메뉴 건너뛰기




Volumn 37, Issue 2, 2015, Pages 677-686

Involvement of Interleukin 6 in Hepatitis B Viral Infection

Author keywords

HBx; Hepatitis B; Interleukin 6; SNP

Indexed keywords

AMINO ACID; INTERLEUKIN 6; IL6 PROTEIN, HUMAN;

EID: 84941247594     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000430386     Document Type: Article
Times cited : (52)

References (77)
  • 1
    • 0027524806 scopus 로고
    • Clinical aspects of hepatitis-b virus-infection
    • Wright TL, Lau JYN: Clinical aspects of hepatitis-b virus-infection. Lancet 1993;342:1340-1344.
    • (1993) Lancet , vol.342 , pp. 1340-1344
    • Wright, T.L.1    Lau, J.Y.N.2
  • 2
    • 0028916425 scopus 로고
    • Hepatitis-b virus immunopathogenesis
    • Chisari FV, Ferrari C: Hepatitis-b virus immunopathogenesis. Annu Rev Immunol 1995;13:29-60.
    • (1995) Annu Rev Immunol , vol.13 , pp. 29-60
    • Chisari, F.V.1    Ferrari, C.2
  • 4
    • 84957437886 scopus 로고    scopus 로고
    • Cytokine-mediated immunopathogenesis of hepatitis b virus infections
    • Li X, Liu X, Tian L, Chen Y: Cytokine-mediated immunopathogenesis of hepatitis b virus infections. Clin Rev Allergy Immunol DOI:10.1007/s12016-014-8465-4.
    • Clin Rev Allergy Immunol
    • Li, X.1    Liu, X.2    Tian, L.3    Chen, Y.4
  • 5
    • 22144446395 scopus 로고    scopus 로고
    • Relationship between serum cytokine levels and histopathological changes of liver in patients with hepatitis b
    • Akpolat N, Yahsi S, Godekmerdan A, Demirbag K, Yalniz M: Relationship between serum cytokine levels and histopathological changes of liver in patients with hepatitis b. World J Gastroenterol 2005;11:3260-3263.
    • (2005) World J Gastroenterol , vol.11 , pp. 3260-3263
    • Akpolat, N.1    Yahsi, S.2    Godekmerdan, A.3    Demirbag, K.4    Yalniz, M.5
  • 6
    • 84886605654 scopus 로고    scopus 로고
    • Impact of interleukin-6 in hematological malignancies
    • Burger R: Impact of interleukin-6 in hematological malignancies. Transfus Med Hemother 2013;40:336-343.
    • (2013) Transfus Med Hemother , vol.40 , pp. 336-343
    • Burger, R.1
  • 7
    • 84869834766 scopus 로고    scopus 로고
    • Role of il-6 in asthma and other inflammatory pulmonary diseases
    • Rincon M, Irvin CG: Role of il-6 in asthma and other inflammatory pulmonary diseases. Int J Biol Sci 2012;8:1281-1290.
    • (2012) Int J Biol Sci , vol.8 , pp. 1281-1290
    • Rincon, M.1    Irvin, C.G.2
  • 8
    • 84555205600 scopus 로고    scopus 로고
    • Il-6/il-6 receptor system and its role in physiological and pathological conditions
    • Mihara M, Hashizume M, Yoshida H, Suzuki M, Shiina M: Il-6/il-6 receptor system and its role in physiological and pathological conditions. Clin Sci (Lond) 2012;122:143-159.
    • (2012) Clin Sci (Lond) , vol.122 , pp. 143-159
    • Mihara, M.1    Hashizume, M.2    Yoshida, H.3    Suzuki, M.4    Shiina, M.5
  • 10
    • 0029932769 scopus 로고    scopus 로고
    • Purification and characterization of the soluble interleukin-6 receptor from human plasma and identification of an isoform generated through alternative splicing
    • Muller-Newen G, Kohne C, Keul R, Hemmann U, Muller-Esterl W, Wijdenes J, Brakenhoff JP, Hart MH, Heinrich PC: Purification and characterization of the soluble interleukin-6 receptor from human plasma and identification of an isoform generated through alternative splicing. Eur J Biochem 1996;236:837-842.
