메뉴 건너뛰기




Volumn 19, Issue 4, 2015, Pages 194-205

Effects of peptone supplementation in different culture media on growth, metabolic pathway and productivity of CHO DG44 cells; a new insight into amino acid profiles

Author keywords

CHO cells; Culture media; Peptones; Recombinant proteins

Indexed keywords

AMINO ACID; PEPTONE; PROTEIN HYDROLYSATE; CULTURE MEDIUM;

EID: 84943242732     PISSN: 1028852X     EISSN: None     Source Type: Journal    
DOI: 10.7508/ibj.2015.04.002     Document Type: Article
Times cited : (27)

References (46)
  • 1
    • 18344416903 scopus 로고    scopus 로고
    • The use of peptones as medium additives for the production of a recombinant therapeutic protein in high density perfusion cultures of mammalian cells
    • Heidemann R, Zhang C, Qi H, Larrick RJ, Rozales C, Park S et al. The use of peptones as medium additives for the production of a recombinant therapeutic protein in high density perfusion cultures of mammalian cells. Cytotechnology. 2000 Feb; 32(2):157-67.
    • (2000) Cytotechnology , vol.32 , Issue.2 , pp. 157-167
    • Heidemann, R.1    Zhang, C.2    Qi, H.3    Larrick, R.J.4    Rozales, C.5    Park, S.6
  • 2
    • 0032618453 scopus 로고    scopus 로고
    • Safety issues of animal products used in serum-free media
    • Merten OW. Safety issues of animal products used in serum-free media. Dev Biol Stand. 1999; 99:167-80.
    • (1999) Dev Biol Stand , vol.99 , pp. 167-180
    • Merten, O.W.1
  • 3
    • 33750370939 scopus 로고    scopus 로고
    • Usability of sizeexcluded fractions of soy protein hydrolysates for growth and viability of Chinese hamster ovary cells in protein-free suspension culture
    • Chun BH, Kim JH, Lee HJ, Chung N. Usability of sizeexcluded fractions of soy protein hydrolysates for growth and viability of Chinese hamster ovary cells in protein-free suspension culture. Bioresour Technol. 2007 Mar; 98(5):1000-5.
    • (2007) Bioresour Technol , vol.98 , Issue.5 , pp. 1000-1005
    • Chun, B.H.1    Kim, J.H.2    Lee, H.J.3    Chung, N.4
  • 4
    • 1242292973 scopus 로고    scopus 로고
    • Yeast hydrolysate as a low-cost additive to serum-free medium for the production of human thrombopoietin in suspension cultures of Chinese hamster ovary cells
    • Sung YH, Lim SW, Chung JY, Lee GM. Yeast hydrolysate as a low-cost additive to serum-free medium for the production of human thrombopoietin in suspension cultures of Chinese hamster ovary cells. Appl Microbiol Biotechnol. 2004 Feb; 63(5):527-36.
    • (2004) Appl Microbiol Biotechnol , vol.63 , Issue.5 , pp. 527-536
    • Sung, Y.H.1    Lim, S.W.2    Chung, J.Y.3    Lee, G.M.4
  • 5
    • 0034281499 scopus 로고    scopus 로고
    • Plant protein hydrolysates. Preparation of defined peptide fractions promoting growth and production in animal cells cultures. Biotechnol Prog
    • Franek F, Hohenwarter O, Katinger H. Plant protein hydrolysates. Preparation of defined peptide fractions promoting growth and production in animal cells cultures. Biotechnol Prog. 2000 Sep-Oct; 16(5):688-92.
    • (2000) Sep-Oct , vol.16 , Issue.5 , pp. 688-692
    • Franek, F.1    Hohenwarter, O.2    Katinger, H.3
  • 6
    • 0141867826 scopus 로고    scopus 로고
    • Large-scale transient transfection of serum-free suspension-growing HEK293 EBNA1 cells: Peptone additives improve cell growth and transfection efficiency
    • Pham PL, Perret S, Doan HC, Cass B, St-Laurent G, Kamen A et al. Large-scale transient transfection of serum-free suspension-growing HEK293 EBNA1 cells: peptone additives improve cell growth and transfection efficiency. Biotechnol Bioeng. 2003 Nov; 84(3):332-42.
