-
1
-
-
0036467638
-
Tumor hypoxia has independent predictor impact only in patients with node-negative cervix cancer.
-
10.1200/JCO.20.3.680, 11821448
-
Fyles A, Milosevic M, Hedley D, Pintilie M, Levin W, Manchul L, Hill RP. Tumor hypoxia has independent predictor impact only in patients with node-negative cervix cancer. J Clin Oncol 2002, 20:680-687. 10.1200/JCO.20.3.680, 11821448.
-
(2002)
J Clin Oncol
, vol.20
, pp. 680-687
-
-
Fyles, A.1
Milosevic, M.2
Hedley, D.3
Pintilie, M.4
Levin, W.5
Manchul, L.6
Hill, R.P.7
-
2
-
-
0029775242
-
Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix.
-
Hockel M, Schlenger K, Aral B, Mitze M, Schaffer U, Vaupel P. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res 1996, 56:4509-4515.
-
(1996)
Cancer Res
, vol.56
, pp. 4509-4515
-
-
Hockel, M.1
Schlenger, K.2
Aral, B.3
Mitze, M.4
Schaffer, U.5
Vaupel, P.6
-
3
-
-
77952107920
-
Assessment of tumour hypoxia for prediction of response to therapy and cancer prognosis.
-
10.1111/j.1582-4934.2009.00944.x, 19840191
-
Jubb AM, Buffa FM, Harris AL. Assessment of tumour hypoxia for prediction of response to therapy and cancer prognosis. J Cell Mol Med 2010, 14:18-29. 10.1111/j.1582-4934.2009.00944.x, 19840191.
-
(2010)
J Cell Mol Med
, vol.14
, pp. 18-29
-
-
Jubb, A.M.1
Buffa, F.M.2
Harris, A.L.3
-
4
-
-
26444466467
-
Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study.
-
10.1016/j.radonc.2005.06.038, 16098619
-
Nordsmark M, Bentzen SM, Rudat V, Brizel D, Lartigau E, Stadler P, Becker A, Adam M, Molls M, Dunst J, Terris DJ, Overgaard J. Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study. Radiother Oncol 2005, 77:18-24. 10.1016/j.radonc.2005.06.038, 16098619.
-
(2005)
Radiother Oncol
, vol.77
, pp. 18-24
-
-
Nordsmark, M.1
Bentzen, S.M.2
Rudat, V.3
Brizel, D.4
Lartigau, E.5
Stadler, P.6
Becker, A.7
Adam, M.8
Molls, M.9
Dunst, J.10
Terris, D.J.11
Overgaard, J.12
-
5
-
-
34547121206
-
Hypoxia in cancer: significance and impact on clinical outcome.
-
10.1007/s10555-007-9055-1, 17440684
-
Vaupel P, Mayer A. Hypoxia in cancer: significance and impact on clinical outcome. Cancer Metastasis Rev 2007, 26:225-239. 10.1007/s10555-007-9055-1, 17440684.
-
(2007)
Cancer Metastasis Rev
, vol.26
, pp. 225-239
-
-
Vaupel, P.1
Mayer, A.2
-
6
-
-
0141869070
-
Investigating hypoxic tumor physiology through gene expression patterns.
-
10.1038/sj.onc.1206703, 12947397
-
Denko NC, Fontana LA, Hudson KM, Sutphin PD, Raychaudhuri S, Altman R, Giaccia AJ. Investigating hypoxic tumor physiology through gene expression patterns. Oncogene 2003, 22:5907-5914. 10.1038/sj.onc.1206703, 12947397.
-
(2003)
Oncogene
, vol.22
, pp. 5907-5914
-
-
Denko, N.C.1
Fontana, L.A.2
Hudson, K.M.3
Sutphin, P.D.4
Raychaudhuri, S.5
Altman, R.6
Giaccia, A.J.7
-
7
-
-
0032053169
-
Oxygen sensing, hypoxia-inducible factor-1 and the regulation of mammalian gene expression.
-
Ratcliffe PJ, O'Rourke JF, Maxwell PH, Pugh CW. Oxygen sensing, hypoxia-inducible factor-1 and the regulation of mammalian gene expression. J Exp Biol 1998, 201:1153-1162.
-
(1998)
J Exp Biol
, vol.201
, pp. 1153-1162
-
-
Ratcliffe, P.J.1
O'Rourke, J.F.2
Maxwell, P.H.3
Pugh, C.W.4
-
8
-
-
0032190614
-
Hypoxia-inducible factor 1: master regulator of O2 homeostasis.
-
10.1016/S0959-437X(98)80016-6, 9794818
-
Semenza GL. Hypoxia-inducible factor 1: master regulator of O2 homeostasis. Curr Opin Genet Dev 1998, 8:588-594. 10.1016/S0959-437X(98)80016-6, 9794818.
-
(1998)
Curr Opin Genet Dev
, vol.8
, pp. 588-594
-
-
Semenza, G.L.1
-
9
-
-
57149142495
-
The impact of O2 availability on human cancer.
-
10.1038/nrc2540, 3140692, 18987634
-
Bertout JA, Patel SA, Simon MC. The impact of O2 availability on human cancer. Nat Rev Cancer 2008, 8:967-975. 10.1038/nrc2540, 3140692, 18987634.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 967-975
-
-
Bertout, J.A.1
Patel, S.A.2
Simon, M.C.3
-
10
-
-
76349095132
-
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics.
-
10.1038/onc.2009.441, 2969168, 19946328
-
Semenza GL. Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene 2010, 29:625-634. 10.1038/onc.2009.441, 2969168, 19946328.
-
(2010)
Oncogene
, vol.29
, pp. 625-634
-
-
Semenza, G.L.1
-
11
-
-
0030460724
-
Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1.
-
10.1074/jbc.271.51.32529, 8955077
-
Semenza GL, Jiang BH, Leung SW, Passantino R, Concordet JP, Maire P, Giallongo A. Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. J Biol Chem 1996, 271:32529-32537. 10.1074/jbc.271.51.32529, 8955077.
-
(1996)
J Biol Chem
, vol.271
, pp. 32529-32537
-
-
Semenza, G.L.1
Jiang, B.H.2
Leung, S.W.3
Passantino, R.4
Concordet, J.P.5
Maire, P.6
Giallongo, A.7
-
12
-
-
0034671307
-
Hypoxia-inducible expression of tumor-associated carbonic anhydrases.
-
Wykoff CC, Beasley NJ, Watson PH, Turner KJ, Pastorek J, Sibtain A, Wilson GD, Turley H, Talks KL, Maxwell PH, Pugh CW, Ratcliffe PJ, Harris AL. Hypoxia-inducible expression of tumor-associated carbonic anhydrases. Cancer Res 2000, 60:7075-7083.
-
(2000)
Cancer Res
, vol.60
, pp. 7075-7083
-
-
Wykoff, C.C.1
Beasley, N.J.2
Watson, P.H.3
Turner, K.J.4
Pastorek, J.5
Sibtain, A.6
Wilson, G.D.7
Turley, H.8
Talks, K.L.9
Maxwell, P.H.10
Pugh, C.W.11
Ratcliffe, P.J.12
Harris, A.L.13
-
13
-
-
0038037735
-
Regulation of angiogenesis by hypoxia: role of the HIF system.
-
10.1038/nm0603-677, 12778166
-
Pugh CW, Ratcliffe PJ. Regulation of angiogenesis by hypoxia: role of the HIF system. Nat Med 2003, 9:677-684. 10.1038/nm0603-677, 12778166.
-
(2003)
Nat Med
, vol.9
, pp. 677-684
-
-
Pugh, C.W.1
Ratcliffe, P.J.2
-
14
-
-
33751277287
-
CAIX is an independent prognostic marker in premenopausal breast cancer patients with one to three positive lymph nodes and a putative marker of radiation resistance.
-
10.1158/1078-0432.CCR-06-0480, 17085655
-
Brennan DJ, Jirstrom K, Kronblad A, Millikan RC, Landberg G, Duffy MJ, Ryden L, Gallagher WM, O'Brien SL. CAIX is an independent prognostic marker in premenopausal breast cancer patients with one to three positive lymph nodes and a putative marker of radiation resistance. Clin Cancer Res 2006, 12:6421-6431. 10.1158/1078-0432.CCR-06-0480, 17085655.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 6421-6431
-
-
Brennan, D.J.1
Jirstrom, K.2
Kronblad, A.3
Millikan, R.C.4
Landberg, G.5
Duffy, M.J.6
Ryden, L.7
Gallagher, W.M.8
O'Brien, S.L.9
-
15
-
-
0035881075
-
Prognostic significance of a novel hypoxia-regulated marker, carbonic anhydrase IX, in invasive breast carcinoma.
-
Chia SK, Wykoff CC, Watson PH, Han C, Leek RD, Pastorek J, Gatter KC, Ratcliffe P, Harris AL. Prognostic significance of a novel hypoxia-regulated marker, carbonic anhydrase IX, in invasive breast carcinoma. J Clin Oncol 2001, 19:3660-3668.
-
(2001)
J Clin Oncol
, vol.19
, pp. 3660-3668
-
-
Chia, S.K.1
Wykoff, C.C.2
Watson, P.H.3
Han, C.4
Leek, R.D.5
Pastorek, J.6
Gatter, K.C.7
Ratcliffe, P.8
Harris, A.L.9
-
16
-
-
33751111993
-
Role of carbonic anhydrase IX expression in prediction of the efficacy and outcome of primary epirubicin/tamoxifen therapy for breast cancer.
-
10.1677/erc.1.01216, 16954440
-
Generali D, Fox SB, Berruti A, Brizzi MP, Campo L, Bonardi S, Wigfield SM, Bruzzi P, Bersiga A, Allevi G, Milani M, Aguggini S, Dogliotti L, Bottini A, Harris AL. Role of carbonic anhydrase IX expression in prediction of the efficacy and outcome of primary epirubicin/tamoxifen therapy for breast cancer. Endocr Relat Cancer 2006, 13:921-930. 10.1677/erc.1.01216, 16954440.
-
(2006)
Endocr Relat Cancer
, vol.13
, pp. 921-930
-
-
Generali, D.1
Fox, S.B.2
Berruti, A.3
Brizzi, M.P.4
Campo, L.5
Bonardi, S.6
Wigfield, S.M.7
Bruzzi, P.8
Bersiga, A.9
Allevi, G.10
Milani, M.11
Aguggini, S.12
Dogliotti, L.13
Bottini, A.14
Harris, A.L.15
-
17
-
-
0344109584
-
Markers of tumor angiogenesis and proteolysis independently define high- and low-risk subsets of node-negative breast cancer patients.
