Melatonin suppresses activation of hepatic stellate cells through RORα-mediated inhibition of 5-lipoxygenase

Journal of Pineal Research

Volumn 59, Issue 3, 2015, Pages 391-404

  Shajari, Shiva ^a   Laliena, Almudena ^a,b   Heegsma, Janette ^a   Tuñõn, María Jesús ^b,c   Moshage, Han ^a   Faber, Klaas Nico ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b UNIVERSITY OF LEÓN   (Spain)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

5 lipoxygenase; hepatic stellate cell; hepatic stellate cell activation; liver fibrosis; melatonin; proliferation; retinoic acid receptor related orphan receptor

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ANTIBODY; ARACHIDONATE 5 LIPOXYGENASE; COLLAGEN 1A1; COLLAGEN TYPE 1; FAT DROPLET; MELATONIN; MELATONIN 1A RECEPTOR; MELATONIN 1B RECEPTOR; MELATONIN RECEPTOR; RETINOID RELATED ORPHAN RECEPTOR ALPHA; UNCLASSIFIED DRUG; ANTIOXIDANT;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME INHIBITION; IMMUNOFLUORESCENCE MICROSCOPY; IN VITRO STUDY; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; STELLATE CELL; ANIMAL; DRUG EFFECTS; ENZYMOLOGY; LIVER CIRRHOSIS; METABOLISM;

ANIMALS; ANTIOXIDANTS; ARACHIDONATE 5-LIPOXYGENASE; HEPATIC STELLATE CELLS; LIVER CIRRHOSIS; MELATONIN; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 1; RATS;

EID: 84942199329     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/jpi.12271     Document Type: Article

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