메뉴 건너뛰기




Volumn 3, Issue 1, 2015, Pages

The angiopoietin-Tie2 signaling axis in the vascular leakage of systemic inflammation

Author keywords

Angiopoietin; Anthrax; ARDS; Barrier function; Endothelium; Inflammation; Lung injury; Malaria; Respiratory distress; Sepsis; Tie1; Tie2; Vascular leakage; VE PTP

Indexed keywords

ANGIOPOIETIN; ANGIOPOIETIN 1; ANGIOPOIETIN 2; ANGIOPOIETIN RECEPTOR; CADHERIN; CD18 ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; MICRORNA; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR B; PROTEIN TYROSINE PHOSPHATASE; RAC1 PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; VASCULOTROPIN RECEPTOR 2;

EID: 84942814326     PISSN: 21688362     EISSN: 21688370     Source Type: Journal    
DOI: 10.4161/21688362.2014.957508     Document Type: Review
Times cited : (79)

References (84)
  • 2
    • 0026695259 scopus 로고
    • Tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors
    • PMID:1630810
    • Dumont DJ, Yamaguchi TP, Conlon RA, Rossant J, Breitman ML. Tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors. Oncogene 1992; 7:1471-80; PMID:1630810.
    • (1992) Oncogene , vol.7 , pp. 1471-1480
    • Dumont, D.J.1    Yamaguchi, T.P.2    Conlon, R.A.3    Rossant, J.4    Breitman, M.L.5
  • 3
    • 0028122465 scopus 로고
    • Dominant- negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo
    • PMID:7958865
    • Dumont DJ, Gradwohl G, Fong GH, Puri MC, Gertsenstein M, Auerbach A, Breitman ML. Dominant- negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo. Genes Dev 1994; 8:1897-909; PMID:7958865; http://dx.doi.org/10.1101/gad.8.16.1897.
    • (1994) Genes Dev , vol.8 , pp. 1897-1909
    • Dumont, D.J.1    Gradwohl, G.2    Fong, G.H.3    Puri, M.C.4    Gertsenstein, M.5    Auerbach, A.6    Breitman, M.L.7
  • 5
    • 0030480322 scopus 로고    scopus 로고
    • Requisite role of angiopoietin-1, a ligand for the tie2 receptor, during embryonic angiogenesis
    • PMID:8980224
    • Suri C, Jones PF, Patan S, Bartunkova S, Maisonpierre PC, Davis S, Sato TN, Yancopoulos GD. Requisite role of angiopoietin-1, a ligand for the tie2 receptor, during embryonic angiogenesis. Cell 1996; 87:1171-80; PMID:8980224; http://dx.doi.org/10.1016/S0092-8674(00)81813-9.
    • (1996) Cell , vol.87 , pp. 1171-1180
    • Suri, C.1    Jones, P.F.2    Patan, S.3    Bartunkova, S.4    Maisonpierre, P.C.5    Davis, S.6    Sato, T.N.7    Yancopoulos, G.D.8
  • 6
    • 35248867961 scopus 로고    scopus 로고
    • Activation of the orphan endothelial receptor tie1 modifies tie2-mediated intracellular signaling and cell survival
    • PMID:17504972
    • Yuan HT, Venkatesha S, Chan B, Deutsch U, Mammoto T, Sukhatme VP, Woolf AS, Karumanchi SA. Activation of the orphan endothelial receptor tie1 modifies tie2-mediated intracellular signaling and cell survival. FASEB J 2007; 21:3171-83; PMID:17504972; http://dx.doi.org/10.1096/fj.07-8487com.
    • (2007) FASEB J , vol.21 , pp. 3171-3183
    • Yuan, H.T.1    Venkatesha, S.2    Chan, B.3    Deutsch, U.4    Mammoto, T.5    Sukhatme, V.P.6    Woolf, A.S.7    Karumanchi, S.A.8
  • 7
    • 77649258840 scopus 로고    scopus 로고
    • Tie1-tie2 interactions mediate functional differences between angiopoietin ligands
    • PMID:20227369
    • Seegar TC, Eller B, Tzvetkova-Robev D, Kolev MV, Henderson SC, Nikolov DB, Barton WA. Tie1-tie2 interactions mediate functional differences between angiopoietin ligands. Mol Cell 2010; 37:643-55; PMID:20227369; http://dx.doi.org/10.1016/j.molcel.2010.02.007.
    • (2010) Mol Cell , vol.37 , pp. 643-655
    • Seegar, T.C.1    Eller, B.2    Tzvetkova-Robev, D.3    Kolev, M.V.4    Henderson, S.C.5    Nikolov, D.B.6    Barton, W.A.7
  • 9
    • 0032480321 scopus 로고    scopus 로고
    • The tek/tie2 receptor signals through a novel dok-related docking protein, dok-r
    • PMID:9764820
    • Jones N, Dumont DJ. The tek/tie2 receptor signals through a novel dok-related docking protein, dok-r. Oncogene 1998; 17:1097-108; PMID:9764820; http://dx.doi.org/10.1038/sj.onc.1202115.