    • (2003) Biotechnol Bioeng , vol.84 , Issue.3 , pp. 332-342
    • Pham, P.L.1    Perret, S.2    Doan, H.C.3    Cass, B.4    St-Laurent, G.5    Kamen, A.6
  • 7
    • 34247598802 scopus 로고    scopus 로고
    • Effect of bioactive peptides isolated from yeastolate, lactalbumin and NZCase in the insect cell growth
    • Mendonca RZ, de Oliveira EC, Pereira CA, Lebrun I. Effect of bioactive peptides isolated from yeastolate, lactalbumin and NZCase in the insect cell growth. Bioprocess Biosyst Eng. 2007 May; 30(3):157-64.
    • (2007) Bioprocess Biosyst Eng , vol.30 , Issue.3 , pp. 157-164
    • Mendonca, R.Z.1    De Oliveira, E.C.2    Pereira, C.A.3    Lebrun, I.4
  • 8
    • 20344377891 scopus 로고    scopus 로고
    • Transient gene expression in HEK293 cells: Peptone addition posttransfection improves recombinant protein synthesis
    • Pham PL, Perret S, Cass B, Carpentier E, St-Laurent G, Bisson L et al.: Transient gene expression in HEK293 cells: peptone addition posttransfection improves recombinant protein synthesis. Biotechnol Bioeng 2005, 90: 332-4.
    • (2005) Biotechnol Bioeng , vol.90 , pp. 332-334
    • Pham, P.L.1    Perret, S.2    Cass, B.3    Carpentier, E.4    St-Laurent, G.5    Bisson, L.6
  • 9
    • 0037277639 scopus 로고    scopus 로고
    • Enhancement of monoclonal antibody production by lysine-containing peptides
    • Jan-Feb
    • Franek F, Eckschlager T, Katinger H. Enhancement of monoclonal antibody production by lysine-containing peptides. Biotechnol Prog. 2003 Jan-Feb; 19(1):169-74.
    • (2003) Biotechnol Prog , vol.19 , Issue.1 , pp. 169-174
    • Franek, F.1    Eckschlager, T.2    Katinger, H.3
  • 10
    • 0030583232 scopus 로고    scopus 로고
    • The protein hydrolysate, Primatone RL, is a cost-effective multiple growth promoter of mammalian cell culture in serum-containing and serumfree media and displays anti-apoptosis properties
    • Schlaeger EJ. The protein hydrolysate, Primatone RL, is a cost-effective multiple growth promoter of mammalian cell culture in serum-containing and serumfree media and displays anti-apoptosis properties. J Immunol Methods. 1996 Aug; 194(2):191-9.
    • (1996) J Immunol Methods , vol.194 , Issue.2 , pp. 191-199
    • Schlaeger, E.J.1
  • 11
    • 84886771024 scopus 로고    scopus 로고
    • Application of statistical techniques for elucidating flow cytometric data of batch and fed-batch cultures
    • Shirsat N, Avesh M, English NJ, Glennon B, Al-Rubeai M. Application of statistical techniques for elucidating flow cytometric data of batch and fed-batch cultures. Biotechnol Appl Biochem. 2013 Sep-Oct; 60(5):536-45.
    • (2013) Biotechnol Appl Biochem , vol.60 , Issue.5 , pp. 536-545
    • Shirsat, N.1    Avesh, M.2    English, N.J.3    Glennon, B.4    Al-Rubeai, M.5
  • 12
    • 84873323391 scopus 로고    scopus 로고
    • Fed-batch CHO cell t-PA production and feed glutamine replacement to reduce ammonia production
    • Kim do Y, Chaudhry MA, Kennard ML, Jardon MA, Braasch K, Dionne B et al. Fed-batch CHO cell t-PA production and feed glutamine replacement to reduce ammonia production. Biotechnol Prog. 2013 Jan-Feb; 29(1):165-75.
    • (2013) Biotechnol Prog , vol.29 , Issue.1 , pp. 165-175
    • Kim Do, Y.1    Chaudhry, M.A.2    Kennard, M.L.3    Jardon, M.A.4    Braasch, K.5    Dionne, B.6
  • 13
    • 84881165507 scopus 로고    scopus 로고
    • Combination of yeast hydrolysates to improve CHO cell growth and IgG production
    • Mosser M, Chevalot I, Olmos E, Blanchard F, Kapel R, Oriol E et al. Combination of yeast hydrolysates to improve CHO cell growth and IgG production. Cytotechnology. 2013 Aug; 65(4):629-41.
