Genetic polymorphism of interleukin-6 influences susceptibility to HBV-related hepatocellular carcinoma in a male Chinese Han population

Human Immunology

Volumn 75, Issue 4, 2014, Pages 297-301

  Tang, Shengli ^a   Yuan, Yufeng ^a   He, Yueming ^a   Pan, Dingyu ^a   Zhang, Yongxi ^a   Liu, Yuanyuan ^b   Liu, Quanyan ^a   Zhang, Zhonglin ^a   Liu, Zhisu ^a  

^a ZHONGNAN HOSPITAL OF WUHAN UNIVERSITY   (China)

^b WUHAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA; INTERLEUKIN 6;

ADULT; ALLELE; ARTICLE; CANCER RISK; CANCER SUSCEPTIBILITY; CASE CONTROL STUDY; CHINESE; CONTROLLED STUDY; DNA SEQUENCE; FEMALE; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENOTYPE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; INTERLEUKIN 6 GENE; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MODEL; PRIORITY JOURNAL; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; VIRUS CARCINOGENESIS;

ADULT; ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; CARCINOMA, HEPATOCELLULAR; CHINA; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; INTERLEUKIN-6; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM STAGING; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; SEX FACTORS; TUMOR BURDEN;

EID: 84895546766     PISSN: 01988859     EISSN: 18791166     Source Type: Journal    
DOI: 10.1016/j.humimm.2014.02.006     Document Type: Article

References (27)

1. Parkin D.M. The global health burden of infection-associated cancers in the year 2002. Int J Cancer 2006, 118:3030-3044.
2. Sener S.F. Disease without borders. CA Cancer J Clin 2005, 55:7-9.
3. Jemal A., Bray F., Center M.M., Ferlay J., Ward E., Forman D. Global cancer statistics. CA Cancer J Clin 2011, 61:69-90.
4. Dickinson J.A., Wun Y.T., Wong S.L. Modelling death rates for carriers of hepatitis B. Epidemiol Infect 2002, 128:83-92.
5. Yang J.D., Roberts L.R. Hepatocellular carcinoma: a global view. Nat Rev Gastroenterol Hepatol 2010, 7:448-458.
6. El-Serag H.B., Rudolph K.L. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 2007, 132:2557-2576.
7. Yu M.W., Hsu F.C., Sheen I.S., Chu C.M., Lin D.Y., Chen C.J., et al. Prospective study of hepatocellular carcinoma and liver cirrhosis in asymptomatic chronic hepatitis B virus carriers. Am J Epidemiol 1997, 145:1039-1047.
8. Yu M.W., Chang H.C., Liaw Y.F., Lin S.M., Lee S.D., Liu C.J., et al. Familial risk of hepatocellular carcinoma among chronic hepatitis B carriers and their relatives. J Natl Cancer Inst 2000, 92:1159-1164.
9. Naugler W.E., Sakurai T., Kim S., Maeda S., Kim K., Elsharkawy A.M., et al. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 2007, 317:121-124.
10. Wong V.W., Yu J., Cheng A.S., Wong G.L., Chan H.Y., Chu E.S., et al. High serum interleukin-6 level predicts future hepatocellular carcinoma development in patients with chronic hepatitis B. Int J Cancer 2009, 124:2766-2770.
11. Georges J.L., Loukaci V., Poirier O., Evans A., Luc G., Arveiler D., et al. Interleukin-6 gene polymorphisms and susceptibility to myocardial infarction: the ECTIM study. Etude Cas-Temoin de l'Infarctus du Myocarde. J Mol Med (Berl) 2001, 79:300-305.
12. Jordanides N., Eskdale J., Stuart R., Gallagher G. Allele associations reveal four prominent haplotypes at the human interleukin-6 (IL-6) locus. Genes Immun 2000, 1:451-455.
13. Ota N., Nakajima T., Nakazawa I., Suzuki T., Hosoi T., Orimo H., et al. A nucleotide variant in the promoter region of the interleukin-6 gene associated with decreased bone mineral density. J Hum Genet 2001, 46:267-272.
14. Tong Y., Wang Z., Geng Y., Liu J., Zhang R., Lin Q., et al. The association of functional polymorphisms of IL-6 gene promoter with ischemic stroke: analysis in two Chinese populations. Biochem Biophys Res Commun 2010, 391:481-485.
15. Fishman D., Faulds G., Jeffery R., Mohamed-Ali V., Yudkin J.S., Humphries S., et al. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 1998, 102:1369-1376.
16. Bao S., Yang W., Zhou S., Ye Z. Relationship between single nucleotide polymorphisms in -174G/C and -634C/G promoter region of interleukin-6 and prostate cancer. J Huazhong Univ Sci Technol Med Sci 2008, 28:693-696.
17. Gangwar R., Mittal B., Mittal R.D. Association of interleukin-6 -174G>C promoter polymorphism with risk of cervical cancer. Int J Biol Markers 2009, 24:11-16.
18. Gaur P., Mittal M., Mohanti B., Das S. Functional variants of IL4 and IL6 genes and risk of tobacco-related oral carcinoma in high-risk Asian Indians. Oral Dis 2011, 17:720-726.
19. Yu Y., Wang W., Zhai S., Dang S., Sun M. IL6 gene polymorphisms and susceptibility to colorectal cancer: a meta-analysis and review. Mol Biol Rep 2012, 39:8457-8463.
20. Zhai R., Liu G., Yang C., Huang C., Wu C., Christiani D.C. The G to C polymorphism at -174 of the interleukin-6 gene is rare in a Southern Chinese population. Pharmacogenetics 2001, 11:699-701.
21. Park B.L., Lee H.S., Kim Y.J., Kim J.Y., Jung J.H., Kim L.H., et al. Association between interleukin 6 promoter variants and chronic hepatitis B progression. Exp Mol Med 2003, 35:76-82.
22. Qiu X.Q., Bei C.H., Yu H.P., Zeng X.Y., Zhong Q.A. Study on the relationship between single-nucleotide polymorphisms in IL-6, IL-10 genes and HBV-related hepatocellular carcinoma. Chin J Epidemiol 2011, 32:510-513.
23. Stephens J.C., Schneider J.A., Tanguay D.A., Choi J., Acharya T., Stanley S.E., et al. Haplotype variation and linkage disequilibrium in 313 human genes. Science 2001, 293:489-493.
24. Terry C.F., Loukaci V., Green F.R. Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation. J Biol Chem 2000, 275:18138-18144.
25. Malarstig A., Wallentin L., Siegbahn A. Genetic variation in the interleukin-6 gene in relation to risk and outcomes in acute coronary syndrome. Thromb Res 2007, 119:467-473.
26. Jang Y., Kim O.Y., Hyun Y.J., Chae J.S., Koh S.J., Heo Y.M., et al. Interleukin-6-572C>G polymorphism-association with inflammatory variables in Korean men with coronary artery disease. Transl Res 2008, 151:154-161.
27. Wang Y.C., Xu G.L., Jia W.D., Han S.J., Ren W.H., Wang W., et al. Estrogen suppresses metastasis in rat hepatocellular carcinoma through decreasing interleukin-6 and hepatocyte growth factor expression. Inflammation 2012, 35:143-149.