-
1
-
-
51449108571
-
Emerging cancer therapeutic opportunities by inhibiting mitotic kinases
-
Perez de Castro, I., De Carcer, G., Montoya, G. & Malumbres, M. Emerging cancer therapeutic opportunities by inhibiting mitotic kinases. Curr Opin Pharmacol 8, 375-83 (2008).
-
(2008)
Curr Opin Pharmacol
, vol.8
, pp. 375-383
-
-
Perez De Castro, I.1
De Carcer, G.2
Montoya, G.3
Malumbres, M.4
-
2
-
-
84896396156
-
Targeting nuclear kinases in cancer: Development of cell cycle kinase inhibitors
-
Pitts, T. M., Davis, S. L., Eckhardt, S. G. & Bradshaw-Pierce, E. L. Targeting nuclear kinases in cancer: development of cell cycle kinase inhibitors. Pharmacol Ther 142, 258-69 (2014).
-
(2014)
Pharmacol Ther
, vol.142
, pp. 258-269
-
-
Pitts, T.M.1
Davis, S.L.2
Eckhardt, S.G.3
Bradshaw-Pierce, E.L.4
-
3
-
-
84864047437
-
Second or third additional chemotherapy drug for non-small cell lung cancer in patients with advanced disease
-
Delbaldo, C. et al. Second or third additional chemotherapy drug for non-small cell lung cancer in patients with advanced disease. Cochrane Database Syst Rev. CD004569, doi: 10.1002/14651858.CD004569.pub2 (2007).
-
(2007)
Cochrane Database Syst Rev.
-
-
Delbaldo, C.1
-
4
-
-
76249089855
-
Annual report to the nation on the status of cancer, 1975-2006, featuring colorectal cancer trends and impact of interventions (risk factors, screening, and treatment) to reduce future rates
-
Edwards, B. K. et al. Annual report to the nation on the status of cancer, 1975-2006, featuring colorectal cancer trends and impact of interventions (risk factors, screening, and treatment) to reduce future rates. Cancer 116, 544-73 (2010).
-
(2010)
Cancer
, vol.116
, pp. 544-573
-
-
Edwards, B.K.1
-
5
-
-
84877774804
-
Rewiring of human lung cell lineage and mitotic networks in lung adenocarcinomas
-
Kim, I. J. et al. Rewiring of human lung cell lineage and mitotic networks in lung adenocarcinomas. Nat Commun 4, 1701 (2013).
-
(2013)
Nat Commun
, vol.4
, pp. 1701
-
-
Kim, I.J.1
-
6
-
-
37549026472
-
Mitotic histone H3 phosphorylation by vaccinia-related kinase 1 in mammalian cells
-
Kang, T. H. et al. Mitotic histone H3 phosphorylation by vaccinia-related kinase 1 in mammalian cells. Mol Cell Biol 27, 8533-46 (2007).
-
(2007)
Mol Cell Biol
, vol.27
, pp. 8533-8546
-
-
Kang, T.H.1
-
7
-
-
33745450085
-
The vaccinia-related kinases phosphorylate the N′ terminus of BAF, regulating its interaction with DNA and its retention in the nucleus
-
Nichols, R. J., Wiebe, M. S. & Traktman, P. The vaccinia-related kinases phosphorylate the N′ terminus of BAF, regulating its interaction with DNA and its retention in the nucleus. Mol Biol Cell 17, 2451-64 (2006).
-
(2006)
Mol Biol Cell
, vol.17
, pp. 2451-2464
-
-
Nichols, R.J.1
Wiebe, M.S.2
Traktman, P.3
-
8
-
-
33846195879
-
Caenorhabditis elegans BAF-1 and its kinase VRK-1 participate directly in post-mitotic nuclear envelope assembly
-
Gorjanacz, M. et al. Caenorhabditis elegans BAF-1 and its kinase VRK-1 participate directly in post-mitotic nuclear envelope assembly. Embo J 26, 132-43 (2007).