-
Eppenberger U, Kueng W, Schlaeppi JM, Roesel JL, Benz C, Mueller H, Matter A, Zuber M, Luescher K, Litschgi M, Schmitt M, Foekens JA, Eppenberger-Castori S. Markers of tumor angiogenesis and proteolysis independently define high- and low-risk subsets of node-negative breast cancer patients. J Clin Oncol 1998, 16:3129-3136.
-
(1998)
J Clin Oncol
, vol.16
, pp. 3129-3136
-
-
Eppenberger, U.1
Kueng, W.2
Schlaeppi, J.M.3
Roesel, J.L.4
Benz, C.5
Mueller, H.6
Matter, A.7
Zuber, M.8
Luescher, K.9
Litschgi, M.10
Schmitt, M.11
Foekens, J.A.12
Eppenberger-Castori, S.13
-
18
-
-
0031032073
-
Prognostic significance of vascular endothelial growth factor protein in node-negative breast carcinoma.
-
10.1093/jnci/89.2.139, 8998183
-
Gasparini G, Toi M, Gion M, Verderio P, Dittadi R, Hanatani M, Matsubara I, Vinante O, Bonoldi E, Boracchi P, Gatti C, Suzuki H, Tominaga T. Prognostic significance of vascular endothelial growth factor protein in node-negative breast carcinoma. J Natl Cancer Inst 1997, 89:139-147. 10.1093/jnci/89.2.139, 8998183.
-
(1997)
J Natl Cancer Inst
, vol.89
, pp. 139-147
-
-
Gasparini, G.1
Toi, M.2
Gion, M.3
Verderio, P.4
Dittadi, R.5
Hanatani, M.6
Matsubara, I.7
Vinante, O.8
Bonoldi, E.9
Boracchi, P.10
Gatti, C.11
Suzuki, H.12
Tominaga, T.13
-
19
-
-
0034034667
-
Correlation of vascular endothelial growth factor content with recurrences, survival, and first relapse site in primary node-positive breast carcinoma after adjuvant treatment.
-
Linderholm B, Grankvist K, Wilking N, Johansson M, Tavelin B, Henriksson R. Correlation of vascular endothelial growth factor content with recurrences, survival, and first relapse site in primary node-positive breast carcinoma after adjuvant treatment. J Clin Oncol 2000, 18:1423-1431.
-
(2000)
J Clin Oncol
, vol.18
, pp. 1423-1431
-
-
Linderholm, B.1
Grankvist, K.2
Wilking, N.3
Johansson, M.4
Tavelin, B.5
Henriksson, R.6
-
20
-
-
0036808431
-
Clinical significance of glucose transporter 1 (GLUT1) expression in human breast carcinoma.
-
Kang SS, Chun YK, Hur MH, Lee HK, Kim YJ, Hong SR, Lee JH, Lee SG, Park YK. Clinical significance of glucose transporter 1 (GLUT1) expression in human breast carcinoma. Jpn J Cancer Res 2002, 93:1123-1128.
-
(2002)
Jpn J Cancer Res
, vol.93
, pp. 1123-1128
-
-
Kang, S.S.1
Chun, Y.K.2
Hur, M.H.3
Lee, H.K.4
Kim, Y.J.5
Hong, S.R.6
Lee, J.H.7
Lee, S.G.8
Park, Y.K.9
-
21
-
-
19944434232
-
Differential prognostic impact of hypoxia induced and diffuse HIF-1α expression in invasive breast cancer.
-
10.1136/jcp.2004.019885, 1770566, 15677538
-
Vleugel MM, Greijer AE, Shvarts A, van der Groep P, van Berkel M, Aarbodem Y, van Tinteren H, Harris AL, van Diest PJ, van der Wall E. Differential prognostic impact of hypoxia induced and diffuse HIF-1α expression in invasive breast cancer. J Clin Pathol 2005, 58:172-177. 10.1136/jcp.2004.019885, 1770566, 15677538.
-
(2005)
J Clin Pathol
, vol.58
, pp. 172-177
-
-
Vleugel, M.M.1
Greijer, A.E.2
Shvarts, A.3
van der Groep, P.4
van Berkel, M.5
Aarbodem, Y.6
van Tinteren, H.7
Harris, A.L.8
van Diest, P.J.9
van der Wall, E.10
-
22
-
-
33751430258
-
Lactate dehydrogenase 5 (LDH-5) expression in endometrial cancer relates to the activated VEGF/VEGFR2(KDR) pathway and prognosis.
-
10.1016/j.ygyno.2006.05.043, 16837029
-
Giatromanolaki A, Sivridis E, Gatter KC, Turley H, Harris AL, Koukourakis MI. Lactate dehydrogenase 5 (LDH-5) expression in endometrial cancer relates to the activated VEGF/VEGFR2(KDR) pathway and prognosis. Gynecol Oncol 2006, 103:912-918. 10.1016/j.ygyno.2006.05.043, 16837029.
-
(2006)
Gynecol Oncol
, vol.103
, pp. 912-918
-
-
Giatromanolaki, A.1
Sivridis, E.2
Gatter, K.C.3
Turley, H.4
Harris, A.L.5
Koukourakis, M.I.6
-
23
-
-
23944498840
-
Lactate dehydrogenase 5 (LDH5) relates to up-regulated hypoxia inducible factor pathway and metastasis in colorectal cancer.
-
10.1007/s10585-005-2343-7, 16132575
-
Koukourakis MI, Giatromanolaki A, Simopoulos C, Polychronidis A, Sivridis E. Lactate dehydrogenase 5 (LDH5) relates to up-regulated hypoxia inducible factor pathway and metastasis in colorectal cancer. Clin Exp Metastasis 2005, 22:25-30. 10.1007/s10585-005-2343-7, 16132575.
-
(2005)
Clin Exp Metastasis
, vol.22
, pp. 25-30
-
-
Koukourakis, M.I.1
Giatromanolaki, A.2
Simopoulos, C.3
Polychronidis, A.4
Sivridis, E.5
-
24
-
-
0141730410
-
Lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosis.
-
10.1038/sj.bjc.6601205, 2394471, 12942121
-
Koukourakis MI, Giatromanolaki A, Sivridis E, Bougioukas G, Didilis V, Gatter KC, Harris AL. Lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosis. Br J Cancer 2003, 89:877-885. 10.1038/sj.bjc.6601205, 2394471, 12942121.
-
(2003)
Br J Cancer
, vol.89
, pp. 877-885
-
-
Koukourakis, M.I.1
Giatromanolaki, A.2
Sivridis, E.3
Bougioukas, G.4
Didilis, V.5
Gatter, K.C.6
Harris, A.L.7
-
25
-
-
33749027749
-
Lactate dehydrogenase 5 expression in operable colorectal cancer: strong association with survival and activated vascular endothelial growth factor pathway - a report of the Tumour Angiogenesis Research Group.
-
10.1200/JCO.2006.05.9501, 16896001
-
Koukourakis MI, Giatromanolaki A, Sivridis E, Gatter KC, Harris AL. Lactate dehydrogenase 5 expression in operable colorectal cancer: strong association with survival and activated vascular endothelial growth factor pathway - a report of the Tumour Angiogenesis Research Group. J Clin Oncol 2006, 24:4301-4308. 10.1200/JCO.2006.05.9501, 16896001.
-
(2006)
J Clin Oncol
, vol.24
, pp. 4301-4308
-
-
Koukourakis, M.I.1
Giatromanolaki, A.2
Sivridis, E.3
Gatter, K.C.4
Harris, A.L.5
-
26
-
-
70449673054
-
Lactate dehydrogenase 5 expression in squamous cell head and neck cancer relates to prognosis following radical or postoperative radiotherapy.
-
10.1159/000259260, 19923867
-
Koukourakis MI, Giatromanolaki A, Winter S, Leek R, Sivridis E, Harris AL. Lactate dehydrogenase 5 expression in squamous cell head and neck cancer relates to prognosis following radical or postoperative radiotherapy. Oncology 2009, 77:285-292. 10.1159/000259260, 19923867.
-
(2009)
Oncology
, vol.77
, pp. 285-292
-
-
Koukourakis, M.I.1
Giatromanolaki, A.2
Winter, S.3
Leek, R.4
Sivridis, E.5
Harris, A.L.6
-
27
-
-
57649086035
-
Serum and tissue LDH levels in patients with breast/gynaecological cancer and benign diseases.
-
10.1159/000183250, 19088479
-
Koukourakis MI, Kontomanolis E, Giatromanolaki A, Sivridis E, Liberis V. Serum and tissue LDH levels in patients with breast/gynaecological cancer and benign diseases. Gynecol Obstet Invest 2009, 67:162-168. 10.1159/000183250, 19088479.
-
(2009)
Gynecol Obstet Invest
, vol.67
, pp. 162-168
-
-
Koukourakis, M.I.1
Kontomanolis, E.2
Giatromanolaki, A.3
Sivridis, E.4
Liberis, V.5
-
28
-
-
79955837932
-
Metabolic markers in relation to hypoxia; staining patterns and colocalization of pimonidazole, HIF-1α, CAIX, LDH-5, GLUT-1, MCT1 and MCT4.
-
10.1186/1471-2407-11-167, 3115911, 21569415
-
Rademakers SE, Lok J, van der Kogel AJ, Bussink J, Kaanders JH. Metabolic markers in relation to hypoxia; staining patterns and colocalization of pimonidazole, HIF-1α, CAIX, LDH-5, GLUT-1, MCT1 and MCT4. BMC Cancer 2011, 11:167. 10.1186/1471-2407-11-167, 3115911, 21569415.
-
(2011)
BMC Cancer
, vol.11
, pp. 167
-
-
Rademakers, S.E.1
Lok, J.2
van der Kogel, A.J.3
Bussink, J.4
Kaanders, J.H.5
-
29
-
-
54549089738
-
Hypoxia signalling through mTOR and the unfolded protein response in cancer.
-
10.1038/nrc2501, 18846101
-
Wouters BG, Koritzinsky M. Hypoxia signalling through mTOR and the unfolded protein response in cancer. Nat Rev Cancer 2008, 8:851-864. 10.1038/nrc2501, 18846101.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 851-864
-
-
Wouters, B.G.1
Koritzinsky, M.2
-
30
-
-
10044276783
-
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex.
-
10.1101/gad.1256804, 534650, 15545625
-
Brugarolas J, Lei K, Hurley RL, Manning BD, Reiling JH, Hafen E, Witters LA, Ellisen LW, Kaelin WG. Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes Dev 2004, 18:2893-2904. 10.1101/gad.1256804, 534650, 15545625.
