Polynucleotide kinase-phosphatase enables neurogenesis via multiple DNA repair pathways to maintain genome stability

EMBO Journal

Volumn 34, Issue 19, 2015, Pages 2465-2480

  Shimada, Mikio ^a,b   Dumitrache, Lavinia C ^a   Russell, Helen R ^a   McKinnon, Peter J ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

DNA repair; neurodevelopment; neurologic disease; polynucleotide kinase phosphatase

Indexed keywords

DNA; PHOSPHATASE; POLYNUCLEOTIDE 5' HYDROXYL KINASE; POLYNUCLEOTIDE KINASE PHOSPHATASE; PROTEIN P53; UNCLASSIFIED DRUG; PHOSPHOTRANSFERASE;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DNA DAMAGE; DNA END JOINING REPAIR; DNA REPAIR; DNA STRAND BREAKAGE; EMBRYO; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; ENZYME INACTIVATION; EXCISION REPAIR; FEMALE; FRAMESHIFT MUTATION; GENE DELETION; GENE EXPRESSION; GENOMIC INSTABILITY; HOMEOSTASIS; HOMOLOGOUS RECOMBINATION; INTERNEURON; MALE; MICROCEPHALY; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; WHITE MATTER; ANIMAL; ENZYMOLOGY; GENETICS; HUMAN; METABOLISM; MUTANT MOUSE STRAIN; OLIGODENDROGLIA; PATHOLOGY;

ANIMALS; DNA REPAIR; FRAMESHIFT MUTATION; GENOMIC INSTABILITY; HUMANS; MICE; MICE, MUTANT STRAINS; MICROCEPHALY; NEURAL STEM CELLS; OLIGODENDROGLIA; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR);

EID: 84942834883     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201591363     Document Type: Article

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