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Volumn 44, Issue 1, 2011, Pages 34-39

A novel variant of t-PA resistant to plasminogen activator inhibitor-1; expression in CHO cells based on in silico experiments

Author keywords

Amidolytic activity; Chinese hamster ovary (CHO); In silico; Plasminogen activator inhibitor 1 (PAI 1); Tissue plasminogen activator (t PA)

Indexed keywords

FIBRINOLYTIC AGENT; PLASMINOGEN ACTIVATOR INHIBITOR 1; RECOMBINANT PROTEIN; TISSUE PLASMINOGEN ACTIVATOR;

EID: 79751491703     PISSN: 19766696     EISSN: 1976670X     Source Type: Journal    
DOI: 10.5483/BMBRep.2011.44.1.34     Document Type: Article
Times cited : (14)

References (38)
  • 1
    • 40749124632 scopus 로고    scopus 로고
    • American Heart Association
    • American Heart Association. (2008) Heart Disease and Stroke Statistics, http://www.americanheart.org/downloadable/heart/1200082005246HS_Stats%202008.final.pdf.
    • (2008) Heart Disease and Stroke Statistics
  • 2
    • 0020384976 scopus 로고
    • Isolation of two variants of native one-chain tissue plasminogen activator
    • Ranby, M., Bergsdorf, N., Pohl, G. and Wallen, P. (1982) Isolation of two variants of native one-chain tissue plasminogen activator. FEBS Lett. 146, 289-292.
    • (1982) FEBS Lett , vol.146 , pp. 289-292
    • Ranby, M.1    Bergsdorf, N.2    Pohl, G.3    Wallen, P.4
  • 4
    • 0020643467 scopus 로고
    • Human plasma proteinase inhibitors
    • Travis, J. and Salvesen, G. S. (1983) Human plasma proteinase inhibitors. Annu. Rev. Biochem. 52, 655-709.
    • (1983) Annu. Rev. Biochem. , vol.52 , pp. 655-709
    • Travis, J.1    Salvesen, G.S.2
  • 5
    • 0001724344 scopus 로고
    • Serpins: the superfamily of plasma serine proteinase inhibitors
    • Barrelland, A. and Salvesen, G. (eds.), Elsevier, North Holland, Amsterdam, Netherland
    • Carrell, R. and Boswell, D. R. (1986) Serpins: the superfamily of plasma serine proteinase inhibitors; in Proteinase Inhibitors, Barrelland, A. and Salvesen, G. (eds.). pp. 403-420, Elsevier, North Holland, Amsterdam, Netherland.
    • (1986) Proteinase Inhibitors , pp. 403-420
    • Carrell, R.1    Boswell, D.R.2
  • 6
    • 0021677450 scopus 로고
    • Detection and partial characterization of an inhibitor of plasminogen activator in human platelets
    • Erickson, L. A., Ginsberg, M. H. and Loskutoff, D. J. (1984) Detection and partial characterization of an inhibitor of plasminogen activator in human platelets. J. Clin. Invest. 74, 1465-1472.
    • (1984) J. Clin. Invest. , vol.74 , pp. 1465-1472
    • Erickson, L.A.1    Ginsberg, M.H.2    Loskutoff, D.J.3
  • 7
    • 0023932693 scopus 로고
    • Kinetic analysis of the interactions between plasminogen activator inhibitor 1 and both urokinase and tissue plasminogen activator
    • Hekman, C. M. and Loskutoff, D. J. (1988) Kinetic analysis of the interactions between plasminogen activator inhibitor 1 and both urokinase and tissue plasminogen activator. Arch. Biochem. Biophys. 262, 199-210.
    • (1988) Arch. Biochem. Biophys. , vol.262 , pp. 199-210
    • Hekman, C.M.1    Loskutoff, D.J.2
  • 8
    • 0023503121 scopus 로고
    • Interaction of one-chain and two-chain tissue plasminogen activator with intact and plasmin-degraded fibrin
    • Higgins, D. L. and Vehar, G. A. (1987) Interaction of one-chain and two-chain tissue plasminogen activator with intact and plasmin-degraded fibrin. Biochemistry 26, 7786-7791.
    • (1987) Biochemistry , vol.26 , pp. 7786-7791
    • Higgins, D.L.1    Vehar, G.A.2
  • 9
    • 0024311846 scopus 로고
