-
2
-
-
79961175481
-
The future of incretin-based therapy: Novel avenues-novel targets
-
Ahrén B. The future of incretin-based therapy: novel avenues-novel targets. Diabetes Obes Metab 13, Suppl 1: 158-166, 2011.
-
(2011)
Diabetes Obes Metab
, vol.13
, Issue.SUPPL. 1
, pp. 158-166
-
-
Ahrén, B.1
-
4
-
-
0025005549
-
Involvement of a-2 adrenergic receptor subtypes in hyperglycemia
-
Angel I, Niddam R, Langer SZ. Involvement of a-2 adrenergic receptor subtypes in hyperglycemia. J Pharmacol Exp Ther 54: 877-882, 1990.
-
(1990)
J Pharmacol Exp Ther
, vol.54
, pp. 877-882
-
-
Angel, I.1
Niddam, R.2
Langer, S.Z.3
-
5
-
-
17944379112
-
Stomach is the major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans
-
Ariyasu H, Takaya K, Tagami T, Ogawa Y, Hosoda K, Akamizu T, Suda M, Koh T, Natsui K, Toyooka S, Shirakami G, Usui T, Shimatsu A, Doi K, Hosoda H, Kojima M, Kangawa K, Nakao K. Stomach is the major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans. J Clin Endocrinol Metab 86: 4753-4758, 2001.
-
(2001)
J Clin Endocrinol Metab
, vol.86
, pp. 4753-4758
-
-
Ariyasu, H.1
Takaya, K.2
Tagami, T.3
Ogawa, Y.4
Hosoda, K.5
Akamizu, T.6
Suda, M.7
Koh, T.8
Natsui, K.9
Toyooka, S.10
Shirakami, G.11
Usui, T.12
Shimatsu, A.13
Doi, K.14
Hosoda, H.15
Kojima, M.16
Kangawa, K.17
Nakao, K.18
-
6
-
-
0036310678
-
2+ channels accounts for first-phase insulin secretion in mouse β-cells
-
2+ channels accounts for first-phase insulin secretion in mouse β-cells. Diabetes 51, Suppl 1: S74-S82, 2002.
-
(2002)
Diabetes
, vol.51
, Issue.SUPPL. 1
-
-
Barg, S.1
Eliasson, L.2
Renström, E.3
Rorsman, P.4
-
8
-
-
17844372569
-
G protein βγ directly regulates SNARE protein fusion machinery for secretory granule exocytosis
-
Blackmer T, Larsen EC, Takahashi M, Martin TF, Alford S, Hamm HE. G protein βγ directly regulates SNARE protein fusion machinery for secretory granule exocytosis. Nat Neurosci 8: 421-425, 2005.
-
(2005)
Nat Neurosci
, vol.8
, pp. 421-425
-
-
Blackmer, T.1
Larsen, E.C.2
Takahashi, M.3
Martin, T.F.4
Alford, S.5
Hamm, H.E.6
-
9
-
-
77955509318
-
-
Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are associated with reduced glucose-stimulated (β-cell function in middle-aged Danish people
-
Boesgaard TW, Grarup N, Jorgenson T, Borch-Johnsen K, Meta-Analysis of Glucose and Insulin-Related Trait Consortium (MAGIC), Hansen T, Pedersen O. Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are associated with reduced glucose-stimulated (β-cell function in middle-aged Danish people. Diabetologia 53: 1647-1655, 2010.
-
(2010)
Diabetologia
, vol.53
, pp. 1647-1655
-
-
Boesgaard, T.W.1
Grarup, N.2
Jorgenson, T.3
Borch-Johnsen, K.4
-
10
-
-
0036905264
-
-
Move over protein kinase C, you've got company: alternative cellular effectors of diacylglycerol and phorbol esters
-
Brose N, Rosenmund C. Move over protein kinase C, you've got company: alternative cellular effectors of diacylglycerol and phorbol esters. J Cell Sci 115: 4399-4411, 2002.
-
(2002)
J Cell Sci
, vol.115
, pp. 4399-4411
-
-
Brose, N.1
Rosenmund, C.2
-
11
-
-
79952090059
-
Physiological sensing of carbon dioxide/bicarbon-ate/pH via cyclic nucleotide signaling
-
Buck J, Levin LR. Physiological sensing of carbon dioxide/bicarbon-ate/pH via cyclic nucleotide signaling. Sensors (Basel) 11: 2112-2128, 2011.
-
(2011)
Sensors (Basel)
, vol.11
, pp. 2112-2128
-
-
Buck, J.1
Levin, L.R.2
-
12
-
-
0035510916
-
The dephosphins: Dephosphorylation by calcineurin triggers synaptic vesicle endocytosis
-
Cousin MA, Robinson PJ. The dephosphins: dephosphorylation by calcineurin triggers synaptic vesicle endocytosis. Trends Neurosci 24: 659-665, 2001.
-
(2001)
Trends Neurosci
, vol.24
, pp. 659-665
-
-
Cousin, M.A.1
Robinson, P.J.2
-
13
-
-
80053007224
-
Palmitoylation targets AKAP79 protein to lipid rafts and promotes its regulation of calcium-sensitive adenylyl cyclase type 8
-
Delint-Ramirez I, Willoughby D, Hammond GV, Ayling LJ, Cooper DM. Palmitoylation targets AKAP79 protein to lipid rafts and promotes its regulation of calcium-sensitive adenylyl cyclase type 8. J Biol Chem 286: 32962-32975, 2011.
-
(2011)
J Biol Chem
, vol.286
, pp. 32962-32975
-
-
Delint-Ramirez, I.1
Willoughby, D.2
Hammond, G.V.3
Ayling, L.J.4
Cooper, D.M.5
-
14
-
-
0142125207
-
Type VIII adenylyl cyclase in rat (β-cells: Coincidence signal detector/generator for glucose and GLP-1
-
Delmeire D, Flamez D, Hinke SA, Cali JJ, Pipeleers D, Schuit F. Type VIII adenylyl cyclase in rat (β-cells: coincidence signal detector/generator for glucose and GLP-1. Diabetologia 46: 1383-1393, 2003.
-
(2003)
Diabetologia
, vol.46
, pp. 1383-1393
-
-
Delmeire, D.1
Flamez, D.2
Hinke, S.A.3
Cali, J.J.4
Pipeleers, D.5
Schuit, F.6
-
15
-
-
70350469968
-
Adenylyl cyclase-A-kinase anchoring protein complexes: The next dimension in cAMP signaling
-
Dessauer CW. Adenylyl cyclase-A-kinase anchoring protein complexes: the next dimension in cAMP signaling. Mol Pharmacol 76: 935-941, 2009.
-
(2009)
Mol Pharmacol
, vol.76
, pp. 935-941
-
-
Dessauer, C.W.1
-
16
-
-
9444264700
-
2+ signaling in β-cells: Implication in the glycemic control in rodents
-
2+ signaling in β-cells: implication in the glycemic control in rodents. Diabetes 53: 3142-3151, 2004.
-
(2004)
Diabetes
, vol.53
, pp. 3142-3151
-
-
Dezaki, K.1
Hosoda, H.2
Kakei, M.3
Hashiguchi, S.4
Watanabe, M.5
Kan-Gawa, K.6
Yada, T.7
-
17
-
-
34548436635
-
2+ signaling and insulin release in islet β-cells: Novel signal transduction of ghrelin
-
2+ signaling and insulin release in islet β-cells: novel signal transduction of ghrelin. Diabetes 56: 2319-2327, 2007.
-
(2007)
Diabetes
, vol.56
, pp. 2319-2327
-
-
Dezaki, K.1
Kakei, M.2
Yada, T.3
-
18
-
-
43049170316
-
Ghrelin is a physiological regulator of insulin release in pancreatic islets and glucose homeostasis
-
Dezaki K, Sone H, Yada T. Ghrelin is a physiological regulator of insulin release in pancreatic islets and glucose homeostasis. Pharmacol Ther 118: 239-249, 2008.
-
(2008)
Pharmacol Ther
, vol.118
, pp. 239-249
-
-
Dezaki, K.1
Sone, H.2
Yada, T.3
-
19
-
-
0035904785
-
Insulinotropic meglitinide analogues
-
Dornhorst A. Insulinotropic meglitinide analogues. Lancet 358: 1709-1716, 2001.
-
(2001)
Lancet
, vol.358
, pp. 1709-1716
-
-
Dornhorst, A.1
-
20
-
-
0347359228
-
Hyperinsulinism in infancy: From basic science to clinical disease
-
Dunne MJ, Cosgrove KE, Shepherd RM, Aynsley-Green A, Lindley KJ. Hyperinsulinism in infancy: from basic science to clinical disease. Physiol Rev 84: 239-275, 2004.