-
(2007)
Embo J
, vol.26
, pp. 132-143
-
-
Gorjanacz, M.1
-
9
-
-
50249107835
-
Live cell imaging and electron microscopy reveal dynamic processes of BAF-directed nuclear envelope assembly
-
Haraguchi, T. et al. Live cell imaging and electron microscopy reveal dynamic processes of BAF-directed nuclear envelope assembly. J Cell Sci 121, 2540-54 (2008).
-
(2008)
J Cell Sci
, vol.121
, pp. 2540-2554
-
-
Haraguchi, T.1
-
10
-
-
55049133579
-
VRK1 phosphorylates CREB and mediates CCND1 expression
-
Kang, T. H., Park, D. Y., Kim, W. & Kim, K. T. VRK1 phosphorylates CREB and mediates CCND1 expression. J Cell Sci 121, 3035-41 (2008).
-
(2008)
J Cell Sci
, vol.121
, pp. 3035-3041
-
-
Kang, T.H.1
Park, D.Y.2
Kim, W.3
Kim, K.T.4
-
11
-
-
5344259041
-
c-Jun phosphorylation by the human vaccinia-related kinase 1 (VRK1) and its cooperation with the N-terminal kinase of c-Jun (JNK)
-
Sevilla, A., Santos, C. R., Barcia, R., Vega, F. M. & Lazo, P. A. c-Jun phosphorylation by the human vaccinia-related kinase 1 (VRK1) and its cooperation with the N-terminal kinase of c-Jun (JNK). Oncogene 23, 8950-8 (2004).
-
(2004)
Oncogene
, vol.23
, pp. 8950-8958
-
-
Sevilla, A.1
Santos, C.R.2
Barcia, R.3
Vega, F.M.4
Lazo, P.A.5
-
12
-
-
3042639759
-
Human vaccinia-related kinase 1 (VRK1) activates the ATF2 transcriptional activity by novel phosphorylation on Thr-73 and Ser-62 and cooperates with JNK
-
Sevilla, A., Santos, C. R., Vega, F. M. & Lazo, P. A. Human vaccinia-related kinase 1 (VRK1) activates the ATF2 transcriptional activity by novel phosphorylation on Thr-73 and Ser-62 and cooperates with JNK. J Biol Chem 279, 27458-65 (2004).
-
(2004)
J Biol Chem
, vol.279
, pp. 27458-27465
-
-
Sevilla, A.1
Santos, C.R.2
Vega, F.M.3
Lazo, P.A.4
-
13
-
-
45749138359
-
Human VRK1 is an early response gene and its loss causes a block in cell cycle progression
-
Valbuena, A., Lopez-Sanchez, I. & Lazo, P. A. Human VRK1 is an early response gene and its loss causes a block in cell cycle progression. PLoS One 3, e1642 (2008).
-
(2008)
PLoS One
, vol.3
-
-
Valbuena, A.1
Lopez-Sanchez, I.2
Lazo, P.A.3
-
14
-
-
0034721101
-
The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein
-
Lopez-Borges, S. & Lazo, P. A. The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein. Oncogene 19, 3656-64 (2000).
-
(2000)
Oncogene
, vol.19
, pp. 3656-3664
-
-
Lopez-Borges, S.1
Lazo, P.A.2
-
15
-
-
84863623166
-
Vaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damage
-
Sanz-Garcia, M., Monsalve, D. M., Sevilla, A. & Lazo, P. A. Vaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damage. J Biol Chem 287, 23757-68 (2012).
-
(2012)
J Biol Chem
, vol.287
, pp. 23757-23768
-
-
Sanz-Garcia, M.1
Monsalve, D.M.2
Sevilla, A.3
Lazo, P.A.4
-
16
-
-
67650675111
-
Impact of natural products on developing new anti-cancer agents
-
Cragg, G. M., Grothaus, P. G. & Newman, D. J. Impact of natural products on developing new anti-cancer agents. Chem Rev 109, 3012-43 (2009).