-
(2004)
Genes Dev
, vol.18
, pp. 2893-2904
-
-
Brugarolas, J.1
Lei, K.2
Hurley, R.L.3
Manning, B.D.4
Reiling, J.H.5
Hafen, E.6
Witters, L.A.7
Ellisen, L.W.8
Kaelin, W.G.9
-
31
-
-
37248999267
-
Bnip3 mediates the hypoxia-induced inhibition on mammalian target of rapamycin by interacting with Rheb.
-
10.1074/jbc.M705231200, 17928295
-
Li Y, Wang Y, Kim E, Beemiller P, Wang CY, Swanson J, You M, Guan KL. Bnip3 mediates the hypoxia-induced inhibition on mammalian target of rapamycin by interacting with Rheb. J Biol Chem 2007, 282:35803-35813. 10.1074/jbc.M705231200, 17928295.
-
(2007)
J Biol Chem
, vol.282
, pp. 35803-35813
-
-
Li, Y.1
Wang, Y.2
Kim, E.3
Beemiller, P.4
Wang, C.Y.5
Swanson, J.6
You, M.7
Guan, K.L.8
-
32
-
-
34547134517
-
Hypoxia-inducible factor 1α is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif.
-
10.1074/jbc.M611782200, 17502379
-
Land SC, Tee AR. Hypoxia-inducible factor 1α is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif. J Biol Chem 2007, 282:20534-20543. 10.1074/jbc.M611782200, 17502379.
-
(2007)
J Biol Chem
, vol.282
, pp. 20534-20543
-
-
Land, S.C.1
Tee, A.R.2
-
33
-
-
0028307739
-
Hypoxia and drug resistance.
-
10.1007/BF00689633, 7923547
-
Teicher BA. Hypoxia and drug resistance. Cancer Metastasis Rev 1994, 13:139-168. 10.1007/BF00689633, 7923547.
-
(1994)
Cancer Metastasis Rev
, vol.13
, pp. 139-168
-
-
Teicher, B.A.1
-
34
-
-
79957534572
-
Targeting hypoxia in cancer therapy.
-
Wilson WR, Hay MP. Targeting hypoxia in cancer therapy. Nat Rev Cancer 11:393-410.
-
Nat Rev Cancer
, vol.11
, pp. 393-410
-
-
Wilson, W.R.1
Hay, M.P.2
-
35
-
-
0038282482
-
The hypoxia-inducible factor-1 α is a negative factor for tumor therapy.
-
10.1038/sj.onc.1206385, 12761491
-
Unruh A, Ressel A, Mohamed HG, Johnson RS, Nadrowitz R, Richter E, Katschinski DM, Wenger RH. The hypoxia-inducible factor-1 α is a negative factor for tumor therapy. Oncogene 2003, 22:3213-3220. 10.1038/sj.onc.1206385, 12761491.
-
(2003)
Oncogene
, vol.22
, pp. 3213-3220
-
-
Unruh, A.1
Ressel, A.2
Mohamed, H.G.3
Johnson, R.S.4
Nadrowitz, R.5
Richter, E.6
Katschinski, D.M.7
Wenger, R.H.8
-
36
-
-
33748037026
-
Hypoxia-inducible factor-1α expression predicts a poor response to primary chemoendocrine therapy and disease-free survival in primary human breast cancer.
-
10.1158/1078-0432.CCR-05-2690, 16899602
-
Generali D, Berruti A, Brizzi MP, Campo L, Bonardi S, Wigfield S, Bersiga A, Allevi G, Milani M, Aguggini S, Gandolfi V, Dogliotti L, Bottini A, Harris AL, Fox SB. Hypoxia-inducible factor-1α expression predicts a poor response to primary chemoendocrine therapy and disease-free survival in primary human breast cancer. Clin Cancer Res 2006, 12:4562-4568. 10.1158/1078-0432.CCR-05-2690, 16899602.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 4562-4568
-
-
Generali, D.1
Berruti, A.2
Brizzi, M.P.3
Campo, L.4
Bonardi, S.5
Wigfield, S.6
Bersiga, A.7
Allevi, G.8
Milani, M.9
Aguggini, S.10
Gandolfi, V.11
Dogliotti, L.12
Bottini, A.13
Harris, A.L.14
Fox, S.B.15
-
37
-
-
58249084142
-
Phosphorylated ERα, HIF-1α, and MAPK signaling as predictors of primary endocrine treatment response and resistance in patients with breast cancer.
-
10.1200/JCO.2007.13.7083, 19064988
-
Generali D, Buffa FM, Berruti A, Brizzi MP, Campo L, Bonardi S, Bersiga A, Allevi G, Milani M, Aguggini S, Papotti M, Dogliotti L, Bottini A, Harris AL, Fox SB. Phosphorylated ERα, HIF-1α, and MAPK signaling as predictors of primary endocrine treatment response and resistance in patients with breast cancer. J Clin Oncol 2009, 27:227-234. 10.1200/JCO.2007.13.7083, 19064988.
-
(2009)
J Clin Oncol
, vol.27
, pp. 227-234
-
-
Generali, D.1
Buffa, F.M.2
Berruti, A.3
Brizzi, M.P.4
Campo, L.5
Bonardi, S.6
Bersiga, A.7
Allevi, G.8
Milani, M.9
Aguggini, S.10
Papotti, M.11
Dogliotti, L.12
Bottini, A.13
Harris, A.L.14
Fox, S.B.15
-
38
-
-
0043123069
-
Carbonic anhydrase-9 expression levels and prognosis in human breast cancer: association with treatment outcome.
-
10.1038/sj.bjc.6601122, 2394253, 12865916
-
Span PN, Bussink J, Manders P, Beex LV, Sweep CG. Carbonic anhydrase-9 expression levels and prognosis in human breast cancer: association with treatment outcome. Br J Cancer 2003, 89:271-276. 10.1038/sj.bjc.6601122, 2394253, 12865916.
-
(2003)
Br J Cancer
, vol.89
, pp. 271-276
-
-
Span, P.N.1
Bussink, J.2
Manders, P.3
Beex, L.V.4
Sweep, C.G.5
-
39
-
-
38349155463
-
Tumor angiogenic and hypoxic profiles predict radiographic response and survival in malignant astrocytoma patients treated with bevacizumab and irinotecan.
-
10.1200/JCO.2007.13.3652, 18182667
-
Sathornsumetee S, Cao Y, Marcello JE, Herndon JE, McLendon RE, Desjardins A, Friedman HS, Dewhirst MW, Vredenburgh JJ, Rich JN. Tumor angiogenic and hypoxic profiles predict radiographic response and survival in malignant astrocytoma patients treated with bevacizumab and irinotecan. J Clin Oncol 2008, 26:271-278. 10.1200/JCO.2007.13.3652, 18182667.
-
(2008)
J Clin Oncol
, vol.26
, pp. 271-278
-
-
Sathornsumetee, S.1
Cao, Y.2
Marcello, J.E.3
Herndon, J.E.4
McLendon, R.E.5
Desjardins, A.6
Friedman, H.S.7
Dewhirst, M.W.8
Vredenburgh, J.J.9
Rich, J.N.10
-
40
-
-
80053222067
-
Use of pretreatment serum CA9 (carbonic anhydrase 9) to predict PFS and survival in trastuzumab-treated metastatic breast cancer.
-
Leitzel H HH, Shrivastava V, Anyanwu U, Ali SM, Koestler W, Fuchs E, Brown-Shimer S, Carney W, Lipton A. Use of pretreatment serum CA9 (carbonic anhydrase 9) to predict PFS and survival in trastuzumab-treated metastatic breast cancer. J Clin Oncol 2009, 27:11092.
-
(2009)
J Clin Oncol
, vol.27
, pp. 11092
-
-
Leitzel H, H.H.1
Shrivastava, V.2
Anyanwu, U.3
Ali, S.M.4
Koestler, W.5
Fuchs, E.6
Brown-Shimer, S.7
Carney, W.8
Lipton, A.9
-
41
-
-
0027489912
-
Overexpression of Glut-1 glucose transporter in human breast cancer. An immunohistochemical study.
-
10.1002/1097-0142(19931115)72:10<2979::AID-CNCR2820721020>3.0.CO;2-X, 8221565
-
Brown RS, Wahl RL. Overexpression of Glut-1 glucose transporter in human breast cancer. An immunohistochemical study. Cancer 1993, 72:2979-2985. 10.1002/1097-0142(19931115)72:10<2979::AID-CNCR2820721020>3.0.CO;2-X, 8221565.
-
(1993)
Cancer
, vol.72
, pp. 2979-2985
-
-
Brown, R.S.1
Wahl, R.L.2
-
42
-
-
35148870732
-
Glut-1 antibodies induce growth arrest and apoptosis in human cancer cell lines.
-
10.1016/j.canlet.2007.07.021, 17910902
-
Rastogi S, Banerjee S, Chellappan S, Simon GR. Glut-1 antibodies induce growth arrest and apoptosis in human cancer cell lines. Cancer Lett 2007, 257:244-251. 10.1016/j.canlet.2007.07.021, 17910902.
-
(2007)
Cancer Lett
, vol.257
, pp. 244-251
-
-
Rastogi, S.1
Banerjee, S.2
Chellappan, S.3
Simon, G.R.4
-
43
-
-
0035878753
-
High tumor levels of vascular endothelial growth factor predict poor response to systemic therapy in advanced breast cancer.
-
Foekens JA, Peters HA, Grebenchtchikov N, Look MP, Meijer-van Gelder ME, Geurts-Moespot A, van der Kwast TH, Sweep CG, Klijn JG. High tumor levels of vascular endothelial growth factor predict poor response to systemic therapy in advanced breast cancer. Cancer Res 2001, 61:5407-5414.
-
(2001)
Cancer Res
, vol.61
, pp. 5407-5414
-
-
Foekens, J.A.1
Peters, H.A.2
Grebenchtchikov, N.3
Look, M.P.4
Meijer-van Gelder, M.E.5
Geurts-Moespot, A.6
van der Kwast, T.H.7
Sweep, C.G.8
Klijn, J.G.9
-
44
-
-
79957894276
-
Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases.
-
10.1038/nrd3455, 21629292
-
Carmeliet P, Jain RK. Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases. Nat Rev Drug Discov 2011, 10:417-427. 10.1038/nrd3455, 21629292.
-
(2011)
Nat Rev Drug Discov
, vol.10
, pp. 417-427
-
-
Carmeliet, P.1
Jain, R.K.2
-
45
-
-
84855167770
-
Assessing early therapeutic response to bevacizumab in primary breast cancer using magnetic resonance imaging and gene expression profiles.
