Advances in zinc finger engineering

Current Opinion in Structural Biology

Volumn 10, Issue 4, 2000, Pages 411-416

  Choo, Yen ^a,b   Isalan, Mark ^a,b  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b Gendaq Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; INTEGRASE; METHYLTRANSFERASE; TRANSCRIPTION FACTOR; ZINC FINGER PROTEIN;

DNA SEQUENCE; GENE EXPRESSION; GENETIC ENGINEERING; PHAGE DISPLAY; PRIORITY JOURNAL; REVIEW;

EID: 0033930952     PISSN: 0959440X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-440X(00)00107-X     Document Type: Review

References (43)

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43. Isalan, M.D., Klug, A., Choo. Y. International Patent Application Number WO98/53057. A universal method to engineer customised DNA-binding domains. Premade libraries allow the rapid screening of target sites, while harnessing the synergy between adjacent zinc fingers (see Figure 1c). The process is illustrated by targeting multiple sites in the HIV-1 promoter.