메뉴 건너뛰기




Volumn 46, Issue 3, 2011, Pages 671-681

Characterisation of beneficial and detrimental effects of a soy peptone, as an additive for CHO cell cultivation

Author keywords

IFN production; Antioxidant; Cell growth; CHO cells; Purification; Soy peptone

Indexed keywords

ANION EXCHANGE CHROMATOGRAPHY; ANTIOXIDANT; ANTIOXIDANT ACTIVITIES; BENEFICIAL COMPOUNDS; CHARACTERISATION; CHEMICAL FAMILY; CHEMICAL NATURE; CHINESE HAMSTER OVARY CELLS; CHO CELL; CULTIVATION MEDIA; CULTURE MEDIUM; CURRENT TRENDS; DETRIMENTAL EFFECTS; GEL FILTRATION; GLYCOSYLATIONS; MAMMALIAN CELLS; PHENOLIC COMPOUNDS; PLANT PROTEINS; POST-TRANSLATIONAL MODIFICATIONS; PROTEIN PRODUCTION; SOY PEPTONE; VIABLE CELLS;

EID: 79951512333     PISSN: 13595113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.procbio.2010.11.012     Document Type: Article
Times cited : (21)

References (56)
  • 1
    • 8344271026 scopus 로고    scopus 로고
    • Production of recombinant protein therapeutics in cultivated mammalian cells
    • DOI 10.1038/nbt1026
    • F.M. Wurm Production of recombinant protein therapeutics in cultivated mammalian cells Nat Biotechnol 22 2004 1393 1398 (Pubitemid 39482858)
    • (2004) Nature Biotechnology , vol.22 , Issue.11 , pp. 1393-1398
    • Wurm, F.M.1
  • 2
    • 64349114245 scopus 로고    scopus 로고
    • Emerging trends in plasma-free manufacturing of recombinant protein therapeutics expressed in mammalian cells
    • L. Grillberger, T.R. Kreil, S. Nasr, and M. Reiter Emerging trends in plasma-free manufacturing of recombinant protein therapeutics expressed in mammalian cells Biotechnol J 4 2009 186 201
    • (2009) Biotechnol J , vol.4 , pp. 186-201
    • Grillberger, L.1    Kreil, T.R.2    Nasr, S.3    Reiter, M.4
  • 3
    • 0026291446 scopus 로고
    • An overview of bovine spongiform encephalopathy
    • R.H. Kimberlin An overview of bovine spongiform encephalopathy Dev Biol Stand 75 1991 75 82
    • (1991) Dev Biol Stand , vol.75 , pp. 75-82
    • Kimberlin, R.H.1
  • 4
    • 0028470844 scopus 로고
    • Ensuring safety and consistency in cell culture production processes: Viral screening and inactivation
    • DOI 10.1016/0167-7799(94)90136-8
    • P.D. Minor Ensuring safety and consistency in cell culture production processes: viral screening and inactivation Trends Biotechnol 12 1994 257 261 (Pubitemid 24221971)
    • (1994) Trends in Biotechnology , vol.12 , Issue.7 , pp. 257-261
    • Minor, P.D.1
  • 6
    • 0030583232 scopus 로고    scopus 로고
    • The protein hydrolysate, Primatone RL, is a cost-effective multiple growth promoter of mammalian cell culture in serum-containing and serum-free media and displays anti-apoptosis properties
    • DOI 10.1016/0022-1759(96)00080-4
    • E. Schlaeger The protein hydrolysate, Primatone RL, is a cost-effective multiple growth promoter of mammalian cell culture in serum-containing and serum-free media and displays anti-apoptosis properties J Immunol Methods 194 1996 191 199 (Pubitemid 26341991)
    • (1996) Journal of Immunological Methods , vol.194 , Issue.2 , pp. 191-199
    • Schlaeger, E.-J.1
  • 7
    • 1242292973 scopus 로고    scopus 로고
    • Yeast hydrolysate as a low-cost additive to serum-free medium for the production of human thrombopoietin in suspension cultures of Chinese hamster ovary cells
    • DOI 10.1007/s00253-003-1389-1
    • Y.H. Sung, S.W. Lim, J.Y. Chung, and G.M. Lee Yeast hydrolysate as a low-cost additive to serum-free medium for the production of human thrombopoietin in suspension cultures of Chinese hamster ovary cells Appl Microbiol Biotechnol 63 2004 527 536 (Pubitemid 38230510)
