Impaired activity of the bile canalicular organic anion transporter (Mrp2/cmoat) is not the main cause of ethinylestradiol-induced cholestasis in the rat

Hepatology

Volumn 27, Issue 2, 1998, Pages 537-545

  Koopen, Nynke R ^a   Wolters, Henk ^a   Havinga, Rick ^a   Vonk, Roel J ^a   Jansen, Peter L M ^b   Müller, Michael ^b   Kuipers, Folkert ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BILE SALT; BILIRUBIN; CARRIER PROTEIN; ETHINYLESTRADIOL; TAUROCHOLIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANION TRANSPORT; ARTICLE; BILE FLOW; BILE SECRETION; BILIRUBIN BLOOD LEVEL; CHOLESTASIS; CONTROLLED STUDY; INTRAHEPATIC BILE DUCT; LIVER CELL MEMBRANE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANION TRANSPORT PROTEINS; BILE; BILE ACIDS AND SALTS; BILIRUBIN; BLOTTING, WESTERN; BODY WEIGHT; CARRIER PROTEINS; CELL MEMBRANE; CHOLESTASIS; ESTRADIOL CONGENERS; ETHINYL ESTRADIOL; LIPIDS; LIVER; MALE; MEMBRANE TRANSPORT PROTEINS; ORGAN SIZE; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; RATS; RATS, MUTANT STRAINS; RATS, WISTAR; SYMPORTERS; TIME FACTORS;

EID: 0031938026     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510270231     Document Type: Article

References (11)

1. Gumucio JJ, Valdivieso VD. Studies on the mechanism of the ethinylestradiol impairment of bile flow and bile salt secretion in the rat. Gastroenterology 1971;61:334-339.
2. Kreek MJ. Female sex steroids and cholestasis. Semin Liver Dis 1987;7:8-13.
3. Forker EL. The effect of estrogen on bile formation in the rat. J Clin Invest 1969;48:654-663.
4. Iqbal S, Mills CO, Elias E. Biliary permeability during ethinyl estradiol-induced cholestasis studied by segmented retrograde intrabiliary injections in rats. J Hepatol 1985;1:211-219.
5. + ATPase and bile flow by estrogen: effects on liver surface membrane lipid structure and function. Proc Natl Acad Sci U S A 1978;75:4130-4134.
6. + pump function of rat hepatocytes. Am J Physiol 1984;274:G437-G443.
7. Rosario J, Sutherland E, Zaccaro L, Simon FR. Ethinylestradiol administration selectively alters sinusoidal membrane lipid fluidity and protein composition. Biochemistry 1988;27:3939-3946.
8. Vore M. Estrogen cholestasis membranes, metabolites, or receptors? Gastroenterology 1987;93:643-649.
9. Jaeschke H, Trummer E, Krell H. Increase in biliary permeability subsequent to intrahepatic cholestasis by estradiol valerate in rats. Gastroenterology 1987;93:533-538.
10. Boelsterli UA, Rahkit G, Balazs T. Modulation by S-adenosyl methionine of hepatic Na K ATPase, membrane fluidity, and bile flow in rats with ethinyl estradiol-induced cholestasis. HEPATOLOGY 1983;3:12-17.
11. Smith DJ, Gordon ER. Role of liver plasma membrane fluidity in the pathogenesis of estrogen-induced cholestasis. J Lab Clin Med 1988;112:685-697.