메뉴 건너뛰기




Volumn 8, Issue 9, 2012, Pages 1281-1290

Role of IL-6 in asthma and other inflammatory pulmonary diseases

Author keywords

Chronic lung diseases; IL 6

Indexed keywords

INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR;

EID: 84869834766     PISSN: 14492288     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijbs.4874     Document Type: Review
Times cited : (467)

References (87)
  • 1
    • 0344037977 scopus 로고
    • Synthesis of germ-line gamma 1 immunoglobulin heavy-chain transcripts in resting B cells: Induction by interleukin 4 and inhibition by interferon gamma
    • Berton MT, Uhr JW, Vitetta ES. Synthesis of germ-line gamma 1 immunoglobulin heavy-chain transcripts in resting B cells: induction by interleukin 4 and inhibition by interferon gamma. Proceedings of the National Academy of Sciences of the United States of America. 1989; 86: 2829-2833.
    • (1989) Proceedings of the National Academy of Sciences of the United States of America , vol.86 , pp. 2829-2833
    • Berton, M.T.1    Uhr, J.W.2    Vitetta, E.S.3
  • 2
    • 0032968706 scopus 로고    scopus 로고
    • Immunologic basis of antigen-induced airway hyperresponsiveness
    • Wills-Karp M. Immunologic basis of antigen-induced airway hyperresponsiveness. Annu Rev Immunol. 1999; 17: 255-281.
    • (1999) Annu Rev Immunol , vol.17 , pp. 255-281
    • Wills-Karp, M.1
  • 3
    • 0036846875 scopus 로고    scopus 로고
    • Interleukin-13 mediates a fundamental pathway for airway epithelial mucus induced by CD4 T cells and interleukin-9
    • Whittaker L, Niu N, Temann UA, Stoddard A, Flavell RA, Ray A, et al. Interleukin-13 mediates a fundamental pathway for airway epithelial mucus induced by CD4 T cells and interleukin-9. Am J Respir Cell Mol Biol. 2002; 27: 593-602.
    • (2002) Am J Respir Cell Mol Biol , vol.27 , pp. 593-602
    • Whittaker, L.1    Niu, N.2    Temann, U.A.3    Stoddard, A.4    Flavell, R.A.5    Ray, A.6
  • 7
    • 58149300244 scopus 로고    scopus 로고
    • IL-33 induces antigen-specific IL-5+ T cells and promotes allergic-induced airway inflammation independent of IL-4
    • Kurowska-Stolarska M, Kewin P, Murphy G, Russo RC, Stolarski B, Garcia CC, et al. IL-33 induces antigen-specific IL-5+ T cells and promotes allergic-induced airway inflammation independent of IL-4. J Immunol. 2008; 181: 4780-4790.
    • (2008) J Immunol , vol.181 , pp. 4780-4790
    • Kurowska-Stolarska, M.1    Kewin, P.2    Murphy, G.3    Russo, R.C.4    Stolarski, B.5    Garcia, C.C.6
  • 8
    • 25144525707 scopus 로고    scopus 로고
    • A role for TSLP in the development of inflammation in an asthma model
    • Al-Shami A, Spolski R, Kelly J, Keane-Myers A, Leonard WJ. A role for TSLP in the development of inflammation in an asthma model. J Exp Med. 2005; 202: 829-839.
    • (2005) J Exp Med , vol.202 , pp. 829-839
    • Al-Shami, A.1    Spolski, R.2    Kelly, J.3    Keane-Myers, A.4    Leonard, W.J.5
  • 9
    • 0026583649 scopus 로고
    • Expression of the potent inflammatory cytokines, granulocyte-macrophage-colony-stimulating factor and interleukin-6 and interleukin-8, in bronchial epithelial cells of patients with asthma
    • Marini M, Vittori E, Hollemborg J, Mattoli S. Expression of the potent inflammatory cytokines, granulocyte-macrophage-colony-stimulating factor and interleukin-6 and interleukin-8, in bronchial epithelial cells of patients with asthma. J Allergy Clin Immunol. 1992; 89: 1001-1009.
    • (1992) J Allergy Clin Immunol , vol.89 , pp. 1001-1009
    • Marini, M.1    Vittori, E.2    Hollemborg, J.3    Mattoli, S.4
  • 10
    • 0028075824 scopus 로고
    • Cytokine production by epithelial cells
    • Stadnyk AW. Cytokine production by epithelial cells. Faseb J. 1994; 8: 1041-1047.