    • (2004) Applied Microbiology and Biotechnology , vol.63 , Issue.5 , pp. 527-536
    • Sung, Y.H.1    Chung, J.Y.2    Lee, G.M.3    Lim, S.W.4
  • 8
    • 1042265424 scopus 로고    scopus 로고
    • Fortification of a protein-free cell culture medium with plant peptones improves cultivation and productivity of an interferon-γ-producing CHO cell line
    • DOI 10.1290/1543-706X(2003)039<0291:FOAPCC>2.0.CO;2
    • C.C. Burteau, F.R. Verhoeye, J.F. Mols, J.S. Ballez, S.N. Agathos, and Y.J. Schneider Fortification of a protein-free cell culture medium with plant peptones improves cultivation and productivity of an interferon-gamma-producing CHO cell line In Vitro Cell Dev A 39 2003 291 296 (Pubitemid 38200251)
    • (2003) In Vitro Cellular and Developmental Biology - Animal , vol.39 , Issue.7 , pp. 291-296
    • Burteau, C.C.1    Verhoeye, F.R.2    Mols, J.F.3    Ballez, J.-S.4    Agathos, S.N.5    Schneider, Y.-J.6
  • 10
    • 66149184660 scopus 로고    scopus 로고
    • Investigation of proteins and peptides from yeastolate and subsequent impurity testing of drug product
    • L.W. Dick Jr., J.A. Kakaley, D. Mahon, D. Qiu, and K. Cheng Investigation of proteins and peptides from yeastolate and subsequent impurity testing of drug product Biotechnol Prog 25 2009 570 577
    • (2009) Biotechnol Prog , vol.25 , pp. 570-577
    • Dick, Jr.L.W.1    Kakaley, J.A.2    Mahon, D.3    Qiu, D.4    Cheng, K.5
  • 11
    • 33749322995 scopus 로고    scopus 로고
    • Peptide fractions of rapeseed hydrolysates as an alternative to animal proteins in CHO cell culture media
    • DOI 10.1016/j.procbio.2006.06.002, PII S1359511306002364
    • B. Farges-Haddani, B. Tessier, S. Chenu, I. Chevalot, C. Harscoat, and I. Marc Peptide fractions of rapeseed hydrolysates as an alternative to animal proteins in CHO cell culture media Process Biochem 41 2006 2297 2304 (Pubitemid 44488674)
    • (2006) Process Biochemistry , vol.41 , Issue.11 , pp. 2297-2304
    • Farges-Haddani, B.1    Tessier, B.2    Chenu, S.3    Chevalot, I.4    Harscoat, C.5    Marc, I.6    Goergen, J.L.7    Marc, A.8
  • 12
    • 34250635064 scopus 로고    scopus 로고
    • Characterization of yeastolate fractions that promote insect cell growth and recombinant protein production
    • DOI 10.1007/s10616-007-9062-7
    • C. Shen, T. Kiyota, B. Jardin, Y. Konishi, and A. Kamen Characterization of yeastolate fractions that promote insect cell growth and recombinant protein production Cytotechnology 54 2007 25 34 (Pubitemid 46944860)
    • (2007) Cytotechnology , vol.54 , Issue.1 , pp. 25-34
    • Shen, C.F.1    Kiyota, T.2    Jardin, B.3    Konishi, Y.4    Kamen, A.5
  • 13
    • 77952950585 scopus 로고    scopus 로고
    • Optimization of chemically defined cell culture media - Replacing fetal bovine serum in mammalian in vitro methods
    • J. van der Valk, D. Brunner, K. De Smet,. Fex Svenningsen, P. Honegger, and L. Knudsen Optimization of chemically defined cell culture media - replacing fetal bovine serum in mammalian in vitro methods Toxicol in Vitro 24 2010 1053 1063
    • (2010) Toxicol in Vitro , vol.24 , pp. 1053-1063
    • Van Der Valk, J.1    Brunner, D.2    De Smet, K.3    Fex Svenningsen, .4    Honegger, P.5    Knudsen, L.6
  • 14
    • 33750370939 scopus 로고    scopus 로고
    • Usability of size-excluded fractions of soy protein hydrolysates for growth and viability of Chinese hamster ovary cells in protein-free suspension culture
