Biosynthesis of the orthosomycin antibiotic avilamycin A: Deductions from the molecular analysis of the avi biosynthetic gene cluster of Streptomyces viridochromogenes Tü57 and production of new antibiotics

Chemistry and Biology

Volumn 8, Issue 6, 2001, Pages 569-581

  Weitnauer, G ^a   Muhlenweg A ^b   Trefzer, A ^a   Hoffmeister, D ^a   Sussmuth R D ^c,d   Jung, G ^c   Welzel, K ^b   Vente, A ^b   Girreser, U ^e   Bechthold, A ^a,b  

^a UNIVERSITY OF FREIBURG   (Germany)

^b MerLion Pharmaceuticals GmbH   (Germany)

^c UNIVERSITY OF TÜBINGEN   (Germany)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

^e UNIVERSITY OF KIEL   (Germany)

Author keywords

Avilamycin; Gavibamycin; Halogenase; Methyltransferase; Orthosomycin

Indexed keywords

ANTIINFECTIVE AGENT; AVILAMYCIN; BACTERIAL GENE; BIOCHEMICAL PATHWAY; BIOSYNTHESIS; CHEMICAL STRUCTURE; DICHLOROISOEVERNINIC ACID; DNA SEQUENCE; DRUG MANUFACTURE; GAVIBAMYCIN; GENE CLUSTER; GENE SEQUENCING; GENETIC STRAIN; MOLECULAR CLONING; OPEN READING FRAME; POLYKETIDE SYNTHASE;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CLONING, MOLECULAR; GENE ORDER; GENES, REGULATOR; GENETIC COMPLEMENTATION TEST; METHYLTRANSFERASES; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; MUTATION; OLIGOSACCHARIDES; OXIDOREDUCTASES; PARABENS; POLYSACCHARIDES; SEQUENCE ANALYSIS; STREPTOMYCES;

STREPTOMYCES VIRIDOCHROMOGENES;

EID: 0034971593     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(01)00040-0     Document Type: Article

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