메뉴 건너뛰기




Volumn 290, Issue 40, 2015, Pages 24237-24254

Regulation of plasma membrane localization of the Na - Taurocholate cotransporting polypeptide (Ntcp) by hyperosmolarity and tauroursodeoxycholate

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BODY FLUIDS; CELL MEMBRANES; ENZYMES; MAMMALS; PROTEINS; SALTS;

EID: 84943302954     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.666883     Document Type: Article
Times cited : (15)

References (80)
  • 1
    • 83755203890 scopus 로고    scopus 로고
    • The src family kinase fyn mediates hyperosmolarity-induced mrp2 and bsep retrieval from canalicular membrane
    • Cantore, M., Reinehr, R., Sommerfeld, A., Becker, M., and Häussinger, D. (2011) The Src family kinase Fyn mediates hyperosmolarity-induced Mrp2 and Bsep retrieval from canalicular membrane. J. Biol. Chem. 286, 45014-45029
    • (2011) J. Biol. Chem. , vol.286 , pp. 45014-45029
    • Cantore, M.1    Reinehr, R.2    Sommerfeld, A.3    Becker, M.4    Häussinger, D.5
  • 2
    • 0037117313 scopus 로고    scopus 로고
    • Genetic defects in hepatobiliary transport
    • Elferink, R. O., and Groen, A. K. (2002) Genetic defects in hepatobiliary transport. Biochim. Biophys. Acta 1586, 129-145
    • (2002) Biochim. Biophys. Acta , vol.1586 , pp. 129-145
    • Elferink, R.O.1    Groen, A.K.2
  • 3
    • 0041322990 scopus 로고    scopus 로고
    • Bile salt-induced hepatocyte apoptosis involves epidermal growth factor receptor-dependent CD95 tyrosine phosphorylation
    • Reinehr, R., Graf, D., and Häussinger, D. (2003) Bile salt-induced hepatocyte apoptosis involves epidermal growth factor receptor-dependent CD95 tyrosine phosphorylation. Gastroenterology 125, 839-853
    • (2003) Gastroenterology , vol.125 , pp. 839-853
    • Reinehr, R.1    Graf, D.2    Häussinger, D.3
  • 5
    • 33750970321 scopus 로고    scopus 로고
    • Bile acids inhibit interleukin-6 signaling via gp130 receptor-dependent and - Independent pathways in rat liver
    • Graf, D., Kohlmann, C., Haselow, K., Gehrmann, T., and Bode., J. G., and Häussinger, D. (2006) Bile acids inhibit interleukin-6 signaling via gp130 receptor-dependent and - independent pathways in rat liver. Hepatology 44, 1206-1217
    • (2006) Hepatology , vol.44 , pp. 1206-1217
    • Graf, D.1    Kohlmann, C.2    Haselow, K.3    Gehrmann, T.4    Bode, J.G.5    Häussinger, D.6
  • 6
    • 33847082573 scopus 로고    scopus 로고
    • Hydrophobic bile salts induce hepatocyte shrinkage via NADPH oxidase activation
    • Becker, S., Reinehr, R., Graf, D., vom Dahl, S., and Häussinger, D. (2007) Hydrophobic bile salts induce hepatocyte shrinkage via NADPH oxidase activation. Cell Physiol. Biochem. 19, 89-98
    • (2007) Cell Physiol. Biochem. , vol.19 , pp. 89-98
    • Becker, S.1    Reinehr, R.2    Graf, D.3    Vom Dahl, S.4    Häussinger, D.5
  • 8
    • 0035831094 scopus 로고    scopus 로고
    • Characterization of bile acid transport mediated by multidrug resistance associated protein 2 and bile salt export pump
    • Akita, H., Suzuki, H., Ito, K., Kinoshita, S., Sato, N., Takikawa, H., and Sugiyama, Y. (2001) Characterization of bile acid transport mediated by multidrug resistance associated protein 2 and bile salt export pump. Biochim. Biophys. Acta 1511, 7-16
    • (2001) Biochim. Biophys. Acta , vol.1511 , pp. 7-16
    • Akita, H.1    Suzuki, H.2    Ito, K.3    Kinoshita, S.4    Sato, N.5    Takikawa, H.6    Sugiyama, Y.7
  • 9
    • 0033947842 scopus 로고    scopus 로고
    • Retrieval of the mrp2 gene encoded conjugate export pump from the canalicular membrane contributes to cholestasis induced by tert-butyl hydroperoxide and chloro-dinitrobenzene