-
(2004)
Physiol Rev
, vol.84
, pp. 239-275
-
-
Dunne, M.J.1
Cosgrove, K.E.2
Shepherd, R.M.3
Aynsley-Green, A.4
Lindley, K.J.5
-
21
-
-
0030015561
-
Endocytosis of secretory granules in mouse pancreatic β-cells evoked by transient elevation of cytosolic calcium
-
Eliasson L, Proks P, Ammälä C, Ashcroft FM, Bokvist K, Renström E, Rorsman P, Smith PA. Endocytosis of secretory granules in mouse pancreatic β-cells evoked by transient elevation of cytosolic calcium. J Physiol 493: 755-767, 1996.
-
(1996)
J Physiol
, vol.493
, pp. 755-767
-
-
Eliasson, L.1
Proks, P.2
Ammälä, C.3
Ashcroft, F.M.4
Bokvist, K.5
Renström, E.6
Rorsman, P.7
Smith, P.A.8
-
23
-
-
77953957372
-
Cyclic AMP Signaling in Pancreatic Islets
-
Furman B, Ong WK, Pyne NJ. Cyclic AMP Signaling in Pancreatic Islets. Adv Exp Med Biol 654: 281-304, 2010.
-
(2010)
Adv Exp Med Biol
, vol.654
, pp. 281-304
-
-
Furman, B.1
Ong, W.K.2
Pyne, N.J.3
-
24
-
-
80052645534
-
Glucagon-like peptide-1 analogues for Type 2 diabetes mellitus: Current and emerging agents
-
Gallwitz B. Glucagon-like peptide-1 analogues for Type 2 diabetes mellitus: current and emerging agents. Drugs 71: 1675-1688, 2011.
-
(2011)
Drugs
, vol.71
, pp. 1675-1688
-
-
Gallwitz, B.1
-
27
-
-
17844373228
-
Gβγ acts at the C terminus of SNAP-25 to mediate presynaptic inhibition
-
Gerachshenko T, Blackmer T, Yoon EJ, Bartleson C, Hamm HE, Alford S. Gβγ acts at the C terminus of SNAP-25 to mediate presynaptic inhibition. Nat Neurosci 8: 597-605, 2005.
-
(2005)
Nat Neurosci
, vol.8
, pp. 597-605
-
-
Gerachshenko, T.1
Blackmer, T.2
Yoon, E.J.3
Bartleson, C.4
Hamm, H.E.5
Alford, S.6
-
28
-
-
0036314864
-
Is reduced first-phase insulin release the earliest detectable abnormality in individuals destined to develop type 2 diabetes?
-
Gerich JE. Is reduced first-phase insulin release the earliest detectable abnormality in individuals destined to develop type 2 diabetes? Diabetes 51: S117-S121, 2002.
-
(2002)
Diabetes
, vol.51
-
-
Gerich, J.E.1
-
29
-
-
0030176052
-
Protein kinase C enhances exocytosis from chromaffin cells by increasing the size of the readily releasable pool of secretory granules
-
Gillis KD, Mossner R, Neher E. Protein kinase C enhances exocytosis from chromaffin cells by increasing the size of the readily releasable pool of secretory granules. Neuron 16: 1209-1220, 1996.
-
(1996)
Neuron
, vol.16
, pp. 1209-1220
-
-
Gillis, K.D.1
Mossner, R.2
Neher, E.3
-
30
-
-
26444479437
-
Granuphilin molecularly docks insulin granules to the fusion machinery
-
Gomi H, Mizutani S, Kasai K, Itohara S, Izumi T. Granuphilin molecularly docks insulin granules to the fusion machinery. J Cell Biol 171: 99-109, 2005.
-
(2005)
J Cell Biol
, vol.171
, pp. 99-109
-
-
Gomi, H.1
Mizutani, S.2
Kasai, K.3
Itohara, S.4
Izumi, T.5
-
31
-
-
0037827724
-
Stimulation of cellular signaling and G protein subunit dissociation by G protein βγ subunit-binding peptides
-
Goubaeva F, Ghosh M, Malik S, Yang J, Hinkle PM, Griendling KK, Neubig RR, Smrcka AV. Stimulation of cellular signaling and G protein subunit dissociation by G protein βγ subunit-binding peptides. J Biol Chem 278: 19634-19641, 2003.
-
(2003)
J Biol Chem
, vol.278
, pp. 19634-19641
-
-
Goubaeva, F.1
Ghosh, M.2
Malik, S.3
Yang, J.4
Hinkle, P.M.5
Griendling, K.K.6
Neubig, R.R.7
Smrcka, A.V.8
-
32
-
-
0034105467
-
Adenylyl cyclase isoform expression in non-diabetic and diabetic Goto-Kakizaki (GK) rat pancreas. Evidence for distinct overexpression of type-8 adenylyl cyclase in diabetic GK rat islets
-
Guenifi A, Portela-Gomez GM, Grimelius L, Efendic S, Abdel-Halim SM. Adenylyl cyclase isoform expression in non-diabetic and diabetic Goto-Kakizaki (GK) rat pancreas. Evidence for distinct overexpression of type-8 adenylyl cyclase in diabetic GK rat islets. Histochem Cell Biol 113: 81-89, 2000.
-
(2000)
Histochem Cell Biol
, vol.113
, pp. 81-89
-
-
Guenifi, A.1
Portela-Gomez, G.M.2
Grimelius, L.3
Efendic, S.4
Abdel-Halim, S.M.5
-
33
-
-
0014348106
-
Metabolic effects of pertussis sensitization in mice and rats
-
Gulbenkian A, Schobert L, Nixon C, Tabachnick A. Metabolic effects of pertussis sensitization in mice and rats. Endocrinology 83: 885-892, 1968.
-
(1968)
Endocrinology
, vol.83
, pp. 885-892
-
-
Gulbenkian, A.1
Schobert, L.2
Nixon, C.3
Tabachnick, A.4
-
34
-
-
0141841735
-
A 6-year prospective study on new onset diabetes mellitus, insulin release and insulin sensitivity in renal transplant recipients
-
Hagen M, Hjelmesaeth J, Jenssen T, Morkrid L, Hartmann A. A 6-year prospective study on new onset diabetes mellitus, insulin release and insulin sensitivity in renal transplant recipients. Nephrol Dial Transplant 18: 2154-2159, 2003.
-
(2003)
Nephrol Dial Transplant
, vol.18
, pp. 2154-2159
-
-
Hagen, M.1
Hjelmesaeth, J.2
Jenssen, T.3
Morkrid, L.4
Hartmann, A.5
-
35
-
-
62549104908
-
Kiss-and-run exocytosis and fusion pores of secretory vesicles in human β-cells
-
Hanna ST, Pigeau GM, Galvanovskis J, Clark A, Rorsman P, MacDonald PE. Kiss-and-run exocytosis and fusion pores of secretory vesicles in human β-cells. Pflügers Arch 457: 1343-1350, 2009.
-
(2009)
Pflügers Arch
, vol.457
, pp. 1343-1350
-
-
Hanna, S.T.1
Pigeau, G.M.2
Galvanovskis, J.3
Clark, A.4
Rorsman, P.5
Macdonald, P.E.6
-
36
-
-
12244305595
-
New insights concerning the glucose-dependent insulin secre-tagogue action of glucagon-like peptide in pancreatic β-cells
-
Holz GG. New insights concerning the glucose-dependent insulin secre-tagogue action of glucagon-like peptide in pancreatic β-cells. Horm Metab Res 36: 787-794, 2004.
-
(2004)
Horm Metab Res
, vol.36
, pp. 787-794
-
-
Holz, G.G.1
-
37
-
-
0347990624
-
Epac: A new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic β-cell
-
Holz GG. Epac: a new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic β-cell. Diabetes 53: 5-13, 2004.
-
(2004)
Diabetes
, vol.53
, pp. 5-13
-
-
Holz, G.G.1
-
39
-
-
0027937697
-
Releasable pools and the kinetics of exocytosis in adrenal chromaffin cells
-
Horrigan FT, Bookman RJ. Releasable pools and the kinetics of exocytosis in adrenal chromaffin cells. Neuron 13: 1119-1129, 1994.
-
(1994)
Neuron
, vol.13
, pp. 1119-1129
-
-
Horrigan, F.T.1
Bookman, R.J.2
-
40
-
-
61349111509
-
Insulin granule biogenesis, trafficking and exocytosis
-
Hou JC, Min L, Pessin JE. Insulin granule biogenesis, trafficking and exocytosis. Vitam Horm 80: 473-506, 2009.
