Expression of ghrelin and biological activity of specific receptors for ghrelin and des-acyl ghrelin in human prostate neoplasms and related cell lines

European Journal of Endocrinology

Volumn 150, Issue 2, 2004, Pages 173-184

  Cassoni, Paola ^a   Ghé, Corrado ^a   Marrocco, Tiziana ^a   Tarabra, Elena ^a   Allia, Elena ^a   Catapano, Filomena ^a   Deghenghi, Romano ^b   Ghigo, Ezio ^b   Papotti, Mauro ^a   Muccioli, Giampiero ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GHRELIN; GROWTH HORMONE SECRETAGOGUE; GROWTH HORMONE SECRETAGOGUE RECEPTOR; HORMONE RECEPTOR; MESSENGER RNA; RECEPTOR SUBTYPE; THYROXINE I 125;

ARTICLE; BINDING AFFINITY; BINDING SITE; CANCER CELL CULTURE; CELL MEMBRANE; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME LINKED IMMUNOSORBENT ASSAY; GROWTH CURVE; GROWTH HORMONE RELEASE; HORMONE ACTION; HORMONE BINDING; HORMONE DETERMINATION; HORMONE INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; PRIORITY JOURNAL; PROSTATE CARCINOMA; PROSTATE HYPERTROPHY; PROSTATE TUMOR; PROTEIN EXPRESSION; RADIORECEPTOR ASSAY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANDROGENS; CARCINOMA; CELL DIVISION; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; PEPTIDE HORMONES; PEPTIDES; PROSTATIC HYPERPLASIA; PROSTATIC NEOPLASMS; RECEPTORS, G-PROTEIN-COUPLED; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 12144290080     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.0.1500173     Document Type: Article

References (48)

1. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H & Kangawa K. Ghrelin is a growth hormone-releasing acylated peptide from stomach. Nature 1999 402 656-660.
2. Inui A. Ghrelin: an orexigenic and somatotrophic signal from the stomach. Nature Review Neuroscience 2001 2 551-560.
3. Muccioli G, Tschöp M, Papotti M, Deghenghi R, Heiman M & Ghigo E. Neuroendocrine and peripheral activities of ghrelin: implications in metabolism and obesity. European Journal of Pharmacology 2002 440 235-254.
4. 14-ghrelin, a second endogenous ligand for the growth hormone secretagogue receptor. Journal of Biological Chemistry 2000 275 21995-22000.
5. Hosoda H, Kojima M, Matsuo H & Kangawa K. Ghrelin and desacyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue. Biochemical and Biophysical Research Communications 2000 279 909-913.
6. Torsello A, Ghè C, Bresciani E, Catapano F, Ghigo E, Deghenghi R et al. Short ghrelin peptides neither displace ghrelin binding in vitro nor stimulate GH release in vivo. Endocrinology 2002 143 1968-1971.
7. Broglio F, Benso A, Gottero C, Prodam F, Gauna C, Filtri L et al. Non-acylated ghrelin does not possess pituitaric and pancreatic endocrine activity of acylated ghrelin in humans. Journal of Endocrinological Investigation 2003 26 192-196.
8. Kamegai J, Tamura H, Shimizu T, Ishii S. Sugihara H & Oikawa S. Regulation of the ghrelin gene: growth hormone-releasing hormone upregulates ghrelin mRNA in the pituitary. Endocrinology 2001 142 4154-4157.
9. Cowley MA, Smith RG, Diano S, Tschöp M, Pronchuk N, Grove KL et al. The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 2003 37 649-661.
10. Mori K, Yoshimoto A, Takaya K, Hosoda K, Ariyasu H. Yahata K et al. Kidney produces a novel acylated peptide, ghrelin. FEBS Letters 2000 486 213-216.
11. Gualillo O, Caminos J, Blanco M, Garcia-Caballero T, Kojima M, Kangawa K et al. Ghrelin, a novel placental-derived hormone. Endocrinology 2001 142 788-794.
12. Volante M, Allìa E, Gugliotta F Deghenghi R, Muccioli G, Ghigo E et al. Expression of ghrelin and GH secretagogue receptor by pancreatic islet cells and related endocrine tumors. Journal of Clinical Endocrinology and Metabolism 2002 87 1300-1308.
13. Tena-Sempere M, Barreiro ML, Gonzalez LC, Gaytan F, Zhang FP, Caminos JE et al. Novel expression and functional role of ghrelin in rat testis. Endocrinology 2002 143 717-725.
14. Korbonits M, Bustin SA, Kojima M, Jordan S, Adams EF, Lowe DG et al. The expression of the growth hormone secretagogue receptor ligand ghrelin in normal and abnormal human pituitary and other neuroendocrine tumors. Journal of Clinical Endocrinology and Metabolism 2001 86 881-887.
15. Papotti M, Cassoni P, Volante M, Deghenghi R, Muccioli G & Ghigo F. Ghrelin-producing endocrine tumors of the stomach and intestine. Journal of Clinical Endocrinology and Metabolism 2001 86 5052-5059.
16. Kojima M, Hosoda H, Matsuo H & Kangawa K. Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor. Trends in Endocrinology and Metabolism 2001 12 118-122.
17. 125I-labeled ghrelin to membranes from human hypothalamus and pituitary gland. Journal of Endocrinological Investigation 2001 24 RC7-RC9.
18. Smith RG, Van der Ploeg LH, Howard AD, Feighner SD, Cheng K, Hickey GJ et al. Peptidomimetic regulation of growth hormone secretion. Endocrine Reviews 1997 18 621-645.
19. Smith RG, Palhya OC, Feighner SD, Tan CP, McKee KK, Hreniuk DR et al. Growth hormone releasing substances: types and their receptors. Hormone Research 1999 51 (Suppl. 3) 1-8.
20. Gnanapavan S, Kola B, Bustin SA, Morris DG, McGee P, Fairclough P et al. The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans. Journal of Clinical Endocrinology and Metabolism 2002 87 2988-2991.
21. Broglio F, Arvat E, Benso A, Gottero C, Prodam F, Granata R et al. Ghrelin: much more than a natural growth hormone secretagogue. Israel Medical Association Journal 2002 4 607-613.
22. Cassoni P, Papotti M, Catapano F, Ghè C, Deghenghi R, Ghigo E et al. Specific binding sites for synthetic growth hormone secretagogues in non tumoural and neoplastic human thyroid tissue. Journal of Endocrinology 2000 165 139-146.
23. Cassoni P, Papotti M, Ghè C, Catapano E Sapino A, Graziani A et al. Identification, characterization and biological activity of specific receptors for natural (ghrelin) and synthetic growth hormone secretagogues in human breast carcinomas and cell lines. Journal of Clinical Endocrinology and Metabolism 2001 86 1738-1745.
24. Ghè C, Cassoni P, Catapano F, Marrocco T, Deghenghi R, Ghigo E et al. The antiproliferative effect of synthetic peptidyl GH secretagogues in human CALU-1 lung carcinoma cells. Endocrinology 2002 143 484-491.
25. Volante M, Allia E, Fulcheri E, Cassoni P, Ghigo E, Muccioli G et al. Ghrelin in fetal thyroid and follicular tumors and cell lines: expression and effects on tumor growth. American Journal of Pathology 2003 162 645-654.
