Aromatase overexpression in dysfunctional adipose tissue links obesity to postmenopausal breast cancer

Journal of Steroid Biochemistry and Molecular Biology

Volumn 153, Issue , 2015, Pages 35-44

  Wang, Xuyi ^a   Simpson, Evan R ^a   Brown, Kristy A ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

Abbreviation ASCs adipose stromal cells; AIs aromatase inhibitors; AMPK AMP activated protein kinase; cAMP cyclic AMP; CLS crown like structures; COX 2 cyclooxygenase 2; CREB cAMP response element binding protein; CRTC CREB regulated transcription coactivator; EP receptors E prostanoid receptors; ER estrogen receptor; FSK forskolin; HIF1 hypoxia inducible factor 1 ; IGF I insulin like growth factor I; IL interleukin; JNK c jun NH2 terminal protein kinase; LKB1 liver kinase B1; LRH 1 liver receptor homologue 1; MAPK mitogen activated protein kinase; mTOR rapamycin; NF B nuclear factor kB; PGE2 prostaglandin E2; PI3K phosphatidylinositol 3 kinase; PKA protein kinase A; PKC protein kinase C; PMA phorbol ester; PPAR peroxisome proliferator activated receptor; STAT3 signal transducer and activator of transcription 3; TNF necrosis factor ; WAT white adipose tissue

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; ANASTROZOLE; ANDROGEN; AROMATASE; AROMATASE INHIBITOR; ESTROGEN; ESTROGEN RECEPTOR; EXEMESTANE; FORSKOLIN; INSULIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LEPTIN; LETROZOLE; METFORMIN; PROSTAGLANDIN E2; SOMATOMEDIN C; TAMOXIFEN; TUMOR NECROSIS FACTOR ALPHA; CYP19A1 PROTEIN, HUMAN;

ADIPOSE TISSUE; BREAST CANCER; BREAST CARCINOGENESIS; CANCER RISK; CELL PROLIFERATION; DISEASE ASSOCIATION; ENZYME INHIBITION; ENZYME REGULATION; ESTROGEN SYNTHESIS; GENE OVEREXPRESSION; HUMAN; INFLAMMATION; NONHUMAN; OBESITY; POSTMENOPAUSE; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION; WEIGHT REDUCTION; WHITE ADIPOSE TISSUE; ANIMAL; BREAST; BREAST TUMOR; COMPLICATION; FEMALE; GENETICS; METABOLISM; MOLECULARLY TARGETED THERAPY; PATHOLOGY; UPREGULATION;

ADIPOSE TISSUE; ANIMALS; AROMATASE; AROMATASE INHIBITORS; BREAST; BREAST NEOPLASMS; FEMALE; HUMANS; MOLECULAR TARGETED THERAPY; OBESITY; POSTMENOPAUSE; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84941190426     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2015.07.008     Document Type: Review

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