-
(2009)
Vitam Horm
, vol.80
, pp. 473-506
-
-
Hou, J.C.1
Min, L.2
Pessin, J.E.3
-
41
-
-
9444246501
-
A receptor in pituitary and hypothalamus that functions in growth hormone release
-
Howard AD, Feighner SD, Cully DF, Arena JP, Liberator PA, Rosenblum CL, Hamelin M, Hreniuk DL, Palyha OC, Anderson J, Paress PS, Diaz C, Chou M, Liu KK, McKee KK, Pong SS, Chaung LY, Elbrecht A, Dashkevicz M, Heavens R, Rigby M, Sirinathsinghji DJ, Dean DC, Melillo DG, Patchett AA, Nargund R, Griffin PR, DeMartino JA, Gupta SK, Schaeffer JM, Smith RG, Van der Ploeg LH. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 273: 974-977, 1996.
-
(1996)
Science
, vol.273
, pp. 974-977
-
-
Howard, A.D.1
Feighner, S.D.2
Cully, D.F.3
Arena, J.P.4
Liberator, P.A.5
Rosenblum, C.L.6
Hamelin, M.7
Hreniuk, D.L.8
Palyha, O.C.9
Anderson, J.10
Paress, P.S.11
Diaz, C.12
Chou, M.13
Liu, K.K.14
McKee, K.K.15
Pong, S.S.16
Chaung, L.Y.17
Elbrecht, A.18
Dashkevicz, M.19
Heavens, R.20
Rigby, M.21
Sirinathsinghji, D.J.22
Dean, D.C.23
Melillo, D.G.24
Patchett, A.A.25
Nargund, R.26
Griffin, P.R.27
Demartino, J.A.28
Gupta, S.K.29
Schaeffer, J.M.30
Smith, R.G.31
van der Ploeg, L.H.32
more..
-
42
-
-
0037076352
-
Inositol hexakisphosphate promotes dynamin 1-mediated endocytosis
-
Høy M, Efanov AM, Bertorello AM, Zaitsev SV, Olsen HL, Bokvist K, Leibiger B, Leibiger B, Leibiger IB, Zwiller J, Berggren PO, Gromada J. Inositol hexakisphosphate promotes dynamin 1-mediated endocytosis. Proc Natl Acad Sci USA 99: 6773-6777, 2002.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 6773-6777
-
-
Høy, M.1
Efanov, A.M.2
Bertorello, A.M.3
Zaitsev, S.V.4
Olsen, H.L.5
Bokvist, K.6
Leibiger, B.7
Leibiger, B.8
Leibiger, I.B.9
Zwiller, J.10
Berggren, P.O.11
Gromada, J.12
-
43
-
-
0026073386
-
2+ influx to inhibit insulin secretion in a hamster β-cell line: An action mediated by a guanosine triphosphate-binding protein
-
2+ influx to inhibit insulin secretion in a hamster β-cell line: an action mediated by a guanosine triphosphate-binding protein. Endocrinology 128: 958-964, 1991.
-
(1991)
Endocrinology
, vol.128
, pp. 958-964
-
-
Hsu, W.H.1
Xiang, H.D.2
Rajan, A.S.3
Boyd, A.E.4
-
44
-
-
23844503409
-
Proteomic exploration of pancreatic islets in mice null for the α2A adrenergic receptor
-
Hu X, Friedman D, Hill S, Caprioli R, Nicholson W, Powers AC, Hunter L, Limbird LE. Proteomic exploration of pancreatic islets in mice null for the α2A adrenergic receptor. J Mol Endocrinol 35: 73-88, 2005.
-
(2005)
J Mol Endocrinol
, vol.35
, pp. 73-88
-
-
Hu, X.1
Friedman, D.2
Hill, S.3
Caprioli, R.4
Nicholson, W.5
Powers, A.C.6
Hunter, L.7
Limbird, L.E.8
-
45
-
-
77749306186
-
Exocytosis mechanisms underlying insulin release and glucose uptake: Conserved roles for Munc18c and syntaxin 4
-
Jewell JL, Oh E, Thurmond DC. Exocytosis mechanisms underlying insulin release and glucose uptake: conserved roles for Munc18c and syntaxin 4. Am J Physiol Regul Integr Comp Physiol 298: R517-R531, 2010.
-
(2010)
Am J Physiol Regul Integr Comp Physiol
, vol.298
-
-
Jewell, J.L.1
Oh, E.2
Thurmond, D.C.3
-
46
-
-
0023161312
-
2+-induced insulin secretion from electrically permeabilised islets of Langerhans
-
2+-induced insulin secretion from electrically permeabilised islets of Langerhans. FEBS Lett 219: 139-144, 1987.
-
(1987)
FEBS Lett
, vol.219
, pp. 139-144
-
-
Jones, P.M.1
Fyles, J.M.2
Persaud, S.J.3
Howell, S.L.4
-
47
-
-
71549146561
-
AKAP 18 alpha and gamma have opposing effects on insulin release in INS-1E cells
-
Josefsen K, Lee YC, Thams P, Efendic S, Nielsen JH. AKAP 18 alpha and gamma have opposing effects on insulin release in INS-1E cells. FEBS Lett 584: 81-85, 2010.
-
(2010)
FEBS Lett
, vol.584
, pp. 81-85
-
-
Josefsen, K.1
Lee, Y.C.2
Thams, P.3
Efendic, S.4
Nielsen, J.H.5
-
48
-
-
0037424363
-
2+ release and exocytosis in pancreatic β-cells
-
2+ release and exocytosis in pancreatic β-cells. J Biol Chem 278: 8279-8285, 2003.
-
(2003)
J Biol Chem
, vol.278
, pp. 8279-8285
-
-
Kang, G.1
Joseph, J.W.2
Chepurny, O.G.3
Monaco, M.4
Wheeler, M.B.5
Bos, J.L.6
Schwede, F.7
Genieser, H.G.8
Holz, G.G.9
-
49
-
-
46349109470
-
Docking is not a prerequisite but a temporal restraint for fusion of secretory granules
-
Kasai K, Fujita T, Gomi H, Izumi T. Docking is not a prerequisite but a temporal restraint for fusion of secretory granules. Traffic 9: 1191-1203, 2008.
-
(2008)
Traffic
, vol.9
, pp. 1191-1203
-
-
Kasai, K.1
Fujita, T.2
Gomi, H.3
Izumi, T.4
-
50
-
-
20144373742
-
Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation
-
Kasai K, Ohara-Imaizumi M, Takahashi N, Mizutani S, Zhao S, Kikuta H, Kasai H, Nagamatsu S, Gomi H, Izumi T. Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation. J Clin Invest 115: 388-399, 2005.
-
(2005)
J Clin Invest
, vol.115
, pp. 388-399
-
-
Kasai, K.1
Ohara-Imaizumi, M.2
Takahashi, N.3
Mizutani, S.4
Zhao, S.5
Kikuta, H.6
Kasai, H.7
Nagamatsu, S.8
Gomi, H.9
Izumi, T.10
-
51
-
-
0035824548
-
Critical role of cAMP-GEFII-Rim2 complex in incretin-poten-tiated insulin secretion
-
Kashima Y, Miki T, Shibasaki T, Ozaki N, Miyazaki M, Yano H, Seino S. Critical role of cAMP-GEFII-Rim2 complex in incretin-poten-tiated insulin secretion. J Biol Chem 276: 46046-46053, 2001.
-
(2001)
J Biol Chem
, vol.276
, pp. 46046-46053
-
-
Kashima, Y.1
Miki, T.2
Shibasaki, T.3
Ozaki, N.4
Miyazaki, M.5
Yano, H.6
Seino, S.7
-
52
-
-
0020791359
-
The A protomer of islet-activating protein, pertussis toxin, as an active peptide catalyzing ADP-ribosylation of a membrane protein
-
Katada T, Tamura M, Ui M. The A protomer of islet-activating protein, pertussis toxin, as an active peptide catalyzing ADP-ribosylation of a membrane protein. Arch Biochem Biophys 224: 290-298, 1983.
-
(1983)
Arch Biochem Biophys
, vol.224
, pp. 290-298
-
-
Katada, T.1
Tamura, M.2
Ui, M.3
-
53
-
-
0018773109
-
Effect of in vivo pretreatment of rats with a new protein purified from Bordetella pertussis on in vitro secretion of insulin: Role of calcium
-
Katada T, Ui M. Effect of in vivo pretreatment of rats with a new protein purified from Bordetella pertussis on in vitro secretion of insulin: role of calcium. Endocrinology 104: 1822-1827, 1979.