    • (1998) Oncogene , vol.17 , pp. 1097-1108
    • Jones, N.1    Dumont, D.J.2
  • 10
    • 0036018747 scopus 로고    scopus 로고
    • Mechanisms which mediate the antiapoptotic effects of angiopoietin-1 on endothelial cells
    • PMID:12074640
    • Harfouche R, Hassessian HM, Guo Y, Faivre V, Srikant CB, Yancopoulos GD, Hussain SN. Mechanisms which mediate the antiapoptotic effects of angiopoietin-1 on endothelial cells. Microvasc Res. 2002; 64:135-147; PMID:12074640; http://dx.doi.org/10.1006/mvre.2002.2421.
    • (2002) Microvasc Res , vol.64 , pp. 135-147
    • Harfouche, R.1    Hassessian, H.M.2    Guo, Y.3    Faivre, V.4    Srikant, C.B.5    Yancopoulos, G.D.6    Hussain, S.N.7
  • 11
    • 43549116416 scopus 로고    scopus 로고
    • Basal and angiopoietin-1-mediated endothelial permeability is regulated by sphingosine kinase-1
    • PMID:18199826
    • Li X, Stankovic M, Bonder CS, Hahn CN, Parsons M, Pitson SM, Xia P, Proia RL, Vadas MA, Gamble JR. Basal and angiopoietin-1-mediated endothelial permeability is regulated by sphingosine kinase-1. Blood. 2008; 111:3489-97; PMID:18199826; http://dx.doi.org/10.1182/blood-2007-05-092148.
    • (2008) Blood , vol.111 , pp. 3489-3497
    • Li, X.1    Stankovic, M.2    Bonder, C.S.3    Hahn, C.N.4    Parsons, M.5    Pitson, S.M.6    Xia, P.7    Proia, R.L.8    Vadas, M.A.9    Gamble, J.R.10
  • 13
  • 14
    • 64649084437 scopus 로고    scopus 로고
    • Angiopoietin 2 is a partial agonist/antagonist of tie2 signaling in the endothelium
    • PMID:19223473
    • Yuan HT, Khankin EV, Karumanchi SA, Parikh SM. Angiopoietin 2 is a partial agonist/antagonist of tie2 signaling in the endothelium. Mol Cell Biol 2009; 29:2011-22; PMID:19223473; http://dx.doi.org/10.1128/MCB.01472-08.
    • (2009) Mol Cell Biol , vol.29 , pp. 2011-2022
    • Yuan, H.T.1    Khankin, E.V.2    Karumanchi, S.A.3    Parikh, S.M.4
  • 15
    • 33749414768 scopus 로고    scopus 로고
    • Activation of tie2 by angiopoietin-1 and angiopoietin-2 results in their release and receptor internalization
    • PMID:16895971
    • Bogdanovic E, Nguyen VP, Dumont DJ. Activation of tie2 by angiopoietin-1 and angiopoietin-2 results in their release and receptor internalization. J Cell Sci 2006; 119:3551-60; PMID:16895971; http://dx.doi.org/10.1242/jcs.03077.
    • (2006) J Cell Sci , vol.119 , pp. 3551-3560
    • Bogdanovic, E.1    Nguyen, V.P.2    Dumont, D.J.3
  • 16
    • 24944468632 scopus 로고    scopus 로고
    • Stable interaction between alpha5beta1 integrin and tie2 tyrosine kinase receptor regulates endothelial cell response to ang-1
    • PMID:16157706
    • Cascone I, Napione L, Maniero F, Serini G, Bussolino F. Stable interaction between alpha5beta1 integrin and tie2 tyrosine kinase receptor regulates endothelial cell response to ang-1. J Cell Biol 2005; 170:993-1004; PMID:16157706; http://dx.doi.org/10.1083/jcb.200507082.
    • (2005) J Cell Biol , vol.170 , pp. 993-1004
    • Cascone, I.1    Napione, L.2    Maniero, F.3    Serini, G.4    Bussolino, F.5
  • 18
    • 18644382318 scopus 로고    scopus 로고
    • Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by angiopoietin-.1
    • PMID: 12361603
    • Gale NW, Thurston G, Hackett SF, Renard R, Wang Q, McClain J, Martin C, Witte C, Witte MH, Jackson D, et al. Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by angiopoietin-.1. Dev Cell 2002; 3:411-23; PMID: 12361603; http://dx.doi.org/10.1016/S1534-5807(02)00217-4.
    • (2002) Dev Cell , vol.3 , pp. 411-423
    • Gale, N.W.1    Thurston, G.2    Hackett, S.F.3    Renard, R.4    Wang, Q.5    McClain, J.6    Martin, C.7    Witte, C.8    Witte, M.H.9    Jackson, D.10
  • 19
    • 0030764063 scopus 로고    scopus 로고
    • Tie2 expression and phosphorylation in angiogenic and quiescent adult tissues
    • PMID:9314838
    • Wong AL, Haroon ZA, Werner S, Dewhirst MW, Greenberg CS, Peters KG. Tie2 expression and phosphorylation in angiogenic and quiescent adult tissues. Circ Res 1997; 81:567-74; PMID:9314838; http://dx.doi.org/10.1161/01.RES.81.4.567.
    • (1997) Circ Res , vol.81 , pp. 567-574
    • Wong, A.L.1    Haroon, Z.A.2    Werner, S.3    Dewhirst, M.W.4    Greenberg, C.S.5    Peters, K.G.6
  • 21
    • 0033601357 scopus 로고    scopus 로고
    • Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1
    • PMID: 10617467
    • Thurston G, Suri C, Smith K, McClain J, Sato TN, Yancopoulos GD, McDonald DM. Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. Science 1999; 286:2511-4; PMID: 10617467; http://dx.doi.org/10.1126/science.286.5449.2511.
