N-terminal myristoylation-dependent masking of neutralizing epitopes in the preS1 attachment site of hepatitis B virus

Journal of Hepatology

Volumn 55, Issue 1, 2011, Pages 29-37

  Bremer, Corinna M ^a   Sominskaya, Irina ^b   Skrastina, Dace ^b   Pumpens, Paul ^b   El Wahed, Ahmed Abd ^c   Beutling, Ulrike ^d   Frank, Ronald ^d   Fritz, Hans Joachim ^c   Hunsmann, Gerhard ^c   Gerlich, Wolfram H ^a   Glebe, Dieter ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b UNIVERSITY OF LATVIA   (Latvia)

^c UNIVERSITY OF GÖTTINGEN   (Germany)

^d HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

Epitope masking; Hepatitis B virus; Neutralizing antibodies; preS1; Vaccine

Indexed keywords

EPITOPE; HEPATITIS B SURFACE ANTIGEN; IMMUNOGLOBULIN; PRES1 PEPTIDE; UNCLASSIFIED DRUG; VIRUS PROTEIN;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANTIBODY RESPONSE; ANTIGEN BINDING; ARTICLE; B LYMPHOCYTE; CARBOXY TERMINAL SEQUENCE; CELL ADHESION; CELL CULTURE; CONTROLLED STUDY; DISEASE CARRIER; ENZYME LINKED IMMUNOSORBENT ASSAY; GENOTYPE; HEPATITIS B VIRUS; IC 50; IMMUNOGENICITY; LIVER CELL; MOUSE; MYRISTYLATION; N TERMINAL MYRISTOYLATION DEPENDENT MASKING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; VIRUS ATTACHMENT; VIRUS INFECTIVITY; VIRUS PARTICLE;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, NEUTRALIZING; BINDING SITES; EPITOPE MAPPING; EPITOPES, B-LYMPHOCYTE; GENOTYPE; HEPATITIS B ANTIBODIES; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VACCINES; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; MYRISTIC ACID; PROTEIN PRECURSORS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 79958802112     PISSN: 01688278     EISSN: 01688278     Source Type: Journal    
DOI: 10.1016/j.jhep.2010.10.019     Document Type: Article

References (61)

