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Volumn 54, Issue 1, 2011, Pages 26-33

Hepatitis B virus X protein stimulates IL-6 expression in hepatocytes via a MyD88-dependent pathway

Author keywords

Hepatitis B virus X protein; IL 1 receptor associated kinase; Interleukin 6; Mitogen activated protein kinase; Myeloid differentiation factor 88; Nuclear factor kappa B

Indexed keywords

HEPATITIS B VIRUS X PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; INTERLEUKIN 6; MYELOID DIFFERENTIATION FACTOR 88; SYNAPTOPHYSIN;

EID: 78649630185     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2010.08.006     Document Type: Article
Times cited : (81)

References (39)
  • 1
    • 32044449655 scopus 로고    scopus 로고
    • Worldwide epidemiology of HBV infection, disease burden, and vaccine prevention
    • D. Lavanchy Worldwide epidemiology of HBV infection, disease burden, and vaccine prevention J Clin Virol 34 2005 S1 S3
    • (2005) J Clin Virol , vol.34
    • Lavanchy, D.1
  • 2
    • 71149108706 scopus 로고    scopus 로고
    • Hepatitis B virus X protein: Molecular functions and its role in virus life cycle and pathogenesis
    • S. Benhenda, D. Cougot, M.A. Buendia, and C. Neuveut Hepatitis B virus X protein: molecular functions and its role in virus life cycle and pathogenesis Adv Cancer Res 103 2009 75 109
    • (2009) Adv Cancer Res , vol.103 , pp. 75-109
    • Benhenda, S.1    Cougot, D.2    Buendia, M.A.3    Neuveut, C.4
  • 3
    • 0032772369 scopus 로고    scopus 로고
    • Direct association and nuclear import of the hepatitis B virus X protein with the NF-kappaB inhibitor IkappaBalpha
    • R. Weil, H. Sirma, C. Giannini, D. Kremsdorf, C. Bessia, and C. Dargemont Direct association and nuclear import of the hepatitis B virus X protein with the NF-kappaB inhibitor IkappaBalpha Mol Cell Biol 19 1999 6345 6354
    • (1999) Mol Cell Biol , vol.19 , pp. 6345-6354
    • Weil, R.1    Sirma, H.2    Giannini, C.3    Kremsdorf, D.4    Bessia, C.5    Dargemont, C.6
  • 4
    • 69249110047 scopus 로고    scopus 로고
    • Deregulated direct targets of the hepatitis B virus (HBV) protein, HBx, identified through chromatin immunoprecipitation and expression microarray profiling
    • W.K. Sung, Y. Lu, C.W. Lee, D. Zhang, M. Ronaghi, and C.G. Lee Deregulated direct targets of the hepatitis B virus (HBV) protein, HBx, identified through chromatin immunoprecipitation and expression microarray profiling J Biol Chem 284 2009 21941 21954
    • (2009) J Biol Chem , vol.284 , pp. 21941-21954
    • Sung, W.K.1    Lu, Y.2    Lee, C.W.3    Zhang, D.4    Ronaghi, M.5    Lee, C.G.6
  • 5
    • 0027157304 scopus 로고
    • Hepatitis B × antigen and p53 are associated in vitro and in liver tissues from patients with primary hepatocellular carcinoma
    • M.A. Feitelson, M. Zhu, L.X. Duan, and W.T. London Hepatitis B × antigen and p53 are associated in vitro and in liver tissues from patients with primary hepatocellular carcinoma Oncogene 8 1993 1109 1117
    • (1993) Oncogene , vol.8 , pp. 1109-1117
    • Feitelson, M.A.1    Zhu, M.2    Duan, L.X.3    London, W.T.4
  • 6
    • 0001655748 scopus 로고
    • Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3
    • X.W. Wang, K. Forrester, H. Yeh, M.A. Feitelson, J.R. Gu, and C.C. Harris Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3 Proc Natl Acad Sci USA 91 1994 2230 2234
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 2230-2234
    • Wang, X.W.1    Forrester, K.2    Yeh, H.3    Feitelson, M.A.4    Gu, J.R.5    Harris, C.C.6
  • 7
    • 0026526978 scopus 로고
    • Hepatitis B virus X protein activates transcription factor NF-kappaB without a requirement for protein kinase C
    • R. Lucito, and R.J. Schneider Hepatitis B virus X protein activates transcription factor NF-kappaB without a requirement for protein kinase C J Virol 66 1992 983 991
    • (1992) J Virol , vol.66 , pp. 983-991
    • Lucito, R.1    Schneider, R.J.2
  • 9
    • 0029147911 scopus 로고