    • (1994) Faseb J , vol.8 , pp. 1041-1047
    • Stadnyk, A.W.1
  • 14
    • 57149107119 scopus 로고    scopus 로고
    • The effects of IL-6 on CD4 T cell responses
    • Dienz O, Rincon M. The effects of IL-6 on CD4 T cell responses. Clin Immunol. 2009; 130: 27-33.
    • (2009) Clin Immunol , vol.130 , pp. 27-33
    • Dienz, O.1    Rincon, M.2
  • 15
    • 0031913593 scopus 로고    scopus 로고
    • Interleukin 6 and its receptor: Ten years later
    • Hirano T. Interleukin 6 and its receptor: ten years later. Intern Rev Immunol. 1998; 16: 249-284.
    • (1998) Intern Rev Immunol , vol.16 , pp. 249-284
    • Hirano, T.1
  • 16
    • 77953980528 scopus 로고    scopus 로고
    • IL-6: From its discovery to clinical applications
    • Kishimoto T. IL-6: from its discovery to clinical applications. Int Immunol. 2010; 22: 347-352.
    • (2010) Int Immunol , vol.22 , pp. 347-352
    • Kishimoto, T.1
  • 17
    • 0008249094 scopus 로고    scopus 로고
    • Balance between proinflammatory cytokines and their inhibitors in bronchial lavage from patients with status asthmaticus
    • Tillie-Leblond I, Pugin J, Marquette CH, Lamblin C, Saulnier F, Brichet A, et al. Balance between proinflammatory cytokines and their inhibitors in bronchial lavage from patients with status asthmaticus. Am J Respir Crit Care Med. 1999; 159: 487-494.
    • (1999) Am J Respir Crit Care Med , vol.159 , pp. 487-494
    • Tillie-Leblond, I.1    Pugin, J.2    Marquette, C.H.3    Lamblin, C.4    Saulnier, F.5    Brichet, A.6
  • 18
    • 0029949570 scopus 로고    scopus 로고
    • Inflammatory determinants of asthma severity: Mediator and cellular changes in bronchoalveolar lavage fluid of patients with severe asthma
    • Virchow JCJr., Kroegel C, Walker C, Matthys H. Inflammatory determinants of asthma severity: mediator and cellular changes in bronchoalveolar lavage fluid of patients with severe asthma. J Allergy Clin Immunol. 1996; 98: S27-33S.
    • (1996) J Allergy Clin Immunol , vol.98
    • Virchow, J.C.1    Kroegel, C.2    Walker, C.3    Matthys, H.4
  • 19
    • 77952536377 scopus 로고    scopus 로고
    • Elevation of IL-6 in the allergic asthmatic airway is independent of inflammation but associates with loss of central airway function
    • Neveu WA, Allard JL, Raymond DM, Bourassa LM, Burns SM, Bunn JY, et al. Elevation of IL-6 in the allergic asthmatic airway is independent of inflammation but associates with loss of central airway function. Respir Res. 2010; 11: 28.
    • (2010) Respir Res , vol.11 , pp. 28
    • Neveu, W.A.1    Allard, J.L.2    Raymond, D.M.3    Bourassa, L.M.4    Burns, S.M.5    Bunn, J.Y.6
  • 20
    • 0026485304 scopus 로고
    • Interleukin-6 and its receptor: A paradigm for cytokines
    • Kishimoto T, Akira S, Taga T. Interleukin-6 and its receptor: a paradigm for cytokines. Science. 1992; 258: 593-597.
    • (1992) Science , vol.258 , pp. 593-597
    • Kishimoto, T.1    Akira, S.2    Taga, T.3
  • 21
    • 0031432550 scopus 로고    scopus 로고
    • IL-6-regulated transcription factors
    • Akira S. IL-6-regulated transcription factors. Int J Biochem Cell Biol. 1997; 29: 1401-1418.
    • (1997) Int J Biochem Cell Biol , vol.29 , pp. 1401-1418
    • Akira, S.1
  • 22
    • 0028303977 scopus 로고
    • Molecular cloning of APRF, a novel IFN-stimulated gene factor3 p91-related transcriptional factor involved in the gp130 stimulated signaling pathway
    • Akira S, Nishio Y, Inoue M, Wang X, Wei S, Matsusaka T, et al. Molecular cloning of APRF, a novel IFN-stimulated gene factor3 p91-related transcriptional factor involved in the gp130 stimulated signaling pathway. Cell. 1994; 77: 63-71.
