Involvement of cAMP/EPAC/ TRPM2 activation in glucose-and incretin-induced insulin secretion

Diabetes

Volumn 63, Issue 10, 2014, Pages 3394-3403

  Yosida, Masashi ^a   Dezaki, Katsuya ^a   Uchida, Kunitoshi ^b   Kodera, Shiho ^a   Lam, Nien V ^a   Ito, Kiyonori ^a   Rita, Rauza S ^a   Yamada, Hodaka ^a   Shimomura, Kenju ^a   Ishikawa, San E ^a   Sugawara, Hitoshi ^a   Kawakami, Masanobu ^a,c   Tominaga, Makoto ^b   Yada, Toshihiko ^a,b   Kakei, Masafumi ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE FOR PHYSIOLOGICAL SCIENCES   (Japan)

^c Nerima Hikarigaoka Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM); CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; EXENDIN 4; GLUCOSE; INCRETIN; LIRAGLUTIDE; TRANSIENT RECEPTOR POTENTIAL CHANNEL M2; ACETYLCYSTEINE; CALCIUM; DRUG DERIVATIVE; ERYTHROMYCIN; ERYTHROMYCIN PROPIONATE-N-ACETYLCYSTEINATE; ERYTHROMYCIN STINOPRATE; INSULIN; PEPTIDE; TRANSIENT RECEPTOR POTENTIAL CHANNEL M; TRPM2 PROTEIN, MOUSE; VENOM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CALCIUM SIGNALING; CELL MEMBRANE CONDUCTANCE; CELL MEMBRANE DEPOLARIZATION; CELL MEMBRANE POTENTIAL; CONTROLLED STUDY; GLUCOSE METABOLISM; INSULIN RELEASE; MALE; MEMBRANE DEPOLARIZATION; MOUSE; NERVE CELL EXCITABILITY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; ANIMAL; DRUG EFFECT; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY; SECRETION (PROCESS); SIGNAL TRANSDUCTION; WISTAR RAT;

ACETYLCYSTEINE; ANIMALS; CALCIUM; CYCLIC AMP; ERYTHROMYCIN; GLUCOSE; INCRETINS; INSULIN; INSULIN-SECRETING CELLS; MALE; MICE; MICE, KNOCKOUT; PEPTIDES; RATS, WISTAR; SIGNAL TRANSDUCTION; TRPM CATION CHANNELS; VENOMS;

EID: 84907484945     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db13-1868     Document Type: Article

References (35)