    • The hepatitis B virus HBx protein is a dual specificity cytoplasmic activator of Ras and nuclear activator of transcription factors
    • M. Doria, N. Klein, R. Lucito, and R.J. Schneider The hepatitis B virus HBx protein is a dual specificity cytoplasmic activator of Ras and nuclear activator of transcription factors EMBO J 14 1995 4747 4757
    • (1995) EMBO J , vol.14 , pp. 4747-4757
    • Doria, M.1    Klein, N.2    Lucito, R.3    Schneider, R.J.4
  • 10
    • 0034682769 scopus 로고    scopus 로고
    • Hepatitis B virus X protein inhibits transforming growth factor-β-induced apoptosis through the activation of phosphatidylinositol 3-kinase pathway
    • W.L. Shih, M.L. Kuo, S.E. Chuang, A.L. Cheng, and S.L. Doong Hepatitis B virus X protein inhibits transforming growth factor-β-induced apoptosis through the activation of phosphatidylinositol 3-kinase pathway J Biol Chem 275 2000 25858 25864
    • (2000) J Biol Chem , vol.275 , pp. 25858-25864
    • Shih, W.L.1    Kuo, M.L.2    Chuang, S.E.3    Cheng, A.L.4    Doong, S.L.5
  • 11
    • 0032566516 scopus 로고    scopus 로고
    • HBx protein of hepatitis B virus activates Jak1-STAT signaling
    • Y.H. Lee, and Y. Yun HBx protein of hepatitis B virus activates Jak1-STAT signaling J Biol Chem 273 1998 25510 25515
    • (1998) J Biol Chem , vol.273 , pp. 25510-25515
    • Lee, Y.H.1    Yun, Y.2
  • 13
    • 33646114053 scopus 로고    scopus 로고
    • Hepatitis B virus X protein induces apoptosis in hepatoma cells through inhibiting Bcl-xL expression
    • J. Miao, G.G. Chen, S.Y. Chun, and P.P. Lai Hepatitis B virus X protein induces apoptosis in hepatoma cells through inhibiting Bcl-xL expression Cancer Lett 236 2006 115 124
    • (2006) Cancer Lett , vol.236 , pp. 115-124
    • Miao, J.1    Chen, G.G.2    Chun, S.Y.3    Lai, P.P.4
  • 14
    • 8644286664 scopus 로고    scopus 로고
    • Sustained activation of p38 mitogen-activated protein kinase and c-Jun N-terminal kinase pathways by hepatitis B virus X protein mediates apoptosis via induction of Fas/FasL and tumor necrosis factor (TNF) receptor 1/TNF-alpha expression
    • W.H. Wang, G. Grégori, R.L. Hullinger, and O.M. Andrisani Sustained activation of p38 mitogen-activated protein kinase and c-Jun N-terminal kinase pathways by hepatitis B virus X protein mediates apoptosis via induction of Fas/FasL and tumor necrosis factor (TNF) receptor 1/TNF-alpha expression Mol Cell Biol 42 2004 10352 10365
    • (2004) Mol Cell Biol , vol.42 , pp. 10352-10365
    • Wang, W.H.1    Grégori, G.2    Hullinger, R.L.3    Andrisani, O.M.4
  • 15
    • 34248141100 scopus 로고    scopus 로고
    • A cytokine-mediated link between innate immunity, inflammation, and cancer
    • W.W. Lin, and M. Karin A cytokine-mediated link between innate immunity, inflammation, and cancer J Clin Invest 117 2007 1175 1183
    • (2007) J Clin Invest , vol.117 , pp. 1175-1183
    • Lin, W.W.1    Karin, M.2
  • 16
    • 37849033136 scopus 로고    scopus 로고
    • Role of Toll-like receptors in gastrointestinal malignancies
    • M. Fukata, and M.T. Abreu Role of Toll-like receptors in gastrointestinal malignancies Oncogene 27 2008 234 243
    • (2008) Oncogene , vol.27 , pp. 234-243
    • Fukata, M.1    Abreu, M.T.2
  • 17
  • 18
    • 40649109728 scopus 로고    scopus 로고
    • The wolf in sheep's clothing: The role of interleukin-6 in immunity, inflammation and cancer
    • W.E. Naugler, and M. Karin The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer Trends Mol Med 14 2007 109 119
    • (2007) Trends Mol Med , vol.14 , pp. 109-119
    • Naugler, W.E.1    Karin, M.2
  • 19
    • 34447327216 scopus 로고    scopus 로고
    • Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production
    • W.E. Naugler, T. Sakurai, S. Kim, S. Maeda, K. Kim, and A.M. Elsharkawy Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production Science 317 2007 121 124
    • (2007) Science , vol.317 , pp. 121-124
    • Naugler, W.E.1    Sakurai, T.2    Kim, S.3    Maeda, S.4    Kim, K.5    Elsharkawy, A.M.6
