A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage

Genes and Development

Volumn 27, Issue 20, 2013, Pages 2227-2232

  Richard, Patricia ^a   Feng, Shuang ^a   Manley, James L ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Exosome; Senataxin; Sumoylation

Indexed keywords

AMYOTROPHIC LATERAL SCLEROSIS PROTEIN 4; ATAXIA OCULOMOTOR APRAXIA PROTEIN 2; PROTEIN RRP45; SENATAXIN; SUMO PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; DEGENERATIVE DISEASE; DNA DAMAGE; DNA LIBRARY; DNA REPAIR; EXOSOME; GENE OVEREXPRESSION; GENOMIC INSTABILITY; HYDROPHOBICITY; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; SUMOYLATION;

EXOSOME; SENATAXIN; SUMOYLATION;

AMYOTROPHIC LATERAL SCLEROSIS; APRAXIAS; DNA DAMAGE; EXOSOME MULTIENZYME RIBONUCLEASE COMPLEX; EXOSOMES; HELA CELLS; HUMANS; MUTATION; RNA HELICASES; RNA-BINDING PROTEINS; SMALL UBIQUITIN-RELATED MODIFIER PROTEINS; SUMOYLATION; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 84885926733     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.224923.113     Document Type: Article

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