Endosomal acidification and activation of NADPH oxidase isoforms are upstream events in hyperosmolarity-induced hepatocyte apoptosis

Journal of Biological Chemistry

Volumn 281, Issue 32, 2006, Pages 23150-23166

  Reinehr, Roland ^a   Becker, Stephan ^a   Braun, Juliane ^a   Eberle, Andrea ^a   Grether Beck, Susanne ^b   Häussinger, Dieter ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b IUF LEIBNIZ RESEARCH INSTITUTE FOR ENVIRONMENTAL MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDITY; BIOCHEMISTRY; CELL MEMBRANES; DISEASES; EPIDEMIOLOGY; MOLECULAR BIOLOGY;

PHOSPHORYLATION; RAPID OXIDATIVE STRESS (ROS); SPHINGOMYELINASES;

ENZYMES;

BAFILOMYCIN; CERAMIDE; DEXTRAN; DIHYDRO 4,4' DIISOTHIOCYANO 2,2' STILBENEDISULFONIC ACID; EPIDERMAL GROWTH FACTOR RECEPTOR; FAS ANTIGEN; FLUORESCEIN ISOTHIOCYANATE; GLYCOPROTEIN GP 91; PROTEIN P47; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SERINE; SPHINGOMYELIN PHOSPHODIESTERASE; STRESS ACTIVATED PROTEIN KINASE;

ACIDIFICATION; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL MEMBRANE; ENDOSOME; HYPEROSMOLARITY; KNOCKOUT MOUSE; LIVER CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGENS, CD95; APOPTOSIS; CERAMIDES; ENDOSOMES; HEPATOCYTES; MALE; MICE; MICE, INBRED C57BL; NADPH OXIDASE; OXIDATIVE STRESS; PHOSPHORYLATION; PROTEIN ISOFORMS; PROTEIN KINASE C; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES;

EID: 33747357530     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M601451200     Document Type: Article

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