-
(2009)
Chem Rev
, vol.109
, pp. 3012-3043
-
-
Cragg, G.M.1
Grothaus, P.G.2
Newman, D.J.3
-
17
-
-
0022576865
-
Search for possible antitumor promoters by inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation; ursolic acid and oleanolic acid from an anti-inflammatory Chinese medicinal plant, Glechoma hederaceae L
-
Ohigashi, H., Takamura, H., Koshimizu, K., Tokuda, H. & Ito, Y. Search for possible antitumor promoters by inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation; ursolic acid and oleanolic acid from an anti-inflammatory Chinese medicinal plant, Glechoma hederaceae L. Cancer Lett 30, 143-51 (1986).
-
(1986)
Cancer Lett
, vol.30
, pp. 143-151
-
-
Ohigashi, H.1
Takamura, H.2
Koshimizu, K.3
Tokuda, H.4
Ito, Y.5
-
18
-
-
84928911783
-
Ursolic Acid Attenuates Diabetic Mesangial Cell Injury through the Up-Regulation of Autophagy via miRNA-21/PTEN/Akt/mTOR Suppression
-
Lu, X. et al. Ursolic Acid Attenuates Diabetic Mesangial Cell Injury through the Up-Regulation of Autophagy via miRNA-21/PTEN/Akt/mTOR Suppression. PLoS One 10, e0117400 (2015).
-
(2015)
PLoS One
, vol.10
-
-
Lu, X.1
-
19
-
-
0034193436
-
Ursolic acid inhibits cyclooxygenase-2 transcription in human mammary epithelial cells
-
Subbaramaiah, K., Michaluart, P., Sporn, M. B. & Dannenberg, A. J. Ursolic acid inhibits cyclooxygenase-2 transcription in human mammary epithelial cells. Cancer Res 60, 2399-404 (2000).
-
(2000)
Cancer Res
, vol.60
, pp. 2399-2404
-
-
Subbaramaiah, K.1
Michaluart, P.2
Sporn, M.B.3
Dannenberg, A.J.4
-
20
-
-
17144439794
-
Novel triterpenoids suppress inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2) in mouse macrophages
-
Suh, N. et al. Novel triterpenoids suppress inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2) in mouse macrophages. Cancer Res 58, 717-23 (1998).
-
(1998)
Cancer Res
, vol.58
, pp. 717-723
-
-
Suh, N.1
-
21
-
-
79960009770
-
Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice
-
Shanmugam, M. K. et al. Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice. J Mol Med (Berl) 89, 713-27 (2011).
-
(2011)
J Mol Med (Berl)
, vol.89
, pp. 713-727
-
-
Shanmugam, M.K.1
-
22
-
-
34548693457
-
Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells
-
Pathak, A. K. et al. Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells. Mol Cancer Res 5, 943-55 (2007).
-
(2007)
Mol Cancer Res
, vol.5
, pp. 943-955
-
-
Pathak, A.K.1
-
23
-
-
0042090509
-
Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: Correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1
-
Shishodia, S., Majumdar, S., Banerjee, S. & Aggarwal, B. B. Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1. Cancer Res 63, 4375-83 (2003).
-
(2003)
Cancer Res
, vol.63
, pp. 4375-4383
-
-
Shishodia, S.1
Majumdar, S.2
Banerjee, S.3
Aggarwal, B.B.4
-
24
-
-
84877594282
-
Ursolic acid in cancer prevention and treatment: Molecular targets, pharmacokinetics and clinical studies
-
Shanmugam, M. K. et al. Ursolic acid in cancer prevention and treatment: molecular targets, pharmacokinetics and clinical studies. Biochem Pharmacol 85, 1579-87 (2013).
-
(2013)
Biochem Pharmacol
, vol.85
, pp. 1579-1587
-
-
Shanmugam, M.K.1
-
25
-
-
79957503743
-
In vitro and in vivo anticancer activity evaluation of ursolic acid derivatives
-
Shao, J. W. et al. In vitro and in vivo anticancer activity evaluation of ursolic acid derivatives. Eur J Med Chem 46, 2652-61 (2011).
-
(2011)
Eur J Med Chem
, vol.46
, pp. 2652-2661
-
-
Shao, J.W.1
-
26
-
-
84866392802
-
Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: Chemosensitization with capecitabine
-
Prasad, S. et al. Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine. Clin Cancer Res 18, 4942-53 (2012).