    • DOI 10.1016/j.biortech.2006.04.012, PII S0960852406001714
    • B. Chun, J. Kim, H. Lee, and N. Chung Usability of size-excluded fractions of soy protein hydrolysates for growth and viability of Chinese hamster ovary cells in protein-free suspension culture Bioresour Technol 98 2007 1000 1005 (Pubitemid 44635221)
    • (2007) Bioresource Technology , vol.98 , Issue.5 , pp. 1000-1005
    • Chun, B.-H.1    Kim, J.-H.2    Lee, H.-J.3    Chung, N.4
  • 15
    • 0034281499 scopus 로고    scopus 로고
    • Plant protein hydrolysates: Preparation of defined peptide fractions promoting growth and production in animal cells cultures
    • F. Franek, O. Hohenwarter, and H. Katinger Plant protein hydrolysates: preparation of defined peptide fractions promoting growth and production in animal cells cultures Biotechnol Prog 16 2000 688 692
    • (2000) Biotechnol Prog , vol.16 , pp. 688-692
    • Franek, F.1    Hohenwarter, O.2    Katinger, H.3
  • 16
    • 3042658437 scopus 로고    scopus 로고
    • Gluten of spelt wheat (Triticum aestivum Subspecies spelta) as a source of peptides promoting viability and product yield of mouse hybridoma cell cultures
    • F.J. Franek Gluten of spelt wheat (Triticum aestivum Subspecies spelta) as a source of peptides promoting viability and product yield of mouse hybridoma cell cultures J Agric Food Chem 52 2004 4097 4100
    • (2004) J Agric Food Chem , vol.52 , pp. 4097-4100
    • Franek, F.J.1
  • 17
    • 7444222906 scopus 로고    scopus 로고
    • Antioxidant activity of a peptide isolated from Alaska pollack (Theragra chalcogramma) frame protein hydrolysate
    • DOI 10.1016/j.foodres.2004.07.005, PII S096399690400167X
    • J. Je, P. Park, and S. Kim Antioxidant activity of a peptide isolated from Alaska pollack (Theragra chalcogramma) frame protein hydrolysate Food Res Int 38 2005 45 50 (Pubitemid 39444466)
    • (2005) Food Research International , vol.38 , Issue.1 , pp. 45-50
    • Je, J.-Y.1    Park, P.-J.2    Kim, S.-K.3
  • 18
    • 34548258046 scopus 로고    scopus 로고
    • Purification and characterization of antioxidant peptide from hoki (Johnius belengerii) frame protein by gastrointestinal digestion
    • DOI 10.1016/j.jnutbio.2006.02.006, PII S0955286306000507
    • S. Kim, J. Je, and S. Kim Purification and characterization of antioxidant peptide from hoki (Johnius belengerii) frame protein by gastrointestinal digestion J Nutr Biochem 18 2007 31 38 (Pubitemid 44827717)
    • (2007) Journal of Nutritional Biochemistry , vol.18 , Issue.1 , pp. 31-38
    • Kim, S.-Y.1    Je, J.-Y.2    Kim, S.-K.3
  • 19
    • 29244443998 scopus 로고    scopus 로고
    • Antioxidant properties of ultrafiltration-recovered soy protein fractions from industrial effluents and their hydrolysates
    • DOI 10.1016/j.procbio.2005.07.014, PII S1359511305003168
    • A. Moure, H. Dominguez, and J.C. Parajo Antioxidant properties of ultrafiltration-recovered soy protein fractions from industrial effluents and their hydrolysates Process Biochem 41 2006 447 456 (Pubitemid 41827279)
    • (2006) Process Biochemistry , vol.41 , Issue.2 , pp. 447-456
    • Moure, A.1    Dominguez, H.2    Parajo, J.C.3
  • 20
    • 34548654506 scopus 로고    scopus 로고
    • Hydrolysis of rapeseed protein isolates: Kinetics, characterization and functional properties of hydrolysates
    • DOI 10.1016/j.procbio.2007.07.009, PII S1359511307002061
    • G. Chabanon, I. Chevalot, X. Framboisier, S. Chenu, and I. Marc Hydrolysis of rapeseed protein isolates: kinetics, characterization and functional properties of hydrolysates Process Biochem 42 2007 1419 1428 (Pubitemid 47398971)