    • Schmitt, M., Kubitz, R., Wettstein, M., vom Dahl, S., and Häussinger, D. (2000) Retrieval of the mrp2 gene encoded conjugate export pump from the canalicular membrane contributes to cholestasis induced by tert-butyl hydroperoxide and chloro-dinitrobenzene. Biol. Chem. 381, 487-495
    • (2000) Biol. Chem. , vol.381 , pp. 487-495
    • Schmitt, M.1    Kubitz, R.2    Wettstein, M.3    Vom Dahl, S.4    Häussinger, D.5
  • 10
    • 0035124048 scopus 로고    scopus 로고
    • Regulation of the dynamic localization of the rat bsep gene-encoded bile salt export pump by anisoosmolarity
    • Schmitt, M., Kubitz, R., Lizun, S., Wettstein, M., and Häussinger, D. (2001) Regulation of the dynamic localization of the rat Bsep gene-encoded bile salt export pump by anisoosmolarity. Hepatology 33, 509-518
    • (2001) Hepatology , vol.33 , pp. 509-518
    • Schmitt, M.1    Kubitz, R.2    Lizun, S.3    Wettstein, M.4    Häussinger, D.5
  • 11
    • 33645810797 scopus 로고    scopus 로고
    • Oxidative stress induces internalization of the bile salt export pump, bsep, and bile salt secretory failurein isolated rat hepatocyte couplets: A role for protein kinase C and prevention by protein kinase A
    • Pérez, L. M., Milkiewicz, P., Elias, E., Coleman, R., Sánchez Pozzi, E. J., and Roma, M.G. (2006) Oxidative stress induces internalization of the bile salt export pump, Bsep, and bile salt secretory failurein isolated rat hepatocyte couplets: a role for protein kinase C and prevention by protein kinase A. Toxicol. Sci. 91, 150-158
    • (2006) Toxicol. Sci. , vol.91 , pp. 150-158
    • Pérez, L.M.1    Milkiewicz, P.2    Elias, E.3    Coleman, R.4    Sánchez Pozzi, E.J.5    Roma, M.G.6
  • 12
    • 0031738416 scopus 로고    scopus 로고
    • Up-regulation of the multidrug resistance genes, mrp1 and mdr1b, and down-regulation of the organic anion transporter, mrp2, and the bile salt transporter, spgp, in endotoxemic rat liver
    • Vos, T. A., and Hooiveld., G. J., Koning, H., Childs, S., Meijer, D. K., Moshage, H., Jansen, P. L., and Müller, M. (1998) Up-regulation of the multidrug resistance genes, Mrp1 and Mdr1b, and down-regulation of the organic anion transporter, Mrp2, and the bile salt transporter, Spgp, in endotoxemic rat liver. Hepatology 28, 1637-1644
    • (1998) Hepatology , vol.28 , pp. 1637-1644
    • Vos, T.A.1    Hooiveld, G.J.2    Koning, H.3    Childs, S.4    Meijer, D.K.5    Moshage, H.6    Jansen, P.L.7    Müller, M.8
  • 13
    • 0032524012 scopus 로고    scopus 로고
    • Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors
    • Trauner, M., Arrese, M., Lee, H., Boyer, J. L., and Karpen, S. J. (1998) Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors. J. Clin. Invest. 101, 2092-2100
    • (1998) J. Clin. Invest. , vol.101 , pp. 2092-2100
    • Trauner, M.1    Arrese, M.2    Lee, H.3    Boyer, J.L.4    Karpen, S.J.5
  • 14
    • 0032944048 scopus 로고    scopus 로고
    • Regulation of the multidrug resistance protein 2 in the rat liver by lipopolysaccharide and dexamethasone
    • Kubitz, R., Wettstein, M., Warskulat, U., and Häussinger, D. (1999) Regulation of the multidrug resistance protein 2 in the rat liver by lipopolysaccharide and dexamethasone. Gastroenterology 116, 401-410
    • (1999) Gastroenterology , vol.116 , pp. 401-410
    • Kubitz, R.1    Wettstein, M.2    Warskulat, U.3    Häussinger, D.4
  • 15
    • 0031938026 scopus 로고    scopus 로고
    • Impaired activity of the bile canalicular organic anion transporter (Mrp2/cmoat) is not the main cause of ethinylestradiol-induced cholestasis in the rat
    • Koopen, N. R., Wolters, H., Havinga, R., Vonk, R. J., Jansen, P. L., Müller, M., and Kuipers, F. (1998) Impaired activity of the bile canalicular organic anion transporter (Mrp2/cmoat) is not the main cause of ethinylestradiol-induced cholestasis in the rat. Hepatology 27, 537-545
    • (1998) Hepatology , vol.27 , pp. 537-545