    • (1999) Science , vol.286 , pp. 2511-2514
    • Thurston, G.1    Suri, C.2    Smith, K.3    McClain, J.4    Sato, T.N.5    Yancopoulos, G.D.6    McDonald, D.M.7
  • 22
    • 33645355399 scopus 로고    scopus 로고
    • Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans
    • PMID:16417407
    • Parikh SM, Mammoto T, Schultz A, Yuan HT, Christiani D, Karumanchi SA, Sukhatme VP. Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans. PLoS Med 2006; 3:e46; PMID:16417407; http://dx.doi.org/10.1371/journal.pmed.0030046.
    • (2006) Plos Med , vol.3
    • Parikh, S.M.1    Mammoto, T.2    Schultz, A.3    Yuan, H.T.4    Christiani, D.5    Karumanchi, S.A.6    Sukhatme, V.P.7
  • 24
  • 25
    • 84882661563 scopus 로고    scopus 로고
    • Dysregulation of the angiopoietin-tie-2 axis in sepsis and ards
    • PMID:23652985
    • Parikh SM. Dysregulation of the angiopoietin-tie-2 axis in sepsis and ards. Virulence 2013; 4:517-24; PMID:23652985; http://dx.doi.org/10.4161/viru. 24906.
    • (2013) Virulence , vol.4 , pp. 517-524
    • Parikh, S.M.1
  • 26
    • 0034613356 scopus 로고    scopus 로고
    • Protease-activated receptor-1 down-regulation: A mutant hela cell line suggests novel requirements for par1 phosphorylation and recruitment to clathrincoated pits
    • PMID:10893235
    • Trejo J, Altschuler Y, Fu HW, Mostov KE, Coughlin SR. Protease-activated receptor-1 down-regulation: A mutant hela cell line suggests novel requirements for par1 phosphorylation and recruitment to clathrincoated pits. J Biol Chem 2000; 275:31255-65; PMID:10893235; http://dx.doi.org/10.1074/jbc.M003770200.
    • (2000) J Biol Chem , vol.275 , pp. 31255-31265
    • Trejo, J.1    Altschuler, Y.2    Fu, H.W.3    Mostov, K.E.4    Coughlin, S.R.5
  • 27
    • 84901921079 scopus 로고    scopus 로고
    • Pro-resolving lipid mediators are leads for resolution physiology
    • PMID:24899309
    • Serhan CN. Pro-resolving lipid mediators are leads for resolution physiology. Nature 2014; 510:92-101; PMID:24899309; http://dx.doi.org/10.1038/nature13479.
    • (2014) Nature , vol.510 , pp. 92-101
    • Serhan, C.N.1
  • 28
    • 0021707124 scopus 로고
    • Inherited deficiency of the mac- 1, lfa-1, p150,95 glycoprotein family and its molecular basis
    • PMID:6096477
    • Springer TA, Thompson WS, Miller LJ, Schmalstieg FC, Anderson DC. Inherited deficiency of the mac- 1, lfa-1, p150,95 glycoprotein family and its molecular basis. J Exp Med 1984; 160:1901-18; PMID:6096477; http://dx.doi.org/10.1084/jem.160.6.190129.
    • (1984) J Exp Med , vol.160 , pp. 1901-1918
    • Springer, T.A.1    Thompson, W.S.2    Miller, L.J.3    Schmalstieg, F.C.4    Erson, D.C.5
  • 30
    • 0001359031 scopus 로고
    • Schoefl GI. Studies on inflammation. Ii. The site of action of histamine and serotonin along the vascular tree: A topographic study
    • PMID:14468625
    • Majno G, Palade GE, Schoefl GI. Studies on inflammation. Ii. The site of action of histamine and serotonin along the vascular tree: A topographic study. J Biophys Biochem Cytol 1961; 11:607-26; PMID:14468625; http://dx.doi.org/10.1083/jcb.11.3.607.
    • (1961) J Biophys Biochem Cytol , vol.11 , pp. 607-626
    • Majno, G.1    Palade, G.E.2
  • 31
    • 73049179795 scopus 로고
    • Studies on inflammation.
    • ffect of histamine and serotonin on vascular permeability, PMID:14468626
    • Majno G, Palade GE. Studies on inflammation. Ii.The effect of histamine and serotonin on vascular permeability: An electron microscopic study. J Biophys Biochem Cytol 1961; 11:571-605; PMID:14468626; http://dx.doi.org/10.1083/jcb.11.3.571.
    • (1961) J Biophys Biochem Cytol , vol.11 , pp. 571-605
    • Majno, G.1    Palade, G.E.2
  • 32
    • 41149164199 scopus 로고    scopus 로고
    • Regulation of endothelial junctional permeability
    • PMID:18375586
    • Vandenbroucke E, Mehta D, Minshall R, Malik AB. Regulation of endothelial junctional permeability. Ann N Y Acad Sci 2008; 1123:134-45; PMID:18375586; http://dx.doi.org/10.1196/annals.1420.016.