-
Mehta S, Hughes NP, Buffa FM, Li SP, Adams RF, Adwani A, Taylor NJ, Levitt NC, Padhani AR, Makris A, Harris AL. Assessing early therapeutic response to bevacizumab in primary breast cancer using magnetic resonance imaging and gene expression profiles. J Natl Cancer Inst 2011,
-
(2011)
J Natl Cancer Inst
-
-
Mehta, S.1
Hughes, N.P.2
Buffa, F.M.3
Li, S.P.4
Adams, R.F.5
Adwani, A.6
Taylor, N.J.7
Levitt, N.C.8
Padhani, A.R.9
Makris, A.10
Harris, A.L.11
-
46
-
-
67651166780
-
Increased antitumor activity of bevacizumab in combination with hypoxia inducible factor-1 inhibition.
-
10.1158/1535-7163.MCT-09-0274, 2745101, 19584228
-
Rapisarda A, Hollingshead M, Uranchimeg B, Bonomi CA, Borgel SD, Carter JP, Gehrs B, Raffeld M, Kinders RJ, Parchment R, Anver MR, Shoemaker RH, Melillo G. Increased antitumor activity of bevacizumab in combination with hypoxia inducible factor-1 inhibition. Mol Cancer Ther 2009, 8:1867-1877. 10.1158/1535-7163.MCT-09-0274, 2745101, 19584228.
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 1867-1877
-
-
Rapisarda, A.1
Hollingshead, M.2
Uranchimeg, B.3
Bonomi, C.A.4
Borgel, S.D.5
Carter, J.P.6
Gehrs, B.7
Raffeld, M.8
Kinders, R.J.9
Parchment, R.10
Anver, M.R.11
Shoemaker, R.H.12
Melillo, G.13
-
47
-
-
34248172298
-
Relation of a hypoxia metagene derived from head and neck cancer to prognosis of multiple cancers.
-
10.1158/0008-5472.CAN-06-3322, 17409455
-
Winter SC, Buffa FM, Silva P, Miller C, Valentine HR, Turley H, Shah KA, Cox GJ, Corbridge RJ, Homer JJ, Musgrove B, Slevin N, Sloan P, Price P, West CM, Harris AL. Relation of a hypoxia metagene derived from head and neck cancer to prognosis of multiple cancers. Cancer Res 2007, 67:3441-3449. 10.1158/0008-5472.CAN-06-3322, 17409455.
-
(2007)
Cancer Res
, vol.67
, pp. 3441-3449
-
-
Winter, S.C.1
Buffa, F.M.2
Silva, P.3
Miller, C.4
Valentine, H.R.5
Turley, H.6
Shah, K.A.7
Cox, G.J.8
Corbridge, R.J.9
Homer, J.J.10
Musgrove, B.11
Slevin, N.12
Sloan, P.13
Price, P.14
West, C.M.15
Harris, A.L.16
-
48
-
-
31044444974
-
Reversing hypoxic cell chemoresistance in vitro using genetic and small molecule approaches targeting hypoxia inducible factor-1.
-
Brown LM, Cowen RL, Debray C, Eustace A, Erler JT, Sheppard FC, Parker CA, Stratford IJ, Williams KJ. Reversing hypoxic cell chemoresistance in vitro using genetic and small molecule approaches targeting hypoxia inducible factor-1. Mol Pharmacol 2006, 69:411-418.
-
(2006)
Mol Pharmacol
, vol.69
, pp. 411-418
-
-
Brown, L.M.1
Cowen, R.L.2
Debray, C.3
Eustace, A.4
Erler, J.T.5
Sheppard, F.C.6
Parker, C.A.7
Stratford, I.J.8
Williams, K.J.9
-
49
-
-
1242271198
-
Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: mechanism and therapeutic implications.
-
10.1158/0008-5472.CAN-03-3139, 14983893
-
Rapisarda A, Uranchimeg B, Sordet O, Pommier Y, Shoemaker RH, Melillo G. Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: mechanism and therapeutic implications. Cancer Res 2004, 64:1475-1482. 10.1158/0008-5472.CAN-03-3139, 14983893.
-
(2004)
Cancer Res
, vol.64
, pp. 1475-1482
-
-
Rapisarda, A.1
Uranchimeg, B.2
Sordet, O.3
Pommier, Y.4
Shoemaker, R.H.5
Melillo, G.6
-
50
-
-
4944229705
-
Schedule-dependent inhibition of hypoxia-inducible factor-1α protein accumulation, angiogenesis, and tumor growth by topotecan in U251-HRE glioblastoma xenografts.
-
10.1158/0008-5472.CAN-04-2116, 15466170
-
Rapisarda A, Zalek J, Hollingshead M, Braunschweig T, Uranchimeg B, Bonomi CA, Borgel SD, Carter JP, Hewitt SM, Shoemaker RH, Melillo G. Schedule-dependent inhibition of hypoxia-inducible factor-1α protein accumulation, angiogenesis, and tumor growth by topotecan in U251-HRE glioblastoma xenografts. Cancer Res 2004, 64:6845-6848. 10.1158/0008-5472.CAN-04-2116, 15466170.
-
(2004)
Cancer Res
, vol.64
, pp. 6845-6848
-
-
Rapisarda, A.1
Zalek, J.2
Hollingshead, M.3
Braunschweig, T.4
Uranchimeg, B.5
Bonomi, C.A.6
Borgel, S.D.7
Carter, J.P.8
Hewitt, S.M.9
Shoemaker, R.H.10
Melillo, G.11
-
51
-
-
23044431754
-
A phase II trial with pharmacodynamic endpoints of the proteasome inhibitor bortezomib in patients with metastatic colorectal cancer.
-
10.1158/1078-0432.CCR-05-0081, 16061869
-
Mackay H, Hedley D, Major P, Townsley C, Mackenzie M, Vincent M, Degendorfer P, Tsao MS, Nicklee T, Birle D, Wright J, Siu L, Moore M, Oza A. A phase II trial with pharmacodynamic endpoints of the proteasome inhibitor bortezomib in patients with metastatic colorectal cancer. Clin Cancer Res 2005, 11:5526-5533. 10.1158/1078-0432.CCR-05-0081, 16061869.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 5526-5533
-
-
Mackay, H.1
Hedley, D.2
Major, P.3
Townsley, C.4
Mackenzie, M.5
Vincent, M.6
Degendorfer, P.7
Tsao, M.S.8
Nicklee, T.9
Birle, D.10
Wright, J.11
Siu, L.12
Moore, M.13
Oza, A.14
-
52
-
-
38349092288
-
Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1α.
-
10.1158/1535-7163.MCT-07-0463, 18202012
-
Koh MY, Spivak-Kroizman T, Venturini S, Welsh S, Williams RR, Kirkpatrick DL, Powis G. Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1α. Mol Cancer Ther 2008, 7:90-100. 10.1158/1535-7163.MCT-07-0463, 18202012.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 90-100
-
-
Koh, M.Y.1
Spivak-Kroizman, T.2
Venturini, S.3
Welsh, S.4
Williams, R.R.5
Kirkpatrick, D.L.6
Powis, G.7
-
53
-
-
57749106966
-
A novel mode of action of YC-1 in HIF inhibition: stimulation of FIH-dependent p300 dissociation from HIF-1α.
-
10.1158/1535-7163.MCT-08-0074, 19074848
-
Li SH, Shin DH, Chun YS, Lee MK, Kim MS, Park JW. A novel mode of action of YC-1 in HIF inhibition: stimulation of FIH-dependent p300 dissociation from HIF-1α. Mol Cancer Ther 2008, 7:3729-3738. 10.1158/1535-7163.MCT-08-0074, 19074848.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 3729-3738
-
-
Li, S.H.1
Shin, D.H.2
Chun, Y.S.3
Lee, M.K.4
Kim, M.S.5
Park, J.W.6
-
54
-
-
33749546461
-
Identification of novel small-molecule inhibitors of hypoxia-inducible factor-1 transactivation and DNA binding.
-
10.1158/1535-7163.MCT-05-0443, 16985052
-
Jones DT, Harris AL. Identification of novel small-molecule inhibitors of hypoxia-inducible factor-1 transactivation and DNA binding. Mol Cancer Ther 2006, 5:2193-2202. 10.1158/1535-7163.MCT-05-0443, 16985052.
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 2193-2202
-
-
Jones, D.T.1
Harris, A.L.2
-
55
-
-
33749318557
-
Novel thioredoxin inhibitors paradoxically increase hypoxia-inducible factor-alpha expression but decrease functional transcriptional activity, DNA binding, and degradation.
-
10.1158/1078-0432.CCR-05-2380, 17000671
-
Jones DT, Pugh CW, Wigfield S, Stevens MF, Harris AL. Novel thioredoxin inhibitors paradoxically increase hypoxia-inducible factor-alpha expression but decrease functional transcriptional activity, DNA binding, and degradation. Clin Cancer Res 2006, 12:5384-5394. 10.1158/1078-0432.CCR-05-2380, 17000671.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 5384-5394
-
-
Jones, D.T.1
Pugh, C.W.2
Wigfield, S.3
Stevens, M.F.4
Harris, A.L.5
-
56
-
-
33645066360
-
Effects of transferrin receptor blockade on cancer cell proliferation and hypoxia-inducible factor function and their differential regulation by ascorbate.
-
10.1158/0008-5472.CAN-05-3857, 16510596
-
Jones DT, Trowbridge IS, Harris AL. Effects of transferrin receptor blockade on cancer cell proliferation and hypoxia-inducible factor function and their differential regulation by ascorbate. Cancer Res 2006, 66:2749-2756. 10.1158/0008-5472.CAN-05-3857, 16510596.
-
(2006)
Cancer Res
, vol.66
, pp. 2749-2756
-
-
Jones, D.T.1
Trowbridge, I.S.2
Harris, A.L.3
-
57
-
-
34547092699
-
Targeted cancer gene therapy using a hypoxia inducible factor dependent oncolytic adenovirus armed with interleukin-4.
-
10.1158/0008-5472.CAN-06-3244, 2262867, 17638898
-
Post DE, Sandberg EM, Kyle MM, Devi NS, Brat DJ, Xu Z, Tighiouart M, Van Meir EG. Targeted cancer gene therapy using a hypoxia inducible factor dependent oncolytic adenovirus armed with interleukin-4. Cancer Res 2007, 67:6872-6881. 10.1158/0008-5472.CAN-06-3244, 2262867, 17638898.