26. Baldanzi G, Filigheddu N, Cutrupi S, Catapano F, Bonissoni S, Fubini A et al. Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT. Journal of Cell Biology 2002 159 1029-1037.
27. 14-ghrelin. European Journal of Pharmacology 2003 476 87-95.
28. Torsello A, Bresciani E, Rossoni G, Avallone R, Tulipano G, Cocchi D et al. Ghrelin plays a minor role in the physiological control of cardiac function in the rat. Endocrinology 2003 144 1787-1792.
29. Jeffery PL, Herington AC & Chopin LK. Expression and action of the growth hormone releasing peptide ghrelin and its receptor in prostate cancer cell lines. Journal of Endocrinology 2002 172 R7-R11.
30. Lamharzi N, Schally AV, Koppan M & Kroot K. Growth hormone-releasing hormone antagonist MZ-5-156 inhibits growth of DU-145 human androgen-independent prostate carcinoma in nude mice and suppresses the levels of mRNA expression of insulin-like growth factor II in tumors. Proceedings of the National Academy of Sciences of the USA 1998 95 8864-8868.
31. Plonowsky A, Schally AV, Nagy A, Baodong S & Szepeshazi K. Inhibition of PC-3 human androgen-independent prostate cancer and its metastates by cytotoxic somatostatin analogue AN-238. Cancer Research 1999 59 1947-1953.
32. Gasparian AB, Yao YJ, Kowalezyk D, Lyakh LA, Karseladze A, Slaga TJ et al. The role of IKK in constitutive activation of NF-κB transcription factor in prostate carcinoma cells. Journal of Cell Science 2002 115 141-151.
33. Papotti M, Croce S, Macrì L, Funaro A, Pecchioni C, Schindler M et al. Correlative immunohistochemical and reverse transcriptase-polymerase chain reaction analysis of somatostatin receptor type 2 in neuroendocrine tumors of the lung. Diagnostic Molecular Pathology 2000 9 47-57.
34. Volante M, Pecchioni C & Bussolati G. Post-incubation heating significantly improves tyramide signal amplification. Journal of Histochemistry and Cytochemistry 2000 48 1583-1585.
35. Volante M, Fulcheri E, Allia E, Cerrato M, Pucci A & Papotti M. Ghrelin expression in fetal, infant and adult human lung. Journal of Histochemistry and Cytochemistry 2002 50 1013-1021.
36. Lowry OH, Rosebrough NL, Farr AL & Randall RJ. Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 1951 193 265-275.
37. Scatchard G. The attraction of proteins for small molecules and ions. Annals of the New York Academy of Sciences 1949 51 660-672.
38. Bednarek MA, Feighner SD, Pong SS, McKee KK, Hreniuk DL, Silva MV et al. Structure-function studies on the new growth hormone-releasing peptide, ghrelin: minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a. Journal of Medicinal Chemistry 2001 43 4370-4376.
39. Muccioli G, Ghè C, Ghigo MC, Papotti M, Arvat E, Boghen MF et al. Specific receptors for synthetic GH secretagogues in the human brain and pituitary gland. Journal of Endocrinology 1998 157 99-106.
40. Papotti M, Ghè C, Cassoni P, Catapano F, Deghenghi R, Ghigo E et al. Growth hormone secretagogue binding sites in peripheral human tissues. Journal of Clinical Endocrinology and Metabolism 2000 85 3803-3807.
41. Muccioli G, Broglio F, Valetto MR, Ghè C, Catapano F, Graziani A et al. Growth hormone-releasing peptides and the cardiovascular system. Annales d'Endocrinologie (Paris) 2000 61 27-31.
42. Tanaka M, Hayashida Y, Nakao N, Nakai N & Nakashima K. Testis-specific and developmentally induced expression of a ghrelin gene-derived trancript that encodes a novel polypeptide in the mouse. Biochimica et Biophysica Acta 2001 1522 62-65.
43. Jeffery PL, Herington AC & Chopin LK. The potential autocrine/paracrine roles of ghrelin and its receptor in hormone-dependent cancer. Cytokine and Growth Factor Reviews 2003 14 113-122.
44. Hoelting T, Duh QY. Clark OH & Herfarth C. Somatostatin analog octreotide inhibits the growth of differentiated thyroid cancer cells in vitro but not in vivo. Journal of Clinical Endocrinology and Metabolism 1996 81 2638-2641.
45. Gewies A, Rokhlin OW & Cohen MB. Cytochrome c is involved in Fas-mediated apoptosis of prostatic carcinoma cell lines. Cancer Research 2000 60 2163-2168.
46. Mora LB, Buettner R, Seigne J, Diaz J, Ahmad N, Garcia R et al. Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells. Cancer Research 2002 62 6659-6666.
47. McKee KK, Tan CP, Palhya OC, Liu J, Feighner SD, Hreniuk DR et al. Cloning and characterization of two human G-protein-coupled receptor genes (GPR38 and GPR39) related to growth hormone secretagogue and neurotensin receptors. Genomics 1997 46 426-434.
48. Tan CP, McKee KK, Liu Q, Palyha OC, Feighner SD, Smith RG et al. Cloning and characterization of a human and murine T-cell orphan G-protein-coupled receptor similar to the growth hormone secretagogue and neurotensin receptors. Genomics 1998 52 223-229.