    • (2008) Ann N Y Acad Sci , vol.1123 , pp. 134-145
    • Vandenbroucke, E.1    Mehta, D.2    Minshall, R.3    Malik, A.B.4
  • 33
    • 57749192473 scopus 로고    scopus 로고
    • Organization and signaling of endothelial cell-to-cell junctions in various regions of the blood and lymphatic vascular trees
    • PMID:18855014
    • Dejana E, Orsenigo F, Molendini C, Baluk P, McDonald DM. Organization and signaling of endothelial cell-to-cell junctions in various regions of the blood and lymphatic vascular trees. Cell Tissue Res 2009; 335:17-25; PMID:18855014; http://dx.doi.org/10.1007/s00441-008-0694-5.
    • (2009) Cell Tissue Res , vol.335 , pp. 17-25
    • Dejana, E.1    Orsenigo, F.2    Molendini, C.3    Baluk, P.4    McDonald, D.M.5
  • 35
    • 33745021587 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality
    • PMID:16702604
    • Yano K, Liaw PC, Mullington JM, Shih SC, Okada H, Bodyak N, Kang PM, Toltl L, Belikoff B, Buras J, et al. Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality. J Exp Med 2006; 203:1447-58; PMID:16702604; http://dx.doi.org/10.1084/jem.20060375.
    • (2006) J Exp Med , vol.203 , pp. 1447-1458
    • Yano, K.1    Liaw, P.C.2    Mullington, J.M.3    Shih, S.C.4    Okada, H.5    Bodyak, N.6    Kang, P.M.7    Toltl, L.8    Belikoff, B.9    Buras, J.10
  • 37
    • 77953255522 scopus 로고    scopus 로고
    • Sphk1 regulates proinflammatory responses associated with endotoxin and polymicrobial sepsis
    • PMID:20522778
    • Puneet P, Yap CT, Wong L, Lam Y, Koh DR, Moochhala S, Pfeilschifter J, Huwiler A, Melendez AJ. Sphk1 regulates proinflammatory responses associated with endotoxin and polymicrobial sepsis. Science 2010; 328:1290-4; PMID:20522778; http://dx.doi.org/10.1126/science.1188635.
    • (2010) Science , vol.328 , pp. 1290-1294
    • Puneet, P.1    Yap, C.T.2    Wong, L.3    Lam, Y.4    Koh, D.R.5    Moochhala, S.6    Pfeilschifter, J.7    Huwiler, A.8    Melendez, A.J.9
  • 38
    • 0344443651 scopus 로고    scopus 로고
    • Phosphorylation and action of the immunomodulator fty720 inhibits vascular endothelial cell growth factor-induced vascular permeability
    • PMID: 12954648
    • Sanchez T, Estrada-Hernandez T, Paik JH, Wu MT, Venkataraman K, Brinkmann V, Claffey K, Hla T. Phosphorylation and action of the immunomodulator fty720 inhibits vascular endothelial cell growth factor-induced vascular permeability. J Biol Chem 2003; 278:47281-90; PMID: 12954648; http://dx.doi.org/10.1074/jbc.M306896200.
    • (2003) J Biol Chem , vol.278 , pp. 47281-47290
    • Sanchez, T.1    Estrada-Hernandez, T.2    Paik, J.H.3    Wu, M.T.4    Venkataraman, K.5    Brinkmann, V.6    Claffey, K.7    Hla, T.8
  • 39
    • 11244337801 scopus 로고    scopus 로고
    • Protective role of angiopoietin- 1 in endotoxic shock
    • PMID:15611372
    • Witzenbichler B, Westermann D, Knueppel S, Schultheiss HP, Tschope C. Protective role of angiopoietin- 1 in endotoxic shock. Circulation 2005; 111:97-105; PMID:15611372; http://dx.doi.org/10.1161/01.CIR.0000151287.08202.8E.
    • (2005) Circulation , vol.111 , pp. 97-105
    • Witzenbichler, B.1    Westermann, D.2    Knueppel, S.3    Schultheiss, H.P.4    Tschope, C.5
  • 40
    • 80054953975 scopus 로고    scopus 로고
    • Angiopoietin-1 requires iq domain gtpase-activating protein 1 to activate rac1 and promote endothelial barrier defense
    • PMID:21885850
    • David S, Ghosh CC, Mukherjee A, Parikh SM. Angiopoietin-1 requires iq domain gtpase-activating protein 1 to activate rac1 and promote endothelial barrier defense. Arterioscler Thromb Vasc Biol 2011; 31:2643-52; PMID:21885850; http://dx.doi.org/10.1161/ATVBAHA.111.233189.
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , pp. 2643-2652
    • David, S.1    Ghosh, C.C.2    Mukherjee, A.3    Parikh, S.M.4
  • 41
    • 23844544130 scopus 로고    scopus 로고
    • Angiopoietin-1 promotes cardiac and skeletal myocyte survival through integrins
    • PMID:15692086
    • Dallabrida SM, Ismail N, Oberle JR, Himes BE, Rupnick MA. Angiopoietin-1 promotes cardiac and skeletal myocyte survival through integrins. Circ Res 2005; 96:e8-24; PMID:15692086; http://dx.doi.org/10.1161/01.RES.0000158285.57191.60.