-
(2012)
Clin Cancer Res
, vol.18
, pp. 4942-4953
-
-
Prasad, S.1
-
27
-
-
84863127744
-
Ursolic acid induces apoptosis in human leukaemia cells and exhibits anti-leukaemic activity in nude mice through the PKB pathway
-
Gao, N. et al. Ursolic acid induces apoptosis in human leukaemia cells and exhibits anti-leukaemic activity in nude mice through the PKB pathway. Br J Pharmacol 165, 1813-26 (2012).
-
(2012)
Br J Pharmacol
, vol.165
, pp. 1813-1826
-
-
Gao, N.1
-
28
-
-
66749122969
-
Differential effects of several phytochemicals and their derivatives on murine keratinocytes in vitro and in vivo: Implications for skin cancer prevention
-
Kowalczyk, M. C. et al. Differential effects of several phytochemicals and their derivatives on murine keratinocytes in vitro and in vivo: implications for skin cancer prevention. Carcinogenesis 30, 1008-15 (2009).
-
(2009)
Carcinogenesis
, vol.30
, pp. 1008-1015
-
-
Kowalczyk, M.C.1
-
29
-
-
79959359451
-
NMR solution structure of human vaccinia-related kinase 1 (VRK1) reveals the C-terminal tail essential for its structural stability and autocatalytic activity
-
Shin, J. et al. NMR solution structure of human vaccinia-related kinase 1 (VRK1) reveals the C-terminal tail essential for its structural stability and autocatalytic activity. J Biol Chem 286, 22131-8 (2011).
-
(2011)
J Biol Chem
, vol.286
, pp. 22131-22138
-
-
Shin, J.1
-
30
-
-
8644244682
-
p53 Stabilization and accumulation induced by human vaccinia-related kinase 1
-
Vega, F. M., Sevilla, A. & Lazo, P. A. p53 Stabilization and accumulation induced by human vaccinia-related kinase 1. Mol Cell Biol 24, 10366-80 (2004).
-
(2004)
Mol Cell Biol
, vol.24
, pp. 10366-10380
-
-
Vega, F.M.1
Sevilla, A.2
Lazo, P.A.3
-
31
-
-
84896708836
-
VRK1 interacts with p53 forming a basal complex that is activated by UV-induced DNA damage
-
Lopez-Sanchez, I. et al. VRK1 interacts with p53 forming a basal complex that is activated by UV-induced DNA damage. FEBS Lett 588, 692-700 (2014).
-
(2014)
FEBS Lett
, vol.588
, pp. 692-700
-
-
Lopez-Sanchez, I.1
-
32
-
-
84902000393
-
Polo-like kinase-1 in DNA damage response
-
Hyun, S. Y., Hwang, H. I. & Jang, Y. J. Polo-like kinase-1 in DNA damage response. BMB Rep 47, 249-55 (2014).
-
(2014)
BMB Rep
, vol.47
, pp. 249-255
-
-
Hyun, S.Y.1
Hwang, H.I.2
Jang, Y.J.3
-
33
-
-
84856776536
-
Plk1 and CK2 act in concert to regulate Rad51 during DNA double strand break repair
-
Yata, K. et al. Plk1 and CK2 act in concert to regulate Rad51 during DNA double strand break repair. Mol Cell 45, 371-83 (2012).
-
(2012)
Mol Cell
, vol.45
, pp. 371-383
-
-
Yata, K.1
-
34
-
-
84866904458
-
HnRNP A1 phosphorylated by VRK1 stimulates telomerase and its binding to telomeric DNA sequence
-
Choi, Y. H., Lim, J. K., Jeong, M. W. & Kim, K. T. HnRNP A1 phosphorylated by VRK1 stimulates telomerase and its binding to telomeric DNA sequence. Nucleic Acids Res 40, 8499-518 (2012).
