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Volumn 172, Issue 9, 2004, Pages 5648-5655

IL-6 Prevents T Cell-Mediated Hepatitis via Inhibition of NKT Cells in CD4+ T Cell- and STAT3-Dependent Manners

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; INTERLEUKIN 6; JANUS KINASE; STAT3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 2142764513     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.172.9.5648     Document Type: Article
Times cited : (84)

References (42)
  • 3
    • 15844425587 scopus 로고    scopus 로고
    • Critical involvement of interferon γ in the pathogenesis of T-cell activation-associated hepatitis and regulatory mechanisms of interleukin-6 for the manifestations of hepatitis
    • Mizuhara, H., M. Uno, N. Seki, M. Yamashita, M. Yamaoka, T. Ogawa, K. Kaneda, T. Fujii, H. Senoh, and H. Fujiwara. 1996. Critical involvement of interferon γ in the pathogenesis of T-cell activation-associated hepatitis and regulatory mechanisms of interleukin-6 for the manifestations of hepatitis. Hepatology 23:1608.
    • (1996) Hepatology , vol.23 , pp. 1608
    • Mizuhara, H.1    Uno, M.2    Seki, N.3    Yamashita, M.4    Yamaoka, M.5    Ogawa, T.6    Kaneda, K.7    Fujii, T.8    Senoh, H.9    Fujiwara, H.10
  • 6
    • 0033970969 scopus 로고    scopus 로고
    • Increased toxin-induced liver injury and fibrosis in interleukin-6-deficient mice
    • Kovalovich, K., R. A. DeAngelis, W. Li, E. E. Furth, G. Ciliberto, and R. Taub. 2000. Increased toxin-induced liver injury and fibrosis in interleukin-6-deficient mice. Hepatology 31:149.
    • (2000) Hepatology , vol.31 , pp. 149
    • Kovalovich, K.1    DeAngelis, R.A.2    Li, W.3    Furth, E.E.4    Ciliberto, G.5    Taub, R.6
  • 7
    • 20644465187 scopus 로고    scopus 로고
    • Interleukin-6 protects liver against warm ischemia/reperfusion injury and promotes hepatocyte proliferation in the rodent
    • Camargo, C. A., Jr., J. F. Madden, W. Gao, R. S. Selvan, and P. A. Clavien. 1997. Interleukin-6 protects liver against warm ischemia/reperfusion injury and promotes hepatocyte proliferation in the rodent. Hepatology 26:1513.
    • (1997) Hepatology , vol.26 , pp. 1513
    • Camargo Jr., C.A.1    Madden, J.F.2    Gao, W.3    Selvan, R.S.4    Clavien, P.A.5
  • 8
    • 0345146918 scopus 로고    scopus 로고
    • Role of interleukin-6 in hepatic heat shock protein expression and protection against acetaminophen-induced liver disease
    • Masubuchi, Y., M. Bourdi, T. P. Reilly, M. L. Graf, J. W. George, and L. R. Pohl. 2003. Role of interleukin-6 in hepatic heat shock protein expression and protection against acetaminophen-induced liver disease. Biochem. Biophys. Res. Commun. 304:207.
    • (2003) Biochem. Biophys. Res. Commun. , vol.304 , pp. 207
    • Masubuchi, Y.1    Bourdi, M.2    Reilly, T.P.3    Graf, M.L.4    George, J.W.5    Pohl, L.R.6
  • 9
    • 0034218377 scopus 로고    scopus 로고
    • Distinct effects of systemic infusion of G-CSF vs. IL-6 on lung and liver inflammation and injury in hemorrhagic shock
    • Meng, Z. H., K. Dyer, T. R. Billiar, and D. J. Tweardy. 2000. Distinct effects of systemic infusion of G-CSF vs. IL-6 on lung and liver inflammation and injury in hemorrhagic shock. Shock 14:41.
    • (2000) Shock , vol.14 , pp. 41
    • Meng, Z.H.1    Dyer, K.2    Billiar, T.R.3    Tweardy, D.J.4
  • 10
    • 0036789438 scopus 로고    scopus 로고
    • Cold ischemia decreases liver regeneration after partial liver transplantation in the rat: A TNF-α/IL-6-dependent mechanism
    • Selzner, N., M. Selzner, Y. Tian, Z. Kadry, and P. A. Clavien. 2002. Cold ischemia decreases liver regeneration after partial liver transplantation in the rat: a TNF-α/IL-6-dependent mechanism. Hepatology 36:812.
    • (2002) Hepatology , vol.36 , pp. 812
    • Selzner, N.1    Selzner, M.2    Tian, Y.3    Kadry, Z.4    Clavien, P.A.5
  • 12
    • 0033551802 scopus 로고    scopus 로고
    • Interleukin-6 inhibits transforming growth factor-β-induced apoptosis through the phosphatidylinositol 3-kinase/Akt and signal transducers and activators of transcription 3 pathways
    • Chen, R. H., M. C. Chang, Y. H. Su, Y. T. Tsai, and M. L. Kuo. 1999. Interleukin-6 inhibits transforming growth factor-β-induced apoptosis through the phosphatidylinositol 3-kinase/Akt and signal transducers and activators of transcription 3 pathways. J. Biol. Chem. 274:23013.