    • (2005) Circ Res , vol.96 , pp. e8-e24
    • Dallabrida, S.M.1    Ismail, N.2    Oberle, J.R.3    Himes, B.E.4    Rupnick, M.A.5
  • 42
    • 0035860806 scopus 로고    scopus 로고
    • Angiopoietin-1, unlike angiopoietin-2, is incorporated into the extracellular matrix via its linker peptide region
    • PMID:11447223
    • Xu Y, Yu Q. Angiopoietin-1, unlike angiopoietin-2, is incorporated into the extracellular matrix via its linker peptide region. J Biol Chem 2001; 276:34990-8; PMID:11447223; http://dx.doi.org/10.1074/jbc.M103661200.
    • (2001) J Biol Chem , vol.276 , pp. 34990-34998
    • Xu, Y.1    Yu, Q.2
  • 43
    • 0026013429 scopus 로고
    • The role of integrins in the maintenance of endothelial monolayer integrity
    • PMID:1899416
    • Lampugnani MG, Resnati M, Dejana E, Marchisio PC. The role of integrins in the maintenance of endothelial monolayer integrity. J Cell Biol 1991; 112:479-90; PMID:1899416; http://dx.doi.org/10.1083/jcb.112.3.479.
    • (1991) J Cell Biol , vol.112 , pp. 479-490
    • Lampugnani, M.G.1    Resnati, M.2    Dejana, E.3    Marchisio, P.C.4
  • 44
    • 10944262091 scopus 로고    scopus 로고
    • A short synthetic peptide inhibits signal transduction, migration and angiogenesis mediated by tie2 receptor
    • PMID:14978510
    • Tournaire R, Simon MP, le Noble F, Eichmann A, England P, Pouyssegur J. A short synthetic peptide inhibits signal transduction, migration and angiogenesis mediated by tie2 receptor. EMBO reports 2004; 5:262-7; PMID:14978510; http://dx.doi.org/10.1038/sj.embor.7400100.
    • (2004) EMBO Reports , vol.5 , pp. 262-267
    • Tournaire, R.1    Simon, M.P.2    Le Noble, F.3    Eichmann, A.4    England, P.5    Pouyssegur, J.6
  • 46
    • 80055021582 scopus 로고    scopus 로고
    • The synthetic tie2 agonist peptide vasculotide protects against vascular leakage and reduces mortality in murine abdominal sepsis
    • PMID:22040774
    • Kumpers P, Gueler F, David S, Van Slyke P, Dumont DJ, Park JK, Bockmeyer CL, Parikh SM, Pavenstadt H, Haller H, et al. The synthetic tie2 agonist peptide vasculotide protects against vascular leakage and reduces mortality in murine abdominal sepsis. Crit Care 2011; 15:R261; PMID:22040774; http://dx.doi.org/10.1186/cc10523.
    • (2011) Crit Care , vol.15
    • Kumpers, P.1    Gueler, F.2    David, S.3    Van Slyke, P.4    Dumont, D.J.5    Park, J.K.6    Bockmeyer, C.L.7    Parikh, S.M.8    Pavenstadt, H.9    Haller, H.10
  • 47
    • 79957880117 scopus 로고    scopus 로고
    • Angiopoietin-1 is essential in mouse vasculature during development and in response to injury
    • PMID:21606590
    • Jeansson M, Gawlik A, Anderson G, Li C, Kerjaschki D, Henkelman M, Quaggin SE. Angiopoietin-1 is essential in mouse vasculature during development and in response to injury. J Clin Invest 2011; 121:2278-89; PMID:21606590; http://dx.doi.org/10.1172/JCI46322.
    • (2011) J Clin Invest , vol.121 , pp. 2278-2289
    • Jeansson, M.1    Gawlik, A.2    Erson, G.3    Li, C.4    Kerjaschki, D.5    Henkelman, M.6    Quaggin, S.E.7
  • 49
    • 43049116169 scopus 로고    scopus 로고
    • Differential function of tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1
    • PMID:18425120
    • Fukuhara S, Sako K, Minami T, Noda K, Kim HZ, Kodama T, Shibuya M, Takakura N, Koh GY, Mochizuki N. Differential function of tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1. Nat Cell Biol 2008; 10:513-26; PMID:18425120; http://dx.doi.org/10.1038/ncb1714.
    • (2008) Nat Cell Biol , vol.10 , pp. 513-526
    • Fukuhara, S.1    Sako, K.2    Minami, T.3    Noda, K.4    Kim, H.Z.5    Kodama, T.6    Shibuya, M.7    Takakura, N.8    Koh, G.Y.9    Mochizuki, N.10
  • 52
    • 2542453735 scopus 로고    scopus 로고
    • The tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell weibel-palade bodies
    • PMID:14976056
    • Fiedler U, Scharpfenecker M, Koidl S, Hegen A, Grunow V, Schmidt JM, Kriz W, Thurston G, Augustin HG. The tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell weibel-palade bodies. Blood 2004; 103:4150-6; PMID:14976056; http://dx.doi.org/10.1182/blood-2003-10-3685.
    • (2004) Blood , vol.103 , pp. 4150-4156
    • Fiedler, U.1    Scharpfenecker, M.2    Koidl, S.3    Hegen, A.4    Grunow, V.5    Schmidt, J.M.6    Kriz, W.7    Thurston, G.8    Augustin, H.G.9
  • 54
    • 2442608732 scopus 로고    scopus 로고
    • Angiopoietin-1 modulates endothelial cell function and gene expression via the transcription factor fkhr (Foxo1)
    • PMID:15132996
    • Daly C, Wong V, Burova E, Wei Y, Zabski S, Griffiths J, Lai KM, Lin HC, Ioffe E, Yancopoulos GD, et al. Angiopoietin-1 modulates endothelial cell function and gene expression via the transcription factor fkhr (foxo1). Genes Dev 2004; 18:1060-71; PMID:15132996; http://dx.doi.org/10.1101/gad.1189704.