-
(2012)
Nucleic Acids Res
, vol.40
, pp. 8499-8518
-
-
Choi, Y.H.1
Lim, J.K.2
Jeong, M.W.3
Kim, K.T.4
-
35
-
-
79953859157
-
Cancer therapy based on oncogene addiction
-
McCormick, F. Cancer therapy based on oncogene addiction. J Surg Oncol 103, 464-7 (2011).
-
(2011)
J Surg Oncol
, vol.103
, pp. 464-467
-
-
McCormick, F.1
-
36
-
-
37249003928
-
Oncogene addiction: Setting the stage for molecularly targeted cancer therapy
-
Sharma, S. V. & Settleman, J. Oncogene addiction: setting the stage for molecularly targeted cancer therapy. Genes Dev 21, 3214-31 (2007).
-
(2007)
Genes Dev
, vol.21
, pp. 3214-3231
-
-
Sharma, S.V.1
Settleman, J.2
-
37
-
-
25444497278
-
The concept of synthetic lethality in the context of anticancer therapy
-
Kaelin, W. G. Jr. The concept of synthetic lethality in the context of anticancer therapy. Nat Rev Cancer 5, 689-98 (2005).
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 689-698
-
-
Kaelin, W.G.1
-
38
-
-
0041997348
-
Chemosensitivity linked to p73 function
-
Irwin, M. S. et al. Chemosensitivity linked to p73 function. Cancer Cell 3, 403-10 (2003).
-
(2003)
Cancer Cell
, vol.3
, pp. 403-410
-
-
Irwin, M.S.1
-
39
-
-
0035902115
-
Proliferation, cell cycle and apoptosis in cancer
-
Evan, G. I. & Vousden, K. H. Proliferation, cell cycle and apoptosis in cancer. Nature 411, 342-8 (2001).
-
(2001)
Nature
, vol.411
, pp. 342-348
-
-
Evan, G.I.1
Vousden, K.H.2
-
40
-
-
0032622050
-
p53-independent increase in E2F-1 expression enhances the cytotoxic effects of etoposide and of adriamycin
-
Meng, R. D., Phillips, P. & El-Deiry, W. S. p53-independent increase in E2F-1 expression enhances the cytotoxic effects of etoposide and of adriamycin. Int J Oncol 14, 5-14 (1999).
-
(1999)
Int J Oncol
, vol.14
, pp. 5-14
-
-
Meng, R.D.1
Phillips, P.2
El-Deiry, W.S.3
-
41
-
-
0035815677
-
Oncogenes induce and activate endogenous p73 protein
-
Zaika, A., Irwin, M., Sansome, C. & Moll, U. M. Oncogenes induce and activate endogenous p73 protein. J Biol Chem 276, 11310-6 (2001).
-
(2001)
J Biol Chem
, vol.276
, pp. 11310-11316
-
-
Zaika, A.1
Irwin, M.2
Sansome, C.3
Moll, U.M.4
-
42
-
-
79952215577
-
Downregulation of VRK1 by p53 in response to DNA damage is mediated by the autophagic pathway
-
Valbuena, A., Castro-Obregon, S. & Lazo, P. A. Downregulation of VRK1 by p53 in response to DNA damage is mediated by the autophagic pathway. PLoS One 6, e17320 (2011).
-
(2011)
PLoS One
, vol.6
-
-
Valbuena, A.1
Castro-Obregon, S.2
Lazo, P.A.3
-
43
-
-
33745434781
-
p53 downregulates its activating vaccinia-related kinase 1, forming a new autoregulatory loop
-
Valbuena, A., Vega, F. M., Blanco, S. & Lazo, P. A. p53 downregulates its activating vaccinia-related kinase 1, forming a new autoregulatory loop. Mol Cell Biol 26, 4782-93 (2006).
-
(2006)
Mol Cell Biol
, vol.26
, pp. 4782-4793
-
-
Valbuena, A.1
Vega, F.M.2
Blanco, S.3
Lazo, P.A.4
-
44
-
-
34249006299
-
ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models
-
Donawho, C. K. et al. ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models. Clin Cancer Res 13, 2728-37 (2007).