    • Interaction between plasminogen activator inhibitor type 1 (PAI-1) bound to fibrin and either tissue-type plasminogen activator (t-PA) or urokinase-type plasminogen activator (u-PA). Binding of t-PA/PAI-1 complexes to fibrin mediated by both the finger and the kringle-2 domain of t-PA
    • Wagner, O. F., de Vries, C., Hohmann, C., Veerman, H. and Pannekoek, H. (1989) Interaction between plasminogen activator inhibitor type 1 (PAI-1) bound to fibrin and either tissue-type plasminogen activator (t-PA) or urokinase-type plasminogen activator (u-PA). Binding of t-PA/PAI-1 complexes to fibrin mediated by both the finger and the kringle-2 domain of t-PA. J. Clin. Invest. 84, 647-655.
    • (1989) J. Clin. Invest. , vol.84 , pp. 647-655
    • Wagner, O.F.1    de Vries, C.2    Hohmann, C.3    Veerman, H.4    Pannekoek, H.5
  • 12
    • 0026544292 scopus 로고
    • Biochemical and biologic properties of rt-PA del (K296-G302), a recombinant human tissue-type plasminogen activator deletion mutant resistant to plasminogen activator inhibitor-1
    • Li, X. K., Lijnen, H. R., Nelles, L., Van, H. B., Stassen, J. M. and Collen, D. (1992) Biochemical and biologic properties of rt-PA del (K296-G302), a recombinant human tissue-type plasminogen activator deletion mutant resistant to plasminogen activator inhibitor-1. Blood 79, 417-429.
    • (1992) Blood , vol.79 , pp. 417-429
    • Li, X.K.1    Lijnen, H.R.2    Nelles, L.3    Van, H.B.4    Stassen, J.M.5    Collen, D.6
  • 13
    • 0142209155 scopus 로고    scopus 로고
    • Thrombolysis: newer thrombolytic agents and their role in clinical medicine
    • Nordt, T. K. and Bode, C. (2003) Thrombolysis: newer thrombolytic agents and their role in clinical medicine. Heart 89, 1358-1362.
    • (2003) Heart , vol.89 , pp. 1358-1362
    • Nordt, T.K.1    Bode, C.2
  • 15
    • 0029819362 scopus 로고    scopus 로고
    • The role of thrombolytic drugs in the management of myocardial infarction. Comparative clinical trials
    • Weaver, W. D. (1996) The role of thrombolytic drugs in the management of myocardial infarction. Comparative clinical trials. Eur. Heart J. 17(Suppl F), 9-15.
    • (1996) Eur. Heart J. , vol.17 , Issue.SUPPL. F , pp. 9-15
    • Weaver, W.D.1
  • 18
    • 0029873814 scopus 로고    scopus 로고
    • Comparison of desulfatohirudin (REVASC) and heparin as adjuncts to thrombolytic therapy with reteplase in a canine model of coronary thrombosis
    • Martin, U., Dorge, L. and Fischer, S. Comparison of desulfatohirudin (REVASC) and heparin as adjuncts to thrombolytic therapy with reteplase in a canine model of coronary thrombosis. Br. J. Pharmacol. 118, 271-276.
    • Br. J. Pharmacol. , vol.118 , pp. 271-276
    • Martin, U.1    Dorge, L.2    Fischer, S.3
  • 19
    • 79751473898 scopus 로고    scopus 로고
    • http://www.gene.com/gene/products/information/pdf/activase-prescribing.pdf. 2010.
    • (2010)
  • 20
    • 0035832019 scopus 로고    scopus 로고
    • Antithrombotic therapy in patients with acute coronary syndromes
    • Levine, G. N., Ali, M. N. and Schafer, A. I. (2001) Antithrombotic therapy in patients with acute coronary syndromes. Arch. Intern. Med. 161, 937-948.
    • (2001) Arch. Intern. Med. , vol.161 , pp. 937-948
    • Levine, G.N.1    Ali, M.N.2    Schafer, A.I.3
  • 21
    • 0022401909 scopus 로고
    • Hepatic clearance of tissue-type plasminogen activator in rats
    • Emeis, J. J., van den Hoogen, C. M. and Jense, D. (1985) Hepatic clearance of tissue-type plasminogen activator in rats. Thromb. Haemost. 54, 661-664.
    • (1985) Thromb. Haemost. , vol.54 , pp. 661-664
    • Emeis, J.J.1    van den Hoogen, C.M.2    Jense, D.3
