Modulation of the biliary expression of arylalkylamine N-acetyltransferase alters the autocrine proliferative responses of cholangiocytes in rats

Hepatology

Volumn 57, Issue 3, 2013, Pages 1130-1141

  Renzi, Anastasia ^a,c   Demorrow, Sharon ^a   Onori, Paolo ^b   Carpino, Guido ^f   Mancinelli, Romina ^c   Meng, Fanyin ^a   Venter, Julie ^a   White, Mellanie ^a   Franchitto, Antonio ^c,e   Francis, Heather ^a   Han, Yuyan ^a   Ueno, Yoshiyuki ^d   Dusio, Giuseppina ^a   Jensen, Kendal J ^a   Greene, John J ^a   Glaser, Shannon ^a   Gaudio, Eugenio ^c   Alpini, Gianfranco ^a  

^a TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

^b UNIVERSITY OF L'AQUILA   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d YAMAGATA UNIVERSITY   (Japan)

^e Eleonora Lorillard Spencer Cenci Foundation   (Italy)

^f UNIVERSITY OF ROME FORO ITALICO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ARALKYLAMINE ACETYLTRANSFERASE; BICARBONATE; CHLORIDE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; MELATONIN; SECRETIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANION EXCHANGE; ARTICLE; AUTOCRINE EFFECT; BILE DUCT LIGATION; BILE SECRETION; CELL PROLIFERATION; CELL TYPE; CELLULAR SECRETION; CHOLANGIOCYTE; CONTROLLED STUDY; GENE OVEREXPRESSION; HORMONE RELEASE; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; ANION TRANSPORT PROTEINS; ANTIOXIDANTS; ANTIPORTERS; APOPTOSIS; ARYLALKYLAMINE N-ACETYLTRANSFERASE; AUTOCRINE COMMUNICATION; BILE DUCTS, INTRAHEPATIC; CELL LINE, TRANSFORMED; CELL PROLIFERATION; CHOLESTASIS; GENE KNOCKDOWN TECHNIQUES; MALE; MELATONIN; MICE; PROLIFERATING CELL NUCLEAR ANTIGEN; RATS; RATS, INBRED F344; RECEPTORS, SEROTONIN;

EID: 84874493898     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.26105     Document Type: Article

References (41)