-
(2007)
Clin Cancer Res
, vol.13
, pp. 2728-2737
-
-
Donawho, C.K.1
-
45
-
-
35348861389
-
Induction of apoptosis and regulation of the MAPK pathway by ursolic acid in human leukemia K562 cells
-
Liu, X. S. & Jiang, J. Induction of apoptosis and regulation of the MAPK pathway by ursolic acid in human leukemia K562 cells. Planta Med 73, 1192-4 (2007).
-
(2007)
Planta Med
, vol.73
, pp. 1192-1194
-
-
Liu, X.S.1
Jiang, J.2
-
46
-
-
4444356923
-
Proliferative inhibition, cell-cycle dysregulation, and induction of apoptosis by ursolic acid in human non-small cell lung cancer A549 cells
-
Hsu, Y. L., Kuo, P. L. & Lin, C. C. Proliferative inhibition, cell-cycle dysregulation, and induction of apoptosis by ursolic acid in human non-small cell lung cancer A549 cells. Life Sci 75, 2303-16 (2004).
-
(2004)
Life Sci
, vol.75
, pp. 2303-2316
-
-
Hsu, Y.L.1
Kuo, P.L.2
Lin, C.C.3
-
47
-
-
43449137552
-
Ursolic acid induces apoptosis by activating p53 and caspase-3 gene expressions and suppressing NF-kappaB mediated activation of bcl-2 in B16F-10 melanoma cells
-
Manu, K. A. & Kuttan, G. Ursolic acid induces apoptosis by activating p53 and caspase-3 gene expressions and suppressing NF-kappaB mediated activation of bcl-2 in B16F-10 melanoma cells. Int Immunopharmacol 8, 974-81 (2008).
-
(2008)
Int Immunopharmacol
, vol.8
, pp. 974-981
-
-
Manu, K.A.1
Kuttan, G.2
-
48
-
-
21644440395
-
Ursolic acid induces Bax-dependent apoptosis through the caspase-3 pathway in endometrial cancer SNG-II cells
-
Achiwa, Y., Hasegawa, K., Komiya, T. & Udagawa, Y. Ursolic acid induces Bax-dependent apoptosis through the caspase-3 pathway in endometrial cancer SNG-II cells. Oncol Rep 13, 51-7 (2005).
-
(2005)
Oncol Rep
, vol.13
, pp. 51-57
-
-
Achiwa, Y.1
Hasegawa, K.2
Komiya, T.3
Udagawa, Y.4
-
49
-
-
0027982986
-
Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid
-
Huang, M. T. et al. Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid. Cancer Res 54, 701-8 (1994).
-
(1994)
Cancer Res
, vol.54
, pp. 701-708
-
-
Huang, M.T.1
-
50
-
-
0028066930
-
Induction of differentiation in the cultured F9 teratocarcinoma stem cells by triterpene acids
-
Lee, H. Y., Chung, H. Y., Kim, K. H., Lee, J. J. & Kim, K. W. Induction of differentiation in the cultured F9 teratocarcinoma stem cells by triterpene acids. J Cancer Res Clin Oncol 120, 513-8 (1994).
-
(1994)
J Cancer Res Clin Oncol
, vol.120
, pp. 513-518
-
-
Lee, H.Y.1
Chung, H.Y.2
Kim, K.H.3
Lee, J.J.4
Kim, K.W.5
-
51
-
-
0029156978
-
Anti-angiogenic activity of triterpene acids
-
Sohn, K. H. et al. Anti-angiogenic activity of triterpene acids. Cancer Lett 94, 213-8 (1995).
-
(1995)
Cancer Lett
, vol.94
, pp. 213-218
-
-
Sohn, K.H.1
-
52
-
-
84863463970
-
Ursolic acid induces apoptosis by suppressing the expression of FoxM1 in MCF-7 human breast cancer cells
-
Wang, J. S., Ren, T. N. & Xi, T. Ursolic acid induces apoptosis by suppressing the expression of FoxM1 in MCF-7 human breast cancer cells. Med Oncol 29, 10-5 (2012).
