메뉴 건너뛰기




Volumn 25, Issue 9, 2011, Pages 1600-1611

Ghrelin directly stimulates glucagon secretion from pancreatic α-cells

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; GHRELIN; GHRELIN RECEPTOR; GLUCAGON; GLUCOSE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE;

EID: 80052302779     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2011-1001     Document Type: Article
Times cited : (103)

References (53)
  • 1
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K 1999 Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402:656-660
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 2
    • 42549165949 scopus 로고    scopus 로고
    • Central nervous system regulation of energy metabolism: Ghrelin versus leptin
    • Nogueiras R, Tschöp MH, Zigman JM 2008 Central nervous system regulation of energy metabolism: ghrelin versus leptin. Ann NY Acad Sci 1126:14-19
    • (2008) Ann NY Acad Sci , vol.1126 , pp. 14-19
    • Nogueiras, R.1    Tschöp, M.H.2    Zigman, J.M.3
  • 4
    • 34548436635 scopus 로고    scopus 로고
    • 2+ signaling and insulin release in islet β-cells: Novel signal transduction of ghrelin
    • 2+ signaling and insulin release in islet β-cells: novel signal transduction of ghrelin. Diabetes 56:2319-2327
    • (2007) Diabetes , vol.56 , pp. 2319-2327
    • Dezaki, K.1    Kakei, M.2    Yada, T.3
  • 7
    • 0042626304 scopus 로고    scopus 로고
    • Effects of ghrelin and other neuropeptides (CART, MCH, orexin A and B, and GLP-1) on the release of insulin from isolated rat islets
    • Colombo M, Gregersen S, Xiao J, Hermansen K 2003 Effects of ghrelin and other neuropeptides (CART, MCH, orexin A and B, and GLP-1) on the release of insulin from isolated rat islets. Pancreas 27:161-166
    • (2003) Pancreas , vol.27 , pp. 161-166
    • Colombo, M.1    Gregersen, S.2    Xiao, J.3    Hermansen, K.4
  • 11
    • 0036896934 scopus 로고    scopus 로고
    • Fasting plasma ghrelin levels are negatively correlated with insulin resistance and PAI-1, but not with leptin, in obese children and adolescents
    • Ikezaki A, Hosoda H, Ito K, Iwama S, Miura N, Matsuoka H, Kondo C, Kojima M, Kangawa K, Sugihara S 2002 Fasting plasma ghrelin levels are negatively correlated with insulin resistance and PAI-1, but not with leptin, in obese children and adolescents. Diabetes 51:3408-3411
    • (2002) Diabetes , vol.51 , pp. 3408-3411
    • Ikezaki, A.1    Hosoda, H.2    Ito, K.3    Iwama, S.4    Miura, N.5    Matsuoka, H.6    Kondo, C.7    Kojima, M.8    Kangawa, K.9    Sugihara, S.10
  • 12
    • 0141643291 scopus 로고    scopus 로고
    • Low plasma ghrelin is associated with insulin resistance, hypertension, and the prevalence of type 2 diabetes
    • Pöykkö SM, Kellokoski E, Hörkkö S, Kauma H, Kesäniemi YA, Ukkola O 2003 Low plasma ghrelin is associated with insulin resistance, hypertension, and the prevalence of type 2 diabetes. Diabetes 52:2546-2553
    • (2003) Diabetes , vol.52 , pp. 2546-2553
    • Pöykkö, S.M.1    Kellokoski, E.2    Hörkkö, S.3    Kauma, H.4    Kesäniemi, Y.A.5    Ukkola, O.6
  • 13
    • 33646141847 scopus 로고    scopus 로고
    • Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice
    • Sun Y, Asnicar M, Saha PK, Chan L, Smith RG 2006 Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice. Cell Metab 3:379-386
    • (2006) Cell Metab , vol.3 , pp. 379-386
    • Sun, Y.1    Asnicar, M.2    Saha, P.K.3    Chan, L.4    Smith, R.G.5
  • 14
    • 33845534952 scopus 로고    scopus 로고
    • Blockade of pancreatic isletderived ghrelin enhances insulin secretion to prevent high-fat dietinduced glucose intolerance
    • Dezaki K, Sone H, Koizumi M, Nakata M, Kakei M, Nagai H, Hosoda H, Kangawa K, Yada T 2006 Blockade of pancreatic isletderived ghrelin enhances insulin secretion to prevent high-fat dietinduced glucose intolerance. Diabetes 55:3486-3493
    • (2006) Diabetes , vol.55 , pp. 3486-3493
    • Dezaki, K.1    Sone, H.2    Koizumi, M.3    Nakata, M.4    Kakei, M.5    Nagai, H.6    Hosoda, H.7    Kangawa, K.8    Yada, T.9
  • 20
    • 0036819924 scopus 로고    scopus 로고
    • ParvezH2002 Mechanism of ghrelin-evoked glucagon secretion from the pancreas of diabetic rats