    • (1994) Cell , vol.77 , pp. 63-71
    • Akira, S.1    Nishio, Y.2    Inoue, M.3    Wang, X.4    Wei, S.5    Matsusaka, T.6
  • 23
    • 0026611673 scopus 로고
    • IL-6 and NF-IL6 in acute-phase response and viral infection
    • Akira S, Kishimoto T. IL-6 and NF-IL6 in acute-phase response and viral infection. Immunol Rev. 1992; 127: 25-50.
    • (1992) Immunol Rev , vol.127 , pp. 25-50
    • Akira, S.1    Kishimoto, T.2
  • 24
    • 0037064542 scopus 로고    scopus 로고
    • The role of soluble receptors in cytokine biology: The agonistic properties of the sIL-6R/IL-6 complex
    • Jones SA, Rose-John S. The role of soluble receptors in cytokine biology: the agonistic properties of the sIL-6R/IL-6 complex. Biochim Biophys Acta. 2002; 1592: 251-263.
    • (2002) Biochim Biophys Acta , vol.1592 , pp. 251-263
    • Jones, S.A.1    Rose-John, S.2
  • 25
    • 33748848714 scopus 로고    scopus 로고
    • Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: Role in inflammation and cancer
    • Rose-John S, Scheller J, Elson G, Jones SA. Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer. J Leukoc Biol. 2006; 80: 227-236.
    • (2006) J Leukoc Biol , vol.80 , pp. 227-236
    • Rose-John, S.1    Scheller, J.2    Elson, G.3    Jones, S.A.4
  • 26
    • 0028270409 scopus 로고
    • The soluble human IL-6 receptor. Mutational characterization of the proteolytic cleavage site
    • Mullberg J, Oberthur W, Lottspeich F, Mehl E, Dittrich E, Graeve L, et al. The soluble human IL-6 receptor. Mutational characterization of the proteolytic cleavage site. J Immunol. 1994; 152: 4958-4968.
    • (1994) J Immunol , vol.152 , pp. 4958-4968
    • Mullberg, J.1    Oberthur, W.2    Lottspeich, F.3    Mehl, E.4    Dittrich, E.5    Graeve, L.6
  • 27
    • 0028087834 scopus 로고
    • Soluble interleukin-6 receptors released from T cell or granulocyte/macrophage cell lines and human peripheral blood mononuclear cells are generated through an alternative splicing mechanism
    • Horiuchi S, Koyanagi Y, Zhou Y, Miyamoto H, Tanaka Y, Waki M, et al. Soluble interleukin-6 receptors released from T cell or granulocyte/macrophage cell lines and human peripheral blood mononuclear cells are generated through an alternative splicing mechanism. Eur J Immunol. 1994; 24: 1945-1948.
    • (1994) Eur J Immunol , vol.24 , pp. 1945-1948
    • Horiuchi, S.1    Koyanagi, Y.2    Zhou, Y.3    Miyamoto, H.4    Tanaka, Y.5    Waki, M.6
  • 28
    • 47249089967 scopus 로고    scopus 로고
    • Cutting edge: Soluble IL-6R is produced by IL-6R ectodomain shedding in activated CD4 T cells
    • Briso EM, Dienz O, Rincon M. Cutting edge: soluble IL-6R is produced by IL-6R ectodomain shedding in activated CD4 T cells. J Immunol. 2008; 180: 7102-7106.
    • (2008) J Immunol , vol.180 , pp. 7102-7106
    • Briso, E.M.1    Dienz, O.2    Rincon, M.3
  • 29
    • 77949881389 scopus 로고    scopus 로고
    • Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells
    • Jones GW, McLoughlin RM, Hammond VJ, Parker CR, Williams JD, Malhotra R, et al. Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells. J Immunol. 2010; 184: 2130-2139.
    • (2010) J Immunol , vol.184 , pp. 2130-2139
    • Jones, G.W.1    McLoughlin, R.M.2    Hammond, V.J.3    Parker, C.R.4    Williams, J.D.5    Malhotra, R.6
  • 30
    • 20144375594 scopus 로고    scopus 로고
    • The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo
    • Doganci A, Eigenbrod T, Krug N, De Sanctis GT, Hausding M, Erpenbeck VJ, et al. The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo. J Clin Invest. 2005; 115: 313-325.
    • (2005) J Clin Invest , vol.115 , pp. 313-325
    • Doganci, A.1    Eigenbrod, T.2    Krug, N.3    de Sanctis, G.T.4    Hausding, M.5    Erpenbeck, V.J.6
  • 34
    • 0026719193 scopus 로고
    • Aerosolized antigen exposure without adjuvant causes increased IgE production and increased airway responsiveness in the mouse
    • Renz H, Smith HR, Henson JE, Ray BS, Irvin CG, Gelfand EW. Aerosolized antigen exposure without adjuvant causes increased IgE production and increased airway responsiveness in the mouse. J Allergy Clin Immunol. 1992; 89: 1127-1138.
