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Volumn 7, Issue 8, 2012, Pages

Hindbrain Ghrelin Receptor Signaling Is Sufficient to Maintain Fasting Glucose

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; GHRELIN RECEPTOR; GLUCOSE; PROTEIN C FOS;

EID: 84865661804     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0044089     Document Type: Article
Times cited : (50)

References (37)
  • 1
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, et al. (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402: 656-660.
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5
  • 2
    • 0035133586 scopus 로고    scopus 로고
    • Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin
    • Asakawa A, Inui A, Kaga T, Yuzuriha H, Nagata T, et al. (2001) Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology 120: 337-345.
    • (2001) Gastroenterology , vol.120 , pp. 337-345
    • Asakawa, A.1    Inui, A.2    Kaga, T.3    Yuzuriha, H.4    Nagata, T.5
  • 3
    • 0035433977 scopus 로고    scopus 로고
    • A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans
    • Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE, et al. (2001) A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50: 1714-1719.
    • (2001) Diabetes , vol.50 , pp. 1714-1719
    • Cummings, D.E.1    Purnell, J.Q.2    Frayo, R.S.3    Schmidova, K.4    Wisse, B.E.5
  • 4
    • 38849090670 scopus 로고    scopus 로고
    • Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone
    • Yang J, Brown MS, Liang G, Grishin NV, Goldstein JL, (2008) Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell 132: 387-396.
    • (2008) Cell , vol.132 , pp. 387-396
    • Yang, J.1    Brown, M.S.2    Liang, G.3    Grishin, N.V.4    Goldstein, J.L.5
  • 5
    • 31044451759 scopus 로고    scopus 로고
    • Mice lacking ghrelin receptors resist the development of diet-induced obesity
    • Zigman JM, Nakano Y, Coppari R, Balthasar N, Marcus JN, et al. (2005) Mice lacking ghrelin receptors resist the development of diet-induced obesity. J Clin Invest 115: 3564-3572.
    • (2005) J Clin Invest , vol.115 , pp. 3564-3572
    • Zigman, J.M.1    Nakano, Y.2    Coppari, R.3    Balthasar, N.4    Marcus, J.N.5
  • 6
    • 0035843183 scopus 로고    scopus 로고
    • A role for ghrelin in the central regulation of feeding
    • Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, et al. (2001) A role for ghrelin in the central regulation of feeding. Nature 409: 194-198.
    • (2001) Nature , vol.409 , pp. 194-198
    • Nakazato, M.1    Murakami, N.2    Date, Y.3    Kojima, M.4    Matsuo, H.5
  • 8
    • 77950371376 scopus 로고    scopus 로고
    • Ghrelin increases the rewarding value of high-fat diet in an orexin-dependent manner
    • Perello M, Sakata I, Birnbaum S, Chuang JC, Osborne-Lawrence S, et al. (2010) Ghrelin increases the rewarding value of high-fat diet in an orexin-dependent manner. Biol Psychiatry 67: 880-886.
    • (2010) Biol Psychiatry , vol.67 , pp. 880-886
    • Perello, M.1    Sakata, I.2    Birnbaum, S.3    Chuang, J.C.4    Osborne-Lawrence, S.5
  • 9
    • 77952165770 scopus 로고    scopus 로고
    • Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice
    • Zhao TJ, Liang G, Li RL, Xie X, Sleeman MW, et al. (2010) Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice. Proc Natl Acad Sci U S A 107: 7467-7472.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 7467-7472
    • Zhao, T.J.1    Liang, G.2    Li, R.L.3    Xie, X.4    Sleeman, M.W.5
  • 10
    • 43049170316 scopus 로고    scopus 로고
    • Ghrelin is a physiological regulator of insulin release in pancreatic islets and glucose homeostasis
    • Dezaki K, Sone H, Yada T, (2008) Ghrelin is a physiological regulator of insulin release in pancreatic islets and glucose homeostasis. Pharmacol Ther 118: 239-249.
    • (2008) Pharmacol Ther , vol.118 , pp. 239-249
    • Dezaki, K.1    Sone, H.2    Yada, T.3
  • 11
    • 84861558069 scopus 로고    scopus 로고
    • Profound hypoglycemia in starved, ghrelin-deficient mice is caused by decreased gluconeogenesis and reversed by lactate or fatty acids
    • Li RL, Sherbet DP, Elsbernd BL, Goldstein JL, Brown MS, et al. (2012) Profound hypoglycemia in starved, ghrelin-deficient mice is caused by decreased gluconeogenesis and reversed by lactate or fatty acids. J Biol Chem.
    • (2012) J Biol Chem
    • Li, R.L.1    Sherbet, D.P.2    Elsbernd, B.L.3    Goldstein, J.L.4    Brown, M.S.5
  • 12
  • 13
    • 84857375127 scopus 로고    scopus 로고
    • The GOAT-ghrelin system is not essential for hypoglycemia prevention during prolonged calorie restriction
    • Yi CX, Heppner KM, Kirchner H, Tong J, Bielohuby M, et al. (2012) The GOAT-ghrelin system is not essential for hypoglycemia prevention during prolonged calorie restriction. PLoS One 7: e32100.