    • Koopen, N.R.1    Wolters, H.2    Havinga, R.3    Vonk, R.J.4    Jansen, P.L.5    Müller, M.6    Kuipers, F.7
  • 16
    • 17144473982 scopus 로고    scopus 로고
    • Cyclosporin A induced internalization of the bile salt export pump in isolated rat hepatocyte couplets
    • Román, I. D., Fernández-Moreno, M. D., Fueyo, J. A., Roma, M. G., and Coleman, R. (2003) Cyclosporin A induced internalization of the bile salt export pump in isolated rat hepatocyte couplets. Toxicol. Sci. 71, 276-281
    • (2003) Toxicol. Sci. , vol.71 , pp. 276-281
    • Román, I.D.1    Fernández-Moreno, M.D.2    Fueyo, J.A.3    Roma, M.G.4    Coleman, R.5
  • 17
    • 0030731742 scopus 로고    scopus 로고
    • Osmodependent dynamic localization of the multidrug resistance protein 2 in the rat hepatocyte canalicular membrane
    • Kubitz, R., D'urso, D., Keppler, D., and Häussinger, D. (1997) Osmodependent dynamic localization of the multidrug resistance protein 2 in the rat hepatocyte canalicular membrane. Gastroenterology 113, 1438-1442
    • (1997) Gastroenterology , vol.113 , pp. 1438-1442
    • Kubitz, R.1    D'Urso, D.2    Keppler, D.3    Häussinger, D.4
  • 18
    • 0032738402 scopus 로고    scopus 로고
    • Regulation of bile salt export pump mRNA levels by dexamethasone and osmolarity in cultured rat hepatocytes
    • Warskulat, U., Kubitz, R., Wettstein, M., Stieger, B., and Meier., P. J., and Häussinger, D. (1999) Regulation of bile salt export pump mRNA levels by dexamethasone and osmolarity in cultured rat hepatocytes. Biol. Chem. 380, 1273-1279
    • (1999) Biol. Chem. , vol.380 , pp. 1273-1279
    • Warskulat, U.1    Kubitz, R.2    Wettstein, M.3    Stieger, B.4    Meier, P.J.5    Häussinger, D.6
  • 19
    • 3042594002 scopus 로고    scopus 로고
    • Involvement of integrins and src in tauroursodeoxy-cholate-induced and swelling-induced choleresis
    • Häussinger, D., and Kurz., A. K., Wettstein, M., Graf, D., Vom Dahl, S., and Schliess, F. (2003) Involvement of integrins and Src in tauroursodeoxy-cholate-induced and swelling-induced choleresis. Gastroenterology 124, 1476-1487
    • (2003) Gastroenterology , vol.124 , pp. 1476-1487
    • Häussinger, D.1    Kurz, A.K.2    Wettstein, M.3    Graf, D.4    Vom Dahl, S.5    Schliess, F.6
  • 20
    • 0029820811 scopus 로고    scopus 로고
    • Regulation and functional significance of liver cell volume
    • Häussinger, D. (1996) Regulation and functional significance of liver cell volume. Prog. Liver Dis. 14, 29-53
    • (1996) Prog. Liver Dis. , vol.14 , pp. 29-53
    • Häussinger, D.1
  • 22
    • 35748970159 scopus 로고    scopus 로고
    • Osmosensing and signaling in the regulation of Mammalian cell function
    • Schliess, F., Reinehr, R., and Häussinger, D. (2007) Osmosensing and signaling in the regulation of mammalian cell function. FEBS J. 274, 5799-5803
    • (2007) FEBS J. , vol.274 , pp. 5799-5803
    • Schliess, F.1    Reinehr, R.2    Häussinger, D.3
  • 23
    • 0027159022 scopus 로고
    • Involvement of microtubules in the swelling-induced stimulation of transcellular taurocholate transport in perfused rat liver
    • Häussinger, D., Saha, N, Hallbrucker, C, Lang, F., and Gerok, W. (1993) Involvement of microtubules in the swelling-induced stimulation of transcellular taurocholate transport in perfused rat liver. Biochem. J. 291, 355-360
    • (1993) Biochem. J. , vol.291 , pp. 355-360
    • Häussinger, D.1    Saha, N.2    Hallbrucker, C.3    Lang, F.4    Gerok, W.5
  • 24
    • 0030031467 scopus 로고    scopus 로고
    • Regulation of taurocholate excretion by a hypo-osmolarity-activated signal transduction pathway in rat liver
    • Noé, B., Schliess, F., Wettstein, M., Heinrich, S., and Häussinger, D. (1996) Regulation of taurocholate excretion by a hypo-osmolarity-activated signal transduction pathway in rat liver. Gastroenterology 110, 858-865