1. Kanno N, LeSage G, Glaser S, Alpini G. Regulation of cholangiocyte bicarbonate secretion. Am J Physiol Gastrointest Liver Physiol 2001; 281: G612-G625.
2. Alpini G, Lenzi R, Sarkozi L, Tavoloni N. Biliary physiology in rats with bile ductular cell hyperplasia. Evidence for a secretory function of proliferated bile ductules. J Clin Invest 1988; 81: 569-578.
3. Alpini G, Ulrich CD, 2nd, Phillips JO, Pham LD, Miller LJ, LaRusso NF. Upregulation of secretin receptor gene expression in rat cholangiocytes after bile duct ligation. Am J Physiol Gastrointest Liver Physiol 1994; 266: G922-G928.
4. Alpini G, Ulrich C, Roberts S, Phillips JO, Ueno Y, Podila PV, et al. Molecular and functional heterogeneity of cholangiocytes from rat liver after bile duct ligation. Am J Physiol Gastrointest Liver Physiol 1997; 272: G289-G297.
5. Alvaro D, Cho WK, Mennone A, Boyer JL. Effect of secretion on intracellular pH regulation in isolated rat bile duct epithelial cells. J Clin Invest 1993; 92: 1314-1325.
6. Alpini G, Prall RT, LaRusso NF. The pathobiology of biliary epithelia. In: Arias IM, Boyer JL, Chisari FV, Fausto N, Jakoby W, Schachter D, et al., eds. The Liver: Biology and Pathobiology, 4th edition. Philadelphia, PA: Lippincott Williams & Wilkins; 2001: 421-435.
7. Glaser S, Lam IP, Franchitto A, Gaudio E, Onori P, Chow BK, et al. Knockout of secretin receptor reduces large cholangiocyte hyperplasia in mice with extrahepatic cholestasis induced by bile duct ligation. HEPATOLOGY 2010; 52: 204-214.
8. LeSage G, Glaser S, Marucci L, Benedetti A, Phinizy JL, Rodgers R, et al. Acute carbon tetrachloride feeding induces damage of large but not small cholangiocytes from BDL rat liver. Am J Physiol Gastrointest Liver Physiol 1999; 276: G1289-G1301.
9. Alvaro D, Mancino MG, Glaser S, Gaudio E, Marzioni M, Francis H, Alpini G. Proliferating cholangiocytes: a neuroendocrine compartment in the diseased liver. Gastroenterology 2007; 132: 415-431.
10. Gaudio E, Barbaro B, Alvaro D, Glaser S, Francis H, Ueno Y, et al. Vascular endothelial growth factor stimulates rat cholangiocyte proliferation via an autocrine mechanism. Gastroenterology 2006; 130: 1270-1282.
11. Iuvone PM, Tosini G, Pozdeyev N, Haque R, Klein DC, Chaurasia SS. Circadian clocks, clock networks, arylalkylamine N-acetyltransferase, and melatonin in the retina. Prog Retin Eye Res 2005; 24: 433-456.
12. Reiter RJ. Pineal melatonin: cell biology of its synthesis and of its physiological interactions. Endocr Rev 1991; 12: 151-180.
13. Bubenik GA. Gastrointestinal melatonin: localization, function, and clinical relevance. Dig Dis Sci 2002; 47: 2336-2348.
14. Esrefoglu M, Gul M, Emre MH, Polat A, Selimoglu MA. Protective effect of low dose of melatonin against cholestatic oxidative stress after common bile duct ligation in rats. World J Gastroenterol 2005; 11: 1951-1956.
15. Tahan G, Akin H, Aydogan F, Ramadan SS, Yapicier O, Tarcin O, et al. Melatonin ameliorates liver fibrosis induced by bile-duct ligation in rats. Can J Surg 2010; 53: 313-318.
16. Renzi A, Glaser S, DeMorrow S, Mancinelli R, Meng F, Franchitto A, et al. Melatonin inhibits cholangiocyte hyperplasia in cholestatic rats by interaction with MT1 but not MT2 melatonin receptors. Am J Physiol Gastrointest Liver Physiol 2011; 301: G634-G643.
17. Arora V, Knapp DC, Reddy MT, Weller DD, Iversen PL. Bioavailability and efficacy of antisense morpholino oligomers targeted to c-myc and cytochrome P-450 3A2 following oral administration in rats. J Pharm Sci 2002; 91: 1009-1018.
18. Glaser S, Gaudio E, Rao A, Pierce LM, Onori P, Franchitto A, et al. Morphological and functional heterogeneity of the mouse intrahepatic biliary epithelium. Lab Invest 2009; 89: 456-469.
19. Ueno Y, Alpini G, Yahagi K, Kanno N, Moritoki Y, Fukushima K, et al. Evaluation of differential gene expression by microarray analysis in small and large cholangiocytes isolated from normal mice. Liver Int 2003; 23: 449-459.
20. Mancinelli R, Franchitto A, Gaudio E, Onori P, Glaser S, Francis H, et al. After damage of large bile ducts by gamma-aminobutyric acid, small ducts replenish the biliary tree by amplification of calcium-dependent signaling and de novo acquisition of large cholangiocyte phenotypes. Am J Pathol 2010; 176: 1790-1800.
21. 3/CaMK I/CREB pathway. Am J Physiol Cell Physiol 2008; 295: C499-C513.