  • 24
    • 75649130086 scopus 로고    scopus 로고
    • Pharmaco-Informatics: Homology Modelling of the Target Protein (GP1, 2) for Ebola Hemorrhagic Fever and Predicting an Ayurvedic Remediation of the Disease
    • Bagchi, P., Mahesh, M. and Somashekhar, R. (2009) Pharmaco-Informatics: Homology Modelling of the Target Protein (GP1, 2) for Ebola Hemorrhagic Fever and Predicting an Ayurvedic Remediation of the Disease. J. Proteomics. Bioinform. 2, 287-294.
    • (2009) J. Proteomics. Bioinform. , vol.2 , pp. 287-294
    • Bagchi, P.1    Mahesh, M.2    Somashekhar, R.3
  • 26
    • 0030454399 scopus 로고    scopus 로고
    • Tissue-type plasminogen activator: characteristics, applications and production technology
    • Rouf, S. A., Moo-Young, M. and Chisti, Y. (1996) Tissue-type plasminogen activator: characteristics, applications and production technology. Biotechnol. Adv. 14, 239-266.
    • (1996) Biotechnol. Adv. , vol.14 , pp. 239-266
    • Rouf, S.A.1    Moo-Young, M.2    Chisti, Y.3
  • 31
    • 0024381603 scopus 로고
    • Serpin-resistant mutants of human tissue-type plasminogen activator
    • Madison, E. L., Goldsmith, E. J., Gerard, R. D., Gething, M. J. and Sambrook, J. F. (1989) Serpin-resistant mutants of human tissue-type plasminogen activator. Nature 339, 721-724.
    • (1989) Nature , vol.339 , pp. 721-724
    • Madison, E.L.1    Goldsmith, E.J.2    Gerard, R.D.3    Gething, M.J.4    Sambrook, J.F.5
  • 32
    • 0001040367 scopus 로고
    • An algorithm for protein secondary structure prediction based on class prediction
    • Deleage, G. and Roux, B. (1987) An algorithm for protein secondary structure prediction based on class prediction. Protein Eng. 1, 289-294.
    • (1987) Protein Eng , vol.1 , pp. 289-294
    • Deleage, G.1    Roux, B.2
  • 33
    • 0018854046 scopus 로고
    • Electrophoretic analysis of plasminogen activators in polyacrylamide gels containing sodium dodecyl sulfate and copolymerized substrates
    • Heussen, C. and Dowdle, E. B. (1980) Electrophoretic analysis of plasminogen activators in polyacrylamide gels containing sodium dodecyl sulfate and copolymerized substrates. Anal. Biochem. 102, 196-202.
    • (1980) Anal. Biochem. , vol.102 , pp. 196-202
    • Heussen, C.1    Dowdle, E.B.2
  • 34
    • 0026071384 scopus 로고
    • Polymerization site in the beta chain of fibrin: mapping of the B beta 1-55 sequence
    • Pandya, B. V., Gabriel, J. L., O'Brien, J. and Budzynski, A. Z. (1991) Polymerization site in the beta chain of fibrin: mapping of the B beta 1-55 sequence. Biochemistry 30, 162-168.
    • (1991) Biochemistry , vol.30 , pp. 162-168
    • Pandya, B.V.1    Gabriel, J.L.2    O'Brien, J.3    Budzynski, A.Z.4
  • 35
    • 0021053614 scopus 로고
    • Evidence for a rapid inhibitor to tissue plasminogen activator in plasma
    • Chmielewska, J., Ranby, M. and Wiman, B. (1983) Evidence for a rapid inhibitor to tissue plasminogen activator in plasma. Thromb. Res. 31, 427-436.
    • (1983) Thromb. Res. , vol.31 , pp. 427-436
    • Chmielewska, J.1    Ranby, M.2    Wiman, B.3
  • 36
    • 0030034993 scopus 로고    scopus 로고
    • PAI-1-resistant t-PA: low doses prevent fibrin deposition in rabbits with increased PAI-1 activity
    • Krishnamurti, C., Keyt, B., Maglasang, P. and Alving, B. M. (1996) PAI-1-resistant t-PA: low doses prevent fibrin deposition in rabbits with increased PAI-1 activity. Blood 87, 14-19.
    • (1996) Blood , vol.87 , pp. 14-19
    • Krishnamurti, C.1    Keyt, B.2    Maglasang, P.3    Alving, B.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.