    • (1996) Gastroenterology , vol.110 , pp. 858-865
    • Noé, B.1    Schliess, F.2    Wettstein, M.3    Heinrich, S.4    Häussinger, D.5
  • 25
    • 0034910937 scopus 로고    scopus 로고
    • Tauroursodesoxycholate-induced choleresis involves p38(MAPK) activation and translocation of the bile salt export pump in rats
    • Kurz, A. K., Graf, D., Schmitt, M., Vom Dahl, S., and Häussinger, D. (2001) Tauroursodesoxycholate-induced choleresis involves p38(MAPK) activation and translocation of the bile salt export pump in rats. Gastroenterology 121, 407-419
    • (2001) Gastroenterology , vol.121 , pp. 407-419
    • Kurz, A.K.1    Graf, D.2    Schmitt, M.3    Vom Dahl, S.4    Häussinger, D.5
  • 26
    • 0031979439 scopus 로고    scopus 로고
    • Cyclic AMP stimulates sorting of the canalicular organic anion transporter (Mrp2/cMoat) to the apical domain in hepatocyte couplets
    • Roelofsen, H., and Soroka., C. J., Keppler, D., and Boyer, J. L. (1998) Cyclic AMP stimulates sorting of the canalicular organic anion transporter (Mrp2/cMoat) to the apical domain in hepatocyte couplets. J. Cell Sci. 111, 1137-1145
    • (1998) J. Cell Sci. , vol.111 , pp. 1137-1145
    • Roelofsen, H.1    Soroka, C.J.2    Keppler, D.3    Boyer, J.L.4
  • 27
    • 0038102936 scopus 로고    scopus 로고
    • Mechanisms by which cAMP increases bile acid secretion in rat liver and canalicular membrane vesicles
    • Misra, S., Varticovski, L., and Arias, I. M. (2003) Mechanisms by which cAMP increases bile acid secretion in rat liver and canalicular membrane vesicles. Am. J. Physiol. Gastrointest. Liver Physiol. 285, G316-G324
    • (2003) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.285 , pp. G316-G324
    • Misra, S.1    Varticovski, L.2    Arias, I.M.3
  • 29
    • 0035038177 scopus 로고    scopus 로고
    • Tauroursodeoxycholic acid inserts the apical conjugate export pump, mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver
    • Beuers, U., Bilzer, M., Chittattu, A., Kullak-Ublick, G. A., Keppler, D., Paumgartner, G., and Dombrowski, F. (2001) Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver. Hepatology 33, 1206-1216
    • (2001) Hepatology , vol.33 , pp. 1206-1216
    • Beuers, U.1    Bilzer, M.2    Chittattu, A.3    Kullak-Ublick, G.A.4    Keppler, D.5    Paumgartner, G.6    Dombrowski, F.7
  • 34
    • 0031738338 scopus 로고    scopus 로고
    • Sodium taurocholate cotransporting polypeptide is a serine, threonine phosphoprotein and is dephosphorylated by cyclic adenosine monophosphate
    • Mukhopadhyay, S., Ananthanarayanan, M., Stieger, B., Meier, P. J., Suchy, F. J., and Anwer, M. S. (1998) Sodium taurocholate cotransporting polypeptide is a serine, threonine phosphoprotein and is dephosphorylated by cyclic adenosine monophosphate. Hepatology 28, 1629-1636
    • (1998) Hepatology , vol.28 , pp. 1629-1636
    • Mukhopadhyay, S.1    Ananthanarayanan, M.2    Stieger, B.3    Meier, P.J.4    Suchy, F.J.5    Anwer, M.S.6
  • 35
    • 84891854345 scopus 로고    scopus 로고
    • Sodium-dependent bile salt transporters of the SLC10A transporter family: More than solute transporters
    • Anwer, M. S., and Stieger, B. (2014) Sodium-dependent bile salt transporters of the SLC10A transporter family: more than solute transporters. Pflugers Arch. 466, 77-89
    • (2014) Pflugers Arch. , vol.466 , pp. 77-89
    • Anwer, M.S.1    Stieger, B.2
  • 38
    • 0034703036 scopus 로고    scopus 로고
    • +/taurocholate cotransport polypeptide is mediated via the phosphoinositide 3-kinase signaling pathway
    • +/taurocholate cotransport polypeptide is mediated via the phosphoinositide 3-kinase signaling pathway. J. Biol. Chem. 275, 29754-29760
