TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function

Nature Genetics

Volumn 46, Issue 5, 2014, Pages 516-521

  Gómez Herreros, Fernando ^a   Schuurs Hoeijmakers, Janneke H M ^b,c   McCormack, Mark ^d   Greally, Marie T ^e   Rulten, Stuart ^a   Romero Granados, Rocío ^f   Counihan, Timothy J ^g   Chaila, Elijah ^h   Conroy, Judith ⁱ   Ennis, Sean ⁱ   Delanty, Norman ^d,h   Cortés Ledesma, Felipe ^f   De Brouwer, Arjan P M ^b,c   Cavalleri, Gianpiero L ^d   El Khamisy, Sherif F ^j,k   De Vries, Bert B A ^b,c   Caldecott, Keith W ^a  

^a UNIVERSITY OF SUSSEX   (United Kingdom)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c RADBOUD UNIVERSITY   (Netherlands)

^d ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^e OUR LADY S CHILDREN S HOSPITAL   (Ireland)

^f UNIVERSITY OF SEVILLE   (Spain)

^g UNIVERSITY HOSPITAL GALWAY   (Ireland)

^h BEAUMONT HOSPITAL   (Ireland)

ⁱ UNIVERSITY COLLEGE DUBLIN   (Ireland)

^j UNIVERSITY OF SHEFFIELD   (United Kingdom)

^k ZEWAIL CITY OF SCIENCE AND TECHNOLOGY   (Egypt)

more..

Author keywords

[No Author keywords available]

Indexed keywords

DNA TOPOISOMERASE (ATP HYDROLYSING); PHOSPHODIESTERASE; TYROSYL DNA PHOSPHODIESTERASE 2; UNCLASSIFIED DRUG; ESTERASE; TYROSYL DNA PHOSPHODIESTERASE 2 ENZYME;

ADULT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ATAXIA; BRAIN DEVELOPMENT; BRAIN FUNCTION; CASE REPORT; CELL DENSITY; CEREBELLUM; CHILD; CHROMOSOME BREAKAGE; CONTROLLED STUDY; DNA REPAIR; DOUBLE STRANDED DNA BREAK; ENZYME ACTIVITY; EPILEPSY; GENE MUTATION; GENETIC TRANSCRIPTION; GENOTYPE; HOMOZYGOSITY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; INTELLECTUAL IMPAIRMENT; INTERNEURON; MALE; MECHANICAL TORSION; MISSENSE MUTATION; MITOSIS; NERVE CELL; NERVE CELL DIFFERENTIATION; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; SCHOOL CHILD; SEIZURE; YOUNG ADULT; ANIMAL EXPERIMENT; GENE EXPRESSION; GENE INACTIVATION; MOUSE;

ABNORMALITIES, MULTIPLE; ANIMALS; ANTIGENS, NEOPLASM; ATAXIA; BASE SEQUENCE; BRAIN; CHROMATIN IMMUNOPRECIPITATION; DNA BREAKS, DOUBLE-STRANDED; DNA TOPOISOMERASES, TYPE II; DNA-BINDING PROTEINS; EXOME; FLUORESCENT ANTIBODY TECHNIQUE; HOMOZYGOTE; HUMANS; INTELLECTUAL DISABILITY; MICE; MICROARRAY ANALYSIS; MOLECULAR SEQUENCE DATA; NEURONS; NUCLEAR PROTEINS; REAL-TIME POLYMERASE CHAIN REACTION; SEIZURES; SEQUENCE ANALYSIS, DNA; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 84899521838     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.2929     Document Type: Article

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