    • Adeghate E, ParvezH2002 Mechanism of ghrelin-evoked glucagon secretion from the pancreas of diabetic rats. Neuroendocrinol Lett 23:432-436
    • Neuroendocrinol Lett , vol.23 , pp. 432-436
    • Adeghate, E.1
  • 25
    • 13844275996 scopus 로고    scopus 로고
    • Ghrelin activates neuronal constitutive nitric oxide synthase in pancreatic islet cells while inhibiting insulin release and stimulating glucagon release
    • Qader SS, Lundquist I, Ekelund M, Håkanson R, Salehi A 2005 Ghrelin activates neuronal constitutive nitric oxide synthase in pancreatic islet cells while inhibiting insulin release and stimulating glucagon release. Regul Pept 128:51-56
    • (2005) Regul Pept , vol.128 , pp. 51-56
    • Qader, S.S.1    Lundquist, I.2    Ekelund, M.3    Håkanson, R.4    Salehi, A.5
  • 26
    • 1542270842 scopus 로고    scopus 로고
    • Effects of ghrelin on insulin and glucagon secretion: A study of isolated pancreatic islets and intact mice
    • Salehi A, Doronville de la Cour C, Håkanson R, Lundquist I 2004 Effects of ghrelin on insulin and glucagon secretion: a study of isolated pancreatic islets and intact mice. Regul Pept 118:143-150
    • (2004) Regul Pept , vol.118 , pp. 143-150
    • Salehi, A.1    Doronville de la Cour, C.2    Håkanson, R.3    Lundquist, I.4
  • 27
    • 38149098503 scopus 로고    scopus 로고
    • Proghrelin-derived peptides influence the secretion of insulin, glucagon, pancreatic polypeptide and somatostatin: A study on isolated islets from mouse and rat pancreas
    • Qader SS, Håkanson R, Rehfeld JF, Lundquist I, Salehi A 2008 Proghrelin-derived peptides influence the secretion of insulin, glucagon, pancreatic polypeptide and somatostatin: a study on isolated islets from mouse and rat pancreas. Regul Pept 146:230-237
    • (2008) Regul Pept , vol.146 , pp. 230-237
    • Qader, S.S.1    Håkanson, R.2    Rehfeld, J.F.3    Lundquist, I.4    Salehi, A.5
  • 28
    • 31344456245 scopus 로고    scopus 로고
    • Effects of ghrelin injection on plasma concentrations of glucose, pancreatic hormones and cortisol in Holstein dairy cattle
    • Itoh F, Komatsu T, Kushibiki S, Hodate K 2006 Effects of ghrelin injection on plasma concentrations of glucose, pancreatic hormones and cortisol in Holstein dairy cattle. Comp Biochem Physiol A Mol Integr Physiol 143:97-102
    • (2006) Comp Biochem Physiol a Mol Integr Physiol , vol.143 , pp. 97-102
    • Itoh, F.1    Komatsu, T.2    Kushibiki, S.3    Hodate, K.4
  • 33
    • 27844448098 scopus 로고    scopus 로고
    • Regulation of glucagon secretion at low glucose concentrations: Evidence for adenosine triphosphate-sensitive potassium channel involvement
    • Muñoz A, Hu M, Hussain K, Bryan J, Aguilar-Bryan L, Rajan AS 2005 Regulation of glucagon secretion at low glucose concentrations: evidence for adenosine triphosphate-sensitive potassium channel involvement. Endocrinology 146:5514-5521
    • (2005) Endocrinology , vol.146 , pp. 5514-5521
    • Muñoz, A.1    Hu, M.2    Hussain, K.3    Bryan, J.4    Aguilar-Bryan, L.5    Rajan, A.S.6
  • 36
    • 2942597289 scopus 로고    scopus 로고
    • KorbonitsM2004 Ghrelin exerts a proliferative effect on a rat pituitary somatotroph cell line via the mitogenactivated protein kinase pathway
    • Nanzer AM, Khalaf S, Mozid AM, Fowkes RC, Patel MV, Burrin JM, Grossman AB, KorbonitsM2004 Ghrelin exerts a proliferative effect on a rat pituitary somatotroph cell line via the mitogenactivated protein kinase pathway. Eur J Endocrinol 151:233-240
    • Eur J Endocrinol , vol.151 , pp. 233-240
    • Nanzer, A.M.1    Khalaf, S.2    Mozid, A.M.3    Fowkes, R.C.4    Patel, M.V.5    Burrin, J.M.6    Grossman, A.B.7
  • 41
    • 69249218916 scopus 로고    scopus 로고
    • Calcium signals activated by ghrelin and D-Lys(3)- GHRP-6 ghrelin antagonist in developing dorsal root ganglion glial cells
    • Erriquez J, Bernascone S, Ciarletta M, Filigheddu N, Graziani A, Distasi C 2009 Calcium signals activated by ghrelin and D-Lys(3)- GHRP-6 ghrelin antagonist in developing dorsal root ganglion glial cells. Cell Calcium 46:197-208
    • (2009) Cell Calcium , vol.46 , pp. 197-208
    • Erriquez, J.1    Bernascone, S.2    Ciarletta, M.3    Filigheddu, N.4    Graziani, A.5    Distasi, C.6
  • 42