    • (1992) J Allergy Clin Immunol , vol.89 , pp. 1127-1138
    • Renz, H.1    Smith, H.R.2    Henson, J.E.3    Ray, B.S.4    Irvin, C.G.5    Gelfand, E.W.6
  • 35
    • 0028328436 scopus 로고
    • Impaired immune and acute-phase responses in interleukin-6-deficient mice
    • Kopf M, Baumann H, Freer G, Freudenberg M, Lamers M, Kishimoto T, et al. Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature. 1994; 368: 339-342.
    • (1994) Nature , vol.368 , pp. 339-342
    • Kopf, M.1    Baumann, H.2    Freer, G.3    Freudenberg, M.4    Lamers, M.5    Kishimoto, T.6
  • 36
    • 0034292488 scopus 로고    scopus 로고
    • Endogenous and exogenous IL-6 inhibit aeroallergen-induced Th2 inflammation
    • Wang J, Homer RJ, Chen Q, Elias JA. Endogenous and exogenous IL-6 inhibit aeroallergen-induced Th2 inflammation. J Immunol. 2000; 165: 4051-4061.
    • (2000) J Immunol , vol.165 , pp. 4051-4061
    • Wang, J.1    Homer, R.J.2    Chen, Q.3    Elias, J.A.4
  • 37
    • 0028173026 scopus 로고
    • Airway epithelial cell expression of interleukin-6 in transgenic mice. Uncoupling of airway inflammation and bronchial hyperreactivity
    • DiCosmo BF, Geba GP, Picarella D, Elias JA, Rankin JA, Stripp BR, et al. Airway epithelial cell expression of interleukin-6 in transgenic mice. Uncoupling of airway inflammation and bronchial hyperreactivity. J Clin Invest. 1994; 94: 2028-2035.
    • (1994) J Clin Invest , vol.94 , pp. 2028-2035
    • Dicosmo, B.F.1    Geba, G.P.2    Picarella, D.3    Elias, J.A.4    Rankin, J.A.5    Stripp, B.R.6
  • 38
    • 4143119932 scopus 로고    scopus 로고
    • Enhanced airway inflammation and decreased subepithelial fibrosis in interleukin 6-deficient mice following chronic exposure to aerosolized antigen
    • Qiu Z, Fujimura M, Kurashima K, Nakao S, Mukaida N. Enhanced airway inflammation and decreased subepithelial fibrosis in interleukin 6-deficient mice following chronic exposure to aerosolized antigen. Clin Exp Allergy. 2004; 34: 1321-1328.
    • (2004) Clin Exp Allergy , vol.34 , pp. 1321-1328
    • Qiu, Z.1    Fujimura, M.2    Kurashima, K.3    Nakao, S.4    Mukaida, N.5
  • 39
    • 45749111446 scopus 로고    scopus 로고
    • Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants
    • Eisenbarth SC, Colegio OR, O'Connor W, Sutterwala FS, Flavell RA. Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants. Nature. 2008; 453: 1122-1126.
    • (2008) Nature , vol.453 , pp. 1122-1126
    • Eisenbarth, S.C.1    Colegio, O.R.2    O'Connor, W.3    Sutterwala, F.S.4    Flavell, R.A.5
  • 40
    • 68149183241 scopus 로고    scopus 로고
    • IL-6 is required for airway mucus production induced by inhaled fungal allergens
    • Neveu W, Allard JB, Dienz O, Wargo MJ, Ciliberto G, Whittaker LA, et al. IL-6 is required for airway mucus production induced by inhaled fungal allergens. J Immunol. 2009; 183: 1732-1738.
    • (2009) J Immunol , vol.183 , pp. 1732-1738
    • Neveu, W.1    Allard, J.B.2    Dienz, O.3    Wargo, M.J.4    Ciliberto, G.5    Whittaker, L.A.6
  • 41
    • 33749532124 scopus 로고    scopus 로고
    • Aspergillus fumigatus generates an enhanced Th2-biased immune response in mice with defective cystic fibrosis transmembrane conductance regulator
    • Allard JB, Poynter ME, Marr KA, Cohn L, Rincon M, Whittaker LA. Aspergillus fumigatus generates an enhanced Th2-biased immune response in mice with defective cystic fibrosis transmembrane conductance regulator. J Immunol. 2006; 177: 5186-5194.