    • (2013) Cytotechnology , vol.65 , Issue.4 , pp. 629-641
    • Mosser, M.1    Chevalot, I.2    Olmos, E.3    Blanchard, F.4    Kapel, R.5    Oriol, E.6
  • 14
    • 79952573871 scopus 로고    scopus 로고
    • Proteomic understanding of intracellular responses of recombinant Chinese hamster ovary cells cultivated in serum-free medium supplemented with hydrolysates
    • Kim JY, Kim YG, Han YK, Choi HS, Kim YH, Lee GM. Proteomic understanding of intracellular responses of recombinant Chinese hamster ovary cells cultivated in serum-free medium supplemented with hydrolysates. Appl Microbiol Biotechnol. 2011 MAr; 89(6):1917-28.
    • (2011) Appl Microbiol Biotechnol , vol.89 , Issue.6 , pp. 1917-1928
    • Kim, J.Y.1    Kim, Y.G.2    Han, Y.K.3    Choi, H.S.4    Kim, Y.H.5    Lee, G.M.6
  • 15
    • 84876491458 scopus 로고    scopus 로고
    • Rational development of a serum-free medium and fed-batch process for a GS-CHO cell line expressing recombinant antibody
    • Zhang H, Wang HF, Liu MF, Zhang TF, Zhang JF, Wang XF et al. Rational development of a serum-free medium and fed-batch process for a GS-CHO cell line expressing recombinant antibody. Cytotechnology. 2013 May; 65(3):363-78.
    • (2013) Cytotechnology , vol.65 , Issue.3 , pp. 363-378
    • Zhang, H.1    Wang, H.F.2    Liu, M.F.3    Zhang, T.F.4    Zhang, J.F.5    Wang, X.F.6
  • 17
    • 84876959581 scopus 로고    scopus 로고
    • Advances in mammalian cell line development technologies for recombinant protein production
    • Lai T, Yang Y, Kong S. Advances in mammalian cell line development technologies for recombinant protein production. Pharmaceuticals (Basel). 2013; 6(5):579-603.
    • (2013) Pharmaceuticals (Basel) , vol.6 , Issue.5 , pp. 579-603
    • Lai, T.1    Yang, Y.2    Kong, S.3
  • 19
    • 79953249519 scopus 로고    scopus 로고
    • Increase in efficiency of media utilization for recombinant protein production in Chinese hamster ovary culture through dilution. Biotechnol Appl Biochem
    • Thombre S, Gadgil M. Increase in efficiency of media utilization for recombinant protein production in Chinese hamster ovary culture through dilution. Biotechnol Appl Biochem. 2011 Jan-Feb; 58(1):25-31.
    • (2011) Jan-Feb , vol.58 , Issue.1 , pp. 25-31
    • Thombre, S.1    Gadgil, M.2
  • 20
    • 84856559861 scopus 로고    scopus 로고
    • Controlled release of nutrients to mammalian cells cultured in shake flasks. Biotechnol Prog
    • Hegde S, Pant T, Pradhan K, Badiger M, Gadgil M. Controlled release of nutrients to mammalian cells cultured in shake flasks. Biotechnol Prog. 2012 Jan-Feb; 28(1):188-95.
    • (2012) Jan-Feb , vol.28 , Issue.1 , pp. 188-195
    • Hegde, S.1    Pant, T.2    Pradhan, K.3    Badiger, M.4    Gadgil, M.5
  • 21
    • 79751491703 scopus 로고    scopus 로고
    • A novel variant of t-PA resistant to plasminogen activator inhibitor-1; expression in CHO cells based on in silico experiments
    • Davami F, Sardari S, Majidzadeh AK, Hemayatkar M, Barkhordari F, Enayati S et al. A novel variant of t-PA resistant to plasminogen activator inhibitor-1; expression in CHO cells based on in silico experiments. BMB Rep. 2011 Jan; 44(1):34-9.
