메뉴 건너뛰기




Volumn 92, Issue 1-4, 2010, Pages 54-61

Protection from hepatic lipid accumulation and inflammation by genetic ablation of 5-lipoxygenase

Author keywords

5 Lipoxygenase; Knockout mice; Lipid metabolism

Indexed keywords

ADENOSINE TRIPHOSPHATE CITRATE LYASE; ARACHIDONATE 5 LIPOXYGENASE; CARBON TETRACHLORIDE; CCAAT ENHANCER BINDING PROTEIN; ELONGATION FACTOR; ELONGATION OF VERY LONG CHAIN FATTY ACID 6; FATTY ACID SYNTHASE; LIPIN 1; PHOSPHATASE; UNCLASSIFIED DRUG;

EID: 77952322894     PISSN: 10988823     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.prostaglandins.2010.03.001     Document Type: Article
Times cited : (20)

References (31)
  • 1
    • 0020597565 scopus 로고
    • Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation
    • Samuelsson B. Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. Science 220 (1983) 568-575
    • (1983) Science , vol.220 , pp. 568-575
    • Samuelsson, B.1
  • 2
    • 0035976575 scopus 로고    scopus 로고
    • Prostaglandins and leukotrienes: advances in eicosanoid biology
    • Funk C.D. Prostaglandins and leukotrienes: advances in eicosanoid biology. Science 294 (2001) 1871-1875
    • (2001) Science , vol.294 , pp. 1871-1875
    • Funk, C.D.1
  • 3
    • 0019311062 scopus 로고
    • 4, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes
    • 4, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes. Nature 286 (1980) 264-265
    • (1980) Nature , vol.286 , pp. 264-265
    • Ford-Hutchinson, A.W.1    Bray, M.A.2    Doig, M.V.3
  • 4
    • 0019254822 scopus 로고
    • Leukotrienes are potent constrictors of human bronchi
    • Dahlen S.E., Hedqvist P., Hammarstrom S., et al. Leukotrienes are potent constrictors of human bronchi. Nature 288 (1980) 484-486
    • (1980) Nature , vol.288 , pp. 484-486
    • Dahlen, S.E.1    Hedqvist, P.2    Hammarstrom, S.3
  • 5
    • 0242611540 scopus 로고    scopus 로고
    • Cyclooxygenase-2 and 5-lipoxygenase converging functions on cell proliferation and tumor angiogenesis: implications for cancer therapy
    • Romano M., and Clària J. Cyclooxygenase-2 and 5-lipoxygenase converging functions on cell proliferation and tumor angiogenesis: implications for cancer therapy. FASEB J 17 (2003) 1986-1995
    • (2003) FASEB J , vol.17 , pp. 1986-1995
    • Romano, M.1    Clària, J.2
  • 6
    • 34347397335 scopus 로고    scopus 로고
    • 5-Lipoxygenase: regulation of expression and enzyme activity
    • Radmark O., Werz O., Steinhilber D., et al. 5-Lipoxygenase: regulation of expression and enzyme activity. Trends Biochem Sci 32 (2007) 332-341
    • (2007) Trends Biochem Sci , vol.32 , pp. 332-341
    • Radmark, O.1    Werz, O.2    Steinhilber, D.3
  • 7
    • 0025806326 scopus 로고
    • The sensitized liver represents a rich source of endogenous leukotrienes
    • Hagmann W., Kaiser I., and Jakschik B.A. The sensitized liver represents a rich source of endogenous leukotrienes. Hepatology 13 (1991) 482-488
    • (1991) Hepatology , vol.13 , pp. 482-488
    • Hagmann, W.1    Kaiser, I.2    Jakschik, B.A.3
  • 8
    • 0033852479 scopus 로고    scopus 로고
    • Hepatocyte-derived cysteinyl leukotrienes modulate vascular tone in experimental cirrhosis
    • Titos E., Clària J., Bataller R., et al. Hepatocyte-derived cysteinyl leukotrienes modulate vascular tone in experimental cirrhosis. Gastroenterology 119 (2000) 794-805