-
(2007)
Cancer Res
, vol.67
, pp. 6872-6881
-
-
Post, D.E.1
Sandberg, E.M.2
Kyle, M.M.3
Devi, N.S.4
Brat, D.J.5
Xu, Z.6
Tighiouart, M.7
Van Meir, E.G.8
-
58
-
-
77954815583
-
Antisense HIF-1α prevents acquired tumor resistance to angiostatin gene therapy.
-
10.1038/cgt.2010.7, 20348876
-
Sun X, Vale M, Jiang X, Gupta R, Krissansen GW. Antisense HIF-1α prevents acquired tumor resistance to angiostatin gene therapy. Cancer Gene Ther 2010, 17:532-540. 10.1038/cgt.2010.7, 20348876.
-
(2010)
Cancer Gene Ther
, vol.17
, pp. 532-540
-
-
Sun, X.1
Vale, M.2
Jiang, X.3
Gupta, R.4
Krissansen, G.W.5
-
59
-
-
33751543273
-
Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy.
-
10.1080/09553000601002324, 17118889
-
Tatum JL, Kelloff GJ, Gillies RJ, Arbeit JM, Brown JM, Chao KS, Chapman JD, Eckelman WC, Fyles AW, Giaccia AJ, Hill RP, Koch CJ, Krishna MC, Krohn KA, Lewis JS, Mason RP, Melillo G, Padhani AR, Powis G, Rajendran JG, Reba R, Robinson SP, Semenza GL, Swartz HM, Vaupel P, Yang D, Croft B, Hoffman J, Liu G, Stone H, et al. Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy. Int J Radiat Biol 2006, 82:699-757. 10.1080/09553000601002324, 17118889.
-
(2006)
Int J Radiat Biol
, vol.82
, pp. 699-757
-
-
Tatum, J.L.1
Kelloff, G.J.2
Gillies, R.J.3
Arbeit, J.M.4
Brown, J.M.5
Chao, K.S.6
Chapman, J.D.7
Eckelman, W.C.8
Fyles, A.W.9
Giaccia, A.J.10
Hill, R.P.11
Koch, C.J.12
Krishna, M.C.13
Krohn, K.A.14
Lewis, J.S.15
Mason, R.P.16
Melillo, G.17
Padhani, A.R.18
Powis, G.19
Rajendran, J.G.20
Reba, R.21
Robinson, S.P.22
Semenza, G.L.23
Swartz, H.M.24
Vaupel, P.25
Yang, D.26
Croft, B.27
Hoffman, J.28
Liu, G.29
Stone, H.30
more..
-
60
-
-
70350532485
-
Initial results of hypoxia imaging using 1-alpha-D: -(5-deoxy-5-[18F]-fluoroarabinofuranosyl)-2-nitroimidazole (18F-FAZA).
-
10.1007/s00259-009-1154-5, 19430784
-
Postema EJ, McEwan AJ, Riauka TA, Kumar P, Richmond DA, Abrams DN, Wiebe LI. Initial results of hypoxia imaging using 1-alpha-D: -(5-deoxy-5-[18F]-fluoroarabinofuranosyl)-2-nitroimidazole (18F-FAZA). Eur J Nucl Med Mol Imaging 2009, 36:1565-1573. 10.1007/s00259-009-1154-5, 19430784.
-
(2009)
Eur J Nucl Med Mol Imaging
, vol.36
, pp. 1565-1573
-
-
Postema, E.J.1
McEwan, A.J.2
Riauka, T.A.3
Kumar, P.4
Richmond, D.A.5
Abrams, D.N.6
Wiebe, L.I.7
-
61
-
-
77956187952
-
PET imaging of hypoxia using [18F]HX4: a phase I trial.
-
10.1007/s00259-010-1437-x, 20369236
-
van Loon J, Janssen MH, Ollers M, Aerts HJ, Dubois L, Hochstenbag M, Dingemans AM, Lalisang R, Brans B, Windhorst B, van Dongen GA, Kolb H, Zhang J, De Ruysscher D, Lambin P. PET imaging of hypoxia using [18F]HX4: a phase I trial. Eur J Nucl Med Mol Imaging 2010, 37:1663-1668. 10.1007/s00259-010-1437-x, 20369236.
-
(2010)
Eur J Nucl Med Mol Imaging
, vol.37
, pp. 1663-1668
-
-
van Loon, J.1
Janssen, M.H.2
Ollers, M.3
Aerts, H.J.4
Dubois, L.5
Hochstenbag, M.6
Dingemans, A.M.7
Lalisang, R.8
Brans, B.9
Windhorst, B.10
van Dongen, G.A.11
Kolb, H.12
Zhang, J.13
De Ruysscher, D.14
Lambin, P.15
-
62
-
-
79851501698
-
Molecular imaging of hypoxia.
-
10.2967/jnumed.110.075663, 21233176
-
Chitneni SK, Palmer GM, Zalutsky MR, Dewhirst MW. Molecular imaging of hypoxia. J Nucl Med 2011, 52:165-168. 10.2967/jnumed.110.075663, 21233176.
-
(2011)
J Nucl Med
, vol.52
, pp. 165-168
-
-
Chitneni, S.K.1
Palmer, G.M.2
Zalutsky, M.R.3
Dewhirst, M.W.4
-
63
-
-
75649117850
-
Large meta-analysis of multiple cancers reveals a common, compact and highly prognostic hypoxia metagene.
-
10.1038/sj.bjc.6605450, 2816644, 20087356
-
Buffa FM, Harris AL, West CM, Miller CJ. Large meta-analysis of multiple cancers reveals a common, compact and highly prognostic hypoxia metagene. Br J Cancer 2010, 102:428-435. 10.1038/sj.bjc.6605450, 2816644, 20087356.
-
(2010)
Br J Cancer
, vol.102
, pp. 428-435
-
-
Buffa, F.M.1
Harris, A.L.2
West, C.M.3
Miller, C.J.4
-
64
-
-
58149157900
-
The genomic analysis of lactic acidosis and acidosis response in human cancers.
-
10.1371/journal.pgen.1000293, 2585811, 19057672
-
Chen JL, Lucas JE, Schroeder T, Mori S, Wu J, Nevins J, Dewhirst M, West M, Chi JT. The genomic analysis of lactic acidosis and acidosis response in human cancers. PLoS Genet 2008, 4:e1000293. 10.1371/journal.pgen.1000293, 2585811, 19057672.
-
(2008)
PLoS Genet
, vol.4
-
-
Chen, J.L.1
Lucas, J.E.2
Schroeder, T.3
Mori, S.4
Wu, J.5
Nevins, J.6
Dewhirst, M.7
West, M.8
Chi, J.T.9
-
65
-
-
33644551073
-
Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers.
-
10.1371/journal.pmed.0030047, 1334226, 16417408
-
Chi JT, Wang Z, Nuyten DS, Rodriguez EH, Schaner ME, Salim A, Wang Y, Kristensen GB, Helland A, Borresen-Dale AL, Giaccia A, Longaker MT, Hastie T, Yang GP, van de Vijver MJ, Brown PO. Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers. PLoS Med 2006, 3:e47. 10.1371/journal.pmed.0030047, 1334226, 16417408.
-
(2006)
PLoS Med
, vol.3
-
-
Chi, J.T.1
Wang, Z.2
Nuyten, D.S.3
Rodriguez, E.H.4
Schaner, M.E.5
Salim, A.6
Wang, Y.7
Kristensen, G.B.8
Helland, A.9
Borresen-Dale, A.L.10
Giaccia, A.11
Longaker, M.T.12
Hastie, T.13
Yang, G.P.14
van de Vijver, M.J.15
Brown, P.O.16
-
66
-
-
33845808289
-
Predicting a local recurrence after breast-conserving therapy by gene expression profiling.
-
10.1186/bcr1614, 1779489, 17069664
-
Nuyten DS, Kreike B, Hart AA, Chi JT, Sneddon JB, Wessels LF, Peterse HJ, Bartelink H, Brown PO, Chang HY, van de Vijver MJ. Predicting a local recurrence after breast-conserving therapy by gene expression profiling. Breast Cancer Res 2006, 8:R62. 10.1186/bcr1614, 1779489, 17069664.
-
(2006)
Breast Cancer Res
, vol.8
-
-
Nuyten, D.S.1
Kreike, B.2
Hart, A.A.3
Chi, J.T.4
Sneddon, J.B.5
Wessels, L.F.6
Peterse, H.J.7
Bartelink, H.8
Brown, P.O.9
Chang, H.Y.10
van de Vijver, M.J.11
-
67
-
-
34250323878
-
Impact of supervised gene signatures of early hypoxia on patient survival.
-
10.1016/j.radonc.2007.05.002, 17532074
-
Seigneuric R, Starmans MH, Fung G, Krishnapuram B, Nuyten DS, van Erk A, Magagnin MG, Rouschop KM, Krishnan S, Rao RB, Evelo CT, Begg AC, Wouters BG, Lambin P. Impact of supervised gene signatures of early hypoxia on patient survival. Radiother Oncol 2007, 83:374-382. 10.1016/j.radonc.2007.05.002, 17532074.
-
(2007)
Radiother Oncol
, vol.83
, pp. 374-382
-
-
Seigneuric, R.1
Starmans, M.H.2
Fung, G.3
Krishnapuram, B.4
Nuyten, D.S.5
van Erk, A.6
Magagnin, M.G.7
Rouschop, K.M.8
Krishnan, S.9
Rao, R.B.10
Evelo, C.T.11
Begg, A.C.12
Wouters, B.G.13
Lambin, P.14
-
68
-
-
77956402239
-
MicroRNA-210 regulates mitochondrial free radical response to hypoxia and Krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU.
-
10.1371/journal.pone.0010345, 2859946, 20436681
-
Favaro E, Ramachandran A, McCormick R, Gee H, Blancher C, Crosby M, Devlin C, Blick C, Buffa F, Li JL, Vojnovic B, Pires das Neves R, Glazer P, Iborra F, Ivan M, Ragoussis J, Harris AL. MicroRNA-210 regulates mitochondrial free radical response to hypoxia and Krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU. PLoS One 2010, 5:e10345. 10.1371/journal.pone.0010345, 2859946, 20436681.
-
(2010)
PLoS One
, vol.5
-
-
Favaro, E.1
Ramachandran, A.2
McCormick, R.3
Gee, H.4
Blancher, C.5
Crosby, M.6
Devlin, C.7
Blick, C.8
Buffa, F.9
Li, J.L.10
Vojnovic, B.11
Pires das Neves, R.12
Glazer, P.13
Iborra, F.14
Ivan, M.15
Ragoussis, J.16
Harris, A.L.17
-
69
-
-
58249088751
-
MicroRNAs: target recognition and regulatory functions.