1. A. Alberti, D. Cavalletto, L. Chemello, F. Belussi, G. Fattovich, and P. Pontisso Fine specificity of human antibody response to the PreS1 domain of hepatitis B virus Hepatology 12 1990 199 203 (Pubitemid 20285780)
2. J.S. Bertino Jr., P. Tirrell, R.N. Greenberg, H.L. Keyserling, G.A. Poland, and D. Gump A comparative trial of standard or high-dose S subunit recombinant hepatitis B vaccine versus a vaccine containing S subunit, pre-S1, and pre-S2 particles for revaccination of healthy adult nonresponders J Infect Dis 175 1997 678 681 (Pubitemid 27086174)
3. A. Bertoletti, C. Ferrari, F. Fiaccadori, A. Penna, R. Margolskee, and H.J. Schlicht HLA class I-restricted human cytotoxic T cells recognize endogenously synthesized hepatitis B virus nucleocapsid antigen Proc Natl Acad Sci USA 88 1991 10445 10449 (Pubitemid 21915852)
4. C.M. Bremer, C. Bung, N. Kott, M. Hardt, and D. Glebe Hepatitis B virus infection is dependent on cholesterol in the viral envelope Cell Microbiol 11 2009 249 260
5. V. Bruss, J. Hagelstein, E. Gerhardt, and P.R. Galle Myristylation of the large surface protein is required for HBV in vitro infectivity Virology 218 1996 396 399 (Pubitemid 26164741)
6. W.F. Carman, A.R. Zanetti, P. Karayiannis, J. Waters, G. Manzillo, and E. Tanzi Vaccine-induced escape mutant of HBV Lancet 336 1990 325 329
7. X. Chen, M. Li, X. Le, W. Ma, and B. Zhou Recombinant hepatitis B core antigen carrying preS1 epitopes induce immune response against chronic HBV infection Vaccine 22 2004 439 446 (Pubitemid 37510275)
8. P. Chouteau, J. Le Seyec, I. Cannie, M. Nassal, C. Guguen-Guillouzo, and P. Gripon A short N-proximal region in the large envelope protein harbors a determinant that contributes to the species specificity of human HBV J Virol 75 2001 11565 11572 (Pubitemid 33063248)
9. P. Coursaget, Y. Buisson, C. Bourdil, B. Yvonnet, C. Molinie, and M.T. Diop Antibody response to preS1 in hepatitis-B-virus-induced liver disease and after immunization Res Virol 141 1990 563 570
10. A. Dikmans, U. Beutling, E. Schmeisser, S. Thiele, and R. Frank A novel process for manufacturing multipurpose high-density chemical microarrays QSAR Comb Sci 25 2006 1069 1080 (Pubitemid 44831692)
11. E.A. Emini, R.W. Ellis, W.J. Miller, W.J. McAleer, E.M. Scolnick, and R.J. Gerety Production and immunological analysis of recombinant hepatitis B vaccine J Infect 13 1986 3 9
12. M. Engelke, K. Mills, S. Seitz, P. Simon, P. Gripon, and M. Schnolzer Characterization of a hepatitis B and hepatitis delta virus receptor binding site Hepatology 43 2006 750 760
13. M. Fortuin, V. Karthigesu, L. Allison, C. Howard, S. Hoare, and M. Mendy Breakthrough infections and identification of a viral variant in Gambian children immunized with hepatitis B vaccine J Infect Dis 169 1994 1374 1376 (Pubitemid 24164609)
14. R. Frank Spot-synthesis: an easy technique for the positionally addressable, parallel chemical synthesis on a membrane support Tetrahedron 48 1992 9217 9232
15. H. Gerlach, V. Laumann, S. Martens, C.F. Becker, R.S. Goody, and M. Geyer HIV-1 Nef membrane association depends on charge, curvature, composition and sequence Nat Chem Biol 6 2010 46 53
16. V. Germaschewski, and K. Murray Screening a monoclonal antibody with a fusion-phage display library shows a discontinuity in a linear epitope within PreS1 of HBV J Med Virol 45 1995 300 305
17. D. Glebe, M. Aliakbari, P. Krass, E.V. Knoop, K.P. Valerius, and W.H. Gerlich Pre-s1 antigen-dependent infection of Tupaia hepatocyte cultures with human HBV J Virol 77 2003 9511 9521 (Pubitemid 37011046)
18. D. Glebe, and S. Urban Viral and cellular determinants involved in hepadnaviral entry World J Gastroenterol 13 2007 22 38 (Pubitemid 46165460)
19. D. Glebe, S. Urban, E.V. Knoop, N. Cag, P. Krass, and S. Grün Mapping of the HBV attachment site by use of infection-inhibiting preS1 lipopeptides and tupaia hepatocytes Gastroenterology 129 2005 234 245 (Pubitemid 41002057)
20. P. Gripon, I. Cannie, and S. Urban Efficient inhibition of HBV infection by acylated peptides derived from the large viral surface protein J Virol 79 2005 1613 1622 (Pubitemid 40459108)