22. Glaser S, DeMorrow S, Francis H, Ueno Y, Gaudio E, Vaculin S, et al. Progesterone stimulates the proliferation of female and male cholangiocytes via autocrine/paracrine mechanisms. Am J Physiol Gastrointest Liver Physiol 2008; 295: G124-G136.
23. Mancinelli R, Onori P, Gaudio E, DeMorrow S, Franchitto A, Francis H, et al. Follicle-stimulating hormone increases cholangiocyte proliferation by an autocrine mechanism via cAMP-dependent phosphorylation of ERK1/2 and Elk-1. Am J Physiol Gastrointest Liver Physiol 2009; 297: G11-G26.
24. Onori P, Wise C, Gaudio E, Franchitto A, Francis H, Carpino G, et al. Secretin inhibits cholangiocarcinoma growth via dysregulation of the cAMP-dependent signaling mechanisms of secretin receptor. Int J Cancer 2010; 127: 43-54.
25. Yang L, Wu X, Wang Y, Zhang K, Wu J, Yuan YC, et al. FZD7 has a critical role in cell proliferation in triple negative breast cancer. Oncogene 2011; 30: 4437-4446.
26. Francis H, LeSage G, DeMorrow S, Alvaro D, Ueno Y, Venter J, et al. The alpha2-adrenergic receptor agonist UK 14, 304 inhibits secretin-stimulated ductal secretion by downregulation of the cAMP system in bile duct-ligated rats. Am J Physiol Cell Physiol 2007; 293: C1252-C1262.
27. Humphries A, Wells T, Baler R, Klein DC, Carter DA. Rodent Aanat: intronic E-box sequences control tissue specificity but not rhythmic expression in the pineal gland. Mol Cell Endocrinol 2007; 270: 43-49.
28. Alpini G, Glaser SS, Ueno Y, Pham L, Podila PV, Caligiuri A, et al. Heterogeneity of the proliferative capacity of rat cholangiocytes after bile duct ligation. Am J Physiol Gastrointest Liver Physiol 1998; 274: G767-G775.
29. + transport in human biliary cell lines. Gastroenterology 1993; 104: 1796-1805.
30. Marzioni M, Glaser S, Francis H, Marucci L, Benedetti A, Alvaro D, et al. Autocrine/paracrine regulation of the growth of the biliary tree by the neuroendocrine hormone serotonin. Gastroenterology 2005; 128: 121-137.
31. Alpini G, Invernizzi P, Gaudio E, Venter J, Kopriva S, Bernuzzi F, et al. Serotonin metabolism is dysregulated in cholangiocarcinoma, which has implications for tumor growth. Cancer Res 2008; 68: 9184-9193.
32. Fabris L, Cadamuro M, Fiorotto R, Roskams T, Spirli C, Melero S, et al. Effects of angiogenic factor overexpression by human and rodent cholangiocytes in polycystic liver diseases. HEPATOLOGY 2006; 43: 1001-1012.
33. Han Y, Demorrow S, Invernizzi P, Jing Q, Glaser S, Renzi A, et al. Melatonin exerts by an autocrine loop antiproliferative effects in cholangiocarcinoma: its synthesis is reduced favoring cholangiocarcinoma growth. Am J Physiol Gastrointest Liver Physiol 2011; 301: G623-G633.
34. Summerton JE. Morpholino, siRNA, and S-DNA compared: impact of structure and mechanism of action on off-target effects and sequence specificity. Curr Top Med Chem 2007; 7: 651-660.
35. Monga SP, Monga HK, Tan X, Mule K, Pediaditakis P, Michalopoulos GK. Beta-catenin antisense studies in embryonic liver cultures: role in proliferation, apoptosis, and lineage specification. Gastroenterology 2003; 124: 202-216.
36. Cui S, Capecci LM, Matthews RP. Disruption of planar cell polarity activity leads to developmental biliary defects. Dev Biol 2011; 351: 229-241.
37. Polat A, Emre MH. Effects of melatonin or acetylsalicylic acid on gastric oxidative stress after bile duct ligation in rats. J Gastroenterol 2006; 41: 433-439.
38. Dollins AB, Zhdanova IV, Wurtman RJ, Lynch HJ, Deng MH. Effect of inducing nocturnal serum melatonin concentrations in daytime on sleep, mood, body temperature, and performance. Proc Natl Acad Sci U S A 1994; 91: 1824-1828.
39. Glaser S, Onori P, Meng F, Franchitto A, Mancinelli R, Venter J, et al. Lack of the expression of the secretin-secretin receptor signaling axis exacerbates carbon tetrachloride-induced damage of large cholangiocytes. HEPATOLOGY 2011; 54: A135.
40. Glaser S, Gaudio E, Onori P, Venter J, Chow B, Franchitto A, et al. Knockout of the gene for secretin inhibits biliary hyperplasia of large cholangiocytes in cholestatic mice by an autocrine mechanism. HEPATOLOGY 2009; 50: 1075.
41. Alvaro D, Invernizzi P, Onori P, Franchitto A, De Santis A, Crosignani A, et al. Estrogen receptors in cholangiocytes and the progression of primary biliary cirrhosis. J Hepatol 2004; 41: 905-912.