-
(1979)
Endocrinology
, vol.104
, pp. 1822-1827
-
-
Katada, T.1
Ui, M.2
-
54
-
-
0019198301
-
Slow interaction of islet-activating protein with pancreatic islets during primary culture to cause reversal of α-adrenergic inhibition of insulin secretion
-
Katada T, Ui M. Slow interaction of islet-activating protein with pancreatic islets during primary culture to cause reversal of α-adrenergic inhibition of insulin secretion. J Biol Chem 255: 9580-9588, 1980.
-
(1980)
J Biol Chem
, vol.255
, pp. 9580-9588
-
-
Katada, T.1
Ui, M.2
-
55
-
-
0020137319
-
Direct modification of the membrane adenylate cyclase system by islet-activating protein due to ADP-ribosylation
-
Katada T, Ui M. Direct modification of the membrane adenylate cyclase system by islet-activating protein due to ADP-ribosylation. Proc Nat1 Acad Sci USA 79: 3129-3133, 1982.
-
(1982)
Proc Nat1 Acad Sci USA
, vol.79
, pp. 3129-3133
-
-
Katada, T.1
Ui, M.2
-
56
-
-
0020490738
-
ADP ribosylation of the specific membrane protein of C6 cells by islet-activating protein associated with modification of adenylate cyclase activity
-
Katada T, Ui M. ADP ribosylation of the specific membrane protein of C6 cells by islet-activating protein associated with modification of adenylate cyclase activity. J Biol Chem 257: 7210-7216, 1982.
-
(1982)
J Biol Chem
, vol.257
, pp. 7210-7216
-
-
Katada, T.1
Ui, M.2
-
57
-
-
41949090763
-
Gαz negatively regulates insulin secretion and glucose clearance
-
Kimple ME, Joseph JW, Bailey CL, Fueger PT, Hendry IA, New-gard CB, Casey PJ. Gαz negatively regulates insulin secretion and glucose clearance. J Biol Chem 283: 4560-4567, 2008.
-
(2008)
J Biol Chem
, vol.283
, pp. 4560-4567
-
-
Kimple, M.E.1
Joseph, J.W.2
Bailey, C.L.3
Fueger, P.T.4
Hendry, I.A.5
New-Gard, C.B.6
Casey, P.J.7
-
58
-
-
24744463879
-
A role for Gz in pancreatic islet β-cell biology
-
Kimple ME, Nixon AB, Kelly P, Bailey CL, Young KH, Fields TA, Casey PJ. A role for Gz in pancreatic islet β-cell biology. J Biol Chem 280: 31708-31713, 2005.
-
(2005)
J Biol Chem
, vol.280
, pp. 31708-31713
-
-
Kimple, M.E.1
Nixon, A.B.2
Kelly, P.3
Bailey, C.L.4
Young, K.H.5
Fields, T.A.6
Casey, P.J.7
-
59
-
-
55049133869
-
The GDP-dependent Rab27a effector coronin 3 controls endocy-tosis of secretory membrane in insulin-secreting cell lines
-
Kimura T, Kaneko Y, Yamada S, Ishihara H, Senda T, Iwamatsu A, Niki I. The GDP-dependent Rab27a effector coronin 3 controls endocy-tosis of secretory membrane in insulin-secreting cell lines. J Cell Sci 121: 3092-3098, 2008.
-
(2008)
J Cell Sci
, vol.121
, pp. 3092-3098
-
-
Kimura, T.1
Kaneko, Y.2
Yamada, S.3
Ishihara, H.4
Senda, T.5
Iwamatsu, A.6
Niki, I.7
-
60
-
-
0029000615
-
Preventing non-insulin-dependent diabetes
-
Knowler WC, Narayan KM, Hanson RL, Nelson RG, Bennett PH, Tuomilehto J, Scherstén B, Pettitt DJ. Preventing non-insulin-dependent diabetes. Diabetes 44: 483-488, 1995.
-
(1995)
Diabetes
, vol.44
, pp. 483-488
-
-
Knowler, W.C.1
Narayan, K.M.2
Hanson, R.L.3
Nelson, R.G.4
Bennett, P.H.5
Tuomilehto, J.6
Scherstén, B.7
Pettitt, D.J.8
-
61
-
-
0028963518
-
Time course of action of pertussis toxin to block the inhibition of stimulated insulin release by norepinephrine
-
Komatsu M, McDermott AM, Gillison SL, Sharp GWG. Time course of action of pertussis toxin to block the inhibition of stimulated insulin release by norepinephrine. Endocrinology 136: 1857-1863, 1995.
-
(1995)
Endocrinology
, vol.136
, pp. 1857-1863
-
-
Komatsu, M.1
McDermott, A.M.2
Gillison, S.L.3
Sharp, G.W.G.4
-
62
-
-
76149107841
-
Small G proteins in islet β-cell function
-
Kowluru A. Small G proteins in islet β-cell function. Endocr Rev 31: 52-78, 2010.
-
(2010)
Endocr Rev
, vol.31
, pp. 52-78
-
-
Kowluru, A.1
-
63
-
-
1642423546
-
Syntaxin-6 SNARE involvement in secretory and endocytic pathways of cultured pancreatic β-cells
-
Kuliawat R, Kalinina E, Bock J, Fricker L, McGraw TE, Kim SR, Zhong J, Scheller R, Arvan P. Syntaxin-6 SNARE involvement in secretory and endocytic pathways of cultured pancreatic β-cells. Mol Biol Cell 15: 1690-1701, 2004.
-
(2004)
Mol Biol Cell
, vol.15
, pp. 1690-1701
-
-
Kuliawat, R.1
Kalinina, E.2
Bock, J.3
Fricker, L.4
McGraw, T.E.5
Kim, S.R.6
Zhong, J.7
Scheller, R.8
Arvan, P.9
-
64
-
-
33745291822
-
Munc13-1 deficiency reduces insulin secretion and causes abnormal glucose tolerance
-
Kwan EP, Xie L, Sheu L, Nolan CJ, Prentki M, Betz A, Brose N, Gaisano HY. Munc13-1 deficiency reduces insulin secretion and causes abnormal glucose tolerance. Diabetes 55: 1421-1429, 2006.
-
(2006)
Diabetes
, vol.55
, pp. 1421-1429
-
-
Kwan, E.P.1
Xie, L.2
Sheu, L.3
Nolan, C.J.4
Prentki, M.5
Betz, A.6
Brose, N.7
Gaisano, H.Y.8
-
65
-
-
0033556082
-
Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion
-
Lang J. Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion. Eur J Biochem 259: 3-17, 1999.
-
(1999)
Eur J Biochem
, vol.259
, pp. 3-17
-
-
Lang, J.1
-
67
-
-
70450175713
-
The GTPase RalA regulates different steps of the secretory process in pancreatic β-cells
-
Ljubicic S, Bezzi P, Vitale N, Regazzi R. The GTPase RalA regulates different steps of the secretory process in pancreatic β-cells. PLos One 4: e7770, 2009.
-
(2009)
PLos One
, vol.4
-
-
Ljubicic, S.1
Bezzi, P.2
Vitale, N.3
Regazzi, R.4
-
68
-
-
49649090688
-
The RalA GTPase is a central regulator of insulin exocytosis from pancreatic islet β-cells
-
Lopez JA, Kwan EP, Xie L, He Y, James DE, Gaisano HY. The RalA GTPase is a central regulator of insulin exocytosis from pancreatic islet β-cells. J Biol Chem 283: 17939-17945, 2008.
-
(2008)
J Biol Chem
, vol.283
, pp. 17939-17945
-
-
Lopez, J.A.1
Kwan, E.P.2
Xie, L.3
He, Y.4
James, D.E.5
Gaisano, H.Y.6
-
69
-
-
43049174988
-
Overlapping functions of different dynamin isoforms in clathrin-dependent and -independent endocytosis in pancreatic β-cells
-
Lu J, He Z, Fan J, Xu P, Chen L. Overlapping functions of different dynamin isoforms in clathrin-dependent and -independent endocytosis in pancreatic β-cells. Biochem Biophys Res Commun 371: 315-319, 2008.
-
(2008)
Biochem Biophys Res Commun
, vol.371
, pp. 315-319
-
-
Lu, J.1
He, Z.2
Fan, J.3
Xu, P.4
Chen, L.5
-
70
-
-
0030626935
-
G-protein-coupled receptors and their regulation: Activation of the MAP kinase signaling pathway by G-protein-coupled receptors
-
Luttrell LM, van Biesen T, Hawes BE, Koch WJ, Krueger KM, Touhara K, Lefkowitz RJ. G-protein-coupled receptors and their regulation: activation of the MAP kinase signaling pathway by G-protein-coupled receptors. Adv Second Messenger Phosphoprotein Res 31: 263-277, 1997.
