Insulin-like growth factor I enhances the expression of aromatase P450 by inhibiting autophagy

Endocrinology

Volumn 151, Issue 10, 2010, Pages 4949-4958

  Zhang, Bo ^a   Shozu, Makio ^b   Okada, Masahiko ^a   Ishikawa, Hiroshi ^b   Kasai, Tadayuki ^a   Murakami, Kouich ^a   Nomura, Kazuhito ^a   Harada, Nobuhiro ^c   Inoue, Masaki ^a  

^a KANAZAWA UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCE   (Japan)

^b CHIBA UNIVERSITY   (Japan)

^c FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATASE; DEXAMETHASONE; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; PEPSTATIN; RAPAMYCIN; SOMATOMEDIN C; PROTEINASE INHIBITOR;

ARTICLE; AUTOPHAGY; CELL PROLIFERATION; CELL TRANSPORT; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEGRADATION; HUMAN; HUMAN CELL; LYSOSOME; MICROSOME; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STABILITY; DOWN REGULATION; DRUG EFFECTS; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PROTEIN PROCESSING; TUMOR CELL LINE; UPREGULATION;

AROMATASE; AUTOPHAGY; CELL LINE, TUMOR; DEXAMETHASONE; DOWN-REGULATION; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INSULIN-LIKE GROWTH FACTOR I; LYSOSOMES; PEPSTATINS; PROTEASE INHIBITORS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STABILITY; RNA, MESSENGER; UP-REGULATION;

EID: 77957265788     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2010-0294     Document Type: Article

References (55)

