Balancing between affinity and speed in target DNA search by zinc-finger proteins via modulation of dynamic conformational ensemble

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 37, 2015, Pages E5142-E5149

  Zandarashvili, Levani ^a   Esadze, Alexandre ^a   Vuzman, Dana ^b   Kemme, Catherine A ^a   Levy, Yaakov ^b   Iwahara, Junji ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

DNA scanning; Dynamics; Kinetics; Protein DNA interactions; Target search

Indexed keywords

DNA; DNA BINDING PROTEIN; DOUBLE STRANDED DNA; TRANSCRIPTION FACTOR EGR 1; ZINC FINGER NUCLEASE; ZINC FINGER PROTEIN; EARLY GROWTH RESPONSE FACTOR 1; EGR1 PROTEIN, HUMAN; PROTEIN BINDING;

ARTICLE; BINDING AFFINITY; DIFFUSION COEFFICIENT; DISSOCIATION; DNA CLEAVAGE; FLUORESCENCE ANALYSIS; HYDROGEN BOND; IONIC STRENGTH; MOLECULAR DYNAMICS; MOLECULAR RECOGNITION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DNA BINDING; PROTEIN ENGINEERING; AMINO ACID SEQUENCE; CHEMISTRY; CONFORMATION; GENOME; HUMAN; MOLECULAR GENETICS; MUTAGENESIS; MUTATION; STATIC ELECTRICITY; THERMODYNAMICS;

AMINO ACID SEQUENCE; DNA; EARLY GROWTH RESPONSE PROTEIN 1; GENOME; HUMANS; HYDROGEN BONDING; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR CONFORMATION; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MUTATION; PROTEIN BINDING; PROTEIN ENGINEERING; STATIC ELECTRICITY; THERMODYNAMICS; ZINC FINGERS;

EID: 84941730368     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1507726112     Document Type: Article

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