Human STELLAR, NANOG, and GDF3 Genes Are Expressed in Pluripotent Cells and Map to Chromosome 12p13, a Hotspot for Teratocarcinoma

Stem Cells

Volumn 22, Issue 2, 2004, Pages 169-179

  Clark, Amander T ^a,b   Rodriguez, Ryan T ^a   Bodnar, Megan S ^a   Abeyta, Michael J ^a,b   Cedars, Marcelle I ^a   Turek, Paul J ^a,b   Firpo, Meri T ^a   Pera, Renee A Reijo ^a,b  

^a Center for Reproductive Sciences   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Embryonal carcinoma; GDF3; Germ cell; Human embryonic stem cells; NANOG; OCT 4; Ovary; Pluripotent; STELLAR; Teratoma; Testis

Indexed keywords

AMINO ACID SEQUENCE; ARTICLE; CHROMOSOME 12P; EMBRYO CELL; GDF3 GENE; GENE; GENE LOCATION; HOMEOBOX; HUMAN; HUMAN CELL; NANOG GENE; NUCLEOTIDE SEQUENCE; OCT 4 GENE; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STELLAR GENE; STEM CELL; TERATOCARCINOMA;

MURINAE; STELLA;

EID: 1442336166     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.22-2-169     Document Type: Article

References (23)

1. Thompson J, Itskovitz-Eldor J, Shapiro S et al. Embryonic stem cell lines derived from human blastocysts. Science 1998;282:1145-1147.
2. Hanna LA, Foreman RK, Tarasenko IA et al. Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo. Genes Dev 2002;16:2650-2661.
3. Feldman B, Poueymirou W, Papaioannou VE et al. Requirement of FGF-4 for postimplantation mouse development. Science 1995;267:246-249.
4. Mitsui K, Tokuzawa Y, Itoh H et al. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell 2003;113:631-642.
5. Chambers I, Colby D, Robertson M et al. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 2003;113:643-655.
6. Matsuda T, Nakamura T, Nakao K et al. STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells. EMBO J 1999;15:4261-4269.
7. Rose-John S. GP130 stimulation and the maintenance of stem cells. Trends Biotechnol 2002;20:417-419.
8. Burdon T, Smith A, Savatier P. Signalling cell cycle and pluripotency in embryonic stem cells. Trends Cell Biol 2002;12:432-438.
9. Lin H, Lei JQ, Wininger D et al. Multilineage potential of homozygous stem cells derived from metaphase II oocytes. STEM CELLS 2003;21:152-161.
10. Pesce M, Wang X, Wolgemuth DJ et al. Differential expression of the Oct-4 transcription factor during mouse germ cell differentiation. Mech Dev 1998;71:89-98.
11. de Jong B, Oosterhuis JW, Castedo SM et al. Pathogenesis of adult testicular germ cell tumors. A cytogenic model. Cancer Genet Cytogenet 1990;48:143-167.
12. Murty VV, Dmitrovsky E, Bosl GJ et al. Nonrandom chromosomal abnormalities in testicular and ovarian germ cell tumor cell lines. Cancer Genet Cytogenet 1990;50:67-73.
13. Saitou M, Barton SC, Surani MA. A molecular programme for the specification of germ cell fate in mice. Nature 2002;418:293-300.
14. Pfaffl M, Horgan G, Dempfle L. Relative expression software tool (REST) for groupwise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res 2002;30:e36.
15. Moore F, Jaruzelska J, Fox M et al. Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins. Proc Natl Acad Sci USA 2003;100:538-543.
16. Sato M, Kimura T, Kurokawa K et al. Identification of PGC7, a new gene expressed specifically in preimplantation embryos and germ cells. Mech Dev 2002;113:91-94.
17. Caricasole AA, van Schaik RH, Zeinstra LM et al. Human growth-differentiation factor 3 (hgdf3): developmental regulation in human teratocarcinoma cell lines and expression in primary testicular germ cell tumors. Oncogene 1998;16:95-103.
18. Lee JH, Lee DR, Yoon SJ et al. Expression of DAZ (deleted in azoospermia), DAZL1 (Daz-like) and protamine-2 in testis and its application for diagnosis of spermatogenic non-obstructive azoospermia. Mol Hum Reprod 1998;4:827-834.
19. Cooke HJ, Lee M, Kerr S et al. A murine homologue of the human DAZ gene is autosomal and expressed only in male and female gonads. Hum Mol Genet 1996;5:513-516.
20. Wang S-H, Tsai M-S, Chiang M-F et al. A novel NK-type homeobox gene ENK (early embryo specific NK) preferentially expressed in embryonic stem cells. Gene Expr Patterns 2003;3:99-103.
21. McPherron AC, Lee SJ. GDF-3 and GDF-9: two new members of the transforming growth factor-beta superfamily containing a novel pattern of cysteines. J Biol Chem 1993;268:3444-3449.
22. Swanson W, Vacquier V. The rapid evolution of reproductive proteins. Nat Rev Genet 2002;3:137-144.
23. Makalowski W, Boguski M. Evolutionary parameters of the transcribed mammalian genome: an analysis of 2,820 orthologous rodent and human sequences. Proc Natl Acad Sci USA 1998;95:9407-9412.