    • (2000) Gastroenterology , vol.119 , pp. 794-805
    • Titos, E.1    Clària, J.2    Bataller, R.3
  • 9
    • 25644456834 scopus 로고    scopus 로고
    • Inhibition of 5-lipoxygenase-activating protein abrogates experimental liver injury: role of Kupffer cells
    • Titos E., Clària J., Planagumà A., et al. Inhibition of 5-lipoxygenase-activating protein abrogates experimental liver injury: role of Kupffer cells. J Leukoc Biol 78 (2005) 871-878
    • (2005) J Leukoc Biol , vol.78 , pp. 871-878
    • Titos, E.1    Clària, J.2    Planagumà, A.3
  • 10
    • 0141595006 scopus 로고    scopus 로고
    • Inhibition of 5-lipoxygenase induces cell growth arrest and apoptosis in rat Kupffer cells: implications for liver fibrosis
    • Titos E., Clària J., Planagumà A., et al. Inhibition of 5-lipoxygenase induces cell growth arrest and apoptosis in rat Kupffer cells: implications for liver fibrosis. FASEB J 17 (2003) 1745-1747
    • (2003) FASEB J , vol.17 , pp. 1745-1747
    • Titos, E.1    Clària, J.2    Planagumà, A.3
  • 11
    • 36348999868 scopus 로고    scopus 로고
    • Comparative protection against liver inflammation and fibrosis by a selective cyclooxygenase-2 inhibitor and a nonredox-type 5-lipoxygenase inhibitor
    • Horrillo R., Planagumà A., González-Périz A., et al. Comparative protection against liver inflammation and fibrosis by a selective cyclooxygenase-2 inhibitor and a nonredox-type 5-lipoxygenase inhibitor. J Pharmacol Exp Ther 323 (2007) 778-786
    • (2007) J Pharmacol Exp Ther , vol.323 , pp. 778-786
    • Horrillo, R.1    Planagumà, A.2    González-Périz, A.3
  • 12
    • 62549127839 scopus 로고    scopus 로고
    • Improvement of hepatic fibrosis by leukotriene inhibition in cholestatic rats
    • El-Swefy S., and Hassanen S.I. Improvement of hepatic fibrosis by leukotriene inhibition in cholestatic rats. Ann Hepatol 8 (2009) 41-49
    • (2009) Ann Hepatol , vol.8 , pp. 41-49
    • El-Swefy, S.1    Hassanen, S.I.2
  • 13
    • 59649097994 scopus 로고    scopus 로고
    • Regulatory effects of arachidonate 5-lipoxygenase on hepatic microsomal TG transfer protein activity and VLDL-triglyceride and apoB secretion in obese mice
    • López-Parra M., Titos E., Horrillo R., et al. Regulatory effects of arachidonate 5-lipoxygenase on hepatic microsomal TG transfer protein activity and VLDL-triglyceride and apoB secretion in obese mice. J Lipid Res 49 (2008) 2513-2523
    • (2008) J Lipid Res , vol.49 , pp. 2513-2523
    • López-Parra, M.1    Titos, E.2    Horrillo, R.3
  • 14
    • 0347418277 scopus 로고    scopus 로고
    • Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis
    • Dwyer J.H., Allayee H., Dwyer K.M., et al. Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis. N Engl J Med 350 (2004) 29-37
    • (2004) N Engl J Med , vol.350 , pp. 29-37
    • Dwyer, J.H.1    Allayee, H.2    Dwyer, K.M.3
  • 15
    • 33644621593 scopus 로고    scopus 로고
    • ALOX5AP expression, but not gene haplotypes, is associated with obesity and insulin resistance
    • Kaaman M., Ryden M., Axelsson T., et al. ALOX5AP expression, but not gene haplotypes, is associated with obesity and insulin resistance. Int J Obes (Lond) 30 (2006) 447-452
    • (2006) Int J Obes (Lond) , vol.30 , pp. 447-452
    • Kaaman, M.1    Ryden, M.2    Axelsson, T.3
