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Volumn 53, Issue 5, 2012, Pages 875-885

Hepatitis B precore protein: Pathogenic potential and therapeutic promise

Author keywords

Chronic hepatitis B; Hepatitis B e antigen; Intrabody; Precore protein

Indexed keywords

ADEFOVIR; ALPHA INTERFERON; ENTECAVIR; HEPATITIS B ANTIBODY; HEPATITIS B CORE ANTIGEN; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B VIRUS X PROTEIN; HEPATITIS B(E) ANTIGEN; IMMUNOGLOBULIN; IMMUNOGLOBULIN G; LAMIVUDINE; NUCLEOSIDE DERIVATIVE; PEGINTERFERON ALPHA; TELBIVUDINE; TENOFOVIR; VIRUS DNA;

EID: 84864583849     PISSN: 05135796     EISSN: None     Source Type: Journal    
DOI: 10.3349/ymj.2012.53.5.875     Document Type: Review
Times cited : (27)

References (73)
  • 1
    • 0029784673 scopus 로고    scopus 로고
    • Global status of hepatitis B immunisation
    • Kane MA. Global status of hepatitis B immunisation. Lancet 1996;348:6.
    • (1996) Lancet , vol.348 , pp. 696
    • Kane, M.A.1
  • 2
    • 1642410856 scopus 로고    scopus 로고
    • Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures
    • Lavanchy D. Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. J Viral Hepat 2004;11:97-107.
    • (2004) J Viral Hepat , vol.11 , pp. 97-107
    • Lavanchy, D.1
  • 3
    • 83455179343 scopus 로고    scopus 로고
    • HBV genotypes: Relevance to natural history, pathogenesis and treatment of chronic hepatitis B
    • Kim BK, Revill PA, Ahn SH. HBV genotypes: relevance to natural history, pathogenesis and treatment of chronic hepatitis B. Antivir Ther 2011;16:1169-86.
    • (2011) Antivir Ther , vol.16 , pp. 1169-1186
    • Kim, B.K.1    Revill, P.A.2    Ahn, S.H.3
  • 4
    • 35448983168 scopus 로고    scopus 로고
    • The natural history of chronic hepatitis B
    • Lai CL, Yuen MF. The natural history of chronic hepatitis B. J Viral Hepat 2007;14 Suppl 1:6-10.
    • (2007) J Viral Hepat , vol.14 , Issue.SUPPL. 1 , pp. 6-10
    • Lai, C.L.1    Yuen, M.F.2
  • 5
    • 65049088247 scopus 로고    scopus 로고
    • The influence of hepatitis B virus genotype and subgenotype on the natural history of chronic hepatitis B
    • McMahon BJ. The influence of hepatitis B virus genotype and subgenotype on the natural history of chronic hepatitis B. Hepatol Int 2009;3:334-42.
    • (2009) Hepatol Int , vol.3 , pp. 334-342
    • McMahon, B.J.1
  • 6
    • 0142151773 scopus 로고    scopus 로고
    • Exploring the biological basis of hepatitis B e antigen in hepatitis B virus infection
    • Milich D, Liang TJ. Exploring the biological basis of hepatitis B e antigen in hepatitis B virus infection. Hepatology 2003;38:1075-86.
    • (2003) Hepatology , vol.38 , pp. 1075-1086
    • Milich, D.1    Liang, T.J.2
  • 7
    • 0023220790 scopus 로고
    • Expression of the precore region of an avian hepatitis B virus is not required for viral replication
    • Chang C, Enders G, Sprengel R, Peters N, Varmus HE, Ganem D. Expression of the precore region of an avian hepatitis B virus is not required for viral replication. J Virol 1987;61:3322-5.
    • (1987) J Virol , vol.61 , pp. 3322-3325
    • Chang, C.1    Enders, G.2    Sprengel, R.3    Peters, N.4    Varmus, H.E.5    Ganem, D.6
  • 8
    • 6944244922 scopus 로고    scopus 로고
    • A function of the hepatitis B virus precore protein is to regulate the immune response to the core antigen
    • Chen MT, Billaud JN, Sällberg M, Guidotti LG, Chisari FV, Jones J, et al. A function of the hepatitis B virus precore protein is to regulate the immune response to the core antigen. Proc Natl Acad Sci U S A 2004;101:14913-8.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 14913-14918
    • Chen, M.T.1    Billaud, J.N.2    Sällberg, M.3    Guidotti, L.G.4    Chisari, F.V.5    Jones, J.6
  • 10
    • 33847701354 scopus 로고    scopus 로고
    • Chronic hepatitis B
    • Lok AS, McMahon BJ. Chronic hepatitis B. Hepatology 2007;45: 507-39.