    • (2011) BMB Rep , vol.44 , Issue.1 , pp. 34-39
    • Davami, F.1    Sardari, S.2    Majidzadeh, A.K.3    Hemayatkar, M.4    Barkhordari, F.5    Enayati, S.6
  • 23
    • 84855223748 scopus 로고    scopus 로고
    • Combined TGE-SGE expression of novel PAI-1-resistant t-PA in CHO DG44 cells using orbitally shaking disposable bioreactors
    • Davami F, Barkhordari F, Alebouyeh M, Adeli A, Mahboudi F. Combined TGE-SGE expression of novel PAI-1-resistant t-PA in CHO DG44 cells using orbitally shaking disposable bioreactors. J Microbiol Biotechnol. 2011 Dec; 21(12):1299-305.
    • (2011) J Microbiol Biotechnol , vol.21 , Issue.12 , pp. 1299-1305
    • Davami, F.1    Barkhordari, F.2    Alebouyeh, M.3    Adeli, A.4    Mahboudi, F.5
  • 24
    • 14244252530 scopus 로고    scopus 로고
    • Orbital shaker technology for the cultivation of mammalian cells in suspension
    • Muller N, Girard P, Hacker DL, Jordan M, Wurm FM. Orbital shaker technology for the cultivation of mammalian cells in suspension. Biotechnol Bioeng. 2005 Feb; 89(4):400-6.
    • (2005) Biotechnol Bioeng , vol.89 , Issue.4 , pp. 400-406
    • Muller, N.1    Girard, P.2    Hacker, D.L.3    Jordan, M.4    Wurm, F.M.5
  • 25
    • 33748996938 scopus 로고    scopus 로고
    • New disposable tubes for rapid and precise biomass assessment for suspension cultures of mammalian cells
    • Stettler M, Jaccard N, Hacker D, De JM, Wurm FM, Jordan M. New disposable tubes for rapid and precise biomass assessment for suspension cultures of mammalian cells. Biotechnol Bioeng. 2006 Dec; 95(6): 1228-33.
    • (2006) Biotechnol Bioeng , vol.95 , Issue.6 , pp. 1228-1233
    • Stettler, M.1    Jaccard, N.2    Hacker, D.3    De, J.M.4    Wurm, F.M.5    Jordan, M.6
  • 26
    • 0003443846 scopus 로고
    • 2nd. Edn., Academic Press, London, Academic Press
    • Bergmeyer HU. Methods of Enzymatic Analysis. 2nd. Edn., Academic Press, London, Academic Press; 1974, pp: 574-9.
    • (1974) Methods of Enzymatic Analysis , pp. 574-579
    • Bergmeyer, H.U.1
  • 27
    • 0033811042 scopus 로고    scopus 로고
    • Examination of four different instruments for measuring blood lactate concentration
    • Medbo JI, Mamen A, Holt Olsen O, Evertsen F. Examination of four different instruments for measuring blood lactate concentration. Scand J Clin Lab Invest. 2000 Aug; 60(5):367-80.
    • (2000) Scand J Clin Lab Invest , vol.60 , Issue.5 , pp. 367-380
    • Medbo, J.I.1    Mamen, A.2    Holt Olsen, O.3    Evertsen, F.4
  • 28
    • 23844433927 scopus 로고    scopus 로고
    • Animal cell cultures: Recent achievements and perspectives in the production of biopharmaceuticals
    • Butler M. Animal cell cultures: recent achievements and perspectives in the production of biopharmaceuticals. Appl Microbiol Biotechnol. 2005 Aug; 68(3):283-91.
    • (2005) Appl Microbiol Biotechnol , vol.68 , Issue.3 , pp. 283-291
    • Butler, M.1
  • 29
    • 67349115980 scopus 로고    scopus 로고
    • Development of serum-free medium supplemented with hydrolysates for the production of therapeutic antibodies in CHO cell cultures using design of experiments
    • Kim SH, Lee GM. Development of serum-free medium supplemented with hydrolysates for the production of therapeutic antibodies in CHO cell cultures using design of experiments. Appl Microbiol Biotechnol. 2009 June, 83: 639-48.