    • (2007) Process Biochemistry , vol.42 , Issue.10 , pp. 1419-1428
    • Chabanon, G.1    Chevalot, I.2    Framboisier, X.3    Chenu, S.4    Marc, I.5
  • 21
    • 64149097583 scopus 로고    scopus 로고
    • Isolation of bioactive peptides from tryptone that modulate lipase production in Yarrowia lipolytica
    • S. Turki, I.B. Kraeim, F. Weeckers, P. Thonart, and H. Kallel Isolation of bioactive peptides from tryptone that modulate lipase production in Yarrowia lipolytica Bioresour Technol 100 2009 2724 2731
    • (2009) Bioresour Technol , vol.100 , pp. 2724-2731
    • Turki, S.1    Kraeim, I.B.2    Weeckers, F.3    Thonart, P.4    Kallel, H.5
  • 26
    • 0034918705 scopus 로고    scopus 로고
    • Effect of antioxidants on the apoptosis of CHO cells and production of tissue plasminogen activator in suspension culture
    • DOI 10.1016/S1389-1723(01)80177-8
    • Z. Yun, M. Takagi, and T. Yoshida Effect of antioxidants on the apoptosis of CHO cells and production of tissue plasminogen activator in suspension culture J Biosci Bioeng 91 2001 581 585 (Pubitemid 32664716)
    • (2001) Journal of Bioscience and Bioengineering , vol.91 , Issue.6 , pp. 581-585
    • Yun, Z.1    Takagi, M.2    Yoshida, T.3
  • 27
    • 0024559010 scopus 로고
    • Optimisation of hybridoma cell growth and monoclonal antibody secretion in a chemically defined, serum- and protein-free culture medium
    • Y.J. Schneider Optimisation of hybridoma cell growth and monoclonal antibody secretion in a chemically defined, serum- and protein-free culture medium J Immunol Methods 116 1989 65 77
    • (1989) J Immunol Methods , vol.116 , pp. 65-77
    • Schneider, Y.J.1
  • 29
    • 0035339420 scopus 로고    scopus 로고
    • A ninhydrin-based assay to quantitate the total protein content of tissue samples
    • DOI 10.1006/abio.2001.5050
    • B. Starcher A ninhydrin-based assay to quantitate the total protein content of tissue samples Anal Biochem 292 2001 125 129 (Pubitemid 32417730)
    • (2001) Analytical Biochemistry , vol.292 , Issue.1 , pp. 125-129
    • Starcher, B.1
  • 30
    • 33847381260 scopus 로고
    • Qualitative test for carbohydrate material
    • R. Dreywood Qualitative test for carbohydrate material Ind Eng Chem 18 1946 499
    • (1946) Ind Eng Chem , vol.18 , pp. 499
    • Dreywood, R.1
  • 31
    • 33748306088 scopus 로고    scopus 로고
    • Ochratoxin A, hydroxymethylfurfural and vitamin C levels of sun-dried grapes and sultanas
    • DOI 10.1111/j.1745-4549.2006.00088.x
    • N. Caglarirmak Ochratoxin A, hydroxymethylfurfural and vitamin c levels of sun-dried grapes and sultanas J Food Process Pres 30 2006 549 562 (Pubitemid 44330403)
    • (2006) Journal of Food Processing and Preservation , vol.30 , Issue.5 , pp. 549-562
    • Caglarirmak, N.1
  • 32
    • 68949128599 scopus 로고    scopus 로고
    • Optimization of hydrolysis of sardine Sardina pilchardus heads with Protamex: Enhancement of lipid and phospholipid extraction
    • J. Dumay, M. Allery, C. Donnay-Moreno, G. Barnathan, P. Jaouen, and M.E. Carbonneau Optimization of hydrolysis of sardine Sardina pilchardus heads with Protamex: enhancement of lipid and phospholipid extraction J Sci Food Agric 89 2009 1599 1606
    • (2009) J Sci Food Agric , vol.89 , pp. 1599-1606
    • Dumay, J.1    Allery, M.2    Donnay-Moreno, C.3    Barnathan, G.4    Jaouen, P.5    Carbonneau, M.E.6
  • 33
    • 67349115980 scopus 로고    scopus 로고