    • (1996) Eur J Biochem , vol.236 , pp. 837-842
    • Muller-Newen, G.1    Kohne, C.2    Keul, R.3    Hemmann, U.4    Muller-Esterl, W.5    Wijdenes, J.6    Brakenhoff, J.P.7    Hart, M.H.8    Heinrich, P.C.9
  • 11
    • 2142764513 scopus 로고    scopus 로고
    • Il-6 prevents t cell-mediated hepatitis via inhibition of nkt cells in cd4+ t cell-and stat3-dependent manners
    • Sun R, Tian Z, Kulkarni S, Gao B: Il-6 prevents t cell-mediated hepatitis via inhibition of nkt cells in cd4+ t cell-and stat3-dependent manners. J Immunol 2004;172:5648-5655.
    • (2004) J Immunol , vol.172 , pp. 5648-5655
    • Sun, R.1    Tian, Z.2    Kulkarni, S.3    Gao, B.4
  • 12
    • 84869797922 scopus 로고    scopus 로고
    • Il-6 trans-signaling via the soluble il-6 receptor: Importance for the pro-inflammatory activities of il-6
    • Rose-John S: Il-6 trans-signaling via the soluble il-6 receptor: Importance for the pro-inflammatory activities of il-6. Int J Biol Sci 2012;8:1237-1247.
    • (2012) Int J Biol Sci , vol.8 , pp. 1237-1247
    • Rose-John, S.1
  • 13
    • 84904617950 scopus 로고    scopus 로고
    • The biology and medical implications of interleukin-6
    • Tanaka T, Kishimoto T: The biology and medical implications of interleukin-6. Cancer Immunol Res 2014;2:288-294.
    • (2014) Cancer Immunol Res , vol.2 , pp. 288-294
    • Tanaka, T.1    Kishimoto, T.2
  • 16
    • 78751560494 scopus 로고    scopus 로고
    • Pathogen recognition by the innate immune system
    • Kumar H, Kawai T, Akira S: Pathogen recognition by the innate immune system. Int Rev Immunol 2011;30:16-34.
    • (2011) Int Rev Immunol , vol.30 , pp. 16-34
    • Kumar, H.1    Kawai, T.2    Akira, S.3
  • 17
    • 33845951211 scopus 로고    scopus 로고
    • Damps, pamps and alarmins: All we need to know about danger
    • Bianchi ME: Damps, pamps and alarmins: All we need to know about danger. J Leukocyte Biol 2007;81:1-5.
    • (2007) J Leukocyte Biol , vol.81 , pp. 1-5
    • Bianchi, M.E.1
  • 18
  • 19
    • 0041589356 scopus 로고    scopus 로고
    • Serum cytokine profiles associated with clinical presentation in Vietnamese infected with hepatitis b virus
    • Song le H, Binh VQ, Duy DN, Kun JF, Bock TC, Kremsner PG, Luty AJ: Serum cytokine profiles associated with clinical presentation in vietnamese infected with hepatitis b virus. J Clin Virol 2003;28:93-103.
    • (2003) J Clin Virol , vol.28 , pp. 93-103
    • Song Le, H.1    Binh, V.Q.2    Duy, D.N.3    Kun, J.F.4    Bock, T.C.5    Kremsner, P.G.6    Luty, A.J.7
  • 20
    • 79952709719 scopus 로고    scopus 로고
    • Roles of circulating soluble interleukin (il)-6 receptor and il-6 receptor expression on cd4+ t cells in patients with chronic hepatitis b
    • Zhang F, Yao S, Zhang M, Yuan J, Chen X, Zhou B: Roles of circulating soluble interleukin (il)-6 receptor and il-6 receptor expression on cd4+ t cells in patients with chronic hepatitis b. Int J Infect Dis 2011;15:e267-271.
    • (2011) Int J Infect Dis , vol.15 , pp. e267-271
    • Zhang, F.1    Yao, S.2    Zhang, M.3    Yuan, J.4    Chen, X.5    Zhou, B.6
  • 21
    • 84896970631 scopus 로고    scopus 로고
    • Rather than rs1800796 polymorphism, expression of interleukin-6 is associated with disease progression of chronic hbv infection in a Chinese han population
    • Tang S, Liu Z, Zhang Y, He Y, Pan D, Liu Y, Liu Q, Zhang Z, Yuan Y: Rather than rs1800796 polymorphism, expression of interleukin-6 is associated with disease progression of chronic hbv infection in a chinese han population. Dis Markers 2013;35:799-805.