  • 16
    • 0021368902 scopus 로고
    • Sex differences in the susceptibility of rats to carbon tetrachloride-alcohol-induced liver injury
    • Siegers C.P., Reichl W., and Younes M. Sex differences in the susceptibility of rats to carbon tetrachloride-alcohol-induced liver injury. Agents Actions 14 (1984) 121-123
    • (1984) Agents Actions , vol.14 , pp. 121-123
    • Siegers, C.P.1    Reichl, W.2    Younes, M.3
  • 17
    • 0142121516 scopus 로고    scopus 로고
    • Exploration, normalization, and summaries of high density oligonucleotide array probe level data
    • Irizarry R.A., Hobbs B., Collin F., et al. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 4 (2003) 249-264
    • (2003) Biostatistics , vol.4 , pp. 249-264
    • Irizarry, R.A.1    Hobbs, B.2    Collin, F.3
  • 18
    • 33644872577 scopus 로고    scopus 로고
    • Limma: linear models for microarray data
    • Gentleman R., Carey V., Dudoit S., Irizarry R., and Huber W. (Eds), Springer, New York
    • Smyth G.K. Limma: linear models for microarray data. In: Gentleman R., Carey V., Dudoit S., Irizarry R., and Huber W. (Eds). Bioinformatics and computational biology solutions using R and bioconductor. 2005 ed. (2009), Springer, New York 397-420
    • (2009) Bioinformatics and computational biology solutions using R and bioconductor. 2005 ed. , pp. 397-420
    • Smyth, G.K.1
  • 19
    • 33745815985 scopus 로고    scopus 로고
    • AMP-activated protein kinase signaling in metabolic regulation
    • Long Y.C., and Zierath J.R. AMP-activated protein kinase signaling in metabolic regulation. J Clin Invest 116 (2006) 1776-1783
    • (2006) J Clin Invest , vol.116 , pp. 1776-1783
    • Long, Y.C.1    Zierath, J.R.2
  • 20
    • 33745183847 scopus 로고    scopus 로고
    • Functions of AMP-activated protein kinase in adipose tissue
    • Daval M., Foufelle F., and Ferre P. Functions of AMP-activated protein kinase in adipose tissue. J Physiol 574 (2006) 55-62
    • (2006) J Physiol , vol.574 , pp. 55-62
    • Daval, M.1    Foufelle, F.2    Ferre, P.3
  • 21
    • 84863494132 scopus 로고    scopus 로고
    • Lipin proteins and metabolic homeostasis
    • Reue K., and Dwyer J.R. Lipin proteins and metabolic homeostasis. J Lipid Res 50 (2009) S109-S114
    • (2009) J Lipid Res , vol.50
    • Reue, K.1    Dwyer, J.R.2
  • 22
    • 77950619121 scopus 로고    scopus 로고
    • 5-Lipoxygenase deficiency reduces hepatic inflammation and tumor necrosis factor alpha-induced hepatocyte damage in hyperlipidemia-prone ApoE-null mice
    • Martínez-Clemente M., Ferré N., González-Périz A., et al. 5-Lipoxygenase deficiency reduces hepatic inflammation and tumor necrosis factor alpha-induced hepatocyte damage in hyperlipidemia-prone ApoE-null mice. Hepatology 51 (2010) 817-827
    • (2010) Hepatology , vol.51 , pp. 817-827
    • Martínez-Clemente, M.1    Ferré, N.2    González-Périz, A.3
  • 23
    • 77951630780 scopus 로고    scopus 로고
    • 5-Lipoxygenase activating protein signals adipose tissue inflammation and lipid dysfunction in experimental obesity
    • Horrillo R., González-Périz A., Martínez-Clemente M., et al. 5-Lipoxygenase activating protein signals adipose tissue inflammation and lipid dysfunction in experimental obesity. J Immunol 184 (2010) 3978-3987
    • (2010) J Immunol , vol.184 , pp. 3978-3987