    • Development of serum-free medium supplemented with hydrolysates for the production of therapeutic antibodies in CHO cell cultures using design of experiments
    • S. Kim, and G. Lee Development of serum-free medium supplemented with hydrolysates for the production of therapeutic antibodies in CHO cell cultures using design of experiments Appl Microbiol Biotechnol 83 2009 639 648
    • (2009) Appl Microbiol Biotechnol , vol.83 , pp. 639-648
    • Kim, S.1    Lee, G.2
  • 34
    • 44349125801 scopus 로고    scopus 로고
    • Systems biotechnology of mammalian cell factories
    • DOI 10.1093/bfgp/eln012, Special Issue: Outlook and Tools to Maximize Proteomics Information
    • P.M. O'Callaghan, and D.C. James Systems biotechnology of mammalian cell factories Brief Funct Genomic Proteomic 7 2008 95 110 (Pubitemid 351728951)
    • (2008) Briefings in Functional Genomics and Proteomics , vol.7 , Issue.2 , pp. 95-110
    • O'Callaghan, P.M.1    James, D.C.2
  • 35
    • 0037457338 scopus 로고    scopus 로고
    • Stability of protein production from recombinant mammalian cells
    • DOI 10.1002/bit.10517
    • L.M. Barnes, C.M. Bentley, and A.J. Dickson Stability of protein production from recombinant mammalian cells Biotechnol Bioeng 81 2003 631 639 (Pubitemid 36258516)
    • (2003) Biotechnology and Bioengineering , vol.81 , Issue.6 , pp. 631-639
    • Barnes, L.M.1    Bentley, C.M.2    Dickson, A.J.3
  • 36
    • 34250191004 scopus 로고    scopus 로고
    • Differences in optimal pH and temperature for cell growth and antibody production between two Chinese hamster ovary clones derived from the same parental clone
    • H.S. Kim, and G.M. Lee Differences in optimal pH and temperature for cell growth and antibody production between two Chinese hamster ovary clones derived from the same parental clone J Microbiol Biotechnol 17 2007 712 720 (Pubitemid 46894838)
    • (2007) Journal of Microbiology and Biotechnology , vol.17 , Issue.5 , pp. 712-720
    • Kim, S.H.1    Lee, G.M.2
  • 37
    • 10044226092 scopus 로고    scopus 로고
    • Enhancing effect of low culture temperature on specific antibody productivity of recombinant Chinese hamster ovary cells: Clonal variation
    • S.K. Yoon, S.O. Hwang, and G.M. Lee Enhancing effect of low culture temperature on specific antibody productivity of recombinant Chinese hamster ovary cells: clonal variation Biotechnol Prog 20 2004 1683 1688
    • (2004) Biotechnol Prog , vol.20 , pp. 1683-1688
    • Yoon, S.K.1    Hwang, S.O.2    Lee, G.M.3
  • 38
    • 79951510576 scopus 로고    scopus 로고
    • Partial replacement of chemically defined media with plant-derived protein hydrolysates
    • J. Babcock, C. Wilcox, and H. Huttinga Partial replacement of chemically defined media with plant-derived protein hydrolysates Biopharm Int 23 2010 36 42
    • (2010) Biopharm Int , vol.23 , pp. 36-42
    • Babcock, J.1    Wilcox, C.2    Huttinga, H.3
  • 39
    • 2942621925 scopus 로고    scopus 로고
    • Comprehensive phytochemical profile of soy protein isolate
    • N. Fang, S. Yu, and T.M. Badger Comprehensive phytochemical profile of soy protein isolate J Agric Food Chem 52 2004 4012 4020
    • (2004) J Agric Food Chem , vol.52 , pp. 4012-4020
    • Fang, N.1    Yu, S.2    Badger, T.M.3
  • 40
    • 0034101865 scopus 로고    scopus 로고
    • Isolation and characterization of free radical scavenging activities peptides derived from casein
    • DOI 10.1016/S0955-2863(99)00083-2, PII S0955286399000832
