Serum cytokine/chemokine profiles in acute exacerbation of chronic hepatitis B: Clinical and mechanistic implications

Journal of Gastroenterology and Hepatology (Australia)

Volumn 29, Issue 8, 2014, Pages 1629-1636

  Wu, Hui Lin ^a   Kao, Jia Horng ^a   Chen, Ting Chih ^a   Wu, Wen Hsuan ^a   Liu, Chen Hua ^a   Su, Tung Hung ^a   Yang, Hung Chih ^a   Chen, Ding Shinn ^a,b   Chen, Pei Jer ^a   Liu, Chun Jen ^a  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^b GENOMICS RESEARCH CENTER   (Taiwan)

Author keywords

Acute exacerbation; Chemokine; Cytokine; Hepatitis B

Indexed keywords

ALANINE AMINOTRANSFERASE; CHEMOKINE; CXCL9 CHEMOKINE; CYTOKINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; HEPATITIS B(E) ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; TUMOR NECROSIS FACTOR ALPHA; VIRUS DNA; BIOLOGICAL MARKER;

ACUTE EXACERBATION; ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; CHRONIC HEPATITIS; CLINICAL FEATURE; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE EXACERBATION; FEMALE; HEPATITIS B; HEPATITIS B VIRUS GENOTYPE B; HEPATITIS B VIRUS GENOTYPE C; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RECEIVER OPERATING CHARACTERISTIC; VIRUS LOAD; VIRUS REPLICATION; BLOOD; FOLLOW UP; GENETICS; HEPATITIS B VIRUS; MIDDLE AGED; VIROLOGY;

ADULT; ALANINE TRANSAMINASE; BIOLOGICAL MARKERS; CHEMOKINE CXCL10; CHEMOKINES; CYTOKINES; DISEASE PROGRESSION; DNA, VIRAL; FEMALE; FOLLOW-UP STUDIES; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; INTERLEUKIN-10; INTERLEUKIN-4; INTERLEUKIN-6; MALE; MIDDLE AGED; VIRAL LOAD;

EID: 84904890987     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/jgh.12606     Document Type: Article

References (33)