    • (2000) J. Biol. Chem. , vol.275 , pp. 29754-29760
    • Webster, C.R.1    Blanch, C.J.2    Phillips, J.3    Anwer, M.S.4
  • 39
    • 0027998655 scopus 로고
    • Pharmacology of ursodeoxycholic acid, an enterohepatic drug
    • Hofmann, A. F. (1994) Pharmacology of ursodeoxycholic acid, an enterohepatic drug. Scand. J. Gastroenterol. Suppl. 204, 1-15
    • (1994) Scand. J. Gastroenterol. Suppl. , vol.204 , pp. 1-15
    • Hofmann, A.F.1
  • 42
    • 0025876404 scopus 로고
    • A multicenter, controlled trial of ursodiol for the treatment of primary biliary cirrhosis. UDCA-PBC study group
    • Poupon, R. E., Balkau, B., Eschwège, E., and Poupon, R. (1991) A multicenter, controlled trial of ursodiol for the treatment of primary biliary cirrhosis. UDCA-PBC Study Group. N. Engl. J. Med. 324, 1548-1554
    • (1991) N. Engl. J. Med. , vol.324 , pp. 1548-1554
    • Poupon, R.E.1    Balkau, B.2    Eschwège, E.3    Poupon, R.4
  • 43
    • 84868698756 scopus 로고    scopus 로고
    • Ursodeoxycholic acid and bile-acid mimetics as therapeutic agents for cholestatic liver diseases: An overview of their mechanisms of action
    • Poupon, R. (2012) Ursodeoxycholic acid and bile-acid mimetics as therapeutic agents for cholestatic liver diseases: an overview of their mechanisms of action. Clin. Res. Hepatol. Gastroenterol. 36, S3-S12
    • (2012) Clin. Res. Hepatol. Gastroenterol. , vol.36 , pp. S3-S12
    • Poupon, R.1
  • 44
    • 84942878841 scopus 로고    scopus 로고
    • New paradigms in the treatment of hepatic cholestasis: From UDCA to FXR, PXR and beyond
    • Beuers, U, Trauner, M., Jansen, P., and Poupon, R. (2015) New paradigms in the treatment of hepatic cholestasis: from UDCA to FXR, PXR and beyond. J. Hepatol. 62, S25-37
    • (2015) J. Hepatol. , vol.62 , pp. S25-S37
    • Beuers, U.1    Trauner, M.2    Jansen, P.3    Poupon, R.4
  • 46
    • 0036241214 scopus 로고    scopus 로고
    • Taurolithocholic acid-3 sulfate induces CD95 trafficking and apoptosis in a c-jun N-terminal kinase-dependent manner
    • Graf, D., and Kurz., A. K., Fischer, R., Reinehr, R., and Häussinger, D. (2002) Taurolithocholic acid-3 sulfate induces CD95 trafficking and apoptosis in a c-Jun N-terminal kinase-dependent manner. Gastroenterology 122, 1411-1427
    • (2002) Gastroenterology , vol.122 , pp. 1411-1427
    • Graf, D.1    Kurz, A.K.2    Fischer, R.3    Reinehr, R.4    Häussinger, D.5
  • 47
    • 0036725044 scopus 로고    scopus 로고
    • Ursodeoxycholic acid in cholestatic liver disease: Mechanisms of action and therapeutic use revisited
    • Paumgartner, G., and Beuers, U (2002) Ursodeoxycholic acid in cholestatic liver disease: mechanisms of action and therapeutic use revisited. Hepatology 36, 525-531
    • (2002) Hepatology , vol.36 , pp. 525-531
    • Paumgartner, G.1    Beuers, U.2
  • 48
    • 84874487986 scopus 로고    scopus 로고
    • α5β1-integrins are sensors for tauroursodeoxycholic acid in hepatocytes
    • Gohlke, H., Schmitz, B., Sommerfeld, A., Reinehr, R., and Häussinger, D. (2013) α5β1-integrins are sensors for tauroursodeoxycholic acid in hepatocytes. Hepatology 57, 1117-1129
    • (2013) Hepatology , vol.57 , pp. 1117-1129
    • Gohlke, H.1    Schmitz, B.2    Sommerfeld, A.3    Reinehr, R.4    Häussinger, D.5
  • 49
    • 84930509242 scopus 로고    scopus 로고
    • Tauroursodeoxy-cholate protects rat hepatocytes from bile acid-induced apoptosis via β1-integrin- and protein kinase A-dependent mechanisms
    • Sommerfeld, A., Reinehr, R., and Häussinger, D. (2015) Tauroursodeoxy-cholate protects rat hepatocytes from bile acid-induced apoptosis via β1-integrin- and protein kinase A-dependent mechanisms. Cell Physiol. Biochem. 36, 866-883
    • (2015) Cell Physiol. Biochem. , vol.36 , pp. 866-883
    • Sommerfeld, A.1    Reinehr, R.2    Häussinger, D.3