    • 33751069321 scopus 로고    scopus 로고
    • Meat hydrolysate and essential amino acid-induced glucagon-like peptide-1 secretion, in the human NCI-H716 enteroendocrine cell line, is regulated by extracellular signal-regulated kinase1/2 and p38 mitogen-activated protein kinases
    • Reimer RA 2006 Meat hydrolysate and essential amino acid-induced glucagon-like peptide-1 secretion, in the human NCI-H716 enteroendocrine cell line, is regulated by extracellular signal-regulated kinase1/2 and p38 mitogen-activated protein kinases. J Endocrinol 191:159-170
    • (2006) J Endocrinol , vol.191 , pp. 159-170
    • Reimer, R.A.1
  • 43
    • 44149101935 scopus 로고    scopus 로고
    • ERK activation is only one role of PKC in TCR-independent cytotoxic T cell granule exocytosis
    • Pores-Fernando AT, Gaur S, Grybko MJ, Zweifach A 2008 ERK activation is only one role of PKC in TCR-independent cytotoxic T cell granule exocytosis. Biochem Biophys Res Commun 371:630-634
    • (2008) Biochem Biophys Res Commun , vol.371 , pp. 630-634
    • Pores-Fernando, A.T.1    Gaur, S.2    Grybko, M.J.3    Zweifach, A.4
  • 44
    • 7044249536 scopus 로고    scopus 로고
    • Palmitate stimulation of glucagon secretion in mouse pancreatic α-cells results from activation of L-type calcium channels and elevation of cytoplasmic calcium
    • Olofsson CS, Salehi A, Göpel SO, Holm C, Rorsman P 2004 Palmitate stimulation of glucagon secretion in mouse pancreatic α-cells results from activation of L-type calcium channels and elevation of cytoplasmic calcium. Diabetes 53:2836-2843
    • (2004) Diabetes , vol.53 , pp. 2836-2843
    • Olofsson, C.S.1    Salehi, A.2    Göpel, S.O.3    Holm, C.4    Rorsman, P.5
  • 45
    • 34250010912 scopus 로고    scopus 로고
    • 2+]i oscillation parameters and secretion: Differential effects associated with in vivo and in vitro meiotic maturation
    • 2+]i oscillation parameters and secretion: differential effects associated with in vivo and in vitro meiotic maturation. Dev Biol 306:538-548
    • (2007) Dev Biol , vol.306 , pp. 538-548
    • Matson, S.1    Ducibella, T.2
  • 49
    • 52949142260 scopus 로고    scopus 로고
    • Research resource: Nuclear hormone receptor expression in the endocrine pancreas
    • Chuang JC, Cha JY, Garmey JC, Mirmira RG, Repa JJ 2008 Research resource: nuclear hormone receptor expression in the endocrine pancreas. Mol Endocrinol 22:2353-2363
    • (2008) Mol Endocrinol , vol.22 , pp. 2353-2363
    • Chuang, J.C.1    Cha, J.Y.2    Garmey, J.C.3    Mirmira, R.G.4    Repa, J.J.5
  • 50
    • 0028926254 scopus 로고
    • Morphological and functional characterization of β TC-6 cells-an insulin-secreting cell line derived from transgenic mice
    • Poitout V, Stout LE, Armstrong MB, Walseth TF, Sorenson RL, Robertson RP 1995 Morphological and functional characterization of β TC-6 cells-an insulin-secreting cell line derived from transgenic mice. Diabetes 44:306-313
    • (1995) Diabetes , vol.44 , pp. 306-313
    • Poitout, V.1    Stout, L.E.2    Armstrong, M.B.3    Walseth, T.F.4    Sorenson, R.L.5    Robertson, R.P.6
  • 51
    • 0025349639 scopus 로고
    • Proglucagon processing similar to normal islets in pancreatic α-like cell line derived from transgenic mouse tumor
    • Powers AC, Efrat S, Mojsov S, Spector D, Habener JF, Hanahan D 1990 Proglucagon processing similar to normal islets in pancreatic α-like cell line derived from transgenic mouse tumor. Diabetes 39: 406-414
    • (1990) Diabetes , vol.39 , pp. 406-414
    • Powers, A.C.1    Efrat, S.2    Mojsov, S.3    Spector, D.4    Habener, J.F.5    Hanahan, D.6
  • 52
    • 0025281303 scopus 로고
    • Establishment of a pancreatic β cell line that retains glucose-inducible insulin secretion: Special reference to expression of glucose transporter isoforms
    • Miyazaki J, Araki K, Yamato E, Ikegami H, Asano T, Shibasaki Y, Oka Y, Yamamura K 1990 Establishment of a pancreatic β cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms. Endocrinology 127: 126-132
    • (1990) Endocrinology , vol.127 , pp. 126-132
    • Miyazaki, J.1    Araki, K.2    Yamato, E.3    Ikegami, H.4    Asano, T.5    Shibasaki, Y.6    Oka, Y.7    Yamamura, K.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.