1. Seto WK, Lai CL, Yuen MF. Acute-on-chronic liver failure in chronic hepatitis B. J. Gastroenterol. Hepatol. 2012; 27: 662-669.
2. Kumar M, Chauhan R, Gupta N, Hissar S, Sakhuja P, Sarin SK. Spontaneous increases in alanine aminotransferase levels in asymptomatic chronic hepatitis B virus-infected patients. Gastroenterology 2009; 136: 1272-1280.
3. Chisari FV, Ferrari C. Hepatitis B virus immunopathogenesis. Annu. Rev. Immunol. 1995; 13: 29-60.
4. Tsai SL, Chen PJ, Lai MY etal. Acute exacerbations of chronic type B hepatitis are accompanied by increased T cell responses to hepatitis B core and e antigens. Implications for hepatitis B e antigen seroconversion. J. Clin. Invest. 1992; 89: 87-96.
5. Sing GK, Ladhams A, Arnold S etal. A longitudinal analysis of cytotoxic T lymphocyte precursor frequencies to the hepatitis B virus in chronically infected patients. J. Viral Hepat. 2001; 8: 19-29.
6. Hoofnagle JH. Reactivation of hepatitis B. Hepatology 2009; 49 (5 Suppl.): S156-165.
7. Rehermann B, Fowler P, Sidney J etal. The cytotoxic T lymphocyte response to multiple hepatitis B virus polymerase epitopes during and after acute viral hepatitis. J. Exp. Med. 1995; 181: 1047-1058.
8. Naoumov NV, Eddleston AL. Host immune response and variations in the virus genome: pathogenesis of liver damage caused by hepatitis B virus. Gut 1994; 35: 1013-1017.
9. Brunetto MR, Rodriguez UA, Bonino F. Hepatitis B virus mutants. Intervirology 1999; 42: 69-80.
10. Guidotti LG, Rochford R, Chung J, Shapiro M, Purcell R, Chisari FV. Viral clearance without destruction of infected cells during acute HBV infection. Science 1999; 284: 825-829.
11. Liu CJ, Chen PJ, Lai MY, Kao JH, Chen DS. Hepatitis B virus variants in patients receiving lamivudine treatment with breakthrough hepatitis evaluated by serial viral loads and full-length viral sequences. Hepatology 2001; 34: 583-589.
12. Liu CJ, Chen PJ, Lai MY, Kao JH, Chen DS. Evolution of precore/core promoter mutations in hepatitis B carriers with hepatitis B e antigen seroreversion. J. Med. Virol. 2004; 74: 237-245.
13. Liu CJ, Chen PJ, Lai MY etal. A prospective study characterizing full-length hepatitis B virus genomes during acute exacerbation. Gastroenterology 2003; 124: 80-90.
14. Maini MK, Boni C, Ogg GS etal. Direct ex vivo analysis of hepatitis B virus-specific CD8(+) T cells associated with the control of infection. Gastroenterology 1999; 117: 1386-1396.
15. Shimada N, Yamamoto K, Kuroda MJ etal. HBcAg-specific CD8 T cells play an important role in virus suppression, and acute flare-up is associated with the expansion of activated memory T cells. J. Clin. Immunol. 2003; 23: 223-232.
16. Wu Y, Zhang J, Chen S etal. Frequencies of epitope-specific cytotoxic T lymphocytes in active chronic viral hepatitis B infection by using MHC class I peptide tetramers. Immunol. Lett. 2004; 92: 253-258.
17. Thimme R, Wieland S, Steiger C etal. CD8(+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection. J. Virol. 2003; 77: 68-76.
18. Guidotti LG, Chisari FV. Noncytolytic control of viral infections by the innate and adaptive immune response. Annu. Rev. Immunol. 2001; 19: 65-91.
19. Yeh SH, Tsai CY, Kao JH etal. Quantification and genotyping of hepatitis B virus in a single reaction by real-time PCR and melting curve analysis. J. Hepatol. 2004; 41: 659-666.
20. Blackburn SD, Wherry EJ. IL-10, T cell exhaustion and viral persistence. Trends Microbiol. 2007; 15: 143-146.
21. Brooks DG, Trifilo MJ, Edelmann KH etal. Interleukin-10 determines viral clearance or persistence in vivo. Nat. Med. 2006; 12: 1301-1309.
22. Ejrnaes M, Filippi CM, Martinic MM etal. Resolution of a chronic viral infection after interleukin-10 receptor blockade. J. Exp. Med. 2006; 203: 2461-2472.
23. Tilg H, Kaser A, Moschen AR. How to modulate inflammatory cytokines in liver diseases. Liver Int. 2006; 26: 1029-1039.
24. Nelson DR, Tu Z, Soldevila-Pico C etal. Long-term interleukin 10 therapy in chronic hepatitis C patients has a proviral and anti-inflammatory effect. Hepatology 2003; 38: 859-868.
25. Dunn C, Peppa D, Khanna P etal. Temporal analysis of early immune responses in patients with acute hepatitis B virus infection. Gastroenterology 2009; 137: 1289-1300.
26. Pan CJ, Wu HL, Kuo SF etal. Serum interleukin 6 level correlates with outcomes of acute exacerbation of chronic hepatitis B. Hepatol. Int. 2012; 6: 591-597.
27. He G, Dhar D, Nakagawa H etal. Identification of Liver Cancer Progenitors Whose Malignant Progression Depends on Autocrine IL-6 Signaling. Cell 2013; 155: 384-396.
28. Harvey CE, Post JJ, Palladinetti P etal. Expression of the chemokine IP-10 (CXCL10) by hepatocytes in chronic hepatitis C virus infection correlates with histological severity and lobular inflammation. J. Leukoc. Biol. 2003; 74: 360-369.
29. Wang J, Zhao JH, Wang PP, Xiang GJ. Expression of CXC chemokine IP-10 in patients with chronic hepatitis B. Hepatobiliary Pancreat. Dis. Int. 2008; 7: 45-50.
30. Prawitt D, Brixel L, Spangenberg C etal. RNAi knock-down mice: an emerging technology for post-genomic functional genetics. Cytogenet. Genome Res. 2004; 105: 412-421.
31. Liu CJ, Kao JH. Global Perspective on the natural history of chronic hepatitis B: role of hepatitis B virus genotypes A to J. Semin. Liver Dis. 2013; 33: 97-102.
32. Jeng WJ, Sheen IS, Liaw YF. Hepatitis B virus DNA level predicts hepatic decompensation in patients with acute exacerbation of chronic hepatitis B. Clin. Gastroenterol. Hepatol. 2010; 8: 541-545.
33. Jindal A, Kumar M, Sarin SK. Management of acute hepatitis B and reactivation of hepatitis B. Liver Int. 2013; 33 (Suppl. 1): 164-175.