-
10.1016/j.cell.2009.01.002, 19167326
-
Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell 2009, 136:215-233. 10.1016/j.cell.2009.01.002, 19167326.
-
(2009)
Cell
, vol.136
, pp. 215-233
-
-
Bartel, D.P.1
-
70
-
-
38349169664
-
Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?.
-
Filipowicz W, Bhattacharyya SN, Sonenberg N. Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?. Nat Rev Genet 2008, 9:102-114.
-
(2008)
Nat Rev Genet
, vol.9
, pp. 102-114
-
-
Filipowicz, W.1
Bhattacharyya, S.N.2
Sonenberg, N.3
-
71
-
-
4644309196
-
The functions of animal microRNAs.
-
10.1038/nature02871, 15372042
-
Ambros V. The functions of animal microRNAs. Nature 2004, 431:350-355. 10.1038/nature02871, 15372042.
-
(2004)
Nature
, vol.431
, pp. 350-355
-
-
Ambros, V.1
-
72
-
-
60149084560
-
MicroRNAs and cancer: short RNAs go a long way.
-
10.1016/j.cell.2009.02.005, 19239879
-
Ventura A, Jacks T. MicroRNAs and cancer: short RNAs go a long way. Cell 2009, 136:586-591. 10.1016/j.cell.2009.02.005, 19239879.
-
(2009)
Cell
, vol.136
, pp. 586-591
-
-
Ventura, A.1
Jacks, T.2
-
73
-
-
80052223077
-
MicroRNA associated progression pathways and potential therapeutic targets identified by integrated mRNA and microRNA expression profiling in breast cancer.
-
Buffa FM, Camps C, Winchester L, Snell CE, Gee HE, Sheldon H, Taylor M, Harris AL, Ragoussis J. microRNA associated progression pathways and potential therapeutic targets identified by integrated mRNA and microRNA expression profiling in breast cancer. Cancer Res 2011,
-
(2011)
Cancer Res
-
-
Buffa, F.M.1
Camps, C.2
Winchester, L.3
Snell, C.E.4
Gee, H.E.5
Sheldon, H.6
Taylor, M.7
Harris, A.L.8
Ragoussis, J.9
-
74
-
-
51349103144
-
Four miRNAs associated with aggressiveness of lymph node-negative, estrogen receptor-positive human breast cancer.
-
10.1073/pnas.0803304105, 2529088, 18755890
-
Foekens JA, Sieuwerts AM, Smid M, Look MP, de Weerd V, Boersma AW, Klijn JG, Wiemer EA, Martens JW. Four miRNAs associated with aggressiveness of lymph node-negative, estrogen receptor-positive human breast cancer. Proc Natl Acad Sci USA 2008, 105:13021-13026. 10.1073/pnas.0803304105, 2529088, 18755890.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 13021-13026
-
-
Foekens, J.A.1
Sieuwerts, A.M.2
Smid, M.3
Look, M.P.4
de Weerd, V.5
Boersma, A.W.6
Klijn, J.G.7
Wiemer, E.A.8
Martens, J.W.9
-
75
-
-
56949084876
-
MicroRNA profiling as a tool to understand prognosis, therapy response and resistance in breast cancer.
-
10.1016/j.ejca.2008.09.037, 19022662
-
Iorio MV, Casalini P, Tagliabue E, Menard S, Croce CM. MicroRNA profiling as a tool to understand prognosis, therapy response and resistance in breast cancer. Eur J Cancer 2008, 44:2753-2759. 10.1016/j.ejca.2008.09.037, 19022662.
-
(2008)
Eur J Cancer
, vol.44
, pp. 2753-2759
-
-
Iorio, M.V.1
Casalini, P.2
Tagliabue, E.3
Menard, S.4
Croce, C.M.5
-
76
-
-
23844555119
-
MicroRNA gene expression deregulation in human breast cancer.
-
10.1158/0008-5472.CAN-05-1783, 16103053
-
Iorio MV, Ferracin M, Liu CG, Veronese A, Spizzo R, Sabbioni S, Magri E, Pedriali M, Fabbri M, Campiglio M, Menard S, Palazzo JP, Rosenberg A, Musiani P, Volinia S, Nenci I, Calin GA, Querzoli P, Negrini M, Croce CM. MicroRNA gene expression deregulation in human breast cancer. Cancer Res 2005, 65:7065-7070. 10.1158/0008-5472.CAN-05-1783, 16103053.
-
(2005)
Cancer Res
, vol.65
, pp. 7065-7070
-
-
Iorio, M.V.1
Ferracin, M.2
Liu, C.G.3
Veronese, A.4
Spizzo, R.5
Sabbioni, S.6
Magri, E.7
Pedriali, M.8
Fabbri, M.9
Campiglio, M.10
Menard, S.11
Palazzo, J.P.12
Rosenberg, A.13
Musiani, P.14
Volinia, S.15
Nenci, I.16
Calin, G.A.17
Querzoli, P.18
Negrini, M.19
Croce, C.M.20
more..
-
77
-
-
40949137731
-
Hsa-miR-210 Is induced by hypoxia and is an independent prognostic factor in breast cancer.
-
10.1158/1078-0432.CCR-07-1755, 18316553
-
Camps C, Buffa FM, Colella S, Moore J, Sotiriou C, Sheldon H, Harris AL, Gleadle JM, Ragoussis J. hsa-miR-210 Is induced by hypoxia and is an independent prognostic factor in breast cancer. Clin Cancer Res 2008, 14:1340-1348. 10.1158/1078-0432.CCR-07-1755, 18316553.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 1340-1348
-
-
Camps, C.1
Buffa, F.M.2
Colella, S.3
Moore, J.4
Sotiriou, C.5
Sheldon, H.6
Harris, A.L.7
Gleadle, J.M.8
Ragoussis, J.9
-
78
-
-
33847234988
-
A microRNA signature of hypoxia.
-
10.1128/MCB.01395-06, 1820461, 17194750
-
Kulshreshtha R, Ferracin M, Wojcik SE, Garzon R, Alder H, Agosto-Perez FJ, Davuluri R, Liu CG, Croce CM, Negrini M, Calin GA, Ivan M. A microRNA signature of hypoxia. Mol Cell Biol 2007, 27:1859-1867. 10.1128/MCB.01395-06, 1820461, 17194750.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 1859-1867
-
-
Kulshreshtha, R.1
Ferracin, M.2
Wojcik, S.E.3
Garzon, R.4
Alder, H.5
Agosto-Perez, F.J.6
Davuluri, R.7
Liu, C.G.8
Croce, C.M.9
Negrini, M.10
Calin, G.A.11
Ivan, M.12
-
79
-
-
77953483108
-
MicroRNA-210: a unique and pleiotropic hypoxamir.
-
10.4161/cc.9.6.11006, 2912143, 20237418
-
Chan SY, Loscalzo J. MicroRNA-210: a unique and pleiotropic hypoxamir. Cell Cycle 2010, 9:1072-1083. 10.4161/cc.9.6.11006, 2912143, 20237418.
-
(2010)
Cell Cycle
, vol.9
, pp. 1072-1083
-
-
Chan, S.Y.1
Loscalzo, J.2
-
80
-
-
59149091637
-
MicroRNA regulation of DNA repair gene expression in hypoxic stress.
-
10.1158/0008-5472.CAN-08-2516, 2997438, 19141645
-
Crosby ME, Kulshreshtha R, Ivan M, Glazer PM. MicroRNA regulation of DNA repair gene expression in hypoxic stress. Cancer Res 2009, 69:1221-1229. 10.1158/0008-5472.CAN-08-2516, 2997438, 19141645.
-
(2009)
Cancer Res
, vol.69
, pp. 1221-1229
-
-
Crosby, M.E.1
Kulshreshtha, R.2
Ivan, M.3
Glazer, P.M.4
-
81
-
-
47049119934
-
MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3.
-
10.1074/jbc.M800731200, 18417479
-
Fasanaro P, D'Alessandra Y, Di Stefano V, Melchionna R, Romani S, Pompilio G, Capogrossi MC, Martelli F. MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3. J Biol Chem 2008, 283:15878-15883. 10.1074/jbc.M800731200, 18417479.
-
(2008)
J Biol Chem
, vol.283
, pp. 15878-15883
-
-
Fasanaro, P.1
D'Alessandra, Y.2
Di Stefano, V.3
Melchionna, R.4
Romani, S.5
Pompilio, G.6
Capogrossi, M.C.7
Martelli, F.8
-
82
-
-
42549092314
-
MiR-210 links hypoxia with cell cycle regulation and is deleted in human epithelial ovarian cancer.
-
10.4161/cbt.7.2.5297, 18059191
-
Giannakakis A, Sandaltzopoulos R, Greshock J, Liang S, Huang J, Hasegawa K, Li C, O'Brien-Jenkins A, Katsaros D, Weber BL, Simon C, Coukos G, Zhang L. miR-210 links hypoxia with cell cycle regulation and is deleted in human epithelial ovarian cancer. Cancer Biol Ther 2008, 7:255-264. 10.4161/cbt.7.2.5297, 18059191.
-
(2008)
Cancer Biol Ther
, vol.7
, pp. 255-264
-
-
Giannakakis, A.1
Sandaltzopoulos, R.2
Greshock, J.3
Liang, S.4
Huang, J.5
Hasegawa, K.6
Li, C.7
O'Brien-Jenkins, A.8
Katsaros, D.9
Weber, B.L.10
Simon, C.11
Coukos, G.12
Zhang, L.13
-
83
-
-
70349168446
-
Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation.
-
10.1016/j.molcel.2009.09.006, 2782615, 19782034
-
Huang X, Ding L, Bennewith KL, Tong RT, Welford SM, Ang KK, Story M, Le QT, Giaccia AJ. Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation. Mol Cell 2009, 35:856-867. 10.1016/j.molcel.2009.09.006, 2782615, 19782034.
-
(2009)
Mol Cell
, vol.35
, pp. 856-867
-
-
Huang, X.1
Ding, L.2
Bennewith, K.L.3
Tong, R.T.4
Welford, S.M.5
Ang, K.K.6
Story, M.7
Le, Q.T.8
Giaccia, A.J.9
-
84
-
-
70450240736
-
Ischemic preconditioning augments survival of stem cells via miR-210 expression by targeting caspase-8-associated protein 2.