  • 20
    • 32944463507 scopus 로고    scopus 로고
    • Cytokines, STATs and liver disease
    • B. Gao Cytokines, STATs and liver disease Cell Mol Immunol 2 2005 92 100
    • (2005) Cell Mol Immunol , vol.2 , pp. 92-100
    • Gao, B.1
  • 21
    • 0031746396 scopus 로고    scopus 로고
    • Human interleukin 6 gene is activated by hepatitis B virus-X protein in human hepatoma cells
    • Y. Lee, U.S. Park, I. Choi, S.K. Yoon, Y.M. Park, and Y.I. Lee Human interleukin 6 gene is activated by hepatitis B virus-X protein in human hepatoma cells Clin Cancer Res 4 1998 1711 1717
    • (1998) Clin Cancer Res , vol.4 , pp. 1711-1717
    • Lee, Y.1    Park, U.S.2    Choi, I.3    Yoon, S.K.4    Park, Y.M.5    Lee, Y.I.6
  • 22
    • 33750316808 scopus 로고    scopus 로고
    • The interaction of hepatitis B virus X protein and protein phosphatase type 2 Cα and its effect on IL-6
    • J.S. Kim, B. Rho, T.H. Lee, J.M. Lee, S.J. Kim, and J.H. Park The interaction of hepatitis B virus X protein and protein phosphatase type 2 Cα and its effect on IL-6 Biochem Biophys Res Commun 351 2006 253 258
    • (2006) Biochem Biophys Res Commun , vol.351 , pp. 253-258
    • Kim, J.S.1    Rho, B.2    Lee, T.H.3    Lee, J.M.4    Kim, S.J.5    Park, J.H.6
  • 23
    • 0032959637 scopus 로고    scopus 로고
    • Human hepatitis B virus X protein augments the DNA binding of nuclear factor for IL-6 through its basic-leucine zipper domain
    • H. Ohno, S. Kaneko, Y. Lin, K. Kobayashi, and S. Murakami Human hepatitis B virus X protein augments the DNA binding of nuclear factor for IL-6 through its basic-leucine zipper domain J Med Virol 58 1999 11 18
    • (1999) J Med Virol , vol.58 , pp. 11-18
    • Ohno, H.1    Kaneko, S.2    Lin, Y.3    Kobayashi, K.4    Murakami, S.5
  • 24
    • 0032780007 scopus 로고    scopus 로고
    • 4-Hydroxynonenal triggers an epidermal growth factor receptor-linked signal pathway for growth inhibition
    • W. Liu, A.A. Akhand, M. Kato, I. Yokoyama, T. Miyata, and K. Kurokawa 4-Hydroxynonenal triggers an epidermal growth factor receptor-linked signal pathway for growth inhibition J Cell Sci 112 1999 2409 2417
    • (1999) J Cell Sci , vol.112 , pp. 2409-2417
    • Liu, W.1    Akhand, A.A.2    Kato, M.3    Yokoyama, I.4    Miyata, T.5    Kurokawa, K.6
  • 26
    • 0000934401 scopus 로고
    • Production of hepatitis B virus particles in Hep G2 cells transfected with cloned hepatitis B virus DNA
    • M.A. Sells, M.L. Chen, and G. Acs Production of hepatitis B virus particles in Hep G2 cells transfected with cloned hepatitis B virus DNA Proc Natl Acad Sci USA 84 1987 1005 1009
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 1005-1009
    • Sells, M.A.1    Chen, M.L.2    Acs, G.3
  • 27
    • 56549095016 scopus 로고    scopus 로고
    • Characterization of the innate immune signaling pathways in hepatocyte cell lines
    • S. Preiss, A. Thompson, X. Chen, S. Rodgers, V. Markovska, and P. Desmond Characterization of the innate immune signaling pathways in hepatocyte cell lines J Viral Hepat 15 2008 888 900
    • (2008) J Viral Hepat , vol.15 , pp. 888-900
    • Preiss, S.1    Thompson, A.2    Chen, X.3    Rodgers, S.4    Markovska, V.5    Desmond, P.6
  • 28
    • 0037454946 scopus 로고    scopus 로고
    • Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4
    • K. Burns, S. Janssens, B. Brissoni, N. Olivos, R. Beyaert, and J. Tschopp Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4 J Exp Med 197 2003 263 268
    • (2003) J Exp Med , vol.197 , pp. 263-268
    • Burns, K.1    Janssens, S.2    Brissoni, B.3    Olivos, N.4    Beyaert, R.5    Tschopp, J.6
  • 29
    • 33646069914 scopus 로고    scopus 로고
    • Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4
    • J.P. Powers, S. Li, J.C. Jaen, J. Liu, N.P. Walker, and Z. Wang Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4 Bioorg Med Chem Lett 16 2006 2842 2845
    • (2006) Bioorg Med Chem Lett , vol.16 , pp. 2842-2845
