Discovery of new enzymes and metabolic pathways by using structure and genome context

Nature

Volumn 502, Issue 7473, 2013, Pages 698-702

  Zhao, Suwen ^a   Kumar, Ritesh ^b   Sakai, Ayano ^b   Vetting, Matthew W ^c   Wood, B McKay ^b   Brown, Shoshana ^a   Bonanno, Jeffery B ^c   Hillerich, Brandan S ^c   Seidel, Ronald D ^c   Babbitt, Patricia C ^a   Almo, Steven C ^c   Sweedler, Jonathan V ^b   Gerlt, John A ^b   Cronan, John E ^b   Jacobson, Matthew P ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; AMINO ACID DERIVATIVE; BETAINE; EPIMERASE; HYDROXYPROLINE; RACEMASE;

DATABASE; ENZYME; ENZYME ACTIVITY; GENE; GENOME; METABOLITE; SUBSTRATE;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BINDING SITE; CARBON SOURCE; DEMETHYLATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME METABOLISM; ENZYME SPECIFICITY; ENZYME STRUCTURE; EPIMERIZATION; GENE REPRESSION; GENOME; IN VITRO STUDY; METABOLOMICS; MOLECULAR DOCKING; NONHUMAN; OSMOTIC STRESS; PARACOCCUS DENITRIFICANS; PRIORITY JOURNAL; PROTON TRANSPORT; SINORHIZOBIUM MELILOTI; TRANSCRIPTOMICS;

BACTERIA; BACTERIAL PROTEINS; ENZYMES; GENE EXPRESSION PROFILING; GENES, BACTERIAL; GENOME, BACTERIAL; GLYCOLYSIS; KINETICS; METABOLIC NETWORKS AND PATHWAYS; METABOLISM; METABOLOMICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE ANNOTATION; MULTIGENE FAMILY; OPERON; STRUCTURAL HOMOLOGY, PROTEIN; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 84886949770     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature12576     Document Type: Article

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