-
(1997)
Adv Second Messenger Phosphoprotein Res
, vol.31
, pp. 263-277
-
-
Luttrell, L.M.1
van Biesen, T.2
Hawes, B.E.3
Koch, W.J.4
Krueger, K.M.5
Touhara, K.6
Lefkowitz, R.J.7
-
71
-
-
3042592711
-
Direct imaging shows that insulin granule exocytosis occurs by complete vesicle fusion
-
Ma L, Bindokas VP, Kuznetsov A, Rhodes C, Hays L, Edwardson JM, Ueda K, Steiner DF, Philipson LH. Direct imaging shows that insulin granule exocytosis occurs by complete vesicle fusion. Proc Natl Acad Sci USA 101: 9266-9271, 2004.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 9266-9271
-
-
Ma, L.1
Bindokas, V.P.2
Kuznetsov, A.3
Rhodes, C.4
Hays, L.5
Edwardson, J.M.6
Ueda, K.7
Steiner, D.F.8
Philipson, L.H.9
-
72
-
-
30544441347
-
Calcium increases endocy-totic vesicle size and accelerates membrane fission in insulin-secreting INS-1 cells
-
MacDonald PE, Eliasson L, Rorsman P. Calcium increases endocy-totic vesicle size and accelerates membrane fission in insulin-secreting INS-1 cells. J Cell Sci 118: 5911-5920, 2005.
-
(2005)
J Cell Sci
, vol.118
, pp. 5911-5920
-
-
Macdonald, P.E.1
Eliasson, L.2
Rorsman, P.3
-
73
-
-
34247134694
-
The ins and outs of secretion from pancreatic (β-cells: Control of single-vesicle exo- and endocytosis
-
MacDonald PE, Rorsman P. The ins and outs of secretion from pancreatic (β-cells: control of single-vesicle exo- and endocytosis. Physiology 22: 113-121, 2007.
-
(2007)
Physiology
, vol.22
, pp. 113-121
-
-
Macdonald, P.E.1
Rorsman, P.2
-
74
-
-
0027173426
-
Inhibition of insulin secretion: A failsafe system
-
McDermott AM, Sharp GWG. Inhibition of insulin secretion: a failsafe system. Cell Signal 5: 229-234, 1993.
-
(1993)
Cell Signal
, vol.5
, pp. 229-234
-
-
McDermott, A.M.1
Sharp, G.W.G.2
-
75
-
-
0028988140
-
Gi2 and Gi3 proteins mediate the inhibition of adenylyl cyclase by galanin in the RINm5F cell
-
McDermott AM, Sharp GWG. Gi2 and Gi3 proteins mediate the inhibition of adenylyl cyclase by galanin in the RINm5F cell. Diabetes 44: 453-459, 1995.
-
(1995)
Diabetes
, vol.44
, pp. 453-459
-
-
McDermott, A.M.1
Sharp, G.W.G.2
-
76
-
-
0018906965
-
Stimulation of insulin release in the absence of extracellular calcium by isobu-tylmethylxanthine and its inhibition by somatostatin
-
Mandarino L, Itoh M, Blanchard W, Patton G, Gerich JE. Stimulation of insulin release in the absence of extracellular calcium by isobu-tylmethylxanthine and its inhibition by somatostatin. J Endocrinol 106: 430-433, 1980.
-
(1980)
J Endocrinol
, vol.106
, pp. 430-433
-
-
Mandarino, L.1
Itoh, M.2
Blanchard, W.3
Patton, G.4
Gerich, J.E.5
-
77
-
-
56649111420
-
Kinetics of Rab27a-dependent actions on vesicle docking and priming in pancreatic β-cells
-
Merrins MJ, Stuenkel EL. Kinetics of Rab27a-dependent actions on vesicle docking and priming in pancreatic β-cells. J Physiol 586: 5367-5381, 2008.
-
(2008)
J Physiol
, vol.586
, pp. 5367-5381
-
-
Merrins, M.J.1
Stuenkel, E.L.2
-
78
-
-
0033281526
-
Functional correlates of α2A-adrenoceptor gene polymorphism in the HANE study
-
Michel MC, Plogmann C, Philipp T, Brodde OE. Functional correlates of α2A-adrenoceptor gene polymorphism in the HANE study. Nephrol Dial Transplant 14: 2657-2663, 1999.
-
(1999)
Nephrol Dial Transplant
, vol.14
, pp. 2657-2663
-
-
Michel, M.C.1
Plogmann, C.2
Philipp, T.3
Brodde, O.E.4
-
79
-
-
36348981720
-
Dynamin is functionally coupled to insulin granule exocytosis
-
Min L, Leung YM, Tomas A, Watson RT, Gaisano HY, Halban PA, Pessin JE, Hou JC. Dynamin is functionally coupled to insulin granule exocytosis. J Biol Chem 282: 33530-33536, 2007.
-
(2007)
J Biol Chem
, vol.282
, pp. 33530-33536
-
-
Min, L.1
Leung, Y.M.2
Tomas, A.3
Watson, R.T.4
Gaisano, H.Y.5
Halban, P.A.6
Pessin, J.E.7
Hou, J.C.8
-
80
-
-
77955879987
-
Metabolic amplifying pathway increases both phases of insulin secretion independently of β-cell actin microfilaments
-
Mourad NI, Nenquin M, Henquin JC. Metabolic amplifying pathway increases both phases of insulin secretion independently of β-cell actin microfilaments. Am J Physiol Cell Physiol 299: C389-C398, 2010.
-
(2010)
Am J Physiol Cell Physiol
, vol.299
-
-
Mourad, N.I.1
Nenquin, M.2
Henquin, J.C.3
-
81
-
-
0035151221
-
Localization of cellubrevin-related peptide, endobrevin, in the early endosome in pancreatic β cells and its physiological function in exo-endocytosis of secretory granules
-
Nagamatsu S, Nakamichi Y, Watanabe T, Matsushima S, Yamagu-chi S, Ni J, Itagaki E, Ishida H. Localization of cellubrevin-related peptide, endobrevin, in the early endosome in pancreatic β cells and its physiological function in exo-endocytosis of secretory granules. J Cell Sci 114: 219-227, 2001.
-
(2001)
J Cell Sci
, vol.114
, pp. 219-227
-
-
Nagamatsu, S.1
Nakamichi, Y.2
Watanabe, T.3
Matsushima, S.4
Yamagu-Chi, S.5
Ni, J.6
Itagaki, E.7
Ishida, H.8
-
82
-
-
0036314212
-
Modeling phasic insulin release: Immediate and time-dependent effects of glucose
-
Nesher R, Cerasi E. Modeling phasic insulin release: immediate and time-dependent effects of glucose. Diabetes 51, Suppl 1: S53-S59, 2002.
-
(2002)
Diabetes
, vol.51
, Issue.SUPPL. 1
-
-
Nesher, R.1
Cerasi, E.2
-
83
-
-
0025167006
-
Pharmacological characterization of alpha-2 adrenergic receptor subtype involved in the release of insulin from isolated rat pancreatic islets
-
Niddam R, Angel I, Bidet S, Langer SZ. Pharmacological characterization of alpha-2 adrenergic receptor subtype involved in the release of insulin from isolated rat pancreatic islets. J Pharmacol Exp Ther 254: 883-887, 1990.
-
(1990)
J Pharmacol Exp Ther
, vol.254
, pp. 883-887
-
-
Niddam, R.1
Angel, I.2
Bidet, S.3
Langer, S.Z.4
-
85
-
-
34249103872
-
Imaging analysis reveals mechanistic differences between first- and second-phase insulin exocytosis
-
Ohara-Imaizumi M, Fujiwara T, Nakamichi Y, Okamura T, Akimoto Y, Kawai J, Matsushima S, Kawakami H, Watanabe T, Akagawa K, Nagamatsu S. Imaging analysis reveals mechanistic differences between first- and second-phase insulin exocytosis. J Cell Biol 177: 695-705, 2007.