-
10.1074/jbc.M109.020925, 2785158, 19721136
-
Kim HW, Haider HK, Jiang S, Ashraf M. Ischemic preconditioning augments survival of stem cells via miR-210 expression by targeting caspase-8-associated protein 2. J Biol Chem 2009, 284:33161-33168. 10.1074/jbc.M109.020925, 2785158, 19721136.
-
(2009)
J Biol Chem
, vol.284
, pp. 33161-33168
-
-
Kim, H.W.1
Haider, H.K.2
Jiang, S.3
Ashraf, M.4
-
85
-
-
79951678403
-
MiR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity.
-
Puissegur MP, Mazure NM, Bertero T, Pradelli L, Grosso S, Robbe-Sermesant K, Maurin T, Lebrigand K, Cardinaud B, Hofman V, Fourre S, Magnone V, Ricci JE, Pouyssegur J, Gounon P, Hofman P, Barbry P, Mari B. miR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity. Cell Death Differ 2010, 18:465-478.
-
(2010)
Cell Death Differ
, vol.18
, pp. 465-478
-
-
Puissegur, M.P.1
Mazure, N.M.2
Bertero, T.3
Pradelli, L.4
Grosso, S.5
Robbe-Sermesant, K.6
Maurin, T.7
Lebrigand, K.8
Cardinaud, B.9
Hofman, V.10
Fourre, S.11
Magnone, V.12
Ricci, J.E.13
Pouyssegur, J.14
Gounon, P.15
Hofman, P.16
Barbry, P.17
Mari, B.18
-
86
-
-
78650944900
-
MicroRNA-210 regulates cancer cell proliferation through targeting fibroblast growth factor receptor-like 1 (FGFRL1).
-
Tsuchiya S, Fujiwara T, Sato F, Shimada Y, Tanaka E, Sakai Y, Shimizu K, Tsujimoto G. MicroRNA-210 regulates cancer cell proliferation through targeting fibroblast growth factor receptor-like 1 (FGFRL1). J Biol Chem 2010, 286:420-428.
-
(2010)
J Biol Chem
, vol.286
, pp. 420-428
-
-
Tsuchiya, S.1
Fujiwara, T.2
Sato, F.3
Shimada, Y.4
Tanaka, E.5
Sakai, Y.6
Shimizu, K.7
Tsujimoto, G.8
-
87
-
-
69749107748
-
MicroRNA miR-210 modulates cellular response to hypoxia through the MYC antagonist MNT.
-
10.4161/cc.8.17.9387, 19652553
-
Zhang Z, Sun H, Dai H, Walsh RM, Imakura M, Schelter J, Burchard J, Dai X, Chang AN, Diaz RL, Marszalek JR, Bartz SR, Carleton M, Cleary MA, Linsley PS, Grandori C. MicroRNA miR-210 modulates cellular response to hypoxia through the MYC antagonist MNT. Cell Cycle 2009, 8:2756-2768. 10.4161/cc.8.17.9387, 19652553.
-
(2009)
Cell Cycle
, vol.8
, pp. 2756-2768
-
-
Zhang, Z.1
Sun, H.2
Dai, H.3
Walsh, R.M.4
Imakura, M.5
Schelter, J.6
Burchard, J.7
Dai, X.8
Chang, A.N.9
Diaz, R.L.10
Marszalek, J.R.11
Bartz, S.R.12
Carleton, M.13
Cleary, M.A.14
Linsley, P.S.15
Grandori, C.16
-
88
-
-
79957613439
-
MiR-495 is upregulated by E12/E47 in breast cancer stem cells, and promotes oncogenesis and hypoxia resistance via downregulation of E-cadherin and REDD1.
-
10.1038/onc.2010.618, 21258409
-
Hwang-Verslues WW, Chang PH, Wei PC, Yang CY, Huang CK, Kuo WH, Shew JY, Chang KJ, Lee EY, Lee WH. miR-495 is upregulated by E12/E47 in breast cancer stem cells, and promotes oncogenesis and hypoxia resistance via downregulation of E-cadherin and REDD1. Oncogene 2011, 30:2463-2474. 10.1038/onc.2010.618, 21258409.
-
(2011)
Oncogene
, vol.30
, pp. 2463-2474
-
-
Hwang-Verslues, W.W.1
Chang, P.H.2
Wei, P.C.3
Yang, C.Y.4
Huang, C.K.5
Kuo, W.H.6
Shew, J.Y.7
Chang, K.J.8
Lee, E.Y.9
Lee, W.H.10
-
89
-
-
43449102192
-
Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma.
-
10.1111/j.1365-2141.2008.07077.x, 18318758
-
Lawrie CH, Gal S, Dunlop HM, Pushkaran B, Liggins AP, Pulford K, Banham AH, Pezzella F, Boultwood J, Wainscoat JS, Hatton CS, Harris AL. Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma. Br J Haematol 2008, 141:672-675. 10.1111/j.1365-2141.2008.07077.x, 18318758.
-
(2008)
Br J Haematol
, vol.141
, pp. 672-675
-
-
Lawrie, C.H.1
Gal, S.2
Dunlop, H.M.3
Pushkaran, B.4
Liggins, A.P.5
Pulford, K.6
Banham, A.H.7
Pezzella, F.8
Boultwood, J.9
Wainscoat, J.S.10
Hatton, C.S.11
Harris, A.L.12
-
90
-
-
0036278899
-
Overexpression of hypoxia-inducible factor 1α is associated with an unfavorable prognosis in lymph node-positive breast cancer.
-
Schindl M, Schoppmann SF, Samonigg H, Hausmaninger H, Kwasny W, Gnant M, Jakesz R, Kubista E, Birner P, Oberhuber G. Overexpression of hypoxia-inducible factor 1α is associated with an unfavorable prognosis in lymph node-positive breast cancer. Clin Cancer Res 2002, 8:1831-1837.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 1831-1837
-
-
Schindl, M.1
Schoppmann, S.F.2
Samonigg, H.3
Hausmaninger, H.4
Kwasny, W.5
Gnant, M.6
Jakesz, R.7
Kubista, E.8
Birner, P.9
Oberhuber, G.10
-
91
-
-
33847649279
-
HIF-1α and CAIX staining in invasive breast carcinomas: prognosis and treatment outcome.
-
10.1002/ijc.22436, 17245699
-
Trastour C, Benizri E, Ettore F, Ramaioli A, Chamorey E, Pouyssegur J, Berra E. HIF-1α and CAIX staining in invasive breast carcinomas: prognosis and treatment outcome. Int J Cancer 2007, 120:1451-1458. 10.1002/ijc.22436, 17245699.
-
(2007)
Int J Cancer
, vol.120
, pp. 1451-1458
-
-
Trastour, C.1
Benizri, E.2
Ettore, F.3
Ramaioli, A.4
Chamorey, E.5
Pouyssegur, J.6
Berra, E.7
-
92
-
-
0037443587
-
Levels of hypoxia-inducible factor-1α independently predict prognosis in patients with lymph node negative breast carcinoma.
-
10.1002/cncr.11246, 12627523
-
Bos R, van der Groep P, Greijer AE, Shvarts A, Meijer S, Pinedo HM, Semenza GL, van Diest PJ, van der Wall E. Levels of hypoxia-inducible factor-1α independently predict prognosis in patients with lymph node negative breast carcinoma. Cancer 2003, 97:1573-1581. 10.1002/cncr.11246, 12627523.
-
(2003)
Cancer
, vol.97
, pp. 1573-1581
-
-
Bos, R.1
van der Groep, P.2
Greijer, A.E.3
Shvarts, A.4
Meijer, S.5
Pinedo, H.M.6
Semenza, G.L.7
van Diest, P.J.8
van der Wall, E.9
-
93
-
-
3142724677
-
Hypoxia-inducible factor 1α in high-risk breast cancer: an independent prognostic parameter?.
-
10.1186/bcr775, 400672, 15084243
-
Gruber G, Greiner RH, Hlushchuk R, Aebersold DM, Altermatt HJ, Berclaz G, Djonov V. Hypoxia-inducible factor 1α in high-risk breast cancer: an independent prognostic parameter?. Breast Cancer Res 2004, 6:R191-198. 10.1186/bcr775, 400672, 15084243.
-
(2004)
Breast Cancer Res
, vol.6
-
-
Gruber, G.1
Greiner, R.H.2
Hlushchuk, R.3
Aebersold, D.M.4
Altermatt, H.J.5
Berclaz, G.6
Djonov, V.7
-
94
-
-
46949094778
-
Hypoxia-inducible factor 1α is closely linked to an aggressive phenotype in breast cancer.
-
10.1007/s10549-007-9742-1, 17805961
-
Yamamoto Y, Ibusuki M, Okumura Y, Kawasoe T, Kai K, Iyama K, Iwase H. Hypoxia-inducible factor 1α is closely linked to an aggressive phenotype in breast cancer. Breast Cancer Res Treat 2008, 110:465-475. 10.1007/s10549-007-9742-1, 17805961.
-
(2008)
Breast Cancer Res Treat
, vol.110
, pp. 465-475
-
-
Yamamoto, Y.1
Ibusuki, M.2
Okumura, Y.3
Kawasoe, T.4
Kai, K.5
Iyama, K.6
Iwase, H.7
-
95
-
-
33747589866
-
Hypoxia inducible factor-1α correlates with VEGF-C expression and lymphangiogenesis in breast cancer.
-
10.1007/s10549-006-9190-3, 16555123
-
Schoppmann SF, Fenzl A, Schindl M, Bachleitner-Hofmann T, Nagy K, Gnant M, Horvat R, Jakesz R, Birner P. Hypoxia inducible factor-1α correlates with VEGF-C expression and lymphangiogenesis in breast cancer. Breast Cancer Res Treat 2006, 99:135-141. 10.1007/s10549-006-9190-3, 16555123.
-
(2006)
Breast Cancer Res Treat
, vol.99
, pp. 135-141
-
-
Schoppmann, S.F.1
Fenzl, A.2
Schindl, M.3
Bachleitner-Hofmann, T.4
Nagy, K.5
Gnant, M.6
Horvat, R.7
Jakesz, R.8
Birner, P.9
-
96
-
-
23244463512
-
Overexpression of hypoxia-inducible factor HIF-1α predicts early relapse in breast cancer: retrospective study in a series of 745 patients.
-
10.1002/ijc.20984, 15849727
-
Dales JP, Garcia S, Meunier-Carpentier S, Andrac-Meyer L, Haddad O, Lavaut MN, Allasia C, Bonnier P, Charpin C. Overexpression of hypoxia-inducible factor HIF-1α predicts early relapse in breast cancer: retrospective study in a series of 745 patients. Int J Cancer 2005, 116:734-739. 10.1002/ijc.20984, 15849727.