  • 50
    • 0030829597 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases mediate the stimulation of bile acid secretion by tauroursodeoxycholate in rat liver
    • Schliess, F., and Kurz., A. K., vom Dahl, S., and Häussinger, D. (1997) Mitogen-activated protein kinases mediate the stimulation of bile acid secretion by tauroursodeoxycholate in rat liver. Gastroenterology 113, 1306-1314
    • (1997) Gastroenterology , vol.113 , pp. 1306-1314
    • Schliess, F.1    Kurz, A.K.2    Vom Dahl, S.3    Häussinger, D.4
  • 52
    • 84924326333 scopus 로고    scopus 로고
    • Interleukin 6 inhibits HBV entry through NTCP down regulation
    • Bouezzedine, F., Fardel, O., and Gripon, P. (2015) Interleukin 6 inhibits HBV entry through NTCP down regulation. Virology 481, 34-42
    • (2015) Virology , vol.481 , pp. 34-42
    • Bouezzedine, F.1    Fardel, O.2    Gripon, P.3
  • 53
    • 0036828271 scopus 로고    scopus 로고
    • Functional expression of the canalicular bile salt export pump of human liver
    • Noé, J., Stieger, B., and Meier, P. J. (2002) Functional expression of the canalicular bile salt export pump of human liver. Gastroenterology 123, 1659-1666
    • (2002) Gastroenterology , vol.123 , pp. 1659-1666
    • Noé, J.1    Stieger, B.2    Meier, P.J.3
  • 54
    • 0017869009 scopus 로고
    • The use of perfusion of liver and other organs for the study of microsomal electron-transport and cytochrome P-450 systems
    • Sies, H. (1978) The use of perfusion of liver and other organs for the study of microsomal electron-transport and cytochrome P-450 systems. Methods Enzymol. 52, 48-59
    • (1978) Methods Enzymol. , vol.52 , pp. 48-59
    • Sies, H.1
  • 55
    • 0016792015 scopus 로고
    • Role of anion translocation across the mitochondrial membrane in the regulation of urea synthesis from ammonia by isolated rat hepatocytes
    • Meijer, A. J., and Gimpel., J. A., Deleeuw, G. A., Tager, J. M., and Williamson, J. R. (1975) Role of anion translocation across the mitochondrial membrane in the regulation of urea synthesis from ammonia by isolated rat hepatocytes. J. Biol. Chem. 250, 7728-7738
    • (1975) J. Biol. Chem. , vol.250 , pp. 7728-7738
    • Meijer, A.J.1    Gimpel, J.A.2    Deleeuw, G.A.3    Tager, J.M.4    Williamson, J.R.5
  • 57
    • 33747357530 scopus 로고    scopus 로고
    • Endosomal acidification and activation of NADPH oxidase isoforms are upstream events in hyperosmolarity-induced hepatocyte apoptosis
    • Reinehr, R., Becker, S., Braun, J., Eberle, A., Grether-Beck, S., and Haüssinger, D. (2006) Endosomal acidification and activation of NADPH oxidase isoforms are upstream events in hyperosmolarity-induced hepatocyte apoptosis. J. Biol. Chem. 281, 23150-23166
    • (2006) J. Biol. Chem. , vol.281 , pp. 23150-23166
    • Reinehr, R.1    Becker, S.2    Braun, J.3    Eberle, A.4    Grether-Beck, S.5    Haüssinger, D.6
  • 58
    • 0030029143 scopus 로고    scopus 로고
    • Discovery of a novel, potent, and src family-selective tyrosine kinase inhibitor. Study of lck- and FynT-dependent T cell activation
    • Hanke, J. H., and Gardner., J. P., Dow, R. L., Changelian, P. S., Brissette, W. H., Weringer, E. J., Pollok, B. A., and Connelly, P. A. (1996) Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation. J. Biol. Chem. 271, 695-701
    • (1996) J. Biol. Chem. , vol.271 , pp. 695-701
    • Hanke, J.H.1    Gardner, J.P.2    Dow, R.L.3    Changelian, P.S.4    Brissette, W.H.5    Weringer, E.J.6    Pollok, B.A.7    Connelly, P.A.8
  • 59
    • 0034458943 scopus 로고    scopus 로고
    • SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling
    • Blake, R. A., and Broome., M. A., Liu, X., Wu, J., Gishizky, M., Sun, L., and Courtneidge, S. A. (2000) SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling. Mol. Cell. Biol. 20, 9018-9027
