Evernimicin (SCH27899) inhibits a novel ribosome target site: Analysis of 23S ribosomal DNA mutants

Antimicrobial Agents and Chemotherapy

Volumn 44, Issue 11, 2000, Pages 3101-3106

  Adrian, P V ^a   Mendrick, C ^a   Loebenberg, D ^a   McNicholas, P ^a   Shaw, K J ^a   Klugman, K P ^a   Hare, R S ^a   Black, T A ^a  

^a ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

EVERNIMICIN; PROTEIN SYNTHESIS INHIBITOR; RIBOSOME DNA; RIBOSOME RNA;

ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIUM MUTANT; CROSS RESISTANCE; DRUG MECHANISM; DRUG TARGETING; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SEQUENCE ANALYSIS; STREPTOCOCCUS PNEUMONIAE;

ALLELES; AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BASE SEQUENCE; DNA, BACTERIAL; DRUG RESISTANCE, MICROBIAL; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEIC ACID CONFORMATION; RNA, BACTERIAL; RNA, RIBOSOMAL, 23S; STREPTOCOCCUS PNEUMONIAE; TRANSFORMATION, BACTERIAL;

EID: 0033735291     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.44.11.3101-3106.2000     Document Type: Article

References (26)

1. Mutations in ribosomal protein L16 conferring reduced susceptibility to evernimicin (SCH27899): Implications for mechanism of action
2. Construction and initial characterization of Escherichia coli strains with few or no intact chromosomal rRNA operons
3. Novel tRNA gene organization in the 16S-23S intergenic spacer of the Streptococcus pneumoniae rRNA gene cluster
4. Ribosomal protein gene sequence changes in erythromycin-resistant mutants of Escherichia coli
5. Chemical modification of everninomicin
6. Exchange of spacer regions between rRNA operons in Escherichia coli
7. An unmodified heptadecapeptide induces competence for genetic transformation in Streptococcus pneumoniae
8. Antimicrobial activity of everninomicin (evernimicin), an oligosaccharide antimicrobial with a potent Gram-positive spectrum
9. Mapping the inside of the ribosome with an RNA helical ruler
10. Ribosomal protein L16 binds to the 3'-end of transfer RNA
11. Introducing mutations into the single-copy chromosomal 23S rRNA gene of the archaeon Halobacterium halobium by using an rRNA operon-based transformation system
12. Evemimicin binds exclusively to the 50S ribosomal subunit and inhibits translation in cell-free systems derived from both gram-positive and gram-negative bacteria
13. Identification of mutations in 23S rRNA gene of clarithromycin-resistant Mycobacterium intracellulare
14. Interaction of tRNA with 23S rRNA in the ribosomal A, P, and E sites
15. Ribosomal components neighboring the 2475 loop in Escherichia coli 50S subunits
16. RecA-mediated gene conversion and aminoglycoside resistance in strains heterozygous for rRNA
17. The role of RNAs in macrolide resistance
18. Erythromycin resistance due to a mutation in a ribosomal RNA operon of Escherichia coli
19. 'Megaprimer' method of PCR-based mutagenesis: The concentration of megaprimer is a critical factor
20. Structural analysis of RNA using chemical and enzymatic probing monitored by primer extension
21. The importance of the Escherichia coli ribosomal protein L16 for the reconstitution of the peptidyl-tRNA hydrolysis activity of peptide chain termination
22. Mutations in 23S rRNA are associated with clarithromycin resistance in Helicobacter pylori
23. Genetic basis for clarithromycin resistance among isolates of Mycobacterium chelonae and Mycobacterium abscessus
24. Purification and biological studies of everninomicin B
25. Erythromycin resistance by ribosome modification