    • (2013) Dis Markers , vol.35 , pp. 799-805
    • Tang, S.1    Liu, Z.2    Zhang, Y.3    He, Y.4    Pan, D.5    Liu, Y.6    Liu, Q.7    Zhang, Z.8    Yuan, Y.9
  • 23
    • 68949146886 scopus 로고    scopus 로고
    • Hbeag seroconversion as an important end point in the treatment of chronic hepatitis b
    • Liaw YF: Hbeag seroconversion as an important end point in the treatment of chronic hepatitis b. Hepatol Int 2009;3:425-433.
    • (2009) Hepatol Int , vol.3 , pp. 425-433
    • Liaw, Y.F.1
  • 25
    • 84896495791 scopus 로고    scopus 로고
    • A new era for the treatment of inflammatory autoimmune diseases by interleukin-6 blockade strategy
    • Tanaka T, Narazaki M, Ogata A, Kishimoto T: A new era for the treatment of inflammatory autoimmune diseases by interleukin-6 blockade strategy. Semin Immunol 2014;26:88-96.
    • (2014) Semin Immunol , vol.26 , pp. 88-96
    • Tanaka, T.1    Narazaki, M.2    Ogata, A.3    Kishimoto, T.4
  • 26
    • 84893751178 scopus 로고    scopus 로고
    • Interleukin-6; Pathogenesis and treatment of autoimmune inflammatory diseases
    • Toshio Tanaka MN, Kazuya Masuda, Tadamitsu Kishimoto: Interleukin-6; pathogenesis and treatment of autoimmune inflammatory diseases. Inflamm Regen 2013;33:54-65.
    • (2013) Inflamm Regen , vol.33 , pp. 54-65
    • Toshio Tanaka, M.N.1    Masuda, K.2    Kishimoto, T.3
  • 29
    • 45749101288 scopus 로고    scopus 로고
    • Hbv x gene transfection upregulates il-1beta and il-6 gene expression and induces rat glomerular mesangial cell proliferation
    • Lu H, Zhou J: Hbv x gene transfection upregulates il-1beta and il-6 gene expression and induces rat glomerular mesangial cell proliferation. J Huazhong Univ Sci Technolog Med Sci 2008;28:247-250.
    • (2008) J Huazhong Univ Sci Technolog Med Sci , vol.28 , pp. 247-250
    • Lu, H.1    Zhou, J.2
  • 31
    • 78649630185 scopus 로고    scopus 로고
    • Hepatitis b virus x protein stimulates il-6 expression in hepatocytes via a myd88-dependent pathway
    • Xiang WQ, Feng WF, Ke W, Sun Z, Chen Z, Liu W: Hepatitis b virus x protein stimulates il-6 expression in hepatocytes via a myd88-dependent pathway. J Hepatol 2011;54:26-33.
    • (2011) J Hepatol , vol.54 , pp. 26-33
    • Xiang, W.Q.1    Feng, W.F.2    Ke, W.3    Sun, Z.4    Chen, Z.5    Liu, W.6
  • 32
    • 38049093090 scopus 로고    scopus 로고
    • Inflammation, hcc and sex: Il-6 in the centre of the triangle
    • Prieto J: Inflammation, hcc and sex: Il-6 in the centre of the triangle. J Hepatol 2008;48:380-381.
    • (2008) J Hepatol , vol.48 , pp. 380-381
    • Prieto, J.1
  • 33
    • 25844459154 scopus 로고    scopus 로고
    • Nf-kappab: Linking inflammation and immunity to cancer development and progression
    • Karin M, Greten FR: Nf-kappab: Linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 2005;5:749-759.
    • (2005) Nat Rev Immunol , vol.5 , pp. 749-759
    • Karin, M.1    Greten, F.R.2
  • 35
    • 34447327216 scopus 로고    scopus 로고
    • Gender disparity in liver cancer due to sex differences in myd88-dependent il-6 production
    • Naugler WE, Sakurai T, Kim S, Maeda S, Kim K, Elsharkawy AM, Karin M: Gender disparity in liver cancer due to sex differences in myd88-dependent il-6 production. Science 2007;317:121-124.