    • (2004) Genes Dev , vol.18 , pp. 1060-1071
    • Daly, C.1    Wong, V.2    Burova, E.3    Wei, Y.4    Zabski, S.5    Griffiths, J.6    Lai, K.M.7    Lin, H.C.8    Ioffe, E.9    Yancopoulos, G.D.10
  • 55
    • 84875433659 scopus 로고    scopus 로고
    • Mending leaky blood vessels: The angiopoietin-tie2 pathway in sepsis
    • PMID:23378191
    • David S, Kumpers P, van Slyke P, Parikh SM. Mending leaky blood vessels: The angiopoietin-tie2 pathway in sepsis. J Pharmacol Exp Ther 2013; 345:2-6; PMID:23378191; http://dx.doi.org/10.1124/jpet.112.201061.
    • (2013) J Pharmacol Exp Ther , vol.345 , pp. 2-6
    • David, S.1    Kumpers, P.2    Van Slyke, P.3    Parikh, S.M.4
  • 57
    • 53649099512 scopus 로고    scopus 로고
    • Angiopoietin-2, permeability oedema, occurrence and severity of ali/ards in septic and non-septic critically ill patients
    • PMID:18559364
    • van der Heijden M, van Nieuw Amerongen GP, Koolwijk P, van Hinsbergh VW, Groeneveld AB. Angiopoietin-2, permeability oedema, occurrence and severity of ali/ards in septic and non-septic critically ill patients. Thorax 2008; 63:903-9; PMID:18559364; http://dx.doi.org/10.1136/thx.2007.087387.
    • (2008) Thorax , vol.63 , pp. 903-909
    • Van Der Heijden, M.1    Van Nieuw Amerongen, G.P.2    Koolwijk, P.3    Van Hinsbergh, V.W.4    Groeneveld, A.B.5
  • 58
    • 79956207348 scopus 로고    scopus 로고
    • Angpt2 genetic variant is associated with trauma-associated acute lung injury and altered plasma angiopoietin-2 isoform ratio
    • PMID:21257790
    • Meyer NJ, Li M, Feng R, Bradfield J, Gallop R, Bellamy S, Fuchs BD, Lanken PN, Albelda SM, Rushefski M, et al. Angpt2 genetic variant is associated with trauma-associated acute lung injury and altered plasma angiopoietin-2 isoform ratio. Am J Respir Crit Care Med 2011; 183:1344-53; PMID:21257790; http://dx.doi.org/10.1164/rccm.201005-0701OC.
    • (2011) Am J Respir Crit Care Med , vol.183 , pp. 1344-1353
    • Meyer, N.J.1    Li, M.2    Feng, R.3    Bradfield, J.4    Gallop, R.5    Bellamy, S.6    Fuchs, B.D.7    Lanken, P.N.8    Albelda, S.M.9    Rushefski, M.10
  • 59
    • 21244434808 scopus 로고    scopus 로고
    • Oligomerization and multimerization are critical for angiopoietin-1 to bind and phosphorylate tie2
    • PMID:15769741
    • Kim KT, Choi HH, Steinmetz MO, Maco B, Kammerer RA, Ahn SY, Kim HZ, Lee GM, Koh GY. Oligomerization and multimerization are critical for angiopoietin-1 to bind and phosphorylate tie2. J Biol Chem 2005; 280:20126-31; PMID:15769741; http://dx.doi.org/10.1074/jbc.M500292200.
    • (2005) J Biol Chem , vol.280 , pp. 20126-20131
    • Kim, K.T.1    Choi, H.H.2    Steinmetz, M.O.3    Maco, B.4    Kammerer, R.A.5    Ahn, S.Y.6    Kim, H.Z.7    Lee, G.M.8    Koh, G.Y.9
  • 63
    • 79959376030 scopus 로고    scopus 로고
    • Pericyte requirement for anti-leak action of angiopoietin-1 and vascular remodeling in sustained inflammation
    • PMID:21550017
    • Fuxe J, Tabruyn S, Colton K, Zaid H, Adams A, Baluk P, Lashnits E, Morisada T, Le T, O’Brien S, et al. Pericyte requirement for anti-leak action of angiopoietin-1 and vascular remodeling in sustained inflammation. Am J Pathol 2011; 178:2897-909; PMID:21550017; http://dx.doi.org/10.1016/j.ajpath.2011.02.008.
    • (2011) Am J Pathol , vol.178 , pp. 2897-2909
    • Fuxe, J.1    Tabruyn, S.2    Colton, K.3    Zaid, H.4    Adams, A.5    Baluk, P.6    Lashnits, E.7    Morisada, T.8    Le, T.9    O’Brien, S.10
  • 65
    • 79953304687 scopus 로고    scopus 로고
    • Tie1 attenuation reduces murine atherosclerosis in a dose-dependent and shear stress-specific manner
    • PMID:21383501
    • Woo KV, Qu X, Babaev VR, Linton MF, Guzman RJ, Fazio S, Baldwin HS. Tie1 attenuation reduces murine atherosclerosis in a dose-dependent and shear stress-specific manner. J Clin Invest 2011; 121:1624- 35; PMID:21383501; http://dx.doi.org/10.1172/JCI42040.