    • (2009) Appl Microbiol Biotechnol , vol.83 , pp. 639-648
    • Kim, S.H.1    Lee, G.M.2
  • 30
    • 85016253378 scopus 로고    scopus 로고
    • Peptone Supplementation of Culture Medium Has Variable Effects on the Productivity of CHO Cells
    • Davami F, Baldi L, Rajendra Y, Wurm M. Peptone Supplementation of Culture Medium Has Variable Effects on the Productivity of CHO Cells. Int J Mol Cell Med. 2014, 3: 146-56.
    • (2014) Int J Mol Cell Med , vol.3 , pp. 146-156
    • Davami, F.1    Baldi, L.2    Rajendra, Y.3    Wurm, M.4
  • 32
    • 1042265424 scopus 로고    scopus 로고
    • Fortification of a protein-free cell culture medium with plant peptones improves cultivation and productivity of an interferon-gammaproducing CHO cell line
    • Burteau CC, Verhoeye FR, Mols JF, Ballez JS, Agathos SN, Schneider YJ. Fortification of a protein-free cell culture medium with plant peptones improves cultivation and productivity of an interferon-gammaproducing CHO cell line. In vitro Cell Dev Biol Anim. 2003 Jul-Aug; 39(7):291-6.
    • (2003) In Vitro Cell Dev Biol Anim , vol.39 , Issue.7 , pp. 291-296
    • Burteau, C.C.1    Verhoeye, F.R.2    Mols, J.F.3    Ballez, J.S.4    Agathos, S.N.5    Schneider, Y.J.6
  • 33
    • 3042658437 scopus 로고    scopus 로고
    • Gluten of spelt wheat (Triticum aestivum subspecies spelta) as a source of peptides promoting viability and product yield of mouse hybridoma cell cultures
    • Franek F. Gluten of spelt wheat (Triticum aestivum subspecies spelta) as a source of peptides promoting viability and product yield of mouse hybridoma cell cultures. J Agric Food Chem. 2004 Jun; 52(13):4097-100.
    • (2004) J Agric Food Chem , vol.52 , Issue.13 , pp. 4097-4100
    • Franek, F.1
  • 34
    • 0028256601 scopus 로고
    • Peptone, a low-cost growth-promoting nutrient for intensive animal cell culture
    • Jan DC, Jones SJ, Emery AN, al-Rubeai M. Peptone, a low-cost growth-promoting nutrient for intensive animal cell culture. Cytotechnology. 1994; 16(1):17-26.
    • (1994) Cytotechnology , vol.16 , Issue.1 , pp. 17-26
    • Jan, D.C.1    Jones, S.J.2    Emery, A.N.3    Al-Rubeai, M.4
  • 35
    • 0029175679 scopus 로고
    • Development of a serum-free culture medium for the large scale production of recombinant protein from a Chinese hamster ovary cell line
    • Keen MJ, Rapson NT. Development of a serum-free culture medium for the large scale production of recombinant protein from a Chinese hamster ovary cell line. Cytotechnology. 1995 Oct; 17(3):153-63.
    • (1995) Cytotechnology , vol.17 , Issue.3 , pp. 153-163
    • Keen, M.J.1    Rapson, N.T.2
  • 36
    • 0026816686 scopus 로고
    • Effects of ammonia and lactate on hybridoma growth, metabolism, and antibody production
    • Ozturk SS, Riley MR, Palsson BO. Effects of ammonia and lactate on hybridoma growth, metabolism, and antibody production. Biotechnol Bioeng. 1992 Feb; 39(4):418-31.
    • (1992) Biotechnol Bioeng , vol.39 , Issue.4 , pp. 418-431
    • Ozturk, S.S.1    Riley, M.R.2    Palsson, B.O.3
  • 37
    • 0025465312 scopus 로고
    • Growth behavior of Chinese hamster ovary cells in a compact loop bioreactor. 2. Effects of medium components and waste products
    • Kurano N, Leist C, Messi F, Kurano S, Fiechter A. Growth behavior of Chinese hamster ovary cells in a compact loop bioreactor. 2. Effects of medium components and waste products. J Biotechnol. 1990 Jul; 15(1-2):113-28.
    • (1990) J Biotechnol , vol.15 , Issue.1-2 , pp. 113-128
    • Kurano, N.1    Leist, C.2    Messi, F.3    Kurano, S.4    Fiechter, A.5
  • 38
    • 0027952407 scopus 로고
    • Influence of ammonium on growth, metabolism, and productivity of a continuous suspension Chinese hamster ovary cell culture
    • Hansen HA, Emborg C. Influence of ammonium on growth, metabolism, and productivity of a continuous suspension Chinese hamster ovary cell culture. Biotechnol Prog. 1994 Jan-Feb; 10(1):121-4.