    • (1999) J. Biol. Chem. , vol.274 , pp. 23013
    • Chen, R.H.1    Chang, M.C.2    Su, Y.H.3    Tsai, Y.T.4    Kuo, M.L.5
  • 13
    • 0037047360 scopus 로고    scopus 로고
    • STAT3 contributes to the mitogenic response of hepatocytes during liver regeneration
    • Li, W., X. Liang, C. Kellendonk, V. Poli, and R. Taub. 2002. STAT3 contributes to the mitogenic response of hepatocytes during liver regeneration. J. Biol. Chem. 277:28411.
    • (2002) J. Biol. Chem. , vol.277 , pp. 28411
    • Li, W.1    Liang, X.2    Kellendonk, C.3    Poli, V.4    Taub, R.5
  • 17
    • 85047689502 scopus 로고    scopus 로고
    • Hepatoprotection via the IL-6/Stat3 pathway
    • Taub, R. 2003. Hepatoprotection via the IL-6/Stat3 pathway. J. Clin. Invest. 112:978.
    • (2003) J. Clin. Invest. , vol.112 , pp. 978
    • Taub, R.1
  • 19
    • 0026643743 scopus 로고
    • A T cell-dependent experimental liver injury in mice inducible by concanavalin A
    • Tiegs, G., J. Hentschel, and A. Wendel. 1992. A T cell-dependent experimental liver injury in mice inducible by concanavalin A. J. Clin. Invest. 90:196.
    • (1992) J. Clin. Invest. , vol.90 , pp. 196
    • Tiegs, G.1    Hentschel, J.2    Wendel, A.3
  • 21
    • 0034598156 scopus 로고    scopus 로고
    • Augmentation of Vα14 NKT cell-mediated cytotoxicity by interleukin 4 in an autocrine mechanism resulting in the development of concanavalin A-induced hepatitis
    • Kaneko, Y., M. Harada, T. Kawano, M. Yamashita, Y. Shibata, F. Gejyo, T. Nakayama, and M. Taniguchi. 2000. Augmentation of Vα14 NKT cell-mediated cytotoxicity by interleukin 4 in an autocrine mechanism resulting in the development of concanavalin A-induced hepatitis. J. Exp. Med. 191:105.
    • (2000) J. Exp. Med. , vol.191 , pp. 105
    • Kaneko, Y.1    Harada, M.2    Kawano, T.3    Yamashita, M.4    Shibata, Y.5    Gejyo, F.6    Nakayama, T.7    Taniguchi, M.8
  • 23
    • 0042834253 scopus 로고    scopus 로고
    • Crucial role of IL-4/STAT6 in T cell-mediated hepatitis: Up-regulating eotaxins and IL-5 and recruiting leukocytes
    • Jaruga, B., F. Hong, R. Sun, S. Radaeva, and B. Gao, 2003. Crucial role of IL-4/STAT6 in T cell-mediated hepatitis: up-regulating eotaxins and IL-5 and recruiting leukocytes. J. Immunol. 171:3233.
    • (2003) J. Immunol. , vol.171 , pp. 3233
    • Jaruga, B.1    Hong, F.2    Sun, R.3    Radaeva, S.4    Gao, B.5
  • 25
    • 0031154578 scopus 로고    scopus 로고
    • + T cells lose NK1.1 expression upon in vitro activation
    • + T cells lose NK1.1 expression upon in vitro activation. J. Immunol. 158:5112.
    • (1997) J. Immunol. , vol.158 , pp. 5112
    • Chen, H.1    Huang, H.2    Paul, W.E.3
  • 26
    • 0037967918 scopus 로고    scopus 로고
    • Liver NKT cells: An account of heterogeneity
    • Emoto, M., and S. H. Kaufmann. 2003. Liver NKT cells: an account of heterogeneity. Trends Immunol. 24:364.
    • (2003) Trends Immunol. , vol.24 , pp. 364
    • Emoto, M.1    Kaufmann, S.H.2
  • 28
    • 0036597371 scopus 로고    scopus 로고
    • + suppressor T cells: More questions than answers
    • + suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2:389.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 389
    • Shevach, E.M.1
  • 29
    • 0035554676 scopus 로고    scopus 로고
    • Regulatory T cells in the control of immune pathology
    • Maloy, K. J., and F. Powrie. 2001. Regulatory T cells in the control of immune pathology. Nat. Immunol. 2:816.
    • (2001) Nat. Immunol. , vol.2 , pp. 816
    • Maloy, K.J.1    Powrie, F.2
  • 30
    • 0032213273 scopus 로고    scopus 로고
    • Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: Generation and characterization of T cell-specific Stat3-deficient mice
    • Takeda, K., T. Kaisho, N. Yoshida, J. Takeda, T. Kishimoto, and S. Akira. 1998. Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice. J. Immunol. 161:4652.