    • (2012) PLoS One , vol.7
    • Yi, C.X.1    Heppner, K.M.2    Kirchner, H.3    Tong, J.4    Bielohuby, M.5
  • 15
    • 0034060310 scopus 로고    scopus 로고
    • Growth hormone secretagogue activation of the arcuate nucleus and brainstem occurs via a non-noradrenergic pathway
    • Bailey AR, Von Englehardt N, Leng G, Smith RG, Dickson SL, (2000) Growth hormone secretagogue activation of the arcuate nucleus and brainstem occurs via a non-noradrenergic pathway. J Neuroendocrinol 12: 191-197.
    • (2000) J Neuroendocrinol , vol.12 , pp. 191-197
    • Bailey, A.R.1    Von Englehardt, N.2    Leng, G.3    Smith, R.G.4    Dickson, S.L.5
  • 18
    • 27744593324 scopus 로고    scopus 로고
    • Ghrelin induces feeding in the mesolimbic reward pathway between the ventral tegmental area and the nucleus accumbens
    • Naleid AM, Grace MK, Cummings DE, Levine AS, (2005) Ghrelin induces feeding in the mesolimbic reward pathway between the ventral tegmental area and the nucleus accumbens. Peptides 26: 2274-2279.
    • (2005) Peptides , vol.26 , pp. 2274-2279
    • Naleid, A.M.1    Grace, M.K.2    Cummings, D.E.3    Levine, A.S.4
  • 19
    • 33748560432 scopus 로고    scopus 로고
    • Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite
    • Abizaid A, Liu ZW, Andrews ZB, Shanabrough M, Borok E, et al. (2006) Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. J Clin Invest 116: 3229-3239.
    • (2006) J Clin Invest , vol.116 , pp. 3229-3239
    • Abizaid, A.1    Liu, Z.W.2    Andrews, Z.B.3    Shanabrough, M.4    Borok, E.5
  • 20
    • 79957896911 scopus 로고    scopus 로고
    • Leptin receptor expression in hindbrain Glp-1 neurons regulates food intake and energy balance in mice
    • Scott MM, Williams KW, Rossi J, Lee CE, Elmquist JK, (2011) Leptin receptor expression in hindbrain Glp-1 neurons regulates food intake and energy balance in mice. J Clin Invest 121: 2413-2421.
    • (2011) J Clin Invest , vol.121 , pp. 2413-2421
    • Scott, M.M.1    Williams, K.W.2    Rossi, J.3    Lee, C.E.4    Elmquist, J.K.5
  • 22
    • 79551555006 scopus 로고    scopus 로고
    • Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis
    • Rossi J, Balthasar N, Olson D, Scott M, Berglund E, et al. (2011) Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis. Cell Metab 13: 195-204.
    • (2011) Cell Metab , vol.13 , pp. 195-204
    • Rossi, J.1    Balthasar, N.2    Olson, D.3    Scott, M.4    Berglund, E.5
  • 23
    • 0036144322 scopus 로고    scopus 로고
    • Acute central ghrelin and GH secretagogues induce feeding and activate brain appetite centers
    • Lawrence CB, Snape AC, Baudoin FM, Luckman SM, (2002) Acute central ghrelin and GH secretagogues induce feeding and activate brain appetite centers. Endocrinology 143: 155-162.
    • (2002) Endocrinology , vol.143 , pp. 155-162
    • Lawrence, C.B.1    Snape, A.C.2    Baudoin, F.M.3    Luckman, S.M.4
  • 25
    • 46349086081 scopus 로고    scopus 로고
    • Caudal brainstem delivery of ghrelin induces fos expression in the nucleus of the solitary tract, but not in the arcuate or paraventricular nuclei of the hypothalamus
    • Faulconbridge LF, Grill HJ, Kaplan JM, Daniels D, (2008) Caudal brainstem delivery of ghrelin induces fos expression in the nucleus of the solitary tract, but not in the arcuate or paraventricular nuclei of the hypothalamus. Brain Res 1218: 151-157.
    • (2008) Brain Res , vol.1218 , pp. 151-157
    • Faulconbridge, L.F.1    Grill, H.J.2    Kaplan, J.M.3    Daniels, D.4
  • 26
    • 34247162233 scopus 로고    scopus 로고
    • Expression of c-Fos protein in the brain after intravenous injection of ghrelin in rats
    • Takayama K, Johno Y, Hayashi K, Yakabi K, Tanaka T, et al. (2007) Expression of c-Fos protein in the brain after intravenous injection of ghrelin in rats. Neurosci Lett 417: 292-296.
    • (2007) Neurosci Lett , vol.417 , pp. 292-296
    • Takayama, K.1    Johno, Y.2    Hayashi, K.3    Yakabi, K.4    Tanaka, T.5
  • 27
    • 33947388790 scopus 로고    scopus 로고
    • Centrally and peripherally administered ghrelin potently inhibits water intake in rats
    • Hashimoto H, Fujihara H, Kawasaki M, Saito T, Shibata M, et al. (2007) Centrally and peripherally administered ghrelin potently inhibits water intake in rats. Endocrinology 148: 1638-1647.