    • (2006) J Immunol , vol.177 , pp. 5186-5194
    • Allard, J.B.1    Poynter, M.E.2    Marr, K.A.3    Cohn, L.4    Rincon, M.5    Whittaker, L.A.6
  • 42
    • 64049104440 scopus 로고    scopus 로고
    • Th2 allergic immune response to inhaled fungal antigens is modulated by TLR-4-independent bacterial products
    • Allard JB, Rinaldi L, Wargo MJ, Allen G, Akira S, Uematsu S, et al. Th2 allergic immune response to inhaled fungal antigens is modulated by TLR-4-independent bacterial products. Eur J Immunol. 2009; 39: 776-788.
    • (2009) Eur J Immunol , vol.39 , pp. 776-788
    • Allard, J.B.1    Rinaldi, L.2    Wargo, M.J.3    Allen, G.4    Akira, S.5    Uematsu, S.6
  • 43
    • 0028266906 scopus 로고
    • Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion
    • Poli V, Balena R, Fattori E, Markatos A, Yamamoto M, Tanaka H, et al. Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion. EMBO J. 1994; 13: 1189-1196.
    • (1994) EMBO J , vol.13 , pp. 1189-1196
    • Poli, V.1    Balena, R.2    Fattori, E.3    Markatos, A.4    Yamamoto, M.5    Tanaka, H.6
  • 44
    • 34447572925 scopus 로고    scopus 로고
    • Local blockade of IL-6R signaling induces lung CD4+ T cell apoptosis in a murine model of asthma via regulatory T cells
    • Finotto S, Eigenbrod T, Karwot R, Boross I, Doganci A, Ito H, et al. Local blockade of IL-6R signaling induces lung CD4+ T cell apoptosis in a murine model of asthma via regulatory T cells. Int Immunol. 2007; 19: 685-693.
    • (2007) Int Immunol , vol.19 , pp. 685-693
    • Finotto, S.1    Eigenbrod, T.2    Karwot, R.3    Boross, I.4    Doganci, A.5    Ito, H.6
  • 45
    • 81755184476 scopus 로고    scopus 로고
    • Anti-interleukin-6 receptor antibody, tocilizumab, for the treatment of autoimmune diseases
    • Tanaka T, Narazaki M, Kishimoto T. Anti-interleukin-6 receptor antibody, tocilizumab, for the treatment of autoimmune diseases. FEBS Lett. 2011; 585: 3699-3709.
    • (2011) FEBS Lett , vol.585 , pp. 3699-3709
    • Tanaka, T.1    Narazaki, M.2    Kishimoto, T.3
  • 47
    • 44949201115 scopus 로고    scopus 로고
    • A genome-wide association study identifies protein quantitative trait loci (pQTLs)
    • Melzer D, Perry JR, Hernandez D, Corsi AM, Stevens K, Rafferty I, et al. A genome-wide association study identifies protein quantitative trait loci (pQTLs). PLoS Genet. 2008; 4: e1000072.
    • (2008) PLoS Genet , vol.e1000072 , pp. 4
    • Melzer, D.1    Perry, J.R.2    Hernandez, D.3    Corsi, A.M.4    Stevens, K.5    Rafferty, I.6
  • 48
    • 35548974357 scopus 로고    scopus 로고
    • A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects
    • Rafiq S, Frayling TM, Murray A, Hurst A, Stevens K, Weedon MN, et al. A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects. Genes Immun. 2007; 8: 552-559.
    • (2007) Genes Immun , vol.8 , pp. 552-559
    • Rafiq, S.1    Frayling, T.M.2    Murray, A.3    Hurst, A.4    Stevens, K.5    Weedon, M.N.6
  • 49
    • 34147171031 scopus 로고    scopus 로고
    • Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels
    • Reich D, Patterson N, Ramesh V, De Jager PL, McDonald GJ, Tandon A, et al. Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels. Am J Hum Genet. 2007; 80: 716-726.
    • (2007) Am J Hum Genet , vol.80 , pp. 716-726
    • Reich, D.1    Patterson, N.2    Ramesh, V.3    de Jager, P.L.4    McDonald, G.J.5    Tandon, A.6
  • 50
    • 4644371697 scopus 로고    scopus 로고
    • Polymorphisms in the IL-6 receptor (IL-6R) gene: Strong evidence that serum levels of soluble IL-6R are genetically influenced
    • Galicia JC, Tai H, Komatsu Y, Shimada Y, Akazawa K, Yoshie H. Polymorphisms in the IL-6 receptor (IL-6R) gene: strong evidence that serum levels of soluble IL-6R are genetically influenced. Genes Immun. 2004; 5: 513-516.