21. P. Gripon, J. Le Seyec, S. Rumin, and C. Guguen-Guillouzo Myristylation of the HBV large surface protein is essential for viral infectivity Virology 213 1995 292 299
22. P. Gripon, S. Rumin, S. Urban, J. Le Seyec, D. Glaise, and I. Cannie Infection of a human hepatoma cell line by HBV Proc Natl Acad Sci USA 99 2002 15655 15660 (Pubitemid 35403987)
23. T.J. Harrison, E.A. Hopes, C.J. Oon, A.R. Zanetti, and A.J. Zuckerman Independent emergence of a vaccine-induced escape mutant of HBV J Hepatol 13 1991 S105 107
24. K.H. Heermann, U. Goldmann, W. Schwartz, T. Seyffarth, H. Baumgarten, and W.H. Gerlich Large surface proteins of HBV containing the pre-s sequence J Virol 52 1984 396 402 (Pubitemid 15202474)
25. W.G. Hu, J. Wei, H.C. Xia, X.X. Yang, F. Li, and G.D. Li Identification of the immunogenic domains in HBsAg preS1 region using overlapping preS1 fragment fusion proteins World J Gastroenterol 11 2005 2088 2094 (Pubitemid 40542651)
26. X. Huang, D. Lu, G. Ji, Y. Sun, L. Ma, and Z. Chen Hepatitis B virus (HBV) vaccine-induced escape mutants of HBV S gene among children from Qidong area, China Virus Res 99 2004 63 68 (Pubitemid 37542492)
27. W. Jilg Novel hepatitis B vaccines Vaccine 16 1998 S65 68
28. C.A. Jursch, W.H. Gerlich, D. Glebe, S. Schaefer, O. Marie, and O. Thraenhart Molecular approaches to validate disinfectants against human HBV Med Microbiol Immunol (Berl) 190 2002 189 197 (Pubitemid 34230749)
29. A. Kazaks, G. Borisova, S. Cvetkova, L. Kovalevska, V. Ose, and I. Sominskaya Mosaic hepatitis B virus core particles presenting the complete preS sequence of the viral envelope on their surface J Gen Virol 85 Pt 9 2004 2665 2670 (Pubitemid 39214362)
30. J. Köck, M. Nassal, S. MacNelly, T.F. Baumert, H.E. Blum, and F. von Weizsäcker Efficient infection of primary tupaia hepatocytes with purified human and woolly monkey hepatitis B virus J Virol 75 2001 5084 5089 (Pubitemid 32448530)
31. A.K. Kubba, P. Taylor, B. Graneek, and S. Strobel Non-responders to hepatitis B vaccination: a review Commun Dis Public Health 6 2003 106 112
32. M.L. Landrum, K.H. Hullsiek, A. Ganesan, A.C. Weintrob, N.F. Crum-Cianflone, and R.V. Barthel Hepatitis B vaccination and risk of hepatitis B infection in HIV-infected individuals AIDS 24 2010 545 555
33. K. Madalinski, B. Burczynska, K.H. Heermann, A. Uy, and W.H. Gerlich Analysis of viral proteins in circulating immune complexes from chronic carriers of hepatitis B virus Clin Exp Immunol 84 1991 493 500
34. D. Marc, G. Masson, M. Girard, and S. van der Werf Lack of myristoylation of poliovirus capsid polypeptide VP0 prevents the formation of virions or results in the assembly of noninfectious virus particles J Virol 64 1990 4099 4107 (Pubitemid 20279815)
35. S. Maurer-Stroh, and F. Eisenhaber Myristoylation of viral and bacterial proteins Trends Microbiol 12 2004 178 185 (Pubitemid 38393738)
36. W.J. McAleer, E.B. Buynak, R.Z. Maigetter, D.E. Wampler, W.J. Miller, and M.R. Hilleman Human hepatitis B vaccine from recombinant yeast Nature 307 1984 178 180 (Pubitemid 14132908)
37. D.R. Milich T- and B-cell recognition of hepatitis B viral antigens Immunol Today 9 1988 380 386
38. D.R. Milich, A. McLachlan, F.V. Chisari, S.B. Kent, and G.B. Thorton Immune response to the pre-S(1) region of the hepatitis B surface antigen (HBsAg): a pre-S(1)-specific T cell response can bypass nonresponsiveness to the pre-S(2) and S regions of HBsAg J Immunol 137 1986 315 322 (Pubitemid 16100306)
39. D.R. Milich, D.L. Peterson, J. Zheng, J.L. Hughes, R. Wirtz, and F. Schödel The hepatitis nucleocapsid as a vaccine carrier moiety Ann NY Acad Sci 754 1995 187 201
40. A.R. Neurath, B. Seto, and N. Strick Antibodies to synthetic peptides from the preS1 region of the hepatitis B virus (HBV) envelope (env) protein are virus-neutralizing and protective Vaccine 7 1989 234 236 (Pubitemid 19174459)