    • (1994) Biotechnol Prog , vol.10 , Issue.1 , pp. 121-124
    • Hansen, H.A.1    Emborg, C.2
  • 39
    • 0028254527 scopus 로고
    • Emborg. Observations on the influence of glutamine, asparagine and peptone on growth and t-PA production of Chinese hamster ovary (CHO) cells
    • Dyring C, Hansen HA, Emborg. Observations on the influence of glutamine, asparagine and peptone on growth and t-PA production of Chinese hamster ovary (CHO) cells. Cytotechnology. 1994 JAn; 16(1):37-42.
    • (1994) Cytotechnology , vol.16 , Issue.1 , pp. 37-42
    • Dyring, C.1    Hansen, H.A.2
  • 40
    • 0032421111 scopus 로고    scopus 로고
    • Engineering chinese hamster ovary (CHO) cells to achieve an inverse growth–associated production of a foreign protein, β-galactosidase
    • Lee FW, Elias CB, Todd, P, Kompala DS. Engineering chinese hamster ovary (CHO) cells to achieve an inverse growth–associated production of a foreign protein, β-galactosidase. Cytotechnology. 1998 Nov; 28(1-3):73-80.
    • (1998) Cytotechnology , vol.28 , Issue.1-3 , pp. 73-80
    • Lee, F.W.1    Elias, C.B.2    Todd, P.3    Kompala, D.S.4
  • 41
    • 0028178682 scopus 로고
    • Extra-and intracellular amino acid concentrations in continuous Chinese hamster ovary cell culture
    • Hansen HA, Emborg C. Extra-and intracellular amino acid concentrations in continuous Chinese hamster ovary cell culture. Appl Microbiol Biotechnol. 1994 Jul; 41(5):560-4.
    • (1994) Appl Microbiol Biotechnol , vol.41 , Issue.5 , pp. 560-564
    • Hansen, H.A.1    Emborg, C.2
  • 42
    • 79951512333 scopus 로고    scopus 로고
    • Characterisation of beneficial and detrimental effects of a soy peptone, as an additive for CHO cell cultivation
    • Michiels JF, Barbau J, De Boel S, Dessy S, Agathos SN, Schneider YJ. Characterisation of beneficial and detrimental effects of a soy peptone, as an additive for CHO cell cultivation. Process Biochemistry. 2011 Mar; 46(3):671-81.
    • (2011) Process Biochemistry , vol.46 , Issue.3 , pp. 671-681
    • Michiels, J.F.1    Barbau, J.2    De Boel, S.3    Dessy, S.4    Agathos, S.N.5    Schneider, Y.J.6
  • 44
    • 12144267454 scopus 로고    scopus 로고
    • Plant protein hydrolysates support CHO-320 cells proliferation and recombinant IFN-γ production in suspension and inside microcarriers in protein-free media
    • Ballez JS, Mols J, Burteau C, Agathos SN, Schneider YJ. Plant protein hydrolysates support CHO-320 cells proliferation and recombinant IFN-γ production in suspension and inside microcarriers in protein-free media. Cytotechnology. 2004 Mar; 44(3):103-14.
    • (2004) Cytotechnology , vol.44 , Issue.3 , pp. 103-114
    • Ballez, J.S.1    Mols, J.2    Burteau, C.3    Agathos, S.N.4    Schneider, Y.J.5
  • 46
    • 84940318960 scopus 로고    scopus 로고
    • Influence of mixed protein hydrolysates on the growth and viability of Chinese hamster ovary cells
    • Lee JY, Chun BH, Lee JH, Ahn J, Chung N: Influence of mixed protein hydrolysates on the growth and viability of Chinese hamster ovary cells. J Korean Soc Appl Biol Chem. 2009, 52(6): 607-12.
    • (2009) J Korean Soc Appl Biol Chem , vol.52 , Issue.6 , pp. 607-612
    • Lee, J.Y.1    Chun, B.H.2    Lee, J.H.3    Ahn, J.4    Chung, N.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.