    • Horrillo, R.1    González-Périz, A.2    Martínez-Clemente, M.3
  • 24
    • 0037129380 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Angulo P. Nonalcoholic fatty liver disease. N Engl J Med 346 (2002) 1221-1231
    • (2002) N Engl J Med , vol.346 , pp. 1221-1231
    • Angulo, P.1
  • 25
    • 20444473800 scopus 로고    scopus 로고
    • Mechanisms of disease: pathogenesis of nonalcoholic fatty liver disease
    • Sanyal A.J. Mechanisms of disease: pathogenesis of nonalcoholic fatty liver disease. Nat Clin Pract Gastroenterol Hepatol 2 (2005) 46-53
    • (2005) Nat Clin Pract Gastroenterol Hepatol , vol.2 , pp. 46-53
    • Sanyal, A.J.1
  • 26
    • 4644301666 scopus 로고    scopus 로고
    • The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm
    • Zhao L., Moos M.P., Grabner R., et al. The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm. Nat Med 10 (2004) 966-973
    • (2004) Nat Med , vol.10 , pp. 966-973
    • Zhao, L.1    Moos, M.P.2    Grabner, R.3
  • 27
    • 34247123754 scopus 로고    scopus 로고
    • 5-Lipoxygenase-activating protein: a potential link between innate and adaptive immunity in atherosclerosis and adipose tissue inflammation
    • Back M., Sultan A., Ovchinnikova O., and Hansson G.K. 5-Lipoxygenase-activating protein: a potential link between innate and adaptive immunity in atherosclerosis and adipose tissue inflammation. Circ Res 100 (2007) 946-949
    • (2007) Circ Res , vol.100 , pp. 946-949
    • Back, M.1    Sultan, A.2    Ovchinnikova, O.3    Hansson, G.K.4
  • 28
    • 0037178728 scopus 로고    scopus 로고
    • Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice
    • Mehrabian M., Allayee H., Wong J., et al. Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice. Circ Res 91 (2002) 120-126
    • (2002) Circ Res , vol.91 , pp. 120-126
    • Mehrabian, M.1    Allayee, H.2    Wong, J.3
  • 29
    • 27644549928 scopus 로고    scopus 로고
    • Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits
    • Mehrabian M., Allayee H., Stockton J., et al. Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits. Nat Genet 37 (2005) 1224-1233
    • (2005) Nat Genet , vol.37 , pp. 1224-1233
    • Mehrabian, M.1    Allayee, H.2    Stockton, J.3
  • 30
    • 0041707878 scopus 로고    scopus 로고
    • The metabolic effects of inhibitors of 5-lipoxygenase and of cyclooxygenase 1 and 2 are an advancement in the efficacy and safety of anti-inflammatory therapy
    • Celotti F., and Durand T. The metabolic effects of inhibitors of 5-lipoxygenase and of cyclooxygenase 1 and 2 are an advancement in the efficacy and safety of anti-inflammatory therapy. Prostaglandins Other Lipid Mediat 71 (2003) 147-162
    • (2003) Prostaglandins Other Lipid Mediat , vol.71 , pp. 147-162
    • Celotti, F.1    Durand, T.2
  • 31
    • 40149104966 scopus 로고    scopus 로고
    • Attenuation of inflammation and cytokine production in rat colitis by a novel selective inhibitor of leukotriene A4 hydrolase
    • Whittle B.J., Varga C., Berko A., et al. Attenuation of inflammation and cytokine production in rat colitis by a novel selective inhibitor of leukotriene A4 hydrolase. Br J Pharmacol 153 (2008) 983-991
    • (2008) Br J Pharmacol , vol.153 , pp. 983-991
    • Whittle, B.J.1    Varga, C.2    Berko, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.