41. H. Okamoto, K. Yano, Y. Nozaki, A. Matsui, H. Miyazaki, and K. Yamamoto Mutations within the S gene of hepatitis B virus transmitted from mothers to babies immunized with hepatitis B immune globulin and vaccine Pediatr Res 32 1992 264 268
42. P. Pumpens, G.P. Borisova, R.A. Crowther, and E. Grens Hepatitis B virus core particles as epitope carriers Intervirology 38 1995 63 74
43. P. Pumpens, and E. Grens HBV core particles as a carrier for B cell/T cell epitopes Intervirology 44 2001 98 114 (Pubitemid 32757388)
44. P. Rendi-Wagner, D. Shouval, B. Genton, Y. Lurie, H. Rumke, and G. Boland Comparative immunogenicity of a PreS/S hepatitis B vaccine in non- and low responders to conventional vaccine Vaccine 24 2006 2781 2789
45. R. Sahli, R. Freund, T. Dubensky, R. Garcea, R. Bronson, and T. Benjamin Defect in entry and altered pathogenicity of a polyoma virus mutant blocked in VP2 myristylation Virology 192 1993 142 153
46. A. Schulze, A. Schieck, Y. Ni, W. Mier, and S. Urban Fine mapping of pre-S sequence requirements for hepatitis B virus large envelope protein-mediated receptor interaction J. Virol. 84 2010 1989 2000
47. M.Y. Shapira, E. Zeira, R. Adler, and D. Shouval Rapid seroprotection against hepatitis B following the first dose of a Pre-S1/Pre-S2/S vaccine J Hepatol 34 2001 123 127 (Pubitemid 32102561)
48. D. Shouval Hepatitis B vaccines J Hepatol 39 2003 S70 S76
49. D. Skrastina, A. Bulavaite, I. Sominskaya, L. Kovalevska, V. Ose, and D. Priede High immunogenicity of a hydrophilic component of the hepatitis B virus preS1 sequence exposed on the surface of three virus-like particle carriers Vaccine 26 2008 1972 1981
50. I. Sominskaya, P. Pushko, D. Dreilina, T. Kozlovskaya, and P. Pumpen Determination of the minimal length of preS1 epitope recognized by a monoclonal antibody which inhibits attachment of hepatitis B virus to hepatocytes Med Microbiol Immunol 181 1992 215 226
51. S.L. Stramer, U. Wend, D. Candotti, G.A. Foster, F.B. Hollinger, and R.Y. Dodd Nucleic acid testing to detect HBV infection in blood donors N Engl J Med 364 2011 236 247
52. T. Storni, C. Ruedl, K. Schwarz, R.A. Schwendener, W.A. Renner, and M.F. Bachmann Nonmethylated CG motifs packaged into virus-like particles induce protective cytotoxic T cell responses in the absence of systemic side effects J Immunol 172 2004 1777 1785 (Pubitemid 38116826)
53. E. Tabor Infections by hepatitis B surface antigen gene mutants in Europe and North America J Med Virol 78 2006 S43 47
54. R. Ulrich, M. Nassal, H. Meisel, and D.H. Krüger Core particles of hepatitis B virus as carrier for foreign epitopes Adv Virus Res 50 1998 141 182
55. P. Valenzuela, A. Medina, W.J. Rutter, G. Ammerer, and B.D. Hall Synthesis and assembly of hepatitis B virus surface antigen particles in yeast Nature 298 1982 347 350 (Pubitemid 12044287)
56. V. Velu, S. Saravanan, S. Nandakumar, E. Dhevahi, E.M. Shankar, and K.G. Murugavel Transmission of "a" determinant variants of hepatitis B virus in immunized babies born to HBsAg carrier mothers Jpn J Infect Dis 61 2008 73 76 (Pubitemid 351338536)
57. J. Wei, Y.Q. Wang, Z.M. Lu, G.D. Li, Y. Wang, and Z.C. Zhang Detection of anti-preS1 antibodies for recovery of hepatitis B patients by immunoassay World J Gastroenterol 8 2002 276 281 (Pubitemid 34414880)
58. B. Wolters, T. Muller, R.S. Ross, R. Clauberg, U. Werfel, and H. Roggendorf Comparative evaluation of the immunogenicity of combined hepatitis A and B vaccine by a prospective and retrospective trial Hum Vaccin 5 2009
59. L. Zhang, M.A. Agosto, T. Ivanovic, D.S. King, M.L. Nibert, and S.C. Harrison Requirements for the formation of membrane pores by the reovirus myristoylated micro1N peptide J Virol 83 2009 7004 7014
60. X. Zhang, L. Jin, Q. Fang, W.H. Hui, and Z.H. Zhou 3.3 A cryo-EM structure of a nonenveloped virus reveals a priming mechanism for cell entry Cell 141 2010 472 482
61. J.N. Zuckerman, A.J. Zuckerman, I. Symington, W. Du, A. Williams, and B. Dickson Evaluation of a new hepatitis B triple-antigen vaccine in inadequate responders to current vaccines Hepatology 34 2001 798 802 (Pubitemid 32928006)