    • (2004) Genes Immun , vol.5 , pp. 513-516
    • Galicia, J.C.1    Tai, H.2    Komatsu, Y.3    Shimada, Y.4    Akazawa, K.5    Yoshie, H.6
  • 51
    • 0035164602 scopus 로고    scopus 로고
    • The soluble interleukin 6 receptor: Mechanisms of production and implications in disease
    • Jones SA, Horiuchi S, Topley N, Yamamoto N, Fuller GM. The soluble interleukin 6 receptor: mechanisms of production and implications in disease. Faseb J. 2001; 15: 43-58.
    • (2001) Faseb J , vol.15 , pp. 43-58
    • Jones, S.A.1    Horiuchi, S.2    Topley, N.3    Yamamoto, N.4    Fuller, G.M.5
  • 52
    • 84864485029 scopus 로고    scopus 로고
    • The IL6R variation Asp(358)Ala is a potential modifier of lung function in subjects with asthma
    • Aug
    • Hawkins GA, Robinson MB, Hastie AT, Li X, Li H, Moore WC, et al. The IL6R variation Asp(358)Ala is a potential modifier of lung function in subjects with asthma. J Allergy Clin Immunol. 2012 Aug;130(2):510-515.
    • (2012) J Allergy Clin Immunol , vol.130 , Issue.2 , pp. 510-515
    • Hawkins, G.A.1    Robinson, M.B.2    Hastie, A.T.3    Li, X.4    Li, H.5    Moore, W.C.6
  • 55
    • 77950866526 scopus 로고    scopus 로고
    • Sputum biomarker profiles in cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) and association between pulmonary function
    • Eickmeier O, Huebner M, Herrmann E, Zissler U, Rosewich M, Baer PC, et al. Sputum biomarker profiles in cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) and association between pulmonary function. Cytokine. 2010; 50: 152-157.
    • (2010) Cytokine , vol.50 , pp. 152-157
    • Eickmeier, O.1    Huebner, M.2    Herrmann, E.3    Zissler, U.4    Rosewich, M.5    Baer, P.C.6
  • 56
    • 84861410475 scopus 로고    scopus 로고
    • Inflammatory biomarkers improve clinical prediction of mortality in chronic obstructive pulmonary disease
    • Celli BR, Locantore N, Yates J, Tal-Singer R, Miller BE, Bakke P, et al. Inflammatory biomarkers improve clinical prediction of mortality in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2012; 185: 1065-1072.
    • (2012) Am J Respir Crit Care Med , vol.185 , pp. 1065-1072
    • Celli, B.R.1    Locantore, N.2    Yates, J.3    Tal-Singer, R.4    Miller, B.E.5    Bakke, P.6
  • 57
    • 84862100999 scopus 로고    scopus 로고
    • Persistent systemic inflammation is associated with poor clinical outcomes in COPD: A novel phenotype
    • Agusti A, Edwards LD, Rennard SI, MacNee W, Tal-Singer R, Miller BE, et al. Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype. PLoS One. 2012; 7: e37483.
    • (2012) PLoS One , vol.e37483 , pp. 7
    • Agusti, A.1    Edwards, L.D.2    Rennard, S.I.3    Macnee, W.4    Tal-Singer, R.5    Miller, B.E.6
  • 58
    • 68049112522 scopus 로고    scopus 로고
    • Associations of IL6 polymorphisms with lung function decline and COPD
    • He JQ, Foreman MG, Shumansky K, Zhang X, Akhabir L, Sin DD, et al. Associations of IL6 polymorphisms with lung function decline and COPD. Thorax. 2009; 64: 698-704.
    • (2009) Thorax , vol.64 , pp. 698-704
    • He, J.Q.1    Foreman, M.G.2    Shumansky, K.3    Zhang, X.4    Akhabir, L.5    Sin, D.D.6
  • 60
    • 33846111415 scopus 로고    scopus 로고
    • Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans
    • Franceschi C, Capri M, Monti D, Giunta S, Olivieri F, Sevini F, et al. Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev. 2007; 128: 92-105.
    • (2007) Mech Ageing Dev , vol.128 , pp. 92-105
    • Franceschi, C.1    Capri, M.2    Monti, D.3    Giunta, S.4    Olivieri, F.5    Sevini, F.6
  • 61
    • 57349120676 scopus 로고    scopus 로고
    • Future treatments for chronic obstructive pulmonary disease and its comorbidities
    • Barnes PJ. Future treatments for chronic obstructive pulmonary disease and its comorbidities. Proc Am Thorac Soc. 2008; 5: 857-864.