-
(2007)
J Cell Biol
, vol.177
, pp. 695-705
-
-
Ohara-Imaizumi, M.1
Fujiwara, T.2
Nakamichi, Y.3
Okamura, T.4
Akimoto, Y.5
Kawai, J.6
Matsushima, S.7
Kawakami, H.8
Watanabe, T.9
Akagawa, K.10
Nagamatsu, S.11
-
86
-
-
0036534811
-
Monitoring of exocytosis and endocytosis of insulin secretory granules in the pancreatic β-cell line MIN6 using pH-sensitive green fluorescent protein (pHluorin) and confocal laser microscopy
-
Ohara-Imaizumi M, Nakamichi Y, Tanaka T, Katsuta H, Ishida H, Nagamatsu S. Monitoring of exocytosis and endocytosis of insulin secretory granules in the pancreatic β-cell line MIN6 using pH-sensitive green fluorescent protein (pHluorin) and confocal laser microscopy. Biochem J 363: 73-80, 2002.
-
(2002)
Biochem J
, vol.363
, pp. 73-80
-
-
Ohara-Imaizumi, M.1
Nakamichi, Y.2
Tanaka, T.3
Katsuta, H.4
Ishida, H.5
Nagamatsu, S.6
-
87
-
-
0015790475
-
Exocytosis-endocytosis coupling in the pancreatic β-cell
-
Orci L, Malaisse-Lagae F, Ravazzola M, Amherdt M, Renold AE. Exocytosis-endocytosis coupling in the pancreatic β-cell. Science 181: 561-562, 1973.
-
(1973)
Science
, vol.181
, pp. 561-562
-
-
Orci, L.1
Malaisse-Lagae, F.2
Ravazzola, M.3
Amherdt, M.4
Renold, A.E.5
-
88
-
-
84857032200
-
Choreographing the adenylyl cyclase signalosome: Sorting out the partners and the steps
-
Ostrom RS, Bogard AS, Gros R, Feldman RD. Choreographing the adenylyl cyclase signalosome: sorting out the partners and the steps. Naunyn Schmiedebergs Arch Pharmacol 385: 5-12, 2012.
-
(2012)
Naunyn Schmiedebergs Arch Pharmacol
, vol.385
, pp. 5-12
-
-
Ostrom, R.S.1
Bogard, A.S.2
Gros, R.3
Feldman, R.D.4
-
89
-
-
0142247456
-
Inhibition of insulin secretion via distinct signaling pathways in α2-adrenoceptor knockout mice
-
Peterhoff M, Sieg A, Brede M, Chao CM, Hein L, Ullrich S. Inhibition of insulin secretion via distinct signaling pathways in α2-adrenoceptor knockout mice. Eur J Endocrinol 149: 343-350, 2003.
-
(2003)
Eur J Endocrinol
, vol.149
, pp. 343-350
-
-
Peterhoff, M.1
Sieg, A.2
Brede, M.3
Chao, C.M.4
Hein, L.5
Ullrich, S.6
-
91
-
-
0029084911
-
Effects of divalent cations on exocytosis and endocytosis from single mouse pancreatic β-cells
-
Proks P, Ashcroft FM. Effects of divalent cations on exocytosis and endocytosis from single mouse pancreatic β-cells. J Physiol 487: 465-477, 1995.
-
(1995)
J Physiol
, vol.487
, pp. 465-477
-
-
Proks, P.1
Ashcroft, F.M.2
-
92
-
-
0030469605
-
Effects of tacrolimus (FK506) on human insulin gene expression, insulin mRNA levels, and insulin secretion in HIT-T15 cells
-
Redmon JB, Olson LK, Armstrong MB, Greene MJ, Robertson RP. Effects of tacrolimus (FK506) on human insulin gene expression, insulin mRNA levels, and insulin secretion in HIT-T15 cells. J Clin Invest 98: 2786-2793, 1996.
-
(1996)
J Clin Invest
, vol.98
, pp. 2786-2793
-
-
Redmon, J.B.1
Olson, L.K.2
Armstrong, M.B.3
Greene, M.J.4
Robertson, R.P.5
-
93
-
-
0036087085
-
Activation of adenylyl cyclases, regulation of insulin status, and cell survival by Gαolf in pancreatic β-cells
-
Régnauld KL, Leteurtre E, Gutkind SJ, Gespach CP, Emami S. Activation of adenylyl cyclases, regulation of insulin status, and cell survival by Gαolf in pancreatic β-cells. Am J Physiol Regul Integr Comp Physiol 282: R870-R880, 2002.
-
(2002)
Am J Physiol Regul Integr Comp Physiol
, vol.282
-
-
Régnauld, K.L.1
Leteurtre, E.2
Gutkind, S.J.3
Gespach, C.P.4
Emami, S.5
-
94
-
-
0030792753
-
Protein kinase A-dependent and -independent stimulation of exocytosis by cAMP in mouse pancreatic β-cells
-
Renström E, Eliasson L, Rorsman P. Protein kinase A-dependent and -independent stimulation of exocytosis by cAMP in mouse pancreatic β-cells. J Physiol 502: 105-118, 1997.
-
(1997)
J Physiol
, vol.502
, pp. 105-118
-
-
Renström, E.1
Eliasson, L.2
Rorsman, P.3
-
95
-
-
0029006272
-
+atp channel in insulin secreting mammalian HIT and RIN cell lines
-
+atp channel in insulin secreting mammalian HIT and RIN cell lines. J Physiol 485: 73-86, 1995.
-
(1995)
J Physiol
, vol.485
, pp. 73-86
-
-
Ribalet, B.1
Eddlestone, G.T.2
-
96
-
-
34547843507
-
Kiss-and-run, collapse and "readily retrievable" vesicles
-
Rizzoli SO, Jahn R. Kiss-and-run, collapse and "readily retrievable" vesicles. Traffic 8: 1137-1144, 2007.
-
(2007)
Traffic
, vol.8
, pp. 1137-1144
-
-
Rizzoli, S.O.1
Jahn, R.2
-
97
-
-
0031408748
-
2-adrenergic receptors
-
Rodriguez-Pena MS, Collins R, Woodard C, Spiegel AM. Decreased insulin content and secretion in RIN-1046-38 cells over-expressing α2-adrenergic receptors. Endocrine 7: 255-260, 1997.
-
(1997)
Endocrine
, vol.7
, pp. 255-260
-
-
Rodriguez-Pena, M.S.1
Collins, R.2
Woodard, C.3
Spiegel, A.M.4
-
98
-
-
0026074523
-
+ channel in mouse pancreatic β-cells
-
+ channel in mouse pancreatic β-cells. Nature 349: 77-79, 1991.
-
(1991)
Nature
, vol.349
, pp. 77-79
-
-
Rorsman, P.1
Bokvist, K.2
Ammala, C.3
Arkhammar, P.4
Berggren, P.O.5
Larsson, O.6
Wahlander, K.7
-
99
-
-
74249123937
-
Over-expression of α2A-adrenergic receptors contributes to type 2 diabetes
-
Rosengren AH, Jokubka R, Tojjar D, Granhall C, Hansson O, Li DQ, Nagaraj V, Reinbothe TM, Tuncel J, Eliasson L, Groop L, Rorsman P, Salehi A, Lyssenko V, Luthman H, Renström E. Over-expression of α2A-adrenergic receptors contributes to type 2 diabetes. Science 327: 217-220, 2010.
-
(2010)
Science
, vol.327
, pp. 217-220
-
-
Rosengren, A.H.1
Jokubka, R.2
Tojjar, D.3
Granhall, C.4
Hansson, O.5
Li, D.Q.6
Nagaraj, V.7
Reinbothe, T.M.8
Tuncel, J.9
Eliasson, L.10
Groop, L.11
Rorsman, P.12
Salehi, A.13
Lyssenko, V.14
Luthman, H.15
Renström, E.16
-
100
-
-
0001293564
-
Promotion of insulin secretion by glucagon
-
Samols E, Marrii G, Marks V. Promotion of insulin secretion by glucagon. Lancet 2: 415-416, 1965.
-
(1965)
Lancet
, vol.2
, pp. 415-416
-
-
Samols, E.1
Marrii, G.2
Marks, V.3
-
101
-
-
0033623304
-
i in oscillating and non-oscillating HIT-T15 cells
-
2+]i in oscillating and non-oscillating HIT-T15 cells. Cell Calcium 27: 163-173, 2000.
-
(2000)
Cell Calcium
, vol.27
, pp. 163-173
-
-
Schermerhorn, T.1
Sharp, G.W.G.2
-
102
-
-
0028386525
-
G-protein regulation of insulin secretion
-
Seaquist ER, Walseth TF, Redmon JB, Robertson RP. G-protein regulation of insulin secretion. J Lab Clin Med 123: 338-345, 1994.
