ATM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double-strand break repair

EMBO Reports

Volumn 12, Issue 7, 2011, Pages 713-719

  Segal Raz, Hava ^a   Mass, Gilad ^a   Baranes Bachar, Keren ^a   Lerenthal, Yaniv ^a   Wang, Shih Ya ^b   Chung, Young Min ^c   Ziv Lehrman, Shelly ^a   Ström, Cecilia E ^d   Helleday, Thomas ^d,e   Hu, Mickey C T ^c   Chen, David J ^b   Shiloh, Yosef ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d STOCKHOLM UNIVERSITY   (Sweden)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

ATM; DNA damage response; double strand break repair; polynucleotide kinase phosphatase; protein phosphorylation

Indexed keywords

3' PHOSPHATE; ATM PROTEIN; DOUBLE STRANDED DNA; PHOSPHATE; POLYNUCLEOTIDE 5' HYDROXYL KINASE; SERINE; UNCLASSIFIED DRUG;

ARTICLE; CELL SURVIVAL; DNA DAMAGE; DNA REPAIR; DOUBLE STRANDED DNA BREAK; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; PRIORITY JOURNAL;

ANIMALS; CELL CYCLE PROTEINS; CYTOTOXINS; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DNA REPAIR ENZYMES; DNA-BINDING PROTEINS; HEK293 CELLS; HUMANS; MICE; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEINS; ZINOSTATIN;

ATAXIA TELANGIECTASIA;

EID: 79960013303     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/embor.2011.96     Document Type: Article

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