    • (2007) Endocrinology , vol.148 , pp. 1638-1647
    • Hashimoto, H.1    Fujihara, H.2    Kawasaki, M.3    Saito, T.4    Shibata, M.5
  • 28
    • 33845473302 scopus 로고    scopus 로고
    • Rapid changes in the sensitivity of arcuate nucleus neurons to central ghrelin in relation to feeding status
    • Scott V, McDade DM, Luckman SM, (2007) Rapid changes in the sensitivity of arcuate nucleus neurons to central ghrelin in relation to feeding status. Physiol Behav 90: 180-185.
    • (2007) Physiol Behav , vol.90 , pp. 180-185
    • Scott, V.1    McDade, D.M.2    Luckman, S.M.3
  • 29
    • 0041428156 scopus 로고    scopus 로고
    • Hypothalamic paraventricular injections of ghrelin: effect on feeding and c-Fos immunoreactivity
    • Olszewski PK, Grace MK, Billington CJ, Levine AS, (2003) Hypothalamic paraventricular injections of ghrelin: effect on feeding and c-Fos immunoreactivity. Peptides 24: 919-923.
    • (2003) Peptides , vol.24 , pp. 919-923
    • Olszewski, P.K.1    Grace, M.K.2    Billington, C.J.3    Levine, A.S.4
  • 30
    • 51249105332 scopus 로고    scopus 로고
    • Improved insulin sensitivity and metabolic flexibility in ghrelin receptor knockout mice
    • Longo KA, Charoenthongtrakul S, Giuliana DJ, Govek EK, McDonagh T, et al. (2008) Improved insulin sensitivity and metabolic flexibility in ghrelin receptor knockout mice. Regul Pept 150: 55-61.
    • (2008) Regul Pept , vol.150 , pp. 55-61
    • Longo, K.A.1    Charoenthongtrakul, S.2    Giuliana, D.J.3    Govek, E.K.4    McDonagh, T.5
  • 31
    • 78650869242 scopus 로고    scopus 로고
    • Characterization of the insulin sensitivity of ghrelin receptor KO mice using glycemic clamps
    • Qi Y, Longo KA, Giuliana DJ, Gagne S, McDonagh T, et al. (2011) Characterization of the insulin sensitivity of ghrelin receptor KO mice using glycemic clamps. BMC Physiol 11: 1.
    • (2011) BMC Physiol , vol.11 , pp. 1
    • Qi, Y.1    Longo, K.A.2    Giuliana, D.J.3    Gagne, S.4    McDonagh, T.5
  • 32
    • 2542475178 scopus 로고    scopus 로고
    • Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein
    • Chen HY, Trumbauer ME, Chen AS, Weingarth DT, Adams JR, et al. (2004) Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein. Endocrinology 145: 2607-2612.
    • (2004) Endocrinology , vol.145 , pp. 2607-2612
    • Chen, H.Y.1    Trumbauer, M.E.2    Chen, A.S.3    Weingarth, D.T.4    Adams, J.R.5
  • 33
    • 50249120768 scopus 로고    scopus 로고
    • Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance
    • Tong Q, Ye CP, Jones JE, Elmquist JK, Lowell BB, (2008) Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance. Nat Neurosci 11: 998-1000.
    • (2008) Nat Neurosci , vol.11 , pp. 998-1000
    • Tong, Q.1    Ye, C.P.2    Jones, J.E.3    Elmquist, J.K.4    Lowell, B.B.5
  • 34
    • 0036787457 scopus 로고    scopus 로고
    • The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats
    • Date Y, Murakami N, Toshinai K, Matsukura S, Niijima A, et al. (2002) The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats. Gastroenterology 123: 1120-1128.
    • (2002) Gastroenterology , vol.123 , pp. 1120-1128
    • Date, Y.1    Murakami, N.2    Toshinai, K.3    Matsukura, S.4    Niijima, A.5
  • 36
    • 33751120393 scopus 로고    scopus 로고
    • Gut vagal afferents are not necessary for the eating-stimulatory effect of intraperitoneally injected ghrelin in the rat
    • Arnold M, Mura A, Langhans W, Geary N, (2006) Gut vagal afferents are not necessary for the eating-stimulatory effect of intraperitoneally injected ghrelin in the rat. J Neurosci 26: 11052-11060.
    • (2006) J Neurosci , vol.26 , pp. 11052-11060
    • Arnold, M.1    Mura, A.2    Langhans, W.3    Geary, N.4
  • 37
    • 9444264700 scopus 로고    scopus 로고
    • Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating Ca2+ signaling in beta-cells: implication in the glycemic control in rodents
    • Dezaki K, Hosoda H, Kakei M, Hashiguchi S, Watanabe M, et al. (2004) Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating Ca2+ signaling in beta-cells: implication in the glycemic control in rodents. Diabetes 53: 3142-3151.
    • (2004) Diabetes , vol.53 , pp. 3142-3151
    • Dezaki, K.1    Hosoda, H.2    Kakei, M.3    Hashiguchi, S.4    Watanabe, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.