Neurogenesis requires TopBP1 to prevent catastrophic replicative DNA damage in early progenitors

Nature Neuroscience

Volumn 15, Issue 6, 2012, Pages 819-826

  Lee, Youngsoo ^a   Katyal, Sachin ^a   Downing, Susanna M ^a   Zhao, Jingfeng ^a   Russell, Helen R ^a   McKinnon, Peter J ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; CELL CYCLE PROTEIN TOPBP1; PROTEIN P53; TRANSCRIPTION FACTOR EMX1; UNCLASSIFIED DRUG; XRCC1 PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; CELL LOSS; CONTROLLED STUDY; DNA DAMAGE; DNA REPLICATION; DNA STRAND BREAKAGE; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; BRAIN; CARRIER PROTEINS; CELL COUNT; COMET ASSAY; DNA DAMAGE; DNA REPLICATION; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; NEURAL STEM CELLS; NEUROGENESIS; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84861572426     PISSN: 10976256     EISSN: 15461726     Source Type: Journal    
DOI: 10.1038/nn.3097     Document Type: Article

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