Kinetic studies of protein-protein interactions

Current Opinion in Structural Biology

Volumn 12, Issue 1, 2002, Pages 41-47

  Schreiber, Gideon ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING AFFINITY; BIOPHYSICS; CALCULATION; COMPLEX FORMATION; DISSOCIATION; IONIC STRENGTH; KINETICS; MOLECULAR BIOLOGY; MUTATION; PH; PHASE TRANSITION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW; THERMODYNAMICS; VISCOSITY;

EID: 0036468995     PISSN: 0959440X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-440X(02)00287-7     Document Type: Review

References (52)

1. Diffusion-controlled macromolecular interactions
2. Measuring protein-protein interactions
3. Macromolecular crowding: An important but neglected aspect of the intracellular environment
4. Brownian motion in a field of force and the diffusion model of chemical reactions
5. Diffusion-limited rates for monoclonal antibody binding to cytochrome c
6. Inhibitory mechanism of serpins. Interaction of thrombin with antithrombin and protease nexin 1
7. Association and dissociation kinetics of anti-hen egg lysozyme monoclonal antibodies HyHEL-5 and HyHEL-10
8. Association and dissociation kinetics of bobwhite quail lysozyme with monoclonal antibody HyHEL-5
9. Electrostatic aspects of protein protein interactions
10. Predicting the rate enhancement of protein complex formation from the electrostatic energy of interaction
11. Electrostatic enhancement of diffusion-controlled protein-protein association: Comparison of theory and experiment on barnase and barstar
12. Biophysical analysis of the interaction of human Ifnar2 expressed in E. coli with IFNα2
13. Rapid, electrostatic assisted, association of proteins
14. Rational design of faster associating and tighter binding protein complexes
15. Very rapid, ionic strength-dependent association and folding of a heterodimeric leucine zipper
16. Kinetic characterization of the pH-dependent oligomerization of R67 dihydrofolate reductase
17. Energetics of protein-protein interactions: Analysis of the barnase-barstar interface by single mutations and double mutant cycles
18. Evaluation of direct and cooperative contributions towards the strength of buried hydrogen bonds and salt bridges
19. Structural and functional analysis of the 1:1 growth hormone: Receptor complex reveals the molecular basis for receptor affinity
20. Mutational and structural analysis of the binding interface between type I interferons and their receptor Ifnar2
21. New structural and functional aspects of the IFN-receptor interaction revealed by comprehensive mutational analysis of the binding interface
22. A mixed-charge pair in human interleukin 4 dominates high-affinity interaction with the receptor alpha chain
23. New insight into the mechanism of protein-protein association
24. Kinetic epitope mapping of the chicken lysozyme-HyHEL-10 Fab complex: Delineation of docking trajectories
25. Alanine point-mutations in the reactive region of bovine pancreatic trypsin inhibitor: Effects on the kinetics and thermodynamics of binding to beta-trypsin and alpha-chymotrypsin
26. Dynamic properties of the Ras switch I region and its importance for binding to effectors
27. Protein-protein recognition: Exploring the energy funnels near the binding sites
28. Experimental assignment of the structure of the transition state for the association of barnase and barstar
29. Mutations in the complementarity-determining regions do not cause differences in free energy during the process of formation of the activated complex between an antibody and the corresponding protein antigen
30. Detailed mechanism of interaction of bovine-trypsin with soybean trypsin inhibitor (Kunitz). I. Stopped flow measurements
31. Transient kinetic studies on the interaction of Ras and the Ras-binding domain of c-Raf-1 reveal rapid equilibration of the complex
32. The contribution of N-terminal region residues of cystatin A (stefin A) to the affinity and kinetics of inhibition of papain, cathepsin B, and cathepsin L
33. The N-terminal region of cystatin A (stefin A) binds to papain subsequent to the two hairpin loops of the inhibitor. Demonstration of two-step binding by rapid-kinetic studies of cystatin A labeled at the N terminus with a fluorescent reporter group
34. Mutations of an epitope hotspot residue alter rate limiting steps of antigen-antibody protein-protein associations
35. Electrostatic steering and ionic tethering in the formation of thrombin-hirudin complexes: The role of the thrombin anion-binding exosite-I
36. Electrostatic dependence of the thrombin-thrombomodulin interaction
37. Evolution of serpin specificity: Cooperative interactions in the reactive-site loop sequence of antithrombin specifically restrict the inhibition of activated protein C
38. Electrostatic influence of the kinetic of ligand binding to acetylcholinesterase
39. Quantitative evaluation of the chicken lysozyme epitope in the HyHEL-10 Fab complex: Free energies and kinetics
40. Computer simulation of protein-protein interactions
41. Kinetics of association of anti-lysozyme monoclonal antibody D44.1 and hen-egg lysozyme
42. Computer simulation of protein-protein association kinetics: Acetylcholinesterase-fasciculin
43. Protein-protein association: Investigation of factors influencing association rates by brownian dynamics simulations
44. Kinetics of desolvation mediated protein-protein binding
45. Growth hormone binding affinity for its receptor surpasses the requirements for cellular activity
46. Affinity dependence of the B cell response to antigen: A threshold, a ceiling, and the importance of off-rate
47. Kinetic and affinity limits on antibodies produced during immune responses
48. Electrotactins: A class of adhesion proteins with conserved electrostatic and structural motifs
49. Stability versus function: Two competing forces in the evolution of barstar
50. Tryptophan fluorescence as a probe of placental ribonuclease inhibitor binding to angiogenin
51. Quantitative evaluation of the contribution of ionic interactions to the formation of the thrombin-hirudin complex
52. Protein-protein interactions in colicin E9 DNase-immunity protein complexes. 1. Diffusion-controlled association and femtomolar binding for the cognate complex