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 9018-9027
    • Blake, R.A.1    Broome, M.A.2    Liu, X.3    Wu, J.4    Gishizky, M.5    Sun, L.6    Courtneidge, S.A.7
  • 61
    • 0028566190 scopus 로고
    • Involvement of microtubules in the link between cell volume and pH of acidic cellular compartments in rat and human hepatocytes
    • Busch, G. L., Schreiber, R., Dartsch, P. C., Völkl, H., Vom Dahl, S., Häussinger, D., and Lang, F. (1994) Involvement of microtubules in the link between cell volume and pH of acidic cellular compartments in rat and human hepatocytes. Proc. Natl. Acad. Sci. U.S.A. 91, 9165-9169
    • (1994) Proc. Natl. Acad. Sci. U.S.A. , vol.91 , pp. 9165-9169
    • Busch, G.L.1    Schreiber, R.2    Dartsch, P.C.3    Völkl, H.4    Vom Dahl, S.5    Häussinger, D.6    Lang, F.7
  • 62
    • 84919363205 scopus 로고    scopus 로고
    • Metal ion and ligand binding of integrin α5β1
    • Xia, W., and Springer, T. A. (2014) Metal ion and ligand binding of integrin α5β1. Proc. Natl. Acad. Sci. U.S.A. 111, 17863-17868
    • (2014) Proc. Natl. Acad. Sci. U.S.A. , vol.111 , pp. 17863-17868
    • Xia, W.1    Springer, T.A.2
  • 64
    • 0034663645 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase-dependent ras activation by tauroursodesoxycholate in rat liver
    • Kurz, A. K., Block, C., Graf, D., Dahl, S. V., Schliess, F., and Häussinger, D. (2000) Phosphoinositide 3-kinase-dependent Ras activation by tauroursodesoxycholate in rat liver. Biochem. J. 350, 207-213
    • (2000) Biochem. J. , vol.350 , pp. 207-213
    • Kurz, A.K.1    Block, C.2    Graf, D.3    Dahl, S.V.4    Schliess, F.5    Häussinger, D.6
  • 65
    • 84935846641 scopus 로고    scopus 로고
    • Ionic imbalance, in addition to molecular crowding, abates cytoskeletal dynamics and vesicle motility during hypertonic stress
    • Nunes, P., Roth, I., Meda, P., Féraille, E., Brown, D., and Hasler, U. (2015) Ionic imbalance, in addition to molecular crowding, abates cytoskeletal dynamics and vesicle motility during hypertonic stress. Proc. Natl. Acad. Sci. U.S.A. 112, E3104-E3113
    • (2015) Proc. Natl. Acad. Sci. U.S.A. , vol.112 , pp. E3104-E3113
    • Nunes, P.1    Roth, I.2    Meda, P.3    Féraille, E.4    Brown, D.5    Hasler, U.6
  • 66
    • 0037389392 scopus 로고    scopus 로고
    • Hyperosmolarity and CD95L trigger CD95/EGF receptor association and tyrosine phosphorylation of CD95 as prerequisites for CD95 membrane trafficking and DISC formation
    • Reinehr, R., Schliess, F., and Häussinger, D. (2003) Hyperosmolarity and CD95L trigger CD95/EGF receptor association and tyrosine phosphorylation of CD95 as prerequisites for CD95 membrane trafficking and DISC formation. FASEBJ. 17, 731-733
    • (2003) FASEBJ , vol.17 , pp. 731-733
    • Reinehr, R.1    Schliess, F.2    Häussinger, D.3
  • 69
    • 37149046027 scopus 로고    scopus 로고
    • Obstructive cholestasis induces TNF-α- and IL-1-mediated periportal downregulation of bsep and zonal regulation of ntcp, oatp1a4, and oatp1b2
    • Donner, M. G., Schumacher, S., Warskulat, U., Heinemann, J., and Häussinger, D. (2007) Obstructive cholestasis induces TNF-α- and IL-1-mediated periportal downregulation of Bsep and zonal regulation of Ntcp, Oatp1a4, and Oatp1b2. Am. J. Physiol. Gastrointest. Liver Physiol. 293, G1134-G1146
    • (2007) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.293 , pp. G1134-G1146
    • Donner, M.G.1    Schumacher, S.2    Warskulat, U.3    Heinemann, J.4    Häussinger, D.5
  • 70
    • 63849136153 scopus 로고    scopus 로고
    • Protein kinase C isoforms: Multi-functional regulators of cell life and death
    • Reyland, M. E. (2009) Protein kinase C isoforms: Multi-functional regulators of cell life and death. Front. Biosci. 14, 2386-2399