-
(2012)
Med Oncol
, vol.29
, pp. 10-15
-
-
Wang, J.S.1
Ren, T.N.2
Xi, T.3
-
53
-
-
33645673472
-
VRK1 signaling pathway in the context of the proliferation phenotype in head and neck squamous cell carcinoma
-
Santos, C. R. et al. VRK1 signaling pathway in the context of the proliferation phenotype in head and neck squamous cell carcinoma. Mol Cancer Res 4, 177-85 (2006).
-
(2006)
Mol Cancer Res
, vol.4
, pp. 177-185
-
-
Santos, C.R.1
-
54
-
-
0030711601
-
Identification of two novel human putative serine/threonine kinases, VRK1 and VRK2, with structural similarity to vaccinia virus B1R kinase
-
Nezu, J., Oku, A., Jones, M. H. & Shimane, M. Identification of two novel human putative serine/threonine kinases, VRK1 and VRK2, with structural similarity to vaccinia virus B1R kinase. Genomics 45, 327-31 (1997).
-
(1997)
Genomics
, vol.45
, pp. 327-331
-
-
Nezu, J.1
Oku, A.2
Jones, M.H.3
Shimane, M.4
-
55
-
-
77950357889
-
Mice deficient in the serine/threonine protein kinase VRK1 are infertile due to a progressive loss of spermatogonia
-
Wiebe, M. S., Nichols, R. J., Molitor, T. P., Lindgren, J. K. & Traktman, P. Mice deficient in the serine/threonine protein kinase VRK1 are infertile due to a progressive loss of spermatogonia. Biol Reprod 82, 182-93 (2010).
-
(2010)
Biol Reprod
, vol.82
, pp. 182-193
-
-
Wiebe, M.S.1
Nichols, R.J.2
Molitor, T.P.3
Lindgren, J.K.4
Traktman, P.5
-
56
-
-
78650764600
-
Vaccinia-related kinase 1 is required for the maintenance of undifferentiated spermatogonia in mouse male germ cells
-
Choi, Y. H. et al. Vaccinia-related kinase 1 is required for the maintenance of undifferentiated spermatogonia in mouse male germ cells. PLoS One 5, e15254 (2010).
-
(2010)
PLoS One
, vol.5
-
-
Choi, Y.H.1
-
57
-
-
84871865507
-
Defective folliculogenesis in female mice lacking Vaccinia-related kinase 1
-
Kim, J., Choi, Y. H., Chang, S., Kim, K. T. & Je, J. H. Defective folliculogenesis in female mice lacking Vaccinia-related kinase 1. Sci Rep 2, 468 (2012).
-
(2012)
Sci Rep
, vol.2
, pp. 468
-
-
Kim, J.1
Choi, Y.H.2
Chang, S.3
Kim, K.T.4
Je, J.H.5
-
58
-
-
79952900211
-
The kinase VRK1 is required for normal meiotic progression in mammalian oogenesis
-
Schober, C. S., Aydiner, F., Booth, C. J., Seli, E. & Reinke, V. The kinase VRK1 is required for normal meiotic progression in mammalian oogenesis. Mech Dev 128, 178-90 (2011).
-
(2011)
Mech Dev
, vol.128
, pp. 178-190
-
-
Schober, C.S.1
Aydiner, F.2
Booth, C.J.3
Seli, E.4
Reinke, V.5
-
60
-
-
84903827705
-
Genetics of aging, progeria and lamin disorders
-
Ghosh, S. & Zhou, Z. Genetics of aging, progeria and lamin disorders. Curr Opin Genet Dev 26c, 41-46 (2014).
-
(2014)
Curr Opin Genet Dev
, vol.26 C
, pp. 41-46
-
-
Ghosh, S.1
Zhou, Z.2
-
61
-
-
36849090938
-
NHK-1 phosphorylates BAF to allow karyosome formation in the Drosophila oocyte nucleus
-
Lancaster, O. M., Cullen, C. F. & Ohkura, H. NHK-1 phosphorylates BAF to allow karyosome formation in the Drosophila oocyte nucleus. J Cell Biol 179, 817-24 (2007).