    • (2008) Proc Am Thorac Soc , vol.5 , pp. 857-864
    • Barnes, P.J.1
  • 62
    • 60549108257 scopus 로고    scopus 로고
    • Increased reactivity of dendritic cells from aged subjects to self-antigen, the human DNA
    • Agrawal A, Tay J, Ton S, Agrawal S, Gupta S. Increased reactivity of dendritic cells from aged subjects to self-antigen, the human DNA. J Immunol. 2009; 182: 1138-1145.
    • (2009) J Immunol , vol.182 , pp. 1138-1145
    • Agrawal, A.1    Tay, J.2    Ton, S.3    Agrawal, S.4    Gupta, S.5
  • 63
    • 73149118480 scopus 로고    scopus 로고
    • The aging immune system and its relationship to the development of chronic obstructive pulmonary disease
    • Sharma G, Hanania NA, Shim YM. The aging immune system and its relationship to the development of chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2009; 6: 573-580.
    • (2009) Proc Am Thorac Soc , vol.6 , pp. 573-580
    • Sharma, G.1    Hanania, N.A.2    Shim, Y.M.3
  • 66
  • 68
    • 0036645028 scopus 로고    scopus 로고
    • Induction of NFATc2 expression by interleukin 6 promotes T helper type 2 differentiation
    • Diehl S, Chow CW, Weiss L, Palmetshofer A, Twardzik T, Rounds L, et al. Induction of NFATc2 expression by interleukin 6 promotes T helper type 2 differentiation. J Exp Med. 2002; 196: 39-49.
    • (2002) J Exp Med , vol.196 , pp. 39-49
    • Diehl, S.1    Chow, C.W.2    Weiss, L.3    Palmetshofer, A.4    Twardzik, T.5    Rounds, L.6
  • 69
    • 0036889996 scopus 로고    scopus 로고
    • The two faces of IL-6 on Th1/Th2 differentiation
    • Diehl S, Rincon M. The two faces of IL-6 on Th1/Th2 differentiation. Mol Immunol. 2002; 39: 531-536.
    • (2002) Mol Immunol , vol.39 , pp. 531-536
    • Diehl, S.1    Rincon, M.2
  • 71
    • 0034864617 scopus 로고    scopus 로고
    • Cytokine-directed therapies for asthma
    • Barnes PJ. Cytokine-directed therapies for asthma. J Allergy Clin Immunol. 2001; 108: S72-76S.
    • (2001) J Allergy Clin Immunol , vol.108
    • Barnes, P.J.1
  • 72
    • 60549105041 scopus 로고    scopus 로고
    • The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells
    • Dienz O, Eaton SM, Bond JP, Neveu W, Moquin D, Noubade R, et al. The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells. J Exp Med. 2009; 206: 69-78.
    • (2009) J Exp Med , vol.206 , pp. 69-78
    • Dienz, O.1    Eaton, S.M.2    Bond, J.P.3    Neveu, W.4    Moquin, D.5    Noubade, R.6
  • 73
    • 0037159687 scopus 로고    scopus 로고
    • A critical role for IL-21 in regulating immunoglobulin production
    • Ozaki K, Spolski R, Feng CG, Qi CF, Cheng J, Sher A, et al. A critical role for IL-21 in regulating immunoglobulin production. Science. 2002; 298: 1630-1634.
    • (2002) Science , vol.298 , pp. 1630-1634
    • Ozaki, K.1    Spolski, R.2    Feng, C.G.3    Qi, C.F.4    Cheng, J.5    Sher, A.6
  • 74
    • 33750460981 scopus 로고    scopus 로고
    • IgE isotype switch and IgE production are enhanced in IL-21-deficient but not IFN-gamma-deficient mice in a Th2-biased response
    • Shang XZ, Ma KY, Radewonuk J, Li J, Song XY, Griswold DE, et al. IgE isotype switch and IgE production are enhanced in IL-21-deficient but not IFN-gamma-deficient mice in a Th2-biased response. Cell Immunol. 2006; 241: 66-74.
    • (2006) Cell Immunol , vol.241 , pp. 66-74
    • Shang, X.Z.1    Ma, K.Y.2    Radewonuk, J.3    Li, J.4    Song, X.Y.5    Griswold, D.E.6
  • 75
    • 84866167232 scopus 로고    scopus 로고
    • A Phase 1, Randomized, Placebo-Controlled, Dose-Escalation Study of an Anti-IL-13 Monoclonal Antibody in Healthy Subjects and Mild Asthmatics
    • Hodsman GP, Ashman C, Cahn A, De Boever E, Locantore N, Serone A, et al. A Phase 1, Randomized, Placebo-Controlled, Dose-Escalation Study of an Anti-IL-13 Monoclonal Antibody in Healthy Subjects and Mild Asthmatics. Br J Clin Pharmacol. 2012.