    • (1998) J. Immunol. , vol.161 , pp. 4652
    • Takeda, K.1    Kaisho, T.2    Yoshida, N.3    Takeda, J.4    Kishimoto, T.5    Akira, S.6
  • 31
    • 0036676974 scopus 로고    scopus 로고
    • The unconventional lifestyle of NKT cells
    • Kronenberg, M., and L. Gapin. 2002. The unconventional lifestyle of NKT cells. Nat. Rev. Immunol. 2:557.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 557
    • Kronenberg, M.1    Gapin, L.2
  • 32
    • 0030890603 scopus 로고    scopus 로고
    • Mouse CD1-specific NK1 T cells: Development, specificity, and function
    • Bendelac, A., M. N. Rivera, S. H. Park, and J. H. Roark. 1997. Mouse CD1-specific NK1 T cells: development, specificity, and function. Annu. Rev. Immunol. 15:535.
    • (1997) Annu. Rev. Immunol. , vol.15 , pp. 535
    • Bendelac, A.1    Rivera, M.N.2    Park, S.H.3    Roark, J.H.4
  • 33
    • 0037270978 scopus 로고    scopus 로고
    • Hepatic T cells and liver tolerance
    • Crispe, I. N. 2003. Hepatic T cells and liver tolerance. Nat. Rev. Immunol. 3:51.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 51
    • Crispe, I.N.1
  • 36
    • 0033939943 scopus 로고    scopus 로고
    • Activation of hepatic NKT cells and subsequent liver injury following administration of α-galactosylceramide
    • Osman, Y., T. Kawamura, T. Naito, K. Takeda, L. Van Kaer, K. Okumura, and T. Abo. 2000. Activation of hepatic NKT cells and subsequent liver injury following administration of α-galactosylceramide. Eur. J. Immunol. 30:1919.
    • (2000) Eur. J. Immunol. , vol.30 , pp. 1919
    • Osman, Y.1    Kawamura, T.2    Naito, T.3    Takeda, K.4    Van Kaer, L.5    Okumura, K.6    Abo, T.7
  • 37
    • 0036261213 scopus 로고    scopus 로고
    • Liver injury due to sequential activation of natural killer cells and natural killer T cells by carrageenan
    • Abe, T., H. Kawamura, S. Kawabe, H. Watanabe, F. Gejyo, and T. Abo. 2002. Liver injury due to sequential activation of natural killer cells and natural killer T cells by carrageenan. J. Hepatol. 36:614.
    • (2002) J. Hepatol. , vol.36 , pp. 614
    • Abe, T.1    Kawamura, H.2    Kawabe, S.3    Watanabe, H.4    Gejyo, F.5    Abo, T.6
  • 38
    • 0034596944 scopus 로고    scopus 로고
    • Natural killer T cell activation inhibits hepatitis B virus replication in vivo
    • Kakimi, K., L. G. Guidotti, Y. Koezuka, and F. V. Chisari. 2000. Natural killer T cell activation inhibits hepatitis B virus replication in vivo. J. Exp. Med. 192:921.
    • (2000) J. Exp. Med. , vol.192 , pp. 921
    • Kakimi, K.1    Guidotti, L.G.2    Koezuka, Y.3    Chisari, F.V.4
  • 40
    • 0037083464 scopus 로고    scopus 로고
    • Cutting edge: Compartmentalization of Th1-like noninvariant CD1d-reactive T cells in hepatitis C virus-infected liver
    • Exley, M. A., Q. He, O. Cheng, R. J. Wang, C. P. Cheney, S. P. Balk, and M. J. Koziel. 2002. Cutting edge: compartmentalization of Th1-like noninvariant CD1d-reactive T cells in hepatitis C virus-infected liver. J. Immunol. 168:1519.
    • (2002) J. Immunol. , vol.168 , pp. 1519
    • Exley, M.A.1    He, Q.2    Cheng, O.3    Wang, R.J.4    Cheney, C.P.5    Balk, S.P.6    Koziel, M.J.7
  • 41
    • 0042123683 scopus 로고    scopus 로고
    • NKT cells from normal and tumor-bearing human livers are phenotypically and functionally distinct from murine NKT cells
    • Kenna, T., L. G. Mason, S. A. Porcelli, Y. Koezuka, J. E. Hegarty, C. O'Farrelly, and D. G. Doherty. 2003. NKT cells from normal and tumor-bearing human livers are phenotypically and functionally distinct from murine NKT cells. J. Immunol. 171:1775.
    • (2003) J. Immunol. , vol.171 , pp. 1775
    • Kenna, T.1    Mason, L.G.2    Porcelli, S.A.3    Koezuka, Y.4    Hegarty, J.E.5    O'Farrelly, C.6    Doherty, D.G.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.