Protein kinase Cδ differentially regulates cAMP-dependent translocation of NTCP and MRP2 to the plasma membrane

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 303, Issue 5, 2012, Pages

  Park, Se Won ^a   Schonhoff, Christopher M ^a   Webster, Cynthia R L ^a   Sawkat Anwer, M ^a  

^a TUFTS UNIVERSITY   (United States)

Author keywords

DN PKC ; HuH NTCP cells; Rab4; SiRNA PKC

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CARRIER PROTEIN; CYCLIC AMP; MULTIDRUG RESISTANCE PROTEIN 2; PROTEIN KINASE C DELTA; PROTEIN SODIUM TAUROCHOLATE COTRANSPORTING POLYPEPTIDE; RAB PROTEIN; ROTTLERIN; SMALL INTERFERING RNA; TAUROCHOLIC ACID; UNCLASSIFIED DRUG;

ARTICLE; CELL LINE; CELL MEMBRANE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME LOCALIZATION; ENZYME REGULATION; GENE OVEREXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; WILD TYPE;

CELL CULTURE TECHNIQUES; CELL MEMBRANE; CYCLIC AMP; GENE EXPRESSION REGULATION; HUMANS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; PROTEIN KINASE C-DELTA; PROTEIN TRANSPORT; RAB4 GTP-BINDING PROTEINS; SYMPORTERS;

EID: 84865788352     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00529.2011     Document Type: Article

References (41)