    • (2012) Br J Clin Pharmacol
    • Hodsman, G.P.1    Ashman, C.2    Cahn, A.3    de Boever, E.4    Locantore, N.5    Serone, A.6
  • 76
    • 77952022559 scopus 로고    scopus 로고
    • An open-label, single-dose bioavailability study of the pharmacokinetics of CAT-354 after subcutaneous and intravenous administration in healthy males
    • Oh CK, Faggioni R, Jin F, Roskos LK, Wang B, Birrell C, et al. An open-label, single-dose bioavailability study of the pharmacokinetics of CAT-354 after subcutaneous and intravenous administration in healthy males. Br J Clin Pharmacol. 2010; 69: 645-655.
    • (2010) Br J Clin Pharmacol , vol.69 , pp. 645-655
    • Oh, C.K.1    Faggioni, R.2    Jin, F.3    Roskos, L.K.4    Wang, B.5    Birrell, C.6
  • 77
    • 76749141384 scopus 로고    scopus 로고
    • A phase 1 study evaluating the pharmacokinetics, safety and tolerability of repeat dosing with a human IL-13 antibody (CAT-354) in subjects with asthma
    • Singh D, Kane B, Molfino NA, Faggioni R, Roskos L, Woodcock A. A phase 1 study evaluating the pharmacokinetics, safety and tolerability of repeat dosing with a human IL-13 antibody (CAT-354) in subjects with asthma. BMC Pulm Med. 2010; 10: 3.
    • (2010) BMC Pulm Med , vol.10 , pp. 3
    • Singh, D.1    Kane, B.2    Molfino, N.A.3    Faggioni, R.4    Roskos, L.5    Woodcock, A.6
  • 78
    • 0033560126 scopus 로고    scopus 로고
    • Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
    • Zhu Z, Homer RJ, Wang Z, Chen Q, Geba GP, Wang J, et al. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest. 1999; 103: 779-788.
    • (1999) J Clin Invest , vol.103 , pp. 779-788
    • Zhu, Z.1    Homer, R.J.2    Wang, Z.3    Chen, Q.4    Geba, G.P.5    Wang, J.6
  • 79
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 2006; 441: 235-238.
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3    Korn, T.4    Strom, T.B.5    Oukka, M.6
  • 80
    • 32244442562 scopus 로고    scopus 로고
    • TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    • Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity. 2006; 24: 179-189.
    • (2006) Immunity , vol.24 , pp. 179-189
    • Veldhoen, M.1    Hocking, R.J.2    Atkins, C.J.3    Locksley, R.M.4    Stockinger, B.5
  • 84
    • 0344585384 scopus 로고    scopus 로고
    • Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice
    • Nakae S, Nambu A, Sudo K, Iwakura Y. Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice. J Immunol. 2003; 171: 6173-6177.
    • (2003) J Immunol , vol.171 , pp. 6173-6177
    • Nakae, S.1    Nambu, A.2    Sudo, K.3    Iwakura, Y.4
  • 85
    • 21844443152 scopus 로고    scopus 로고
    • Interleukin-17 induces hyperresponsive interleukin-8 and interleukin-6 production to tumor necrosis factor-alpha in structural lung cells
    • van den Berg A, Kuiper M, Snoek M, Timens W, Postma DS, Jansen HM, et al. Interleukin-17 induces hyperresponsive interleukin-8 and interleukin-6 production to tumor necrosis factor-alpha in structural lung cells. Am J Respir Cell Mol Biol. 2005; 33: 97-104.
    • (2005) Am J Respir Cell Mol Biol , vol.33 , pp. 97-104
    • van den Berg, A.1    Kuiper, M.2    Snoek, M.3    Timens, W.4    Postma, D.S.5    Jansen, H.M.6
  • 86
    • 0037436119 scopus 로고    scopus 로고
    • Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells
    • Pasare C, Medzhitov R. Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science. 2003; 299: 1033-1036.
    • (2003) Science , vol.299 , pp. 1033-1036
    • Pasare, C.1    Medzhitov, R.2
  • 87
    • 77954096689 scopus 로고    scopus 로고
    • IL-6: Regulator of Treg/Th17 balance
    • Kimura A, Kishimoto T. IL-6: regulator of Treg/Th17 balance. Eur J Immunol. 2010; 40: 1830-1835.
    • (2010) Eur J Immunol , vol.40 , pp. 1830-1835
    • Kimura, A.1    Kishimoto, T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.