    • (2007) Hepatology , vol.45 , pp. 507-539
    • Lok, A.S.1    McMahon, B.J.2
  • 11
    • 0030782534 scopus 로고    scopus 로고
    • Molecular biology of hepatitis B virus e antigen
    • Ou JH. Molecular biology of hepatitis B virus e antigen. J Gastroenterol Hepatol 1997;12:S178-87.
    • (1997) J Gastroenterol Hepatol , vol.12
    • Ou, J.H.1
  • 12
    • 78650770247 scopus 로고    scopus 로고
    • The clinical implications of hepatitis B virus genotype: Recent advances
    • Lin CL, Kao JH. The clinical implications of hepatitis B virus genotype: recent advances. J Gastroenterol Hepatol 2011;26 Suppl 1:123-30.
    • (2011) J Gastroenterol Hepatol , vol.26 , Issue.SUPPL. 1 , pp. 123-130
    • Lin, C.L.1    Kao, J.H.2
  • 13
    • 80054855341 scopus 로고    scopus 로고
    • Molecular epidemiology of hepatitis B virus
    • Kao JH. Molecular epidemiology of hepatitis B virus. Korean J Intern Med 2011;26:255-61.
    • (2011) Korean J Intern Med , vol.26 , pp. 255-261
    • Kao, J.H.1
  • 15
  • 16
    • 84860337613 scopus 로고    scopus 로고
    • New insight in the pathobiology of hepatitis B virus infection
    • Dandri M, Locarnini S. New insight in the pathobiology of hepatitis B virus infection. Gut 2012;61 Suppl 1:i6-17.
    • (2012) Gut , vol.61 , Issue.SUPPL. 1 , pp. 16-17
    • Dandri, M.1    Locarnini, S.2
  • 17
    • 66149175804 scopus 로고    scopus 로고
    • The natural history of chronic hepatitis B virus infection
    • McMahon BJ. The natural history of chronic hepatitis B virus infection. Hepatology 2009;49(5 Suppl):S45-55.
    • (2009) Hepatology , vol.49 , Issue.5 SUPPL
    • McMahon, B.J.1
  • 18
    • 79958805964 scopus 로고    scopus 로고
    • Let it B in viral hepatitis?
    • Herkel J, Carambia A. Let it B in viral hepatitis? J Hepatol 2011; 55:5-7.
    • (2011) J Hepatol , vol.55 , pp. 5-7
    • Herkel, J.1    Carambia, A.2
  • 19
    • 33745847180 scopus 로고    scopus 로고
    • TLRs, NLRs and RLRs: A trinity of pathogen sensors that co-operate in innate immunity
    • Creagh EM, O'Neill LA. TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity. Trends Immunol 2006;27:352-7.
    • (2006) Trends Immunol , vol.27 , pp. 352-357
    • Creagh, E.M.1    O'Neill, L.A.2
  • 20
    • 0033596121 scopus 로고    scopus 로고
    • Activators and target genes of Rel/NF-kappaB transcription factors
    • Pahl HL. Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene 1999;18:6853-66.
    • (1999) Oncogene , vol.18 , pp. 6853-6866
    • Pahl, H.L.1
  • 21
    • 34548418935 scopus 로고    scopus 로고
    • Toll-like receptors, RIG-I-like RNA helicases and the antiviral innate immune response
    • Thompson AJ, Locarnini SA. Toll-like receptors, RIG-I-like RNA helicases and the antiviral innate immune response. Immunol Cell Biol 2007;85:435-45.
    • (2007) Immunol Cell Biol , vol.85 , pp. 435-445
    • Thompson, A.J.1    Locarnini, S.A.2
  • 22
    • 35648987280 scopus 로고    scopus 로고
    • Pathogen subversion of cell-intrinsic innate immunity
    • Roy CR, Mocarski ES. Pathogen subversion of cell-intrinsic innate immunity. Nat Immunol 2007;8:1179-87.
    • (2007) Nat Immunol , vol.8 , pp. 1179-1187
    • Roy, C.R.1    Mocarski, E.S.2
  • 23
    • 49149128080 scopus 로고    scopus 로고
    • Expression profiles and function of Toll-like receptors 2 and 4 in peripheral blood mononuclear cells of chronic hepatitis B patients
    • Chen Z, Cheng Y, Xu Y, Liao J, Zhang X, Hu Y, et al. Expression profiles and function of Toll-like receptors 2 and 4 in peripheral blood mononuclear cells of chronic hepatitis B patients. Clin Immunol 2008;128:400-8.