    • K. Suetsuna, H. Ukeda, and H. Ochi Isolation and characterization of free radical scavenging activities peptides derived from casein J Nutr Biochem 11 2000 128 131 (Pubitemid 30163084)
    • (2000) Journal of Nutritional Biochemistry , vol.11 , Issue.3 , pp. 128-131
    • Suetsuna, K.1    Ukeda, H.2    Ochi, H.3
  • 41
    • 13244279441 scopus 로고    scopus 로고
    • Antioxidant properties of a radical-scavenging peptide purified from enzymatically prepared fish skin gelatin hydrolysate
    • DOI 10.1021/jf048877v
    • E. Mendis, N. Rajapakse, and S.J. Kim Antioxidant properties of a radical-scavenging peptide purified from enzymatically prepared fish skin gelatin hydrolysate J Agric Food Chem 53 2005 581 587 (Pubitemid 40194376)
    • (2005) Journal of Agricultural and Food Chemistry , vol.53 , Issue.3 , pp. 581-587
    • Mendis, E.1    Rajapakse, N.2    Kim, S.-K.3
  • 42
    • 34247598802 scopus 로고    scopus 로고
    • Effect of bioactive peptides isolated from yeastolate, lactalbumin and NZCase in the insect cell growth
    • DOI 10.1007/s00449-006-0099-3
    • R.Z. Mendona, E.C. de Oliveira, C.A. Pereira, and I. Lebrun Effect of bioactive peptides isolated from yeastolate, lactalbumin and NZCase in the insect cell growth Bioprocess Biosyst Eng 30 2007 157 164 (Pubitemid 46675962)
    • (2007) Bioprocess and Biosystems Engineering , vol.30 , Issue.3 , pp. 157-164
    • Mendonca, R.Z.1    De Oliveira, E.C.2    Pereira, C.A.3    Lebrun, I.4
  • 44
    • 34548506071 scopus 로고    scopus 로고
    • Effect of the phytoestrogen, genistein-8-C-glucoside, on Chinese hamster ovary cells in vitro
    • DOI 10.1016/j.cellbi.2007.05.012, PII S1065699507001631
    • A. Rucinska, S. Kirko, and T. Gabryelak Effect of the phytoestrogen, genistein-8-C-glucoside, on Chinese hamster ovary cells in vitro Cell Biol Int 31 2007 1371 1378 (Pubitemid 47371094)
    • (2007) Cell Biology International , vol.31 , Issue.11 , pp. 1371-1378
    • Rucinska, A.1    Kirko, S.2    Gabryelak, T.3
  • 45
    • 47949102659 scopus 로고    scopus 로고
    • Antiproliferative and antioxidant activities of common vegetables: A comparative study
    • D. Boivin, S. Lamy, S. Lord-Dufour, J. Jackson, E. Beaulieu, and M. Côté Antiproliferative and antioxidant activities of common vegetables: a comparative study Food Chem 112 2009 374 380
    • (2009) Food Chem , vol.112 , pp. 374-380
    • Boivin, D.1    Lamy, S.2    Lord-Dufour, S.3    Jackson, J.4    Beaulieu, E.5    Côté, M.6
  • 48
    • 3142536557 scopus 로고    scopus 로고
    • Prooxidant property of green tea polyphenols epicatechin and epigallocatechin-3-gallate: Implications for anticancer properties
    • DOI 10.1016/j.tiv.2003.12.012, PII S0887233304000050
    • S. Azam, N. Hadi, N.U. Khan, and S.M. Hadi Prooxidant property of green tea polyphenols epicatechin and epigallocatechin-3-gallate: implications for anticancer properties Toxicol In Vitro 18 2004 555 561 (Pubitemid 38900862)
    • (2004) Toxicology in Vitro , vol.18 , Issue.5 , pp. 555-561
    • Azam, S.1    Hadi, N.2    Khan, N.U.3    Hadi, S.M.4
  • 49
    • 0031815389 scopus 로고    scopus 로고
    • Inhibition of growth and induction of apoptosis in human cancer cell lines by tea polyphenols
    • DOI 10.1093/carcin/19.4.611
    • G.Y. Yang, J. Liao, K. Kim, E.J. Yurkow, and C.S. Yang Inhibition of growth and induction of apoptosis in human cancer cell lines by tea polyphenols Carcinogenesis 19 1998 611 616 (Pubitemid 28376804)
    • (1998) Carcinogenesis , vol.19 , Issue.4 , pp. 611-616
    • Yang, G.-Y.1    Liao, J.2    Kim, K.3    Yurkow, E.J.4    Yang, C.S.5
  • 50