-
(1994)
J Lab Clin Med
, vol.123
, pp. 338-345
-
-
Seaquist, E.R.1
Walseth, T.F.2
Redmon, J.B.3
Robertson, R.P.4
-
103
-
-
25444520038
-
PKA-dependent and PKA-independent pathways for cAMP- regulated exocytosis
-
Seino S, Shibasaki T. PKA-dependent and PKA-independent pathways for cAMP- regulated exocytosis. Physiol Rev 85: 1303-1342, 2005.
-
(2005)
Physiol Rev
, vol.85
, pp. 1303-1342
-
-
Seino, S.1
Shibasaki, T.2
-
104
-
-
0030474003
-
Mechanisms of inhibition of insulin release
-
Sharp GWG. Mechanisms of inhibition of insulin release. Am J Physiol Cell Physiol 271: C1781-C1799, 1996.
-
(1996)
Am J Physiol Cell Physiol
, vol.271
-
-
Sharp, G.W.G.1
-
105
-
-
0024513409
-
Galanin can inhibit insulin release by a mechanism other than membrane hyperpolarization or inhibition of adenylate cyclase
-
Sharp GWG, Le Marchand-Brustel Y, Yada T, Russo LL, Bliss CR, Cormont M, Monge L, Van Obberghen E. Galanin can inhibit insulin release by a mechanism other than membrane hyperpolarization or inhibition of adenylate cyclase. J Biol Chem 264: 7302-7309, 1989.
-
(1989)
J Biol Chem
, vol.264
, pp. 7302-7309
-
-
Sharp, G.W.G.1
Le Marchand-Brustel, Y.2
Yada, T.3
Russo, L.L.4
Bliss, C.R.5
Cormont, M.6
Monge, L.7
van Obberghen, E.8
-
106
-
-
37649002935
-
-
Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP
-
Shibasaki T, Takahashi H, Miki T, Sunaga Y, Matsumara K, Ya-manaka M, Zhang C, Tamamoto A, Satoh T, Miyazaki J, Seino S.Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP. Proc Natl Acad Sci USA 104: 19333-19338, 2007.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 19333-19338
-
-
Shibasaki, T.1
Takahashi, H.2
Miki, T.3
Sunaga, Y.4
Matsumara, K.5
Ya-Manaka, M.6
Zhang, C.7
Tamamoto, A.8
Satoh, T.9
Miyazaki, J.10
Seino, S.11
-
107
-
-
1442300757
-
Epinephrine-induced hyperpolarization of islet cells without KATP channels
-
Sieg A, Su J, Munoz A, Buchenau M, Nakazaki M, Aguilar-Bryan L, Bryan J, Ullrich S. Epinephrine-induced hyperpolarization of islet cells without KATP channels. Am J Physiol Endocrinol Metab 286: E463-E471, 2004.
-
(2004)
Am J Physiol Endocrinol Metab
, vol.286
-
-
Sieg, A.1
Su, J.2
Munoz, A.3
Buchenau, M.4
Nakazaki, M.5
Aguilar-Bryan, L.6
Bryan, J.7
Ullrich, S.8
-
108
-
-
15544364238
-
Dynamin 1 phosphorylation and the control of synaptic vesicle endocytosis
-
Smillie KJ, Cousin MA. Dynamin 1 phosphorylation and the control of synaptic vesicle endocytosis. Biochem Soc Symp 72: 87-97, 2005.
-
(2005)
Biochem Soc Symp
, vol.72
, pp. 87-97
-
-
Smillie, K.J.1
Cousin, M.A.2
-
109
-
-
0032081255
-
2+ acts by two separate pathways to modulate the supply of release-competent vesicles in chromaffin cells
-
2+ acts by two separate pathways to modulate the supply of release-competent vesicles in chromaffin cells. Neuron 20: 1243- 1253, 1998.
-
(1998)
Neuron
, vol.20
, pp. 1243-1253
-
-
Smith, C.1
Moser, T.2
Xu, T.3
Neher, E.4
-
110
-
-
0030718608
-
Multiple forms of endocytosis in bovine adrenal chromaffin cells
-
Smith C, Neher E. Multiple forms of endocytosis in bovine adrenal chromaffin cells. J Cell Biol 139: 885-894, 1997.
-
(1997)
J Cell Biol
, vol.139
, pp. 885-894
-
-
Smith, C.1
Neher, E.2
-
111
-
-
37449004981
-
2A-adrenergic receptor knockout mice
-
Sovantus E, Fagerholm V, Rahkonen O, Scheinin M. Reduced blood glucose levels, increased insulin levels and improved glucose tolerance in α2A-adrenergic receptor knockout mice. Eur J Pharmacol 578: 359-364, 2008.
-
(2008)
Eur J Pharmacol
, vol.578
, pp. 359-364
-
-
Sovantus, E.1
Fagerholm, V.2
Rahkonen, O.3
Scheinin, M.4
-
112
-
-
0032192448
-
Regulation of the readily releasable vesicle pool by protein kinase C
-
Stevens CF, Sullivan JM. Regulation of the readily releasable vesicle pool by protein kinase C. Neuron 21: 885-893, 1998.
-
(1998)
Neuron
, vol.21
, pp. 885-893
-
-
Stevens, C.F.1
Sullivan, J.M.2
-
113
-
-
9444238518
-
Stimulation of insulin release by glucose is associated with an increase in the number of docked granules in the β-cells of rat pancreatic islets
-
Straub SG, Shanmugam G, Sharp GWG. Stimulation of insulin release by glucose is associated with an increase in the number of docked granules in the β-cells of rat pancreatic islets. Diabetes 53: 3179-3183, 2004.
-
(2004)
Diabetes
, vol.53
, pp. 3179-3183
-
-
Straub, S.G.1
Shanmugam, G.2
Sharp, G.W.G.3
-
114
-
-
0036868797
-
Glucose-stimulated signaling pathways in biphasic insulin secretion
-
Straub SG, Sharp GWG. Glucose-stimulated signaling pathways in biphasic insulin secretion. Diabetes Metab Res Rev 18: 451-463, 2002.
-
(2002)
Diabetes Metab Res Rev
, vol.18
, pp. 451-463
-
-
Straub, S.G.1
Sharp, G.W.G.2
-
115
-
-
4143118847
-
Hypothesis: One rate-limiting step controls the magnitude of both phases of glucose-stimulated insulin secretion
-
Straub SG, Sharp GWG. Hypothesis: one rate-limiting step controls the magnitude of both phases of glucose-stimulated insulin secretion. Am J Physiol Cell Physiol 287: C565-C571, 2004.
-
(2004)
Am J Physiol Cell Physiol
, vol.287
-
-
Straub, S.G.1
Sharp, G.W.G.2
-
116
-
-
58849092285
-
Membrane fusion: Grappling with SNARE and SM proteins
-
Südhof TC, Rothman JE. Membrane fusion: grappling with SNARE and SM proteins. Science 323: 474-477, 2009.
-
(2009)
Science
, vol.323
, pp. 474-477
-
-
Südhof, T.C.1
Rothman, J.E.2
-
117
-
-
63349087876
-
Rab11 and its effector Rip11 participate in regulation of insulin granule exocytosis
-
Sugawara K, Shibasaki T, Mizoguchi A, Saito T, Seino S. Rab11 and its effector Rip11 participate in regulation of insulin granule exocytosis. Genes Cells 14: 445-456, 2009.
-
(2009)
Genes Cells
, vol.14
, pp. 445-456
-
-
Sugawara, K.1
Shibasaki, T.2
Mizoguchi, A.3
Saito, T.4
Seino, S.5
-
118
-
-
4043183160
-
Adrenal mediation of histamine and serotonin hyperglycemia in normal mice and the absence of adrenal-induced hyperglycemia in pertussis sensitized mice
-
Szentivanyi A, Fishel CW, Talmadge DW. Adrenal mediation of histamine and serotonin hyperglycemia in normal mice and the absence of adrenal-induced hyperglycemia in pertussis sensitized mice. J Infect Dis 113: 86-91, 1963.
-
(1963)
J Infect Dis
, vol.113
, pp. 86-91
-
-
Szentivanyi, A.1
Fishel, C.W.2
Talmadge, D.W.3
-
121
-
-
84880505498
-
Islet activating protein (IAP) derived from the culture supernatant fluid of Bordetella pertussis: Effect on spontaneous diabetic rats
-
Toyota T, Kakizaki M, Kimura K, Yajima M, Okamoto T, Ui M. Islet activating protein (IAP) derived from the culture supernatant fluid of Bordetella pertussis: effect on spontaneous diabetic rats. Diabetologia 14: 319-323, 1978.