-
(2005)
Int J Cancer
, vol.116
, pp. 734-739
-
-
Dales, J.P.1
Garcia, S.2
Meunier-Carpentier, S.3
Andrac-Meyer, L.4
Haddad, O.5
Lavaut, M.N.6
Allasia, C.7
Bonnier, P.8
Charpin, C.9
-
97
-
-
56449095636
-
Hypoxia-inducible factor-2α correlates to distant recurrence and poor outcome in invasive breast cancer.
-
10.1158/0008-5472.CAN-08-1135, 19010893
-
Helczynska K, Larsson AM, Holmquist Mengelbier L, Bridges E, Fredlund E, Borgquist S, Landberg G, Pahlman S, Jirstrom K. Hypoxia-inducible factor-2α correlates to distant recurrence and poor outcome in invasive breast cancer. Cancer Res 2008, 68:9212-9220. 10.1158/0008-5472.CAN-08-1135, 19010893.
-
(2008)
Cancer Res
, vol.68
, pp. 9212-9220
-
-
Helczynska, K.1
Larsson, A.M.2
Holmquist Mengelbier, L.3
Bridges, E.4
Fredlund, E.5
Borgquist, S.6
Landberg, G.7
Pahlman, S.8
Jirstrom, K.9
-
98
-
-
80053222818
-
Phase I accelerated dose-escalating safety and pharmacokinetic (PK) study of aryl-hydrocarbon receptor-mediated aminoflavone prodrug AFP464 in advanced solid tumors.
-
abstract 2561
-
Massard C, Gomez-Roca CA, Bahleda R, Nguyen V, Besse-Hammer T, Awada A, Soria J. Phase I accelerated dose-escalating safety and pharmacokinetic (PK) study of aryl-hydrocarbon receptor-mediated aminoflavone prodrug AFP464 in advanced solid tumors. J Clin Oncol 2010, 28(S15 suppl). abstract 2561.
-
(2010)
J Clin Oncol
, vol.28
, Issue.S15 SUPPL
-
-
Massard, C.1
Gomez-Roca, C.A.2
Bahleda, R.3
Nguyen, V.4
Besse-Hammer, T.5
Awada, A.6
Soria, J.7
-
99
-
-
0027244912
-
Phase II trial of echinomycin for the treatment of advanced renal cell carcinoma. A Southwest Oncology Group study.
-
10.1007/BF00874157, 8262733
-
Marshall ME, Wolf MK, Crawford ED, Taylor S, Blumenstein B, Flanigan R, Meyers FJ, Hynes HE, Barlogie B, Eisenberger M. Phase II trial of echinomycin for the treatment of advanced renal cell carcinoma. A Southwest Oncology Group study. Invest New Drugs 1993, 11:207-209. 10.1007/BF00874157, 8262733.
-
(1993)
Invest New Drugs
, vol.11
, pp. 207-209
-
-
Marshall, M.E.1
Wolf, M.K.2
Crawford, E.D.3
Taylor, S.4
Blumenstein, B.5
Flanigan, R.6
Meyers, F.J.7
Hynes, H.E.8
Barlogie, B.9
Eisenberger, M.10
-
100
-
-
22144496224
-
A phase I trial of 17-allylamino-geldanamycin (17AAG) in patients with advanced cancer.
-
abstract 3030
-
Erlichman C, Toft D, Reid J, Goetz M, Ames M, Mandrekar S, Ajei A, McCollum A, Ivy P. A phase I trial of 17-allylamino-geldanamycin (17AAG) in patients with advanced cancer. J Clin Oncol 2004, 22(14S suppl). abstract 3030.
-
(2004)
J Clin Oncol
, vol.22
, Issue.14 S SUPPL
-
-
Erlichman, C.1
Toft, D.2
Reid, J.3
Goetz, M.4
Ames, M.5
Mandrekar, S.6
Ajei, A.7
McCollum, A.8
Ivy, P.9
-
101
-
-
80053239753
-
Phase I trial of oral sorafenib (B) and intravenous 17-allyl-amino-geldanamycin (A) in advanced malignancies: safety and efficacy in metastatic renal cancer (RCC).
-
Vaishampayan UN, Sausville E, Heilbrun LK, Quinn M, Burger A, Ivy P, Li J, Heath E, Lorusso P. Phase I trial of oral sorafenib (B) and intravenous 17-allyl-amino-geldanamycin (A) in advanced malignancies: safety and efficacy in metastatic renal cancer (RCC). 2008 Genitourinary Cancers Symposium, San Francisco, Abstract and Poster Presentation: abstract 368
-
2008 Genitourinary Cancers Symposium, San Francisco, Abstract and Poster Presentation: abstract 368
-
-
Vaishampayan, U.N.1
Sausville, E.2
Heilbrun, L.K.3
Quinn, M.4
Burger, A.5
Ivy, P.6
Li, J.7
Heath, E.8
Lorusso, P.9
-
102
-
-
79952930841
-
Results from a phase I, dose-escalation study of PX-478, an orally available inhibitor of HIF-1α.
-
abstract 3076
-
Tibes R, Falchook G, Von Hoff DD, Weiss GJ, Iyengar T, Kurzrock R, Pestano L, Lowe AM, Herbst R. Results from a phase I, dose-escalation study of PX-478, an orally available inhibitor of HIF-1α. J Clin Oncol 2010, 28(S15 suppl). abstract 3076.
-
(2010)
J Clin Oncol
, vol.28
, Issue.S15 SUPPL.
-
-
Tibes, R.1
Falchook, G.2
Von Hoff, D.D.3
Weiss, G.J.4
Iyengar, T.5
Kurzrock, R.6
Pestano, L.7
Lowe, A.M.8
Herbst, R.9
-
103
-
-
2542559829
-
Molecular marker profiles predict locoregional control of head and neck squamous cell carcinoma in a randomized trial of continuous hyperfractionated accelerated radiotherapy.
-
10.1158/1078-0432.CCR-03-0248, 15173081
-
Buffa FM, Bentzen SM, Daley FM, Dische S, Saunders MI, Richman PI, Wilson GD. Molecular marker profiles predict locoregional control of head and neck squamous cell carcinoma in a randomized trial of continuous hyperfractionated accelerated radiotherapy. Clin Cancer Res 2004, 10:3745-3754. 10.1158/1078-0432.CCR-03-0248, 15173081.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 3745-3754
-
-
Buffa, F.M.1
Bentzen, S.M.2
Daley, F.M.3
Dische, S.4
Saunders, M.I.5
Richman, P.I.6
Wilson, G.D.7
-
104
-
-
45549086958
-
Hypoxia induces microRNA miR-210 in vitro and in vivo ephrin-A3 and neuronal pentraxin 1 are potentially regulated by miR-210.
-
10.1016/j.febslet.2008.05.048, 18539147
-
Pulkkinen K, Malm T, Turunen M, Koistinaho J, Yla-Herttuala S. Hypoxia induces microRNA miR-210 in vitro and in vivo ephrin-A3 and neuronal pentraxin 1 are potentially regulated by miR-210. FEBS Lett 2008, 582:2397-2401. 10.1016/j.febslet.2008.05.048, 18539147.
-
(2008)
FEBS Lett
, vol.582
, pp. 2397-2401
-
-
Pulkkinen, K.1
Malm, T.2
Turunen, M.3
Koistinaho, J.4
Yla-Herttuala, S.5
-
105
-
-
67649381623
-
MiR-210 promotes osteoblastic differentiation through inhibition of AcvR1b.
-
10.1016/j.febslet.2009.06.006, 19520079
-
Mizuno Y, Tokuzawa Y, Ninomiya Y, Yagi K, Yatsuka-Kanesaki Y, Suda T, Fukuda T, Katagiri T, Kondoh Y, Amemiya T, Tashiro H, Okazaki Y. miR-210 promotes osteoblastic differentiation through inhibition of AcvR1b. FEBS Lett 2009, 583:2263-2268. 10.1016/j.febslet.2009.06.006, 19520079.
-
(2009)
FEBS Lett
, vol.583
, pp. 2263-2268
-
-
Mizuno, Y.1
Tokuzawa, Y.2
Ninomiya, Y.3
Yagi, K.4
Yatsuka-Kanesaki, Y.5
Suda, T.6
Fukuda, T.7
Katagiri, T.8
Kondoh, Y.9
Amemiya, T.10
Tashiro, H.11
Okazaki, Y.12
-
106
-
-
71749100911
-
An integrated approach for experimental target identification of hypoxia-induced miR-210.
-
10.1074/jbc.M109.052779, 2787374, 19826008
-
Fasanaro P, Greco S, Lorenzi M, Pescatori M, Brioschi M, Kulshreshtha R, Banfi C, Stubbs A, Calin GA, Ivan M, Capogrossi MC, Martelli F. An integrated approach for experimental target identification of hypoxia-induced miR-210. J Biol Chem 2009, 284:35134-35143. 10.1074/jbc.M109.052779, 2787374, 19826008.
-
(2009)
J Biol Chem
, vol.284
, pp. 35134-35143
-
-
Fasanaro, P.1
Greco, S.2
Lorenzi, M.3
Pescatori, M.4
Brioschi, M.5
Kulshreshtha, R.6
Banfi, C.7
Stubbs, A.8
Calin, G.A.9
Ivan, M.10
Capogrossi, M.C.11
Martelli, F.12
-
107
-
-
70349478990
-
MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2.
-
10.1016/j.cmet.2009.08.015, 2759401, 19808020
-
Chan SY, Zhang YY, Hemann C, Mahoney CE, Zweier JL, Loscalzo J. MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2. Cell Metab 2009, 10:273-284. 10.1016/j.cmet.2009.08.015, 2759401, 19808020.
-
(2009)
Cell Metab
, vol.10
, pp. 273-284
-
-
Chan, S.Y.1
Zhang, Y.Y.2
Hemann, C.3
Mahoney, C.E.4
Zweier, J.L.5
Loscalzo, J.6
-
108
-
-
77955170881
-
Hypoxia-regulated microRNA-210 modulates mitochondrial function and decreases ISCU and COX10 expression.
-
10.1038/onc.2010.193, 20498629
-
Chen Z, Li Y, Zhang H, Huang P, Luthra R. Hypoxia-regulated microRNA-210 modulates mitochondrial function and decreases ISCU and COX10 expression. Oncogene 2010, 29:4362-4368. 10.1038/onc.2010.193, 20498629.
-
(2010)
Oncogene
, vol.29
, pp. 4362-4368
-
-
Chen, Z.1
Li, Y.2
Zhang, H.3
Huang, P.4
Luthra, R.5
|