1. Anwer MS. Cellular regulation of hepatic bile acid transport in health and cholestasis. Hepatology 39: 581-590, 2004.
2. cdc2. Nature 350: 715-718, 1991.
3. Alvi F, Idkowiak-Baldys J, Baldys A, Raymond JR, Hannun YA. Regulation of membrane trafficking and endocytosis by protein kinase C: emerging role of the pericentrion, a novel protein kinase C-dependent subset of recycling endosomes. Cell Mol Life Sci 64: 263-270, 2007.
4. Awayda MS. Specific and nonspecific effects of protein kinase C on the epithelial Na (+) channel. J Gen Physiol 115: 559-570, 2000.
5. Becker KP, Hannun YA. cPKC-dependent sequestration of membranerecycling components in a subset of recycling endosomes. J Biol Chem 278: 52747-52754, 2003.
6. Doucet JP, Tuana BS. Identification of low molecular weight GTPbinding proteins and their istes of interaction in subcellular fractions from skeletal muscle. J Biol Chem 266: 17613-17620, 1991.
7. Duquesnes N, Lezoualc'h F, Crozatier B. PKC-delta and PKC-epsilon: foes of the same family or strangers? J Mol Cell Cardiol 51: 665, 2011.
8. Farese RV, Sajan MP, Standaert ML. Atypical protein kinase C in insulin action and insulin resistance. Biochem Soc Trans 33: 350-353, 2005.
9. Fitzerald ML, Guy L, Reed GL. Rab6 is phosphorylated in thrombinactivated platelets by a protein kinase C-dependent mechanism: effects on GTP/GDP binding and cellular distribution. Biochem J 342: 353-360, 1999.
10. Formisano P, Oriente F, Fiory F, Caruso M, Miele C, Maitan MA, Andreozzi F, Vigliotta G, Condorelli G, Beguinot F. Insulin-activated protein kinase Cβ bypasses Ras and stimulates mitogen-activated protein kinase activity and cell proliferation in muscle cells. Mol Cell Biol 20: 6323-6333, 2000.
11. Gerez L, Mohrmann K, van Raak M, Jongeneelen M, Zhou XZ, Lu KP, van der Sluijs P. Accumulation of rab4GTP in the cytoplasm and association with the peptidyl-prolyl isomerase Pin1 during mitosis. Mol Biol Cell 11: 2201-2211, 2000.
12. Goerke A, Sakai N, Gutjahr E, Schlapkohl WA, Mushinski JF, Haller H, Kolch W, Saito N, Mischak H. Induction of apoptosis by protein kinase C delta is independent of its kinase activity. J Biol Chem 277: 32054-32062, 2002.
13. Griffin M, Casadio R, Bergamini CM. Transglutaminases: nature's biological glues. Biochem J 368: 377-396, 2002.
14. Gromov PS, Celis JE. Several small GTP-binding proteins are strongly down-regulated in simian virus 40 (SV40) transformed human keratinocytes and may be required for the maintenance of the normal phenotype. Eletrophoresis 15: 474-481, 1994.
15. +/taurocholate cotransport by cyclic AMP. J Biol Chem 268: 17734-17741, 1993.
16. Gschwendt M, Muller HJ, Kielbassa K, Zang R, Kittstein W, Rincke G, Marks F. Rottlerin, a novel protein kinase inhibitor. Biochem Biophys Res Commun 199: 93-98, 1994.
17. Guo J, Cong L, Rybin VO, Gertsberg Z, Steinberg SF. Protein kinase C-δ regulates that subcellular localization of Shc in H2O2-treated cardiomyocytes. Am J Physiol Cell Physiol 299: C770-C778, 2010.
18. Imamura T, Huang J, Usui I, Satoh H, Bever J, Olefsky JM. Insulininduced GLUT4 translocation involves protein kinase C-λ-mediated functional coupling between Rab4 and the motor protein kinesin. Mol Cell Biol 23: 4892-4900, 2003.
19. Kayali AG, Austin DA, Webster NJ. Rottlerin inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes by uncoupling mitochondrial oxidative phosphorylation. Endocrinology 143: 3884-3896, 2002.
20. Li W, Yu JC, Shin DY, Piece JH. Characterization of a PKC δ ATP binding mutant. J Biol Chem 270: 8311-8318, 1995.
21. Loder MK, Melikian HE. The dopamine transporter constitutively internalizes and recycles in a protein kinase C-regulated manner in stably transfected PC12 cell lines. J Biol Chem 278: 22168-22174, 2003.
22. Lowry DH, Rosenberg NJ, Farr AL, Randall RJ. Protein measurement with folin phenol reagent. J Biol Chem 193: 265-275, 1951.
23. McCaffrey MW, Bielli A, Cantalupo G, Mora S, Roberti V, Santillo M, Drummond F, Bucci C. Rab4 affects both recycling and degradative endosomal trafficking. FEBS Lett 495: 21-30, 2001.
24. McConkey M, Gillin H, Webster CRL, Anwer MS. Cross-talk between protein kinases Cζ and B in cyclic AMP-mediated sodium taurocholate co-transporting polypeptide translocation in hepatocytes. J Biol Chem 279: 20882-20888, 2004.
25. McGrath JP, Capon DJ, Goeddel DV, Levinson AD. Comparative biochemical properties of normal and activated human ras p21 protein. Nature 310: 644-649, 1984.
26. +-taurocholate cotransport by translocating transporter to plasma membranes. Am J Physiol Gastrointest Liver Physiol 273: G842-G848, 1997.
27. Ohno S, Konno Y, Akita Y, Yno A, Suzuki K. A point mutation at the putative ATP-binding site of protein kinase C alpha abolishes the kinase activity and renders it down-regulation-insensitive. A molecular link between autophosphorylation and down-regulation. J Biol Chem 265: 6296-6300, 1990.
28. Oka M, Okada T, Nakamura S, Ohba M, Kuroki T, Kikkawa U, Nagai H, Ichihashi M, Nishigori C. PKCδ inhibits PKCα -mediated activation of phospholipase D1 in a manner independent of its protein kinase activity. FEBS Lett 554: 179-184, 2003.
29. Pylypenko O, Goud B. Posttranslational modifications of Rab GTPases help their insertion into membranes. Proc Natl Acad Sci USA 109: 5555-5556, 2012.
30. Roelofsen H, Soroka CJ, Keppler D, Boyer JL. Cyclic AMP stimulates sorting of the canalicular organic anion transporter (Mrp2/cMoat) to the apical domain in hepatocyte couplets. J Cell Sci 111: 1137-1145, 1998.
31. Sarkar S, Bananis E, Nath S, Anwer MS, Wolkoff AW, Murray JW. PKCζ Is required for microtubule-based motility of vesicles containing the ntcp transporter. Traffic 7: 1078-1091, 2006.
32. Saxena S, Singh M, Shibata H, Kaur S, George C. Rab4 GTP/GDP modulates amiloride-sensitive sodium channel (EnaC) function in colonic epithelia. Biochem Biophys Res Commun 340: 726-733, 2006.
33. Schonhoff CM, Gillin H, Webster CRL, Anwer MS. Protein kinase Cδ mediates cyclic adenosine monophosphate- stimulated translocation of sodium taurocholate cotransporting polypeptide and multidrug resistant associated protein 2 in rat hepatocytes. Hepatology 47: 1309-1316, 2008.
34. +taurocholate cotrnasporting polypeptide translocation. Hepatology 48: 1665-1670, 2008.
35. Slotoff SP. Rottlerin is a mitochondrial uncoupler that decreases cellular ATP levels and indirectly block protein kinase C delta tyrosine phosphorylation. J Biol Chem 276: 37986-37992, 2001.
36. Soh JW, Lee EH, Prywes R, Weinstein IB. Novel roles of specific isoforms of protein kinase C in activation of the c-fos serum response element. Mol Cell Biol 19: 1313-1324, 1999.
37. Tapia JA, Garcia-Marin LJ, Jensen RT. Cholecystokinin-stimulated protein kinase C δ kinase activation, tyrosine phosphorylation, and translocation are mediated by Src tyrosine kinases in pancreatic acinar cells. J Biol Chem 278: 35220-35230, 2003.
38. Trauner M, Boyer JL. Bile salt transporters: molecular characterization, function, and regulation. Physiol Rev 83: 633-671, 2003.
39. van der Sluijs P, Hull M, Huber LA, Male P, Goud B, Mellman I. Reversible phosphorylation-dephosphorylation determines the localization of rab4 during the cell cycle. EMBO J 11:4379-89, 1992.
40. Walther DJ, Peter JU, Winter S, ltje MH, Paulmann N, Grohmann M, Vowinckel J, Alamo-Bethencourt V, Wilhelm CS, Ahnert-Hilger G, Bader M. Serotonylation of small GTPases is a signal transduction pathway that triggers platelet α-granule release. Cell 115: 851-862, 2003.
41. +taurocholate cotransport and Ntcp translocation. J Biol Chem 277: 28578-83, 2002.