Melatonin as a negative mitogenic hormonal regulator of human prostate epithelial cell growth: Potential mechanisms and clinical significance

Journal of Pineal Research

Volumn 45, Issue 4, 2008, Pages 403-412

  Tam, Chun W ^a   Chan, Kwok W ^a   Liu, Vincent W S ^a   Pang, Bo ^a   Yao, Kwok Ming ^a   Shiu, Stephen Y W ^a,b  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Melatonin; Mitogenic regulator; MT1 receptor; p27Kip1; Prostate

Indexed keywords

2 IODOMELATONIN; 4 PHENYL 2 PROPIONAMIDOTETRALINE; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIN DEPENDENT KINASE INHIBITOR 1B; HORMONE RECEPTOR BLOCKING AGENT; LUZINDOLE; MELATONIN; MELATONIN 1 RECEPTOR; MELATONIN 2 RECEPTOR; PROTEIN KINASE C; UNCLASSIFIED DRUG;

ARTICLE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; ENZYME ACTIVATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; PROSTATE EPITHELIUM; PROTEIN ANALYSIS; PROTEIN EXPRESSION; UPREGULATION;

ANALYSIS OF VARIANCE; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; CELL PROLIFERATION; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P27; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; GROWTH SUBSTANCES; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; MELATONIN; PROSTATE; PROSTATIC NEOPLASMS; PROTEIN KINASES; RECEPTORS, ANDROGEN; RECEPTORS, MELATONIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TETRAHYDRONAPHTHALENES; TRYPTAMINES;

EID: 53749100168     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/j.1600-079X.2008.00608.x     Document Type: Article

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