Structure and flexibility adaptation in nonspecific and specific protein-DNA complexes

Science

Volumn 305, Issue 5682, 2004, Pages 386-389

  Kalodimos, Charalampos G ^a,c   Biris, Nikolaos ^a,c   Bonvin, Alexandre M J J ^a   Levandoski, Marc M ^b   Guennuegues, Marc ^a   Boelens, Rolf ^a   Kaptein, Robert ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MATERIALS; DNA; ELECTROSTATICS;

DIMERICS; ELECTROSTATIC INTERACTIONS;

PROTEINS;

DNA BINDING PROTEIN; LACTOSE;

BIOLOGY; DNA;

ARTICLE; COMPLEX FORMATION; DNA PROTEIN COMPLEX; DNA SEQUENCE; ELECTRICITY; GENE SWITCHING; LACTOSE OPERON; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DOMAIN; REPRESSOR GENE; SEQUENCE ANALYSIS; STRUCTURE ANALYSIS; TARGET CELL;

BACTERIAL PROTEINS; BASE PAIRING; BINDING SITES; DIFFUSION; DIMERIZATION; DNA, BACTERIAL; ELECTROSTATICS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HYDROGEN BONDING; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; NUCLEIC ACID CONFORMATION; OPERATOR REGIONS (GENETICS); PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; REPRESSOR PROTEINS; THERMODYNAMICS;

EID: 3142657230     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1097064     Document Type: Article

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32. Financial support from the Netherlands Organization for Scientific Research (NWO-CW) is gratefully acknowledged. C.G.K. was supported by a European Union Research Training Network, contract number HPRN CT. 2000 00092. M.L.'s contributions were supported by NIH GM 23467 (T. Record). The atomic coordinates have been deposited in the Protein Data Bank (PDB accession code 1O5L).