    • (2011) J Clin Invest , vol.121
    • Woo, K.V.1    Qu, X.2    Babaev, V.R.3    Linton, M.F.4    Guzman, R.J.5    Fazio, S.6    Baldwin, H.S.7
  • 66
    • 0026452135 scopus 로고
    • Enhanced expression of the tie receptor tyrosine kinase in endothelialcells during neovascularization
    • PMID:1384789
    • Korhonen J, Partanen J, Armstrong E, Vaahtokari A, Elenius K, Jalkanen M, Alitalo K. Enhanced expression of the tie receptor tyrosine kinase in endothelialcells during neovascularization. Blood 1992; 80:2548-55; PMID:1384789.
    • (1992) Blood , vol.80 , pp. 2548-2555
    • Korhonen, J.1    Partanen, J.2    Armstrong, E.3    Vaahtokari, A.4    Elenius, K.5    Jalkanen, M.6    Alitalo, K.7
  • 67
    • 0028670845 scopus 로고
    • Enhanced expression of the tie receptor tyrosine kinase mesenger rna in the vascular endothelium of metastatic melanomas
    • PMID:7987857
    • Kaipainen A, Vlaykova T, Hatva E, Bohling T, Jekunen A, Pyrhonen S, Alitalo K. Enhanced expression of the tie receptor tyrosine kinase mesenger rna in the vascular endothelium of metastatic melanomas. Cancer Res 1994; 54:6571-7; PMID:7987857.
    • (1994) Cancer Res , vol.54 , pp. 6571-6577
    • Kaipainen, A.1    Vlaykova, T.2    Hatva, E.3    Bohling, T.4    Jekunen, A.5    Pyrhonen, S.6    Alitalo, K.7
  • 68
    • 0028867704 scopus 로고
    • The receptor tyrosine kinase tie is required for integrity and survival of vascular endothelial cells
    • PMID:8846781
    • Puri MC, Rossant J, Alitalo K, Bernstein A, Partanen J. The receptor tyrosine kinase tie is required for integrity and survival of vascular endothelial cells. EMBO J 1995; 14:5884-91; PMID:8846781.
    • (1995) EMBO J , vol.14 , pp. 5884-5891
    • Puri, M.C.1    Rossant, J.2    Alitalo, K.3    Bernstein, A.4    Partanen, J.5
  • 72
    • 84914701113 scopus 로고    scopus 로고
    • Abrupt reflow enhances cytokine induced proinflammatory activation of endothelial cells during simulated shock and resuscitation
    • PMID:25051282
    • Li R, Zijlstra JG, Kamps JA, van Meurs M, Molema G. Abrupt reflow enhances cytokine induced proinflammatory activation of endothelial cells during simulated shock and resuscitation. Shock 2014; PMID:25051282.
    • (2014) Shock
    • Li, R.1    Zijlstra, J.G.2    Kamps, J.A.3    Van Meurs, M.4    Molema, G.5
  • 73
    • 70350101449 scopus 로고    scopus 로고
    • Angiopoietin- 1-induced ubiquitylation of tie2 by c-cbl is required for internalization and degradation
    • PMID:19689429
    • Wehrle C, Van Slyke P, Dumont DJ. Angiopoietin- 1-induced ubiquitylation of tie2 by c-cbl is required for internalization and degradation. Biochem J 2009; 423:375-80; PMID:19689429; http://dx.doi.org/10.1042/BJ20091010.
    • (2009) Biochem J , vol.423 , pp. 375-380
    • Wehrle, C.1    Van Slyke, P.2    Dumont, D.J.3
  • 74
    • 0033592739 scopus 로고    scopus 로고
    • Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor tie-2
    • PMID:10557082
    • Fachinger G, Deutsch U, Risau W. Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor tie-2. Oncogene 1999; 18:5948-53; PMID:10557082; http://dx.doi.org/10.1038/sj.onc.1202992.
    • (1999) Oncogene , vol.18 , pp. 5948-5953
    • Fachinger, G.1    Deutsch, U.2    Risau, W.3
  • 75
    • 33745107561 scopus 로고    scopus 로고
    • Vascular endothelial cellspecific phosphotyrosine phosphatase (Ve-ptp) activity is required for blood vessel development
    • PMID:16514057
    • Baumer S, Keller L, Holtmann A, Funke R, August B, Gamp A, Wolburg H, Wolburg-Buchholz K, Deutsch U, Vestweber D. Vascular endothelial cellspecific phosphotyrosine phosphatase (ve-ptp) activity is required for blood vessel development. Blood 2006; 107:4754-62; PMID:16514057; http://dx.doi.org/10.1182/blood-2006-01-0141.