-
(2007)
J Cell Biol
, vol.179
, pp. 817-824
-
-
Lancaster, O.M.1
Cullen, C.F.2
Ohkura, H.3
-
62
-
-
84896297894
-
Depletion of the protein kinase VRK1 disrupts nuclear envelope morphology and leads to BAF retention on mitotic chromosomes
-
Molitor, T. P. & Traktman, P. Depletion of the protein kinase VRK1 disrupts nuclear envelope morphology and leads to BAF retention on mitotic chromosomes. Mol Biol Cell 25, 891-903 (2014).
-
(2014)
Mol Biol Cell
, vol.25
, pp. 891-903
-
-
Molitor, T.P.1
Traktman, P.2
-
63
-
-
84897505936
-
Nuclear assembly as a target for anti-cancer therapies
-
Gorjanacz, M. Nuclear assembly as a target for anti-cancer therapies. Nucleus 5, 47-55 (2014).
-
(2014)
Nucleus
, vol.5
, pp. 47-55
-
-
Gorjanacz, M.1
-
64
-
-
84919705186
-
Brazilin Isolated from Caesalpinia sappan Suppresses Nuclear Envelope Reassembly by Inhibiting Barrier-to-Autointegration Factor Phosphorylation
-
Kim, S. H. et al. Brazilin Isolated from Caesalpinia sappan Suppresses Nuclear Envelope Reassembly by Inhibiting Barrier-to-Autointegration Factor Phosphorylation. J Pharmacol Exp Ther 352, 175-84 (2015).
-
(2015)
J Pharmacol Exp Ther
, vol.352
, pp. 175-184
-
-
Kim, S.H.1
-
65
-
-
84872712508
-
Obtusilactone B from Machilus Thunbergii targets barrier-to-autointegration factor to treat cancer
-
Kim, W. et al. Obtusilactone B from Machilus Thunbergii targets barrier-to-autointegration factor to treat cancer. Mol Pharmacol 83, 367-76 (2013).
-
(2013)
Mol Pharmacol
, vol.83
, pp. 367-376
-
-
Kim, W.1
-
66
-
-
38049155899
-
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases
-
Fedorov, O. et al. A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci USA 104, 20523-8 (2007).
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 20523-20528
-
-
Fedorov, O.1
-
67
-
-
34247350792
-
Insights for the development of specific kinase inhibitors by targeted structural genomics
-
Fedorov, O., Sundstrom, M., Marsden, B. & Knapp, S. Insights for the development of specific kinase inhibitors by targeted structural genomics. Drug Discov Today 12, 365-72 (2007).
-
(2007)
Drug Discov Today
, vol.12
, pp. 365-372
-
-
Fedorov, O.1
Sundstrom, M.2
Marsden, B.3
Knapp, S.4
-
68
-
-
79961147773
-
Differential inhibitor sensitivity between human kinases VRK1 and VRK2
-
Vazquez-Cedeira, M., Barcia-Sanjurjo, I., Sanz-Garcia, M., Barcia, R. & Lazo, P. A. Differential inhibitor sensitivity between human kinases VRK1 and VRK2. PLoS One 6, e23235 (2011).
-
(2011)
PLoS One
, vol.6
-
-
Vazquez-Cedeira, M.1
Barcia-Sanjurjo, I.2
Sanz-Garcia, M.3
Barcia, R.4
Lazo, P.A.5
-
69
-
-
84907930167
-
Luteolin suppresses cancer cell proliferation by targeting vaccinia-related kinase 1
-
Kim, Y. S. et al. Luteolin suppresses cancer cell proliferation by targeting vaccinia-related kinase 1. PLoS One 9, e109655 (2014).
-
(2014)
PLoS One
, vol.9
-
-
Kim, Y.S.1
-
70
-
-
27144532075
-
A potential synergistic anticancer effect of paclitaxel and amifostine on endometrial cancer
-
Dai, D. et al. A potential synergistic anticancer effect of paclitaxel and amifostine on endometrial cancer. Cancer Res 65, 9517-24 (2005).
-
(2005)
Cancer Res
, vol.65
, pp. 9517-9524
-
-
Dai, D.1
|