    • Powers, J.P.1    Li, S.2    Jaen, J.C.3    Liu, J.4    Walker, N.P.5    Wang, Z.6
  • 31
    • 18744399291 scopus 로고    scopus 로고
    • Toll-like receptor signaling inhibits hepatitis B virus replication in vivo
    • M. Isogawa, M.D. Robek, Y. Furuichi, and F.V. Chisari Toll-like receptor signaling inhibits hepatitis B virus replication in vivo J Virol 79 2005 7269 7272
    • (2005) J Virol , vol.79 , pp. 7269-7272
    • Isogawa, M.1    Robek, M.D.2    Furuichi, Y.3    Chisari, F.V.4
  • 32
    • 68949192626 scopus 로고    scopus 로고
    • Lipopolysaccharide inhibition of glucose production through the Toll-like receptor-4, myeloid differentiation factor 88, and nuclear factor kappa B pathway
    • C.F. Raetzsch, N.L. Brooks, J.M. Alderman, K.S. Moore, P.A. Hosick, and S. Klebanov Lipopolysaccharide inhibition of glucose production through the Toll-like receptor-4, myeloid differentiation factor 88, and nuclear factor kappa B pathway Hepatology 50 2009 592 600
    • (2009) Hepatology , vol.50 , pp. 592-600
    • Raetzsch, C.F.1    Brooks, N.L.2    Alderman, J.M.3    Moore, K.S.4    Hosick, P.A.5    Klebanov, S.6
  • 33
    • 44849129576 scopus 로고    scopus 로고
    • Sporozoite-mediated hepatocyte wounding limits Plasmodium parasite development via MyD88-mediated NF-kappa B activation and inducible NO synthase expression
    • R. Torgler, S.E. Bongfen, J.C. Romero, A. Tardivel, M. Thome, and G. Corradin Sporozoite-mediated hepatocyte wounding limits Plasmodium parasite development via MyD88-mediated NF-kappa B activation and inducible NO synthase expression J Immunol 180 2008 3990 3999
    • (2008) J Immunol , vol.180 , pp. 3990-3999
    • Torgler, R.1    Bongfen, S.E.2    Romero, J.C.3    Tardivel, A.4    Thome, M.5    Corradin, G.6
  • 34
    • 0036190849 scopus 로고    scopus 로고
    • Interaction between STAT-3 and HNF-3 leads to the activation of liver-specific hepatitis B virus enhancer 1 function
    • G. Waris, and A. Siddiqui Interaction between STAT-3 and HNF-3 leads to the activation of liver-specific hepatitis B virus enhancer 1 function J Virol 76 2002 2721 2729
    • (2002) J Virol , vol.76 , pp. 2721-2729
    • Waris, G.1    Siddiqui, A.2
  • 35
    • 73149094329 scopus 로고    scopus 로고
    • Not interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection
    • M. Hösel, M. Quasdorff, K. Wiegmann, D. Webb, U. Zedler, and M. Broxtermann Not interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection Hepatology 50 2009 1773 1782
    • (2009) Hepatology , vol.50 , pp. 1773-1782
    • Hösel, M.1    Quasdorff, M.2    Wiegmann, K.3    Webb, D.4    Zedler, U.5    Broxtermann, M.6
  • 36
    • 0242348793 scopus 로고    scopus 로고
    • Stat3 protects against Fas-induced liver injury by redox-dependent and -independent mechanisms
    • S. Haga, K. Terui, H.Q. Zhang, S. Enosawa, W. Ogawa, and H. Inoue Stat3 protects against Fas-induced liver injury by redox-dependent and -independent mechanisms J Clin Invest 112 2003 989 998
    • (2003) J Clin Invest , vol.112 , pp. 989-998
    • Haga, S.1    Terui, K.2    Zhang, H.Q.3    Enosawa, S.4    Ogawa, W.5    Inoue, H.6
  • 37
    • 85047689502 scopus 로고    scopus 로고
    • Hepatoprotection via the IL-6/Stat3 pathway
    • R. Taub Hepatoprotection via the IL-6/Stat3 pathway J Clin Invest 112 2003 978 980
    • (2003) J Clin Invest , vol.112 , pp. 978-980
    • Taub, R.1
  • 39
    • 65449117568 scopus 로고    scopus 로고
    • Hepatitis B virus suppresses toll-like receptor-mediated innate immune responses in murine parenchymal and nonparenchymal liver cells
    • J. Wu, Z. Meng, M. Jiang, R. Pei, M. Trippler, and R. Broering Hepatitis B virus suppresses toll-like receptor-mediated innate immune responses in murine parenchymal and nonparenchymal liver cells Hepatology 49 2009 1132 1140
    • (2009) Hepatology , vol.49 , pp. 1132-1140
    • Wu, J.1    Meng, Z.2    Jiang, M.3    Pei, R.4    Trippler, M.5    Broering, R.6


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