    • (2008) Clin Immunol , vol.128 , pp. 400-408
    • Chen, Z.1    Cheng, Y.2    Xu, Y.3    Liao, J.4    Zhang, X.5    Hu, Y.6
  • 24
    • 80052444371 scopus 로고    scopus 로고
    • The hepatitis B e antigen (HBeAg) targets and suppresses activation of the toll-like receptor signaling pathway
    • Lang T, Lo C, Skinner N, Locarnini S, Visvanathan K, Mansell A. The hepatitis B e antigen (HBeAg) targets and suppresses activation of the toll-like receptor signaling pathway. J Hepatol 2011; 55:762-9.
    • (2011) J Hepatol , vol.55 , pp. 762-769
    • Lang, T.1    Lo, C.2    Skinner, N.3    Locarnini, S.4    Visvanathan, K.5    Mansell, A.6
  • 25
    • 33748768485 scopus 로고    scopus 로고
    • Reduced expression of toll-like receptor 2 on peripheral monocytes in patients with chronic hepatitis B
    • Riordan SM, Skinner N, Kurtovic J, Locarnini S, Visvanathan K. Reduced expression of toll-like receptor 2 on peripheral monocytes in patients with chronic hepatitis B. Clin Vaccine Immunol 2006;13:972-4.
    • (2006) Clin Vaccine Immunol , vol.13 , pp. 972-974
    • Riordan, S.M.1    Skinner, N.2    Kurtovic, J.3    Locarnini, S.4    Visvanathan, K.5
  • 26
    • 65449117568 scopus 로고    scopus 로고
    • Hepatitis B virus suppresses toll-like receptor-mediated innate immune responses in murine parenchymal and nonparenchymal liver cells
    • Wu J, Meng Z, Jiang M, Pei R, Trippler M, Broering R, et al. Hepatitis B virus suppresses toll-like receptor-mediated innate immune responses in murine parenchymal and nonparenchymal liver cells. Hepatology 2009;49:1132-40.
    • (2009) Hepatology , vol.49 , pp. 1132-1140
    • Wu, J.1    Meng, Z.2    Jiang, M.3    Pei, R.4    Trippler, M.5    Broering, R.6
  • 27
    • 74849108037 scopus 로고    scopus 로고
    • Bioinformatic analysis of the hepadnavirus e-antigen and its precursor identifies remarkable sequence conservation in all orthohepadnaviruses
    • Revill P, Yuen L, Walsh R, Perrault M, Locarnini S, Kramvis A. Bioinformatic analysis of the hepadnavirus e-antigen and its precursor identifies remarkable sequence conservation in all orthohepadnaviruses. J Med Virol 2010;82:104-15.
    • (2010) J Med Virol , vol.82 , pp. 104-115
    • Revill, P.1    Yuen, L.2    Walsh, R.3    Perrault, M.4    Locarnini, S.5    Kramvis, A.6
  • 28
    • 44449118948 scopus 로고    scopus 로고
    • Rapid cloning of high-affinity human monoclonal antibodies against influenza virus
    • Wrammert J, Smith K, Miller J, Langley WA, Kokko K, Larsen C, et al. Rapid cloning of high-affinity human monoclonal antibodies against influenza virus. Nature 2008;453:667-71.
    • (2008) Nature , vol.453 , pp. 667-671
    • Wrammert, J.1    Smith, K.2    Miller, J.3    Langley, W.A.4    Kokko, K.5    Larsen, C.6
  • 29
    • 12244271093 scopus 로고    scopus 로고
    • Conversion from intravenous to intramuscular hepatitis B immune globulin in combination with lamivudine is safe and cost-effective in patients receiving long-term prophylaxis to prevent hepatitis B recurrence after liver transplantation
    • Han SH, Martin P, Edelstein M, Hu R, Kunder G, Holt C, et al. Conversion from intravenous to intramuscular hepatitis B immune globulin in combination with lamivudine is safe and cost-effective in patients receiving long-term prophylaxis to prevent hepatitis B recurrence after liver transplantation. Liver Transpl 2003;9:182-7.
    • (2003) Liver Transpl , vol.9 , pp. 182-187
    • Han, S.H.1    Martin, P.2    Edelstein, M.3    Hu, R.4    Kunder, G.5    Holt, C.6
  • 30
    • 77956624003 scopus 로고    scopus 로고
    • Novel mechanism of antibodies to hepatitis B virus in blocking viral particle release from cells
    • Neumann AU, Phillips S, Levine I, Ijaz S, Dahari H, Eren R, et al. Novel mechanism of antibodies to hepatitis B virus in blocking viral particle release from cells. Hepatology 2010;52:875-85.