    • (2007) Science , vol.317 , pp. 121-124
    • Naugler, W.E.1    Sakurai, T.2    Kim, S.3    Maeda, S.4    Kim, K.5    Elsharkawy, A.M.6    Karin, M.7
  • 37
    • 77954019973 scopus 로고    scopus 로고
    • High expression levels of putative hepatic stem/progenitor cell biomarkers related to tumour angiogenesis and poor prognosis of hepatocellular carcinoma
    • Yang XR, Xu Y, Yu B, Zhou J, Qiu SJ, Shi GM, Zhang BH, Wu WZ, Shi YH, Wu B, Yang GH, Ji Y, Fan J: High expression levels of putative hepatic stem/progenitor cell biomarkers related to tumour angiogenesis and poor prognosis of hepatocellular carcinoma. Gut 2010;59:953-962.
    • (2010) Gut , vol.59 , pp. 953-962
    • Yang, X.R.1    Xu, Y.2    Yu, B.3    Zhou, J.4    Qiu, S.J.5    Shi, G.M.6    Zhang, B.H.7    Wu, W.Z.8    Shi, Y.H.9    Wu, B.10    Yang, G.H.11    Ji, Y.12    Fan, J.13
  • 38
    • 84907917653 scopus 로고    scopus 로고
    • Hepatitis b virus x protein promotes hepatocellular carcinoma transformation through interleukin-6 activation of microrna-21 expression
    • Li CH, Xu FY, Chow S, Feng L, Yin DL, Ng TB, Chen YC: Hepatitis b virus x protein promotes hepatocellular carcinoma transformation through interleukin-6 activation of microrna-21 expression. Eur J Cancer 2014;50:2560-2569.
    • (2014) Eur J Cancer , vol.50 , pp. 2560-2569
    • Li, C.H.1    Xu, F.Y.2    Chow, S.3    Feng, L.4    Yin, D.L.5    Ng, T.B.6    Chen, Y.C.7
  • 40
    • 84924326333 scopus 로고    scopus 로고
    • Interleukin 6 inhibits hbv entry through ntcp down regulation
    • Bouezzedine F, Fardel O, Gripon P: Interleukin 6 inhibits hbv entry through ntcp down regulation. Virology 2015;481:34-42.
    • (2015) Virology , vol.481 , pp. 34-42
    • Bouezzedine, F.1    Fardel, O.2    Gripon, P.3
  • 42
    • 84887003072 scopus 로고    scopus 로고
    • Relationship between interleukin-6 polymorphism and susceptibility to chronic hepatitis b virus infection
    • Zhao XM, Gao YF, Zhou Q, Pan FM, Li X: Relationship between interleukin-6 polymorphism and susceptibility to chronic hepatitis b virus infection. World J Gastroenterol 2013;19:6888-6893.
    • (2013) World J Gastroenterol , vol.19 , pp. 6888-6893
    • Zhao, X.M.1    Gao, Y.F.2    Zhou, Q.3    Pan, F.M.4    Li, X.5
  • 44
    • 36949024485 scopus 로고    scopus 로고
    • Role of glycosaminoglycans for binding and infection of hepatitis b virus
    • Leistner CM, Gruen-Bernhard S, Glebe D: Role of glycosaminoglycans for binding and infection of hepatitis b virus. Cell Microbiol 2008;10:122-133.
    • (2008) Cell Microbiol , vol.10 , pp. 122-133
    • Leistner, C.M.1    Gruen-Bernhard, S.2    Glebe, D.3
  • 45
    • 84894230477 scopus 로고    scopus 로고
    • Ntcp and beyond: Opening the door to unveil hepatitis b virus entry
    • Watashi K, Urban S, Li W, Wakita T: Ntcp and beyond: Opening the door to unveil hepatitis b virus entry. Int J Mol Sci 2014;15:2892-2905.
    • (2014) Int J Mol Sci , vol.15 , pp. 2892-2905
    • Watashi, K.1    Urban, S.2    Li, W.3    Wakita, T.4
  • 46
    • 84866160398 scopus 로고    scopus 로고
    • Entry of hepatitis b virus into immortalized human primary hepatocytes by clathrin-dependent endocytosis
    • Huang HC, Chen CC, Chang WC, Tao MH, Huang C: Entry of hepatitis b virus into immortalized human primary hepatocytes by clathrin-dependent endocytosis. J Virol 2012;86:9443-9453.
