The β-cell GHSR and downstream cAMP/TRPM2 signaling account for insulinostatic and glycemic effects of ghrelin

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Kurashina, Tomoyuki ^a   Dezaki, Katsuya ^a   Yoshida, Masashi ^a   Sukma Rita, Rauza ^a   Ito, Kiyonori ^a   Taguchi, Masanobu ^a   Miura, Rina ^a   Tominaga, Makoto ^b   Ishibashi, Shun ^a   Kakei, Masafumi ^a   Yada, Toshihiko ^a,c  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b OKAZAKI INSTITUTE FOR INTEGRATIVE BIOSCIENCE   (Japan)

^c NATIONAL INSTITUTE FOR PHYSIOLOGICAL SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CYCLIC AMP; GHRELIN; GHRELIN RECEPTOR; GLUCOSE; GLUCOSE BLOOD LEVEL; INSULIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL M; TRPM2 PROTEIN, HUMAN;

ANIMAL; BLOOD; DRUG EFFECTS; GENE EXPRESSION; GENETICS; GLUCOSE BLOOD LEVEL; KNOCKOUT MOUSE; MALE; METABOLISM; MOUSE; PANCREAS ISLET; PANCREAS ISLET BETA CELL; SIGNAL TRANSDUCTION;

ANIMALS; BLOOD GLUCOSE; CALCIUM; CYCLIC AMP; GENE EXPRESSION; GHRELIN; GLUCOSE; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MALE; MICE; MICE, KNOCKOUT; RECEPTORS, GHRELIN; SIGNAL TRANSDUCTION; TRPM CATION CHANNELS;

EID: 84941662219     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep14041     Document Type: Article

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