    • (2010) Hepatology , vol.52 , pp. 875-885
    • Neumann, A.U.1    Phillips, S.2    Levine, I.3    Ijaz, S.4    Dahari, H.5    Eren, R.6
  • 31
    • 0042208197 scopus 로고    scopus 로고
    • Endocytosis of hepatitis B immune globulin into hepatocytes inhibits the secretion of hepatitis B virus surface antigen and virions
    • Schilling R, Ijaz S, Davidoff M, Lee JY, Locarnini S, Williams R, et al. Endocytosis of hepatitis B immune globulin into hepatocytes inhibits the secretion of hepatitis B virus surface antigen and virions. J Virol 2003;77:8882-92.
    • (2003) J Virol , vol.77 , pp. 8882-8892
    • Schilling, R.1    Ijaz, S.2    Davidoff, M.3    Lee, J.Y.4    Locarnini, S.5    Williams, R.6
  • 33
    • 13944265920 scopus 로고    scopus 로고
    • Immune tolerance split between hepatitis B virus precore and core proteins
    • Chen M, Sällberg M, Hughes J, Jones J, Guidotti LG, Chisari FV, et al. Immune tolerance split between hepatitis B virus precore and core proteins. J Virol 2005;79:3016-27.
    • (2005) J Virol , vol.79 , pp. 3016-3027
    • Chen, M.1    Sällberg, M.2    Hughes, J.3    Jones, J.4    Guidotti, L.G.5    Chisari, F.V.6
  • 34
    • 0032519919 scopus 로고    scopus 로고
    • The secreted hepatitis B precore antigen can modulate the immune response to the nucleocapsid: A mechanism for persistence
    • Milich DR, Chen MK, Hughes JL, Jones JE. The secreted hepatitis B precore antigen can modulate the immune response to the nucleocapsid: a mechanism for persistence. J Immunol 1998;160: 2013-21.
    • (1998) J Immunol , vol.160 , pp. 2013-2021
    • Milich, D.R.1    Chen, M.K.2    Hughes, J.L.3    Jones, J.E.4
  • 35
    • 79551685528 scopus 로고    scopus 로고
    • Targeting the hepatitis B virus precore antigen with a novel IgNAR single variable domain intrabody
    • Walsh R, Nuttall S, Revill P, Colledge D, Cabuang L, Soppe S, et al. Targeting the hepatitis B virus precore antigen with a novel IgNAR single variable domain intrabody. Virology 2011;411:132-41.
    • (2011) Virology , vol.411 , pp. 132-141
    • Walsh, R.1    Nuttall, S.2    Revill, P.3    Colledge, D.4    Cabuang, L.5    Soppe, S.6
  • 36
    • 0028873905 scopus 로고
    • Analysis of the precore DNA sequence and detection of precore antigen in liver specimens from patients with anti-hepatitis B e-positive chronic hepatitis
    • Dienes HP, Gerken G, Goergen B, Heermann K, Gerlich W, Meyer zum Büschenfelde KH. Analysis of the precore DNA sequence and detection of precore antigen in liver specimens from patients with anti-hepatitis B e-positive chronic hepatitis. Hepatology 1995;21:1-7.
    • (1995) Hepatology , vol.21 , pp. 1-7
    • Dienes, H.P.1    Gerken, G.2    Goergen, B.3    Heermann, K.4    Gerlich, W.5    Meyer zum Büschenfelde, K.H.6
  • 37
    • 20444443547 scopus 로고    scopus 로고
    • Hepatitis B virus DNA-negative dane particles lack core protein but contain a 22-kDa precore protein without C-terminal arginine-rich domain
    • Kimura T, Ohno N, Terada N, Rokuhara A, Matsumoto A, Yagi S, et al. Hepatitis B virus DNA-negative dane particles lack core protein but contain a 22-kDa precore protein without C-terminal arginine-rich domain. J Biol Chem 2005;280:21713-9.
    • (2005) J Biol Chem , vol.280 , pp. 21713-21719
    • Kimura, T.1    Ohno, N.2    Terada, N.3    Rokuhara, A.4    Matsumoto, A.5    Yagi, S.6
  • 38
    • 0037428471 scopus 로고    scopus 로고
    • Proteolytic processing of the hepatitis B virus e antigen precursor. Cleavage at two furin consensus sequences
    • Messageot F, Salhi S, Eon P, Rossignol JM. Proteolytic processing of the hepatitis B virus e antigen precursor. Cleavage at two furin consensus sequences. J Biol Chem 2003;278:891-5.