1. Ashcroft FM, Rorsman P. Diabetes mellitus and the ß cell: the last ten years. Cell 2012;148:1160-1171
2. Leech CA, Habener JF. A role for Ca2+-sensitive nonselective cation channels in regulating the membrane potential of pancreatic beta-cells. Diabetes 1998;47:1066-1073
3. Yada T, Itoh K, Nakata M. Glucagon-like peptide-1-(7-36)amide and a rise in cyclic adenosine 3',5'-monophosphate increase cytosolic free Ca2+ in rat pancreatic beta-cells by enhancing Ca2+ channel activity. Endocrinology 1993; 133:1685-1692
4. Gromada J, Brock B, Schmitz O, Rorsman P. Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential. Basic Clin Pharmacol Toxicol 2004;95:252-262
5. Leech CA, Dzhura I, Chepurny OG, et al. Molecular physiology of glucagon-like peptide-1 insulin secretagogue action in pancreatic ß cells. Prog Biophys Mol Biol 2011;107:236-247
6. Eisfeld J, Lückhoff A. Trpm2. Handbook Exp Pharmacol 2007;237-252
7. Colsoul B, Vennekens R, Nilius B. Transient receptor potential cation channels in pancreatic ß cells. Rev Physiol Biochem Pharmacol 2011;161:87-110
8. Uchida K, Dezaki K, Damdindorj B, et al. Lack of TRPM2 impaired insulin secretion and glucose metabolisms in mice. Diabetes 2011;60:119-126
9. Uchida K, Tominaga M. The role of thermosensitive TRP (transient receptor potential) channels in insulin secretion. Endocr J 2011;58:1021-1028
10. Dezaki K, Damdindorj B, Sone H, et al. Ghrelin attenuates cAMP-PKA signaling to evoke insulinostatic cascade in islet ß-cells. Diabetes 2011;60:2315-2324
11. Yoshida M, Dezaki K, Yamato S, et al. Regulation of voltage-gated K+ channels by glucose metabolism in pancreatic beta-cells. FEES Lett 2009;583: 2225-2230
12. Yamamoto S, Shimizu S, Kiyonaka S, et al. TRPM2-mediated Ca2+influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration. Nat Med 2008;14:738-747
13. Holz GG 4th, Leech CA, Habener JF. Activation of a cAMP-regulated Ca(2+)-signaling pathway in pancreatic beta-cells by the insulinotropic hormone glucagon-like peptide-1. J Biol Chem 1995;270:17749-17757
14. Damdindorj B, Dezaki K, Kurashina T, et al. Exogenous and endogenous ghrelin counteracts GLP-1 action to stimulate cAMP signaling and insulin secretion in islet ß-cells. FEES Lett 2012;586:2555-2562
15. Holz GG, Heart E, Leech CA. Synchronizing Ca2+ and cAMP oscillations in pancreatic beta-cells: a role for glucose metabolism and GLP-1 receptors? Focus on "regulation of cAMP dynamics by Ca2+ and G protein-coupled receptors in the pancreatic beta-cell: a computational approach". Am J Physiol Cell Physiol 2008; 294:C4-C6
16. Shigeto M, Katsura M, Matsuda M, Ohkuma S, Kaku K. Low, but physiological, concentration of GLP-1 stimulates insulin secretion independent of the cAMP-dependent protein kinase pathway. J Pharmacol Sci 2008;108:274-279
17. Almahariq M, Tsalkova T, Mei FC, et al. A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion. Mol Pharmacol 2013; 83:122-128
18. Kogut MH, Genovese KJ, He H. Flagellin and lipopolysaccharide stimulate the MEK-ERK signaling pathway in chicken heterophils through differential activation of the small GTPases, Ras and Rap1. Mol Immunol 2007;44:1729-1736
19. Togashi K, Inada H, Tominaga M. Inhibition of the transient receptor potential cation channel TRPM2 by 2-aminoethoxydiphenyl borate (2-APB). Br J Pharmacol 2008;153:1324-1330
20. Holst JJ. The physiology of glucagon-like peptide 1. Physiol Rev 2007;87: 1409-1439
21. Shibasaki T, Takahashi H, Miki T, et al. Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP. Proc Natl Acad Sci U S A 2007;104:19333-19338
22. Sharp GW. The adenylate cyclase-cyclic AMP system in islets of Langerhans and its role in the control of insulin release. Diabetologia 1979;16:287-296
23. Tian G, Sandler S, Gylfe E, Tengholm A. Glucose- and hormone-induced cAMP oscillations in α- and ß-cells within intact pancreatic islets. Diabetes 2011;60:1535-1543
24. Dyachok O, Idevall-Hagren O, Sågetorp J, et al. Glucose-induced cyclic AMP oscillations regulate pulsatile insulin secretion. Cell Metab 2008;8:26-37
25. Chepurny OG, Kelley GG, Dzhura I, et al. PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2'-0-Me-cAMP-AM in human islets of Langerhans. Am J Physiol Endocrinol Metab 2010;298: E622-E633
26. Song WJ, Mondal P, Li Y, Lee SE, Hussain MA. Pancreatic ß-cell response to increased metabolic demand and to pharmacologic secretagogues requires EPAC2A. Diabetes 2013;62:2796-2807
27. Eliasson L, Ma X, Renström E, et al. SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells. J Gen Physiol 2003; 121:181-197
28. Holz GG. Epac: A new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic beta-cell. Diabetes 2004;53:5-13
29. Seino S. Cell signalling in insulin secretion: the molecular targets of ATP, cAMP and sulfonylurea. Diabetologia 2012;55:2096-2108
30. Takahashi T, Shibasaki T, Takahashi H, et al. Antidiabetic sulfonylureas and cAMP cooperatively activate Epac2A. Sci Signal 2013;6:ra94
31. Nakazaki M, Crane A, Hu M, et al. cAMP-activated protein kinase-independent potentiation of insulin secretion by cAMP is impaired in SUR1 null islets. Diabetes 2002;51:3440-3449
32. Zhang CL, Katoh M, Shibasaki T, et al. The cAMP sensor Epac2 is a direct target of antidiabetic sulfonylurea drugs. Science 2009;325:607-610
33. Togashi K, Hara Y, Tominaga T, et al. TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion. EMBO J 2006;25:1804-1815
34. Kim JW, Roberts CD, Berg SA, Caicedo A, Roper SD, Chaudhari N. Imaging cyclic AMP changes in pancreatic islets of transgenic reporter mice. PLoS ONE 2008;3:e2127
35. Takeda Y, Amano A, Noma A, Nakamura Y, Fujimoto S, Inagaki N. Systems analysis of GLP-1 receptor signaling in pancreatic ß-cells. Am J Physiol Cell Physiol 2011;301 :C792-C803