G.L., Deych E., Holt M.S., Ritchey J.K., DiPersio J.F. BIO5192, a small molecule inhibitor of VLA-4, mobilizes hematopoietic stem and progenitor cells. Blood 2009, 114:1340-1343.
41. Shi Y., Desponts C., Do J.T., Hahm H.S., Scholer H.R., Ding S. Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell 2008, 3:568-574.
42. Shi Y., Do J.T., Desponts C., Hahm H.S., Scholer H.R., Ding S. A combined chemical and genetic approach for the generation of induced pluripotent stem cells. Cell Stem Cell 2008, 2:525-528.
43. Smith A.G. Embryo-derived stem cells: of mice and men. Annu. Rev. Cell Dev. Biol. 2001, 17:435-462.
44. Stadtfeld M., Apostolou E., Ferrari F., Choi J., Walsh R.M., Chen T., Ooi S.S., Kim S.Y., Bestor T.H., Shioda T., et al. Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells. Nat. Genet. 2012, 44(398-405):S391-S392.
45. Stadtfeld M., Apostolou E., Akutsu H., Fukuda A., Follett P., Natesan S., Kono T., Shioda T., Hochedlinger K. Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells. Nature 2010, 465(7295),175-181.
46. Takahashi K., Tanabe K., Ohnuki M., Narita M., Ichisaka T., Tomoda K., Yamanaka S. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007, 131:861-872.
47. Takahashi K., Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006, 126:663-676.
48. Tesar P.J., Chenoweth J.G., Brook F.A., Davies T.J., Evans E.P., Mack D.L., Gardner R.L., McKay R.D. New cell lines from mouse epiblast share defining features with human embryonic stem cells. Nature 2007, 448:196-199.
49. Thier M., Worsdorfer P., Lakes Y.B., Gorris R., Herms S., Opitz T., Seiferling D., Quandel T., Hoffmann P., Nothen M.M., et al. Direct conversion of fibroblasts into stably expandable neural stem cells. Cell Stem Cell 2012, 10(4):473-479.
50. Thomson J.A., Itskovitz-Eldor J., Shapiro S.S., Waknitz M.A., Swiergiel J.J., Marshall V.S., Jones J.M. Embryonic stem cell lines derived from human blastocysts. Science 1998, 282:1145-1147.
51. Thomson J.A., Kalishman J., Golos T.G., Durning M., Harris C.P., Becker R.A., Hearn J.P. Isolation of a primate embryonic stem cell line. Proc. Natl. Acad. Sci. USA 1995, 92:7844-7848.
52. Thomson J.A., Marshall V.S. Primate embryonic stem cells. Curr. Top. Dev. Biol. 1998, 38:133-165.
53. Vallier L., Alexander M., Pedersen R.A. Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells. J. Cell Sci. 2005, 118:4495-4509.
54. Vallier L., Touboul T., Chng Z., Brimpari M., Hannan N., Millan E., Smithers L.E., Trotter M., Rugg-Gunn P., Weber A., et al. Early cell fate decisions of human embryonic stem cells and mouse epiblast stem cells are controlled by the same signalling pathways. PLoS One 2009, 4:e6082.
55. Wang L., Huang W., Su H., Xue Y., Su Z., Liao B., Wang H., Bao X., Qin D., He J., et al. Generation of integration-free neural progenitor cells from cells in human urine. Nat. Methods 2012, 10:84-89.
56. Xu T., Wang X., Zhong B., Nurieva R.I., Ding S., Dong C. Ursolic acid suppresses interleukin-17 (IL-17) production by selectively antagonizing the function of RORγt protein. J. Biol. Chem. 2011, 286:22707-22710.
57. Xu Y., Zhu X., Hahm H.S., Wei W., Hao E., Hayek A., Ding S. Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proc. Natl. Acad. Sci. USA 2010, 107:8129-8134.
58. Ying Q.L., Nichols J., Chambers I., Smith A. BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell 2003, 115:281-292.
59. Ying Q.L., Wray J., Nichols J., Batlle-Morera L., Doble B., Woodgett J., Cohen P., Smith A. The ground state of embryonic stem cell self-renewal. Nature 2008, 453:519-523.
60. Yuan X., Wan H., Zhao X., Zhu S., Zhou Q., Ding S. Combined chemical treatment enables oct4-induced reprogramming from mouse embryonic fibroblasts. Stem Cells 2011, 29(3):549-553.
61. Zhang J., Khvorostov I., Hong J.S., Oktay Y., Vergnes L., Nuebel E., Wahjudi P.N., Setoguchi K., Wang G., Do A., et al. UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells. EMBO J. 2011, 30:4860-4873.
62. Zhou H., Li W., Zhu S., Joo J.Y., Do J.T., Xiong W., Kim J.B., Zhang K., Scholer H.R., Ding S. Conversion of mouse epiblast stem cells to an earlier pluripotency state by small molecules. J. Biol. Chem. 2010, 285:29676-29680.
63. Zhu S., Li W., Zhou H., Wei W., Ambasudhan R., Lin T., Kim J., Zhang K., Ding S. Reprogramming of human primary somatic cells by OCT4 and chemical compounds. Cell Stem Cell 2010, 7:651-655.
64. Tocris Bioscience: (accessed 20.03.14). http://www.tocris.com/.
65. Cell Signaling Technology: (accessed 20.03.14). http://www.cellsignal.com/.
66. Nichols J., Smith A. Naive and primed pluripotent states. Cell Stem Cell 2009, 4(6):487-492.
67. Song M., Paul S., Lim H., Dayem A.A., Cho S.G. Induced pluripotent stem cell research: a revolutionary approach to face the challenges in drug screening. Arch. Pharm. Res. 2012 Feb, 35(2):245-260.
68. Li W., Jiang K., Ding S. Concise review: A chemical approach to control cell fate and function. Stem Cells 2012 Jan, 30(1):61-68.
69. Xu T., Zhang M., Laurent T., Xie M., Ding S. Concise review: Chemical approaches for modulating lineage-specific stem cells and progenitors. Stem Cells Trans. Med. 2013, 2:355-361.