    • (2003) J Biol Chem , vol.278 , pp. 891-895
    • Messageot, F.1    Salhi, S.2    Eon, P.3    Rossignol, J.M.4
  • 40
    • 0034141621 scopus 로고    scopus 로고
    • Full-genome sequence analyses of hepatitis B virus (HBV) strains recovered from chimpanzees infected in the wild: Implications for an origin of HBV
    • Takahashi K, Brotman B, Usuda S, Mishiro S, Prince AM. Full-genome sequence analyses of hepatitis B virus (HBV) strains recovered from chimpanzees infected in the wild: implications for an origin of HBV. Virology 2000;267:58-64.
    • (2000) Virology , vol.267 , pp. 58-64
    • Takahashi, K.1    Brotman, B.2    Usuda, S.3    Mishiro, S.4    Prince, A.M.5
  • 41
    • 79955886209 scopus 로고    scopus 로고
    • Role of the propeptide in controlling conformation and assembly state of hepatitis B virus e-antigen
    • Watts NR, Conway JF, Cheng N, Stahl SJ, Steven AC, Wingfield PT. Role of the propeptide in controlling conformation and assembly state of hepatitis B virus e-antigen. J Mol Biol 2011;409:202-13.
    • (2011) J Mol Biol , vol.409 , pp. 202-213
    • Watts, N.R.1    Conway, J.F.2    Cheng, N.3    Stahl, S.J.4    Steven, A.C.5    Wingfield, P.T.6
  • 43
    • 0037221770 scopus 로고    scopus 로고
    • Effect of the G1896A precore mutation on drug sensitivity and replication yield of lamivudine-resistant HBV in vitro
    • Chen RY, Edwards R, Shaw T, Colledge D, Delaney WE 4th, Isom H, et al. Effect of the G1896A precore mutation on drug sensitivity and replication yield of lamivudine-resistant HBV in vitro. Hepatology 2003;37:27-35.
    • (2003) Hepatology , vol.37 , pp. 27-35
    • Chen, R.Y.1    Edwards, R.2    Shaw, T.3    Colledge, D.4    Delaney IV, W.E.5    Isom, H.6
  • 44
    • 0027241571 scopus 로고
    • Precore-mediated inhibition of hepatitis B virus progeny DNA synthesis
    • Lamberts C, Nassal M, Velhagen I, Zentgraf H, Schröder CH. Precore-mediated inhibition of hepatitis B virus progeny DNA synthesis. J Virol 1993;67:3756-62.
    • (1993) J Virol , vol.67 , pp. 3756-3762
    • Lamberts, C.1    Nassal, M.2    Velhagen, I.3    Zentgraf, H.4    Schröder, C.H.5
  • 45
    • 0024427902 scopus 로고
    • Mutation preventing formation of hepatitis B e antigen in patients with chronic hepatitis B infection
    • Carman WF, Jacyna MR, Hadziyannis S, Karayiannis P, McGarvey MJ, Makris A, et al. Mutation preventing formation of hepatitis B e antigen in patients with chronic hepatitis B infection. Lancet 1989;2:588-91.
    • (1989) Lancet , vol.2 , pp. 588-591
    • Carman, W.F.1    Jacyna, M.R.2    Hadziyannis, S.3    Karayiannis, P.4    McGarvey, M.J.5    Makris, A.6
  • 46
    • 0029817029 scopus 로고    scopus 로고
    • Effects of a naturally occurring mutation in the hepatitis B virus basal core promoter on precore gene expression and viral replication
    • Buckwold VE, Xu Z, Chen M, Yen TS, Ou JH. Effects of a naturally occurring mutation in the hepatitis B virus basal core promoter on precore gene expression and viral replication. J Virol 1996;70:5845-51.
    • (1996) J Virol , vol.70 , pp. 5845-5851
    • Buckwold, V.E.1    Xu, Z.2    Chen, M.3    Yen, T.S.4    Ou, J.H.5
  • 47
    • 0031060322 scopus 로고    scopus 로고
    • Posttranscriptional regulation of hepatitis B virus replication by the precore protein
    • Scaglioni PP, Melegari M, Wands JR. Posttranscriptional regulation of hepatitis B virus replication by the precore protein. J Virol 1997;71:345-53.