    • (2009) Front. Biosci. , vol.14 , pp. 2386-2399
    • Reyland, M.E.1
  • 71
    • 84906795012 scopus 로고    scopus 로고
    • Role of protein kinase C isoforms in bile formation and cholestasis
    • Anwer, M. S. (2014) Role of protein kinase C isoforms in bile formation and cholestasis. Hepatology 60, 1090-1097
    • (2014) Hepatology , vol.60 , pp. 1090-1097
    • Anwer, M.S.1
  • 72
    • 84887583323 scopus 로고    scopus 로고
    • A dileucine motif is involved in plasma membrane expression and endocytosis of rat sodium taurocholate cotransporting polypeptide (Ntcp)
    • Stross, C, Kluge, S., Weissenberger, K., Winands, E., Häussinger, D., and Kubitz, R. (2013) A dileucine motif is involved in plasma membrane expression and endocytosis of rat sodium taurocholate cotransporting polypeptide (Ntcp). Am. J. Physiol. Gastrointest. Liver Physiol. 305, G722-G730
    • (2013) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.305 , pp. G722-G730
    • Stross, C.1    Kluge, S.2    Weissenberger, K.3    Winands, E.4    Häussinger, D.5    Kubitz, R.6
  • 73
    • 2442681520 scopus 로고    scopus 로고
    • Crosstalk between protein kinases Cζ and B in cyclic AMP-mediated sodium taurocholate co-transporting polypeptide translocation in hepatocytes
    • McConkey, M., Gillin, H., Webster, C. R., and Anwer, M. S. (2004) Crosstalk between protein kinases Cζ and B in cyclic AMP-mediated sodium taurocholate co-transporting polypeptide translocation in hepatocytes. J. Biol. Chem. 279, 20882-20888
    • (2004) J. Biol. Chem. , vol.279 , pp. 20882-20888
    • McConkey, M.1    Gillin, H.2    Webster, C.R.3    Anwer, M.S.4
  • 74
    • 33745757459 scopus 로고    scopus 로고
    • PKCζ is required for microtubule-based motility of vesicles containing the ntcp transporter
    • Sarkar, S., Bananis, E., Nath, S., Anwer, M. S., Wolkoff, A. W., and Murray, J. W. (2006) PKCζ is required for microtubule-based motility of vesicles containing the ntcp transporter. Traffic 7, 1078-1091
    • (2006) Traffic , vol.7 , pp. 1078-1091
    • Sarkar, S.1    Bananis, E.2    Nath, S.3    Anwer, M.S.4    Wolkoff, A.W.5    Murray, J.W.6
  • 75
    • 0032985843 scopus 로고    scopus 로고
    • Modulation of protein kinase C by taurolithocholic acid in isolated rat hepatocytes
    • Beuers, U., Probst, I., Soroka, C, and Boyer., J. L., Kullak-Ublick, G. A., and Paumgartner, G. (1999) Modulation of protein kinase C by taurolithocholic acid in isolated rat hepatocytes. Hepatology 29, 477-482
    • (1999) Hepatology , vol.29 , pp. 477-482
    • Beuers, U.1    Probst, I.2    Soroka, C.3    Boyer, J.L.4    Kullak-Ublick, G.A.5    Paumgartner, G.6
  • 76
    • 84879607738 scopus 로고    scopus 로고
    • Taurolithocholate-induced MRP2 retrieval involves MARCKS phosphorylation by protein kinase C in HUH-NTCP cells
    • Schonhoff, C. M., and Webster., C. R., and Anwer, M. S. (2013) Taurolithocholate-induced MRP2 retrieval involves MARCKS phosphorylation by protein kinase C in HUH-NTCP cells. Hepatology 58, 284-292
    • (2013) Hepatology , vol.58 , pp. 284-292
    • Schonhoff, C.M.1    Webster, C.R.2    Anwer, M.S.3
  • 79
    • 84865788352 scopus 로고    scopus 로고
    • Protein kinase cdelta differentially regulates cAMP-dependent translocation of NTCP and MRP2 to the plasma membrane
    • Park, S. W., and Schonhoff., C. M., Webster, C. R., and Anwer, M. S. (2012) Protein kinase Cdelta differentially regulates cAMP-dependent translocation of NTCP and MRP2 to the plasma membrane. Am. J. Physiol. Gastrointest. Liver Physiol. 303, G657-G665
    • (2012) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.303 , pp. G657-G665
    • Park, S.W.1    Schonhoff, C.M.2    Webster, C.R.3    Anwer, M.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.