    • (2006) Blood , vol.107 , pp. 4754-4762
    • Baumer, S.1    Keller, L.2    Holtmann, A.3    Funke, R.4    August, B.5    Gamp, A.6    Wolburg, H.7    Wolburg-Buchholz, K.8    Deutsch, U.9    Vestweber, D.10
  • 76
    • 33847636046 scopus 로고    scopus 로고
    • Vascular endothelial tyrosine phosphatase (Ve-ptp)-null mice undergo vasculogenesis but die embryonically because of defects in angiogenesis
    • PMID:17360632
    • Dominguez MG, Hughes VC, Pan L, Simmons M, Daly C, Anderson K, Noguera-Troise I, Murphy AJ, Valenzuela DM, Davis S, et al. Vascular endothelial tyrosine phosphatase (ve-ptp)-null mice undergo vasculogenesis but die embryonically because of defects in angiogenesis. Proc Natl Acad Sci U S A 2007; 104:3243-8; PMID:17360632; http://dx.doi.org/10.1073/pnas.0611510104.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 3243-3248
    • Dominguez, M.G.1    Hughes, V.C.2    Pan, L.3    Simmons, M.4    Daly, C.5    Erson, K.6    Noguera-Troise, I.7    Murphy, A.J.8    Valenzuela, D.M.9    Davis, S.10
  • 77
    • 84899463890 scopus 로고    scopus 로고
    • Phosphatases and kinases as regulators of the endothelial barrier function
    • PMID:24566520
    • Kuppers V, Vockel M, Nottebaum AF, Vestweber D. Phosphatases and kinases as regulators of the endothelial barrier function. Cell Tissue Res. 2014; 355:577-86; PMID:24566520; http://dx.doi.org/10.1007/s00441-014-1812-1.
    • (2014) Cell Tissue Res , vol.355 , pp. 577-586
    • Kuppers, V.1    Vockel, M.2    Nottebaum, A.F.3    Vestweber, D.4
  • 78
    • 84877788239 scopus 로고    scopus 로고
    • Ve-ptp regulates vegfr2 activity in stalk cells to establish endothelial cell polarity and lumen formation
    • PMID:23575676
    • Hayashi M, Majumdar A, Li X, Adler J, Sun Z, Vertuani S, Hellberg C, Mellberg S, Koch S, Dimberg A, et al. Ve-ptp regulates vegfr2 activity in stalk cells to establish endothelial cell polarity and lumen formation. Nat Commun 2013; 4:1672; PMID:23575676; http://dx.doi.org/10.1038/ncomms2683.
    • (2013) Nat Commun , vol.4 , pp. 1672
    • Hayashi, M.1    Majumdar, A.2    Li, X.3    Adler, J.4    Sun, Z.5    Vertuani, S.6    Hellberg, C.7    Mellberg, S.8    Koch, S.9    Dimberg, A.10
  • 79
    • 18544390381 scopus 로고    scopus 로고
    • Ve-ptp and ve-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts
    • PMID:12234928
    • Nawroth R, Poell G, Ranft A, Kloep S, Samulowitz U, Fachinger G, Golding M, Shima DT, Deutsch U, Vestweber D. Ve-ptp and ve-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts. EMBO J 2002; 21:4885-95; PMID:12234928; http://dx.doi.org/10.1093/emboj/cdf497.
    • (2002) EMBO J , vol.21 , pp. 4885-4895
    • Nawroth, R.1    Poell, G.2    Ranft, A.3    Kloep, S.4    Samulowitz, U.5    Fachinger, G.6    Golding, M.7    Shima, D.T.8    Deutsch, U.9    Vestweber, D.10
  • 80
    • 0031825437 scopus 로고    scopus 로고
    • Vascular endothelial growth factor induces ve-cadherin tyrosine phosphorylation in endothelial cells
    • PMID:9625748
    • Esser S, Lampugnani MG, Corada M, Dejana E, Risau W. Vascular endothelial growth factor induces ve-cadherin tyrosine phosphorylation in endothelial cells. J Cell Sci 1998; 111(Pt 13):1853-65; PMID:9625748.
    • (1998) J Cell Sci , vol.111 , pp. 1853-1865
    • Esser, S.1    Lampugnani, M.G.2    Corada, M.3    Dejana, E.4    Risau, W.5
  • 82
    • 84855493801 scopus 로고    scopus 로고
    • Dissociation of ve-ptp from vecadherin is required for leukocyte extravasation and for vegf-induced vascular permeability in vivo
    • PMID:22025303
    • Broermann A, Winderlich M, Block H, Frye M, Rossaint J, Zarbock A, Cagna G, Linnepe R, Schulte D, Nottebaum AF, et al. Dissociation of ve-ptp from vecadherin is required for leukocyte extravasation and for vegf-induced vascular permeability in vivo. J Exp Med 2011; 208:2393-401; PMID:22025303; http://dx.doi.org/10.1084/jem.20110525.
    • (2011) J Exp Med , vol.208 , pp. 2393-2401
    • Broermann, A.1    Winderlich, M.2    Block, H.3    Frye, M.4    Rossaint, J.5    Zarbock, A.6    Cagna, G.7    Linnepe, R.8    Schulte, D.9    Nottebaum, A.F.10
  • 84
    • 79960638881 scopus 로고    scopus 로고
    • Angiopoietin-2 ties up macrophages in tumor angiogenesis
    • PMID:21576085
    • De Palma M, Naldini L. Angiopoietin-2 ties up macrophages in tumor angiogenesis. Clin Cancer Res 2011; 17:5226-32; PMID:21576085; http://dx.doi.org/10.1158/1078-0432.CCR-10-0171
    • (2011) Clin Cancer Res , vol.17 , pp. 5226-5232
    • De Palma, M.1    Naldini, L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.