    • (2012) J Virol , vol.86 , pp. 9443-9453
    • Huang, H.C.1    Chen, C.C.2    Chang, W.C.3    Tao, M.H.4    Huang, C.5
  • 48
    • 0026573138 scopus 로고
    • Search for hepatitis b virus cell receptors reveals binding sites for interleukin 6 on the virus envelope protein
    • Neurath AR, Strick N, Sproul P: Search for hepatitis b virus cell receptors reveals binding sites for interleukin 6 on the virus envelope protein. J Exp Med 1992;175:461-469.
    • (1992) J Exp Med , vol.175 , pp. 461-469
    • Neurath, A.R.1    Strick, N.2    Sproul, P.3
  • 49
    • 0034987518 scopus 로고    scopus 로고
    • Possible role of human interleukin-6 and soluble interleukin-6 receptor in hepatitis b virus infection
    • Heinz D, Peters M, Prange R, Gerken G, Rose-John S: Possible role of human interleukin-6 and soluble interleukin-6 receptor in hepatitis b virus infection. J Viral Hepat 2001;8:186-193.
    • (2001) J Viral Hepat , vol.8 , pp. 186-193
    • Heinz, D.1    Peters, M.2    Prange, R.3    Gerken, G.4    Rose-John, S.5
  • 51
    • 13744257618 scopus 로고    scopus 로고
    • Efficient inhibition of hepatitis b virus infection by acylated peptides derived from the large viral surface protein
    • Gripon P, Cannie I, Urban S: Efficient inhibition of hepatitis b virus infection by acylated peptides derived from the large viral surface protein. J Virol 2005;79:1613-1622.
    • (2005) J Virol , vol.79 , pp. 1613-1622
    • Gripon, P.1    Cannie, I.2    Urban, S.3
  • 52
    • 84921038448 scopus 로고    scopus 로고
    • A systematic comparison of the impact of inflammatory signaling on absorption, distribution, metabolism, and excretion gene expression and activity in primary human hepatocytes and heparg cells
    • Klein M, Thomas M, Hofmann U, Seehofer D, Damm G, Zanger UM: A systematic comparison of the impact of inflammatory signaling on absorption, distribution, metabolism, and excretion gene expression and activity in primary human hepatocytes and heparg cells. Drug Metab Dispos 2015;43:273-283.
    • (2015) Drug Metab Dispos , vol.43 , pp. 273-283
    • Klein, M.1    Thomas, M.2    Hofmann, U.3    Seehofer, D.4    Damm, G.5    Zanger, U.M.6
  • 53
    • 84856396808 scopus 로고    scopus 로고
    • Hepatocyte polarization is essential for the productive entry of the hepatitis b virus
    • Schulze A, Mills K, Weiss TS, Urban S: Hepatocyte polarization is essential for the productive entry of the hepatitis b virus. Hepatology 2012;55:373-383.
    • (2012) Hepatology , vol.55 , pp. 373-383
    • Schulze, A.1    Mills, K.2    Weiss, T.S.3    Urban, S.4
  • 54
    • 70350333409 scopus 로고    scopus 로고
    • The first transmembrane domain of the hepatitis b virus large envelope protein is crucial for infectivity
    • Lepere-Douard C, Trotard M, Le Seyec J, Gripon P: The first transmembrane domain of the hepatitis b virus large envelope protein is crucial for infectivity. J Virol 2009;83:11819-11829.
    • (2009) J Virol , vol.83 , pp. 11819-11829
    • Lepere-Douard, C.1    Trotard, M.2    Le Seyec, J.3    Gripon, P.4
  • 55
    • 0142211126 scopus 로고    scopus 로고
    • Il-4 suppresses the expression and the replication of hepatitis b virus in the hepatocellular carcinoma cell line hep3b
    • Lin SJ, Shu PY, Chang C, Ng AK, Hu CP: Il-4 suppresses the expression and the replication of hepatitis b virus in the hepatocellular carcinoma cell line hep3b. J Immunol 2003;171:4708-4716.
    • (2003) J Immunol , vol.171 , pp. 4708-4716
    • Lin, S.J.1    Shu, P.Y.2    Chang, C.3    Ng, A.K.4    Hu, C.P.5
  • 56
    • 34548775064 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 suppresses hepatitis b virus replication primarily through transcriptional inhibition of pregenomic RNA
    • Chou YC, Chen ML, Hu CP, Chen YL, Chong CL, Tsai YL, Liu TL, Jeng KS, Chang C: Transforming growth factor-beta1 suppresses hepatitis b virus replication primarily through transcriptional inhibition of pregenomic rna. Hepatology 2007;46:672-681.