    • (1997) J Virol , vol.71 , pp. 345-353
    • Scaglioni, P.P.1    Melegari, M.2    Wands, J.R.3
  • 48
    • 11844293373 scopus 로고    scopus 로고
    • Cellular response to conditional expression of the hepatitis B virus precore and core proteins in cultured hepatoma (Huh-7) cells
    • Locarnini S, Shaw T, Dean J, Colledge D, Thompson A, Li K, et al. Cellular response to conditional expression of the hepatitis B virus precore and core proteins in cultured hepatoma (Huh-7) cells. J Clin Virol 2005;32:113-21.
    • (2005) J Clin Virol , vol.32 , pp. 113-121
    • Locarnini, S.1    Shaw, T.2    Dean, J.3    Colledge, D.4    Thompson, A.5    Li, K.6
  • 49
    • 30344458192 scopus 로고    scopus 로고
    • Cellular and virological mechanisms of HBV drug resistance
    • Locarnini S, Mason WS. Cellular and virological mechanisms of HBV drug resistance. J Hepatol 2006;44:422-31.
    • (2006) J Hepatol , vol.44 , pp. 422-431
    • Locarnini, S.1    Mason, W.S.2
  • 50
    • 47149111970 scopus 로고    scopus 로고
    • The antiviral drug selected hepatitis B virus rtA181T/sW172* mutant has a dominant negative secretion defect and alters the typical profile of viral rebound
    • Warner N, Locarnini S. The antiviral drug selected hepatitis B virus rtA181T/sW172* mutant has a dominant negative secretion defect and alters the typical profile of viral rebound. Hepatology 2008;48:88-98.
    • (2008) Hepatology , vol.48 , pp. 88-98
    • Warner, N.1    Locarnini, S.2
  • 51
    • 83455265341 scopus 로고    scopus 로고
    • Evolution of the hepatitis B surface antigen in European and Asian HBV genotypes during the era of antiviral therapy
    • (Abstract PP05-159)
    • Yuen L, Ayers A, Littlejohn M, Edwards R, Locarnini S. Evolution of the hepatitis B surface antigen in European and Asian HBV genotypes during the era of antiviral therapy. Hepatol Int 2011: 5:3-558 (Abstract PP05-159).
    • (2011) Hepatol Int , vol.5 , pp. 3-558
    • Yuen, L.1    Ayers, A.2    Littlejohn, M.3    Edwards, R.4    Locarnini, S.5
  • 52
    • 84864574861 scopus 로고
    • Treatment of chronic hepatitis B virus infection with monoclonal antibody to the hepatitis B virus surface antigen in two patients with hypogammaglobulinaemia
    • In: Zuckerman AJ, editor. New York: Alan R Liss Inc
    • Lever A, Waters J, Brook G, Karayiannis P, Thomas H. Treatment of chronic hepatitis B virus infection with monoclonal antibody to the hepatitis B virus surface antigen in two patients with hypogammaglobulinaemia. In: Zuckerman AJ, editor. Viral Hep & Liver Dis. New York: Alan R Liss Inc; 1987. p.961-2.
    • (1987) Viral Hep & Liver Dis. , pp. 961-962
    • Lever, A.1    Waters, J.2    Brook, G.3    Karayiannis, P.4    Thomas, H.5
  • 53
    • 0025324843 scopus 로고
    • Monoclonal antibody to HBsAg for chronic hepatitis B virus infection with hypogammaglobulinaemia
    • Lever AM, Waters J, Brook MG, Karayiannis P, Thomas HC. Monoclonal antibody to HBsAg for chronic hepatitis B virus infection with hypogammaglobulinaemia. Lancet 1990;335:1529.
    • (1990) Lancet , vol.335 , pp. 1529
    • Lever, A.M.1    Waters, J.2    Brook, M.G.3    Karayiannis, P.4    Thomas, H.C.5
  • 54
    • 39549114267 scopus 로고    scopus 로고
    • HBeAg and hepatitis B virus DNA as outcome predictors during therapy with peginterferon alfa-2a for HBeAg-positive chronic hepatitis B
    • Fried MW, Piratvisuth T, Lau GK, Marcellin P, Chow WC, Cooksley G, et al. HBeAg and hepatitis B virus DNA as outcome predictors during therapy with peginterferon alfa-2a for HBeAg-positive chronic hepatitis B. Hepatology 2008;47:428-34.
    • (2008) Hepatology , vol.47 , pp. 428-434
    • Fried, M.W.1    Piratvisuth, T.2    Lau, G.K.3    Marcellin, P.4    Chow, W.C.5    Cooksley, G.6
  • 55
    • 84872653871 scopus 로고    scopus 로고
    • National Institutes of Health. RFA-DK-07-011. Released: December
    • National Institutes of Health. RFA-DK-07-011. Hepatitis B clinical research network. http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-07-011.html, Released: December 2007.