-
(1978)
Diabetologia
, vol.14
, pp. 319-323
-
-
Toyota, T.1
Kakizaki, M.2
Kimura, K.3
Yajima, M.4
Okamoto, T.5
Ui, M.6
-
122
-
-
8744220599
-
Mechanisms of dense core vesicle recapture following "kiss and run" ("cavicapture") exocytosis in insulin-secreting cells
-
Tsuboi T, McMahon HT, Rutter GA. Mechanisms of dense core vesicle recapture following "kiss and run" ("cavicapture") exocytosis in insulin-secreting cells. J Biol Chem 279: 47115-47124, 2004.
-
(2004)
J Biol Chem
, vol.279
, pp. 47115-47124
-
-
Tsuboi, T.1
McMahon, H.T.2
Rutter, G.A.3
-
123
-
-
33847067897
-
Raymond JR. Serotonin 5-HT1A receptor stimulates c-Jun N-terminal kinase and induces apoptosis in Chinese hamster ovary fibroblasts
-
Turner JH, Garnovskaya MN, Raymond JR. Serotonin 5-HT1A receptor stimulates c-Jun N-terminal kinase and induces apoptosis in Chinese hamster ovary fibroblasts. Biochim Biophys Acta 1773: 391- 399, 2007.
-
(2007)
Biochim Biophys Acta
, vol.1773
, pp. 391-399
-
-
Turner, J.H.1
Garnovskaya, M.N.2
-
124
-
-
0022370763
-
2+ and insulin release
-
2+ and insulin release. Mol Pharmacol 28: 100-106, 1985.
-
(1985)
Mol Pharmacol
, vol.28
, pp. 100-106
-
-
Ullrich, S.1
-
125
-
-
0033166461
-
Mechanisms underlying phasic and sustained secretion in chromaffin cells from mouse adrenal slices
-
Voets T, Neher E, Moser T. Mechanisms underlying phasic and sustained secretion in chromaffin cells from mouse adrenal slices. Neuron 23: 607-615, 1999.
-
(1999)
Neuron
, vol.23
, pp. 607-615
-
-
Voets, T.1
Neher, E.2
Moser, T.3
-
127
-
-
79952126080
-
1 or Gi proteins
-
Wang Y, Park Bajpayee NS S, Nagaoka Y, Boulay G, Birnbaumer L. Augmented glucose-induced insulin release in mice lacking Go2, but not Go1 or Gi proteins. Proc Natl Acad Sci USA 108: 1693-1698, 2011.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 1693-1698
-
-
Wang, Y.1
Park Bajpayee, N.S.S.2
Nagaoka, Y.3
Boulay, G.4
Birnbaumer, L.5
-
128
-
-
66849115296
-
Mechanisms of biphasic insulin-granule exocytosis-roles of the cytoskeleton, small GTPases and SNARE proteins
-
Wang Z, Thurmond DC. Mechanisms of biphasic insulin-granule exocytosis-roles of the cytoskeleton, small GTPases and SNARE proteins. J Cell Sci 122: 893-903, 2009.
-
(2009)
J Cell Sci
, vol.122
, pp. 893-903
-
-
Wang, Z.1
Thurmond, D.C.2
-
130
-
-
0033561130
-
Two components of transmitter release from the chick presynaptic terminal and their regulation by protein kinase C
-
Yawo H. Two components of transmitter release from the chick presynaptic terminal and their regulation by protein kinase C. J Physiol 516: 461-470, 1999.
-
(1999)
J Physiol
, vol.516
, pp. 461-470
-
-
Yawo, H.1
-
131
-
-
0038660725
-
Insulin secretory deficiency and glucose intolerance in Rab3a null mice
-
Yaekura K, Julyan R, Wicksteed BL, Hays LB, Alarcon C, Sommers S, Poitout V, Baskin DG, Wang Y, Philipson LH, Rhodes CJ. Insulin secretory deficiency and glucose intolerance in Rab3a null mice. J Biol Chem 278: 9715-9721, 2003.
-
(2003)
J Biol Chem
, vol.278
, pp. 9715-9721
-
-
Yaekura, K.1
Julyan, R.2
Wicksteed, B.L.3
Hays, L.B.4
Alarcon, C.5
Sommers, S.6
Poitout, V.7
Baskin, D.G.8
Wang, Y.9
Philipson, L.H.10
Rhodes, C.J.11
-
132
-
-
0036181537
-
The Rab27a/granuphilin complex regulates the exocytosis of insulin-containing dense-core granules
-
Yi Z, Yokota H, Torii S, Aoki T, Hosaka M, Zhao S, Takata K, Takeuchi T, Izumi T. The Rab27a/granuphilin complex regulates the exocytosis of insulin-containing dense-core granules. Mol Cell Biol 22: 1858-1867, 2002.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 1858-1867
-
-
Yi, Z.1
Yokota, H.2
Torii, S.3
Aoki, T.4
Hosaka, M.5
Zhao, S.6
Takata, K.7
Takeuchi, T.8
Izumi, T.9
-
133
-
-
0017912701
-
Islet-activating protein (IAP) in Bordetella pertussis that potentiates insulin secretory response of rats: Purification and characterization
-
Yajima M, Hosoda K, Kanbayashi Y, Nakamura T, Nogimori K, Nakase Y, Ui M. Islet-activating protein (IAP) in Bordetella pertussis that potentiates insulin secretory response of rats: purification and characterization. J Biochem 83: 295-303, 1978.
-
(1978)
J Biochem
, vol.83
, pp. 295-303
-
-
Yajima, M.1
Hosoda, K.2
Kanbayashi, Y.3
Nakamura, T.4
Nogimori, K.5
Nakase, Y.6
Ui, M.7
-
134
-
-
10344221040
-
2+-sensitive pool of granules is regulated by glucose and protein kinases in insulin-secreting INS-1 cells
-
2+-sensitive pool of granules is regulated by glucose and protein kinases in insulin-secreting INS-1 cells. J Gen Physiol 124: 641-651, 2004.
-
(2004)
J Gen Physiol
, vol.124
, pp. 641-651
-
-
Yang, Y.1
Gillis, K.D.2
-
135
-
-
77956750983
-
1/2 subunit
-
Zhao Y, Fang Q, Straub SG, Lindau M, Sharp GWG. Noradrenaline inhibits exocytosis via the G protein βγ subunit and refilling of the readily releasable granule pool via the αi1/2 subunit. J Physiol 588: 3485-3498, 2010.
-
(2010)
J Physiol
, vol.588
, pp. 3485-3498
-
-
Zhao, Y.1
Fang, Q.2
Straub, S.G.3
Lindau, M.4
Sharp, G.W.G.5
-
136
-
-
77956714606
-
Hormonal inhibition of endocytosis: Novel roles for noradrenaline and G-protein Gz
-
Zhao Y, Fang Q, Straub SG, Lindau M, Sharp GWG. Hormonal inhibition of endocytosis: novel roles for noradrenaline and G-protein Gz. J Physiol 588: 3499-3509, 2010.
-
(2010)
J Physiol
, vol.588
, pp. 3499-3509
-
-
Zhao, Y.1
Fang, Q.2
Straub, S.G.3
Lindau, M.4
Sharp, G.W.G.5
-
137
-
-
41949124929
-
o heterotri-meric proteins are required to exert the full effect of norepinephrine on the β-cell Katp channel
-
Zhao Y, Fang Q, Straub SG, Sharp GWG. Both Gi and Go heterotri-meric proteins are required to exert the full effect of norepinephrine on the β-cell Katp channel. J Biol Chem 283: 5306-5316, 2008.
-
(2008)
J Biol Chem
, vol.283
, pp. 5306-5316
-
-
Zhao, Y.1
Fang, Q.2
Straub, S.G.3
Sharp, G.W.G.4
-
138
-
-
77957551212
-
Goto represses insulin secretion by reducing vesicular docking in pancreatic β-cells
-
Zhao A, Ohara-Imaizui M, Brissova M, Benninger RKP, Xu Y, Hao Y, Abramowitz J, Boulay G, Powers AC, Piston D, Jiang M, Nas-gamatsu S, Birnbaumer L, Gu G. Goto represses insulin secretion by reducing vesicular docking in pancreatic β-cells. Diabetes 59: 2522-2529, 2010.
-
(2010)
Diabetes
, vol.59
, pp. 2522-2529
-
-
Zhao, A.1
Ohara-Imaizui, M.2
Brissova, M.3
Benninger, R.K.P.4
Xu, Y.5
Hao, Y.6
Abramowitz, J.7
Boulay, G.8
Powers, A.C.9
Piston, D.10
Jiang, M.11
Nas-Gamatsu, S.12
Birnbaumer, L.13
Gu, G.14
|