    • (2007) Hepatology , vol.46 , pp. 672-681
    • Chou, Y.C.1    Chen, M.L.2    Hu, C.P.3    Chen, Y.L.4    Chong, C.L.5    Tsai, Y.L.6    Liu, T.L.7    Jeng, K.S.8    Chang, C.9
  • 57
    • 22244456417 scopus 로고    scopus 로고
    • Interferon prevents formation of replicationcompetent hepatitis b virus RNA-containing nucleocapsids
    • Wieland SF, Eustaquio A, Whitten-Bauer C, Boyd B, Chisari FV: Interferon prevents formation of replicationcompetent hepatitis b virus rna-containing nucleocapsids. Proc Natl Acad Sci U S A 2005;102:9913-9917.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 9913-9917
    • Wieland, S.F.1    Eustaquio, A.2    Whitten-Bauer, C.3    Boyd, B.4    Chisari, F.V.5
  • 58
    • 0037379219 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha inhibition of hepatitis b virus replication involves disruption of capsid integrity through activation of nf-kappab
    • Biermer M, Puro R, Schneider RJ: Tumor necrosis factor alpha inhibition of hepatitis b virus replication involves disruption of capsid integrity through activation of nf-kappab. J Virol 2003;77:4033-4042.
    • (2003) J Virol , vol.77 , pp. 4033-4042
    • Biermer, M.1    Puro, R.2    Schneider, R.J.3
  • 60
    • 0036238818 scopus 로고    scopus 로고
    • Clinical significance of hepatitis b virus genotypes
    • Chu CJ, Lok AS: Clinical significance of hepatitis b virus genotypes. Hepatology 2002;35:1274-1276.
    • (2002) Hepatology , vol.35 , pp. 1274-1276
    • Chu, C.J.1    Lok, A.S.2
  • 61
    • 0034769202 scopus 로고    scopus 로고
    • Genetic susceptibility in chronic viral hepatitis
    • Thursz M: Genetic susceptibility in chronic viral hepatitis. Antiviral Res 2001;52:113-116.
    • (2001) Antiviral Res , vol.52 , pp. 113-116
    • Thursz, M.1
  • 62
    • 84877250629 scopus 로고    scopus 로고
    • Genetic association of interleukin-6 polymorphism (-174 g/c) with chronic liver diseases and hepatocellular carcinoma
    • Giannitrapani L, Soresi M, Balasus D, Licata A, Montalto G: Genetic association of interleukin-6 polymorphism (-174 g/c) with chronic liver diseases and hepatocellular carcinoma. World J Gastroenterol 2013;19:2449-2455.
    • (2013) World J Gastroenterol , vol.19 , pp. 2449-2455
    • Giannitrapani, L.1    Soresi, M.2    Balasus, D.3    Licata, A.4    Montalto, G.5
  • 63
    • 0038147057 scopus 로고    scopus 로고
    • Association between interieukin 6 promoter variants and chronic hepatitis b progression
    • Park BL, Lee HS, Kim YJ, Kim JY, Jung JH, Kim LH, Shin HD: Association between interieukin 6 promoter variants and chronic hepatitis b progression. Exp Mol Med 2003;35:76-82.
    • (2003) Exp Mol Med , vol.35 , pp. 76-82
    • Park, B.L.1    Lee, H.S.2    Kim, Y.J.3    Kim, J.Y.4    Jung, J.H.5    Kim, L.H.6    Shin, H.D.7
  • 64
    • 0035885733 scopus 로고    scopus 로고
    • The-174/-597 promoter polymorphisms in the interleukin-6 gene are not associated with susceptibility to multiple sclerosis
    • Fedetz M, Matesanz F, Pascual M, Martin J, Fernandez O, Guerrero M, Alcina A: The-174/-597 promoter polymorphisms in the interleukin-6 gene are not associated with susceptibility to multiple sclerosis. J Neurol Sci 2001;190:69-72.