    • (2007) Hepatitis B clinical research network
  • 56
    • 0041322960 scopus 로고    scopus 로고
    • Isolation and characterization of an IgNAR variable domain specific for the human mitochondrial translocase receptor Tom70
    • Nuttall SD, Krishnan UV, Doughty L, Pearson K, Ryan MT, Hoogenraad NJ, et al. Isolation and characterization of an IgNAR variable domain specific for the human mitochondrial translocase receptor Tom70. Eur J Biochem 2003;270:3543-54.
    • (2003) Eur J Biochem , vol.270 , pp. 3543-3554
    • Nuttall, S.D.1    Krishnan, U.V.2    Doughty, L.3    Pearson, K.4    Ryan, M.T.5    Hoogenraad, N.J.6
  • 57
    • 0032578554 scopus 로고    scopus 로고
    • Structural analysis of the nurse shark (new) antigen receptor (NAR): Molecular convergence of NAR and unusual mammalian immunoglobulins
    • Roux KH, Greenberg AS, Greene L, Strelets L, Avila D, McKinney EC, et al. Structural analysis of the nurse shark (new) antigen receptor (NAR): molecular convergence of NAR and unusual mammalian immunoglobulins. Proc Natl Acad Sci U S A 1998;95: 11804-9.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 11804-11809
    • Roux, K.H.1    Greenberg, A.S.2    Greene, L.3    Strelets, L.4    Avila, D.5    McKinney, E.C.6
  • 58
    • 0037133506 scopus 로고    scopus 로고
    • Biophysical properties of camelid V(HH) domains compared to those of human V(H)3 domains
    • Ewert S, Cambillau C, Conrath K, Plückthun A. Biophysical properties of camelid V(HH) domains compared to those of human V(H)3 domains. Biochemistry 2002;41:3628-36.
    • (2002) Biochemistry , vol.41 , pp. 3628-3636
    • Ewert, S.1    Cambillau, C.2    Conrath, K.3    Plückthun, A.4
  • 60
    • 4544250973 scopus 로고    scopus 로고
    • Crystal structure of a shark single-domain antibody V region in complex with lysozyme
    • Stanfield RL, Dooley H, Flajnik MF, Wilson IA. Crystal structure of a shark single-domain antibody V region in complex with lysozyme. Science 2004;305:1770-3.
    • (2004) Science , vol.305 , pp. 1770-1773
    • Stanfield, R.L.1    Dooley, H.2    Flajnik, M.F.3    Wilson, I.A.4
  • 62
    • 27644475866 scopus 로고    scopus 로고
    • Structure of a shark IgNAR antibody variable domain and modeling of an early-developmental isotype
    • Streltsov VA, Carmichael JA, Nuttall SD. Structure of a shark IgNAR antibody variable domain and modeling of an early-developmental isotype. Protein Sci 2005;14:2901-9.
    • (2005) Protein Sci , vol.14 , pp. 2901-2909
    • Streltsov, V.A.1    Carmichael, J.A.2    Nuttall, S.D.3
  • 63
    • 32044433759 scopus 로고    scopus 로고
    • Animal models for the study of HBV replication and its variants
    • Dandri M, Volz TK, Lütgehetmann M, Petersen J. Animal models for the study of HBV replication and its variants. J Clin Virol 2005;34 Suppl 1:S54-62.
    • (2005) J Clin Virol , vol.34 , Issue.SUPPL. 1
    • Dandri, M.1    Volz, T.K.2    Lütgehetmann, M.3    Petersen, J.4
  • 64
    • 0030842540 scopus 로고    scopus 로고
    • Inducible expression of human hepatitis B virus (HBV) in stably transfected hepatoblastoma cells: A novel system for screening potential inhibitors of HBV replication
    • Ladner SK, Otto MJ, Barker CS, Zaifert K, Wang GH, Guo JT, et al. Inducible expression of human hepatitis B virus (HBV) in stably transfected hepatoblastoma cells: a novel system for screening potential inhibitors of HBV replication. Antimicrob Agents Chemother 1997;41:1715-20.
    • (1997) Antimicrob Agents Chemother , vol.41 , pp. 1715-1720
    • Ladner, S.K.1    Otto, M.J.2    Barker, C.S.3    Zaifert, K.4    Wang, G.H.5    Guo, J.T.6
  • 65
    • 0000934401 scopus 로고
    • Production of hepatitis B virus particles in Hep G2 cells transfected with cloned hepatitis B virus DNA
    • Sells MA, Chen ML, Acs G. Production of hepatitis B virus particles in Hep G2 cells transfected with cloned hepatitis B virus DNA. Proc Natl Acad Sci U S A 1987;84:1005-9.