    • 0033039544 scopus 로고    scopus 로고
    • N-acetylcysteine increases the biosynthesis of recombinant EPO in apoptotic Chinese hamster ovary cells
    • K.H. Chang, K.S. Kim, and J.H. Kim N-acetylcysteine increases the biosynthesis of recombinant EPO in apoptotic Chinese hamster ovary cells Free Radic Res 30 1999 85 91 (Pubitemid 29129459)
    • (1999) Free Radical Research , vol.30 , Issue.2 , pp. 85-91
    • Chang, K.H.1    Kim, K.S.2    Kim, J.H.3
  • 51
    • 0001162423 scopus 로고    scopus 로고
    • Overexpression of bcl-2 inhibits sodium butyrate-induced apoptosis in Chinese hamster ovary cells resulting in enhanced humanized antibody production
    • DOI 10.1002/1097-0290(2000)71:3<184::AID-BIT1008>3.0.CO;2-W
    • N.S. Kim, and G.M. Lee Overexpression of bcl-2 inhibits sodium butyrate-induced apoptosis in Chinese hamster ovary cells resulting in enhanced humanized antibody production Biotechnol Bioeng 71 2000 184 193 (Pubitemid 32381138)
    • (2000) Biotechnology and Bioengineering , vol.71 , Issue.3 , pp. 184-193
    • Kim, N.S.1    Lee, G.M.2
  • 52
    • 0141567459 scopus 로고    scopus 로고
    • Physical stability of proteins in aqueous solution: Mechanism and driving forces in nonnative protein aggregation
    • DOI 10.1023/A:1025771421906
    • E.Y. Chi, S. Krishnan, T.W. Randolph, and J.F. Carpenter Physical stability of proteins in aqueous solution: mechanism and driving forces in nonnative protein aggregation Pharm Res 20 2003 1325 1336 (Pubitemid 37164039)
    • (2003) Pharmaceutical Research , vol.20 , Issue.9 , pp. 1325-1336
    • Chi, E.Y.1    Krishnan, S.2    Randolph, T.W.3    Carpenter, J.F.4
  • 54
    • 7044286379 scopus 로고    scopus 로고
    • Fractionation and characterisation for antioxidant activity of hydrolysed whey protein
    • DOI 10.1002/jsfa.1886
    • E.A. Peña-Ramos, Y.L. Xiong, and G.E. Arteaga Fractionation and characterisation for antioxidant activity of hydrolysed whey protein J Sci Food Agric 84 2004 1908 1918 (Pubitemid 39415159)
    • (2004) Journal of the Science of Food and Agriculture , vol.84 , Issue.14 , pp. 1908-1918
    • Pena-Ramos, E.A.1    Xiong, Y.L.2    Arteaga, G.E.3
  • 55
    • 0039978469 scopus 로고    scopus 로고
    • Determination of the peptide size range of an extensively hydrolysed protein hydrolysate
    • O. Tossavainen, E. Syvaoja, J. Tuominen, M. Heinanen, and N. Kalkkinen Determination of the peptide size range of an extensively hydrolysed protein hydrolysate Milchwissenschaft 52 1997 63 67 (Pubitemid 127031912)
    • (1997) Milchwissenschaft , vol.52 , Issue.2 , pp. 63-67
    • Tossavainen, O.1    Syvaeoja, E.-L.2    Tuominen, J.3    Heinaenen, M.4    Kalkkinen, N.5
  • 56
    • 18344416903 scopus 로고    scopus 로고
    • The use of peptones as medium additives for the production of a recombinant therapeutic protein in high density perfusion cultures of mammalian cells
    • DOI 10.1023/A:1008196521213
    • R. Heidemann, C. Zhang, H. Qi, J.L. Rule, C. Rozales, S. Park, S. Chuppa, M. Ray, J. Michaels, K. Konstantinov, and D. Naveh The use of peptones as medium additives for the production of a recombinant therapeutic protein in high density perfusion cultures of mammalian cells Cytotechnology 32 2000 157 167 (Pubitemid 30166230)
    • (2000) Cytotechnology , vol.32 , Issue.2 , pp. 157-167
    • Heidemann, R.1    Zhang, C.2    Qi, H.3    Rule, J.L.4    Rozales, C.5    Park, S.6    Chuppa, S.7    Ray, M.8    Michaels, J.9    Konstantinov, K.10    Naveh, D.11


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.