    • (2001) J Neurol Sci , vol.190 , pp. 69-72
    • Fedetz, M.1    Matesanz, F.2    Pascual, M.3    Martin, J.4    Fernandez, O.5    Guerrero, M.6    Alcina, A.7
  • 66
    • 34250893250 scopus 로고    scopus 로고
    • Association of cytokine genetic polymorphism with hepatitis b infection evolution in adult patients
    • Ribeiro CS, Visentainer JE, Moliterno RA: Association of cytokine genetic polymorphism with hepatitis b infection evolution in adult patients. Mem Inst Oswaldo Cruz 2007;102:435-440.
    • (2007) Mem Inst Oswaldo Cruz , vol.102 , pp. 435-440
    • Ribeiro, C.S.1    Visentainer, J.E.2    Moliterno, R.A.3
  • 67
    • 84895546766 scopus 로고    scopus 로고
    • Genetic polymorphism of interleukin-6 influences susceptibility to hbv-related hepatocellular carcinoma in a male Chinese han population
    • Tang S, Yuan Y, He Y, Pan D, Zhang Y, Liu Y, Liu Q, Zhang Z, Liu Z: Genetic polymorphism of interleukin-6 influences susceptibility to hbv-related hepatocellular carcinoma in a male chinese han population. Hum Immunol 2014;75:297-301.
    • (2014) Hum Immunol , vol.75 , pp. 297-301
    • Tang, S.1    Yuan, Y.2    He, Y.3    Pan, D.4    Zhang, Y.5    Liu, Y.6    Liu, Q.7    Zhang, Z.8    Liu, Z.9
  • 68
    • 84914161389 scopus 로고    scopus 로고
    • Il-6 promoter functional polymorphism-572c/g affects spontaneous clearance of hepatitis b virus infection
    • Lu Y, Peng J, Wang C, Zhu Y, Wang F, Sun Z: Il-6 promoter functional polymorphism-572c/g affects spontaneous clearance of hepatitis b virus infection. Clin Lab 2014;60:1903-1907.
    • (2014) Clin Lab , vol.60 , pp. 1903-1907
    • Lu, Y.1    Peng, J.2    Wang, C.3    Zhu, Y.4    Wang, F.5    Sun, Z.6
  • 73
    • 84863043835 scopus 로고    scopus 로고
    • Tocilizumab for the treatment of rheumatoid arthritis and other systemic autoimmune diseases: Current perspectives and future directions
    • Ogata A, Tanaka T: Tocilizumab for the treatment of rheumatoid arthritis and other systemic autoimmune diseases: Current perspectives and future directions. Int J Rheumatol 2012;2012:1-14.
    • (2012) Int J Rheumatol , vol.2012 , pp. 1-14
    • Ogata, A.1    Tanaka, T.2
  • 74
    • 77955485392 scopus 로고    scopus 로고
    • Nucleos(t)ide analogues only induce temporary hepatitis b e antigen seroconversion in most patients with chronic hepatitis b
    • Reijnders JG, Perquin MJ, Zhang N, Hansen BE, Janssen HL: Nucleos(t)ide analogues only induce temporary hepatitis b e antigen seroconversion in most patients with chronic hepatitis b. Gastroenterology 2010;139:491-498.
    • (2010) Gastroenterology , vol.139 , pp. 491-498
    • Reijnders, J.G.1    Perquin, M.J.2    Zhang, N.3    Hansen, B.E.4    Janssen, H.L.5
  • 75
    • 84864583849 scopus 로고    scopus 로고
    • Hepatitis b precore protein: Pathogenic potential and therapeutic promise
    • Walsh R, Locarnini S: Hepatitis b precore protein: Pathogenic potential and therapeutic promise. Yonsei Med J 2012;53:875-885.
    • (2012) Yonsei Med J , vol.53 , pp. 875-885
    • Walsh, R.1    Locarnini, S.2
  • 76
    • 84901398058 scopus 로고    scopus 로고
    • Immunotherapeutic interventions in chronic hepatitis b virus infection: A review
    • Wang L, Zou ZQ, Liu CX, Liu XZ: Immunotherapeutic interventions in chronic hepatitis b virus infection: A review. J Immunol Methods 2014;407C:1-8.
    • (2014) J Immunol Methods , vol.407 C , pp. 1-8
    • Wang, L.1    Zou, Z.Q.2    Liu, C.X.3    Liu, X.Z.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.