    • (1987) Proc Natl Acad Sci U S A , vol.84 , pp. 1005-1009
    • Sells, M.A.1    Chen, M.L.2    Acs, G.3
  • 66
    • 14944375587 scopus 로고    scopus 로고
    • Immunology of hepatitis B virus and hepatitis C virus infection
    • Rehermann B, Nascimbeni M. Immunology of hepatitis B virus and hepatitis C virus infection. Nat Rev Immunol 2005;5:215-29.
    • (2005) Nat Rev Immunol , vol.5 , pp. 215-229
    • Rehermann, B.1    Nascimbeni, M.2
  • 67
    • 6844258881 scopus 로고    scopus 로고
    • Human monoclonal antibodies specific to hepatitis B virus generated in a human/mouse radiation chimera: The Trimera system
    • Eren R, Lubin I, Terkieltaub D, Ben-Moshe O, Zauberman A, Uhlmann R, et al. Human monoclonal antibodies specific to hepatitis B virus generated in a human/mouse radiation chimera: the Trimera system. Immunology 1998;93:154-61.
    • (1998) Immunology , vol.93 , pp. 154-161
    • Eren, R.1    Lubin, I.2    Terkieltaub, D.3    Ben-Moshe, O.4    Zauberman, A.5    Uhlmann, R.6
  • 68
    • 0033840084 scopus 로고    scopus 로고
    • Preclinical evaluation of two human anti-hepatitis B virus (HBV) monoclonal antibodies in the HBV-trimera mouse model and in HBV chronic carrier chimpanzees
    • Eren R, Ilan E, Nussbaum O, Lubin I, Terkieltaub D, Arazi Y, et al. Preclinical evaluation of two human anti-hepatitis B virus (HBV) monoclonal antibodies in the HBV-trimera mouse model and in HBV chronic carrier chimpanzees. Hepatology 2000;32: 588-96.
    • (2000) Hepatology , vol.32 , pp. 588-596
    • Eren, R.1    Ilan, E.2    Nussbaum, O.3    Lubin, I.4    Terkieltaub, D.5    Arazi, Y.6
  • 69
    • 0033030127 scopus 로고    scopus 로고
    • The hepatitis B virus-trimera mouse: A model for human HBV infection and evaluation of anti-HBV therapeutic agents
    • Ilan E, Burakova T, Dagan S, Nussbaum O, Lubin I, Eren R, et al. The hepatitis B virus-trimera mouse: a model for human HBV infection and evaluation of anti-HBV therapeutic agents. Hepatology 1999;29:553-62.
    • (1999) Hepatology , vol.29 , pp. 553-562
    • Ilan, E.1    Burakova, T.2    Dagan, S.3    Nussbaum, O.4    Lubin, I.5    Eren, R.6
  • 70
    • 17744378552 scopus 로고    scopus 로고
    • Repopulation of mouse liver with human hepatocytes and in vivo infection with hepatitis B virus
    • Dandri M, Burda MR, Török E, Pollok JM, Iwanska A, Sommer G, et al. Repopulation of mouse liver with human hepatocytes and in vivo infection with hepatitis B virus. Hepatology 2001;33:981-8.
    • (2001) Hepatology , vol.33 , pp. 981-988
    • Dandri, M.1    Burda, M.R.2    Török, E.3    Pollok, J.M.4    Iwanska, A.5    Sommer, G.6
  • 71
    • 0029890346 scopus 로고    scopus 로고
    • Hepatitis B virus infection of tupaia hepatocytes in vitro and in vivo
    • Walter E, Keist R, Niederöst B, Pult I, Blum HE. Hepatitis B virus infection of tupaia hepatocytes in vitro and in vivo. Hepatology 1996;24:1-5.
    • (1996) Hepatology , vol.24 , pp. 1-5
    • Walter, E.1    Keist, R.2    Niederöst, B.3    Pult, I.4    Blum, H.E.5
  • 72
    • 33846534236 scopus 로고    scopus 로고
    • The woodchuck as an animal model for pathogenesis and therapy of chronic hepatitis B virus infection
    • Menne S, Cote PJ. The woodchuck as an animal model for pathogenesis and therapy of chronic hepatitis B virus infection. World J Gastroenterol 2007;13:104-24.
    • (2007) World J Gastroenterol , vol.13 , pp. 104-124
    • Menne, S.1    Cote, P.J.2


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