1. Santen RJ, Brodie H, Simpson ER, Siiteri PK, Brodie A 2009 History of aromatase: saga of an important biological mediator and therapeutic target. Endocr Rev 30:343-375
2. Bulun SE, Imir G, Utsunomiya H, Thung S, Gurates B, Tamura M, Lin Z 2005 Aromatase in endometriosis and uterine leiomyomata. J Steroid Biochem Mol Biol 95:57-62
3. Shozu M, Murakami K, Inoue M 2004 Aromatase and leiomyoma of the uterus. Semin Reprod Med 22:51-60
4. Shippen ER, West Jr WJ 2004 Successful treatment of severe endometriosis in two premenopausal women with an aromatase inhibitor. Fertil Steril 81:1395-1398
5. Shozu M, Murakami K, Segawa T, Kasai T, Inoue M 2003 Successful treatment of symptomatic uterine leiomyoma with a nonsteroidal aromatase inhibitor in a perimenopausal woman. Fertil Steril 79: 628-631
6. Bulun SE, Lin Z, Zhao H, Lu M, Amin S, Reierstad S, Chen D 2009 Regulation of aromatase expression in breast cancer tissue. Ann NY Acad Sci 1155:121-131
7. Zhao Y, Mendelson CR, Simpson ER 1995 Characterization of the sequences of the human CYP19 (aromatase) gene that mediate regulation by glucocorticoids in adipose stromal cells and fetal hepatocytes. Mol Endocrinol 9:340-349
8. Zhao Y, Nichols JE, Valdez R, Mendelson CR, Simpson ER 1996 Tumor necrosis factor-α stimulates aromatase gene expression in human adipose stromal cells through use of an activating protein-1 binding site upstream of promoter 1.4. Mol Endocrinol 10:1350-1357
9. Zhao Y, Nichols JE, Bulun SE, Mendelson CR, Simpson ER 1995 Aromatase P450 gene expression in human adipose tissue. Role of a Jak/STAT pathway in regulation of the adipose-specific promoter. J Biol Chem 270:16449-16457
10. Shozu M, Zhao Y, Simpson ER 2000 TGF-beta1 stimulates expression of the aromatase (CYP19) gene in human osteoblast-like cells and THP-1 cells. Mol Cell Endocrinol 160:123-133
11. Shozu M, Sumitani H, Segawa T, Yang HJ, Murakami K, Kasai T, Inoue M 2002 Overexpression of aromatase P-450 in leiomyoma tissues is driven through the promoter I. 4 of aromatase P-450. J Clin Endocrinol Metab 87:2540-2548
12. Shozu M, Zhao Y, Simpson ER 1997 Estrogen biosynthesis in THP1 cells is regulated by promoter switching of the aromatase (CYP19) gene. Endocrinology 138:5125-5135
13. Meng L, Zhou J, Sasano H, Suzuki T, Zeitoun KM, Bulun SE 2001 Tumor necrosis factor α and interleukin 11 secreted by malignant breast epithelial cells inhibit adipocyte differentiation by selectively down-regulating CCAAT/enhancer binding protein α and peroxisome proliferator-activated receptor γ: mechanism of desmoplastic reaction. Cancer Res 61:2250-2255
14. Pollak MN, Schernhammer ES, Hankinson SE 2004 Insulin-like growth factors and neoplasia. Nat Rev Cancer 4:505-518
15. Reed MJ, Topping L, Coldham NG, Purohit A, Ghilchik MW, James VH 1993 Control of aromatase activity in breast cancer cells: the role of cytokines and growth factors. J Steroid Biochem Mol Biol 44:589-596
16. Steinkampf MP, Mendelson CR, Simpson ER 1988 Effects of epidermal growth factor and insulin-like growth factor I on the levels ofmRNAencoding aromatase cytochrome P-450 of human ovarian granulosa cells. Mol Cell Endocrinol 59:93-99
17. Emoto N, Ling N, Baird A 1991 Growth factor-mediated regulation of aromatase activity in human skin fibroblasts. Proc Soc Exp Biol Med 196:351-358
18. Chabrolle C, Tosca L, Ramé C, Lecomte P, Royère D, Dupont J 2009 Adiponectin increases insulin-like growth factor I-induced progesterone and estradiol secretion in human granulosa cells. Fertil Steril 92:1988-1996
19. Randolph Jr JF, Kipersztok S, Ayers JW, Ansbacher R, Peegel H, Menon KM 1987 The effect of insulin on aromatase activity in isolated human endometrial glands and stroma. Am J Obstet Gynecol 157:1534-1539
20. Sirianni R, Chimento A, Malivindi R, Mazzitelli I, Andò S, Pezzi V 2007 Insulin-like growth factor-I, regulating aromatase expression through steroidogenic factor 1, supports estrogen-dependent tumor Leydig cell proliferation. Cancer Res 67:8368-8377
21. Ginther OJ, Bergfelt DR, Beg MA, Meira C, Kot K 2004 In vivo effects of an intrafollicular injection of insulin-like growth factor 1 on the mechanism of follicle deviation in heifers and mares. Biol Reprod 70:99-105
22. Spicer LJ, Chamberlain CS, Maciel SM 2002 Influence of gonadotropins on insulin- and insulin-like growth factor-I (IGF-I)-induced steroid production by bovine granulosa cells. Domest Anim Endocrinol 22:237-254
23. Thierry van Dessel HJ, Lee PD, Faessen G, Fauser BC, Giudice LC 1999 Elevated serum levels of free insulin-like growth factor I in polycystic ovary syndrome. J Clin Endocrinol Metab 84:3030-3035
24. Ayabe T, Tsutsumi O, Sakai H, Yoshikawa H, Yano T, Kurimoto F, Taketani Y 1997 Increased circulating levels of insulin-like growth factor-I and decreased circulating levels of insulin-like growth factor binding protein-1 in postmenopausal women with endometrial cancer. Endocr J 44:419-424
25. Matsuo O, Fukao H, Izaki S, Matsuo C, Ueshima S 1989 Production and characterization of single-chain tissue-type plasminogen activator produced by an established cell line from human uterine muscle. Cell Struct Funct 14:45-60
26. Sourla A, Reyes-Moreno C, Koutsilieris M 1994 Characterization of KW smooth muscle-like human myometrial cells. Anticancer Research 14:1887-1892
27. Sumitani H, Shozu M, Segawa T, Murakami K, Yang HJ, Shimada K, Inoue M 2000 In situ estrogen synthesized by aromatase P450 in uterine leiomyoma cells promotes cell growth probably via an autocrine/ intracrine mechanism. Endocrinology 141:3852-3861
28. Shozu M, Simpson ER 1998 Aromatase expression of human osteoblast- like cells. Mol Cell Endocrinol 139:117-129
29. Harada N 1988 Novel properties of human placental aromatase as cytochrome P-450: purification and characterization of a unique form of aromatase. J Biochem 103:106-113
30. Ishikawa H, Shozu M, Okada M, Inukai M, Zhang B, Kato K, Kasai T, Inoue M 2007 Early growth response gene-1 plays a pivotal role in down-regulation of a cohort of genes in uterine leiomyoma. J Mol Endocrinol 39:333-341
31. Shozu M, Zhao Y, Bulun SE, Simpson ER 1998 Multiple splicing events involved in regulation of human aromatase expression by a novel promoter, I. 6. Endocrinology 139:1610-1617
32. Corbin CJ, Graham-Lorence S, McPhaul M, Mason JI, Mendelson CR, Simpson ER 1988 Isolation of a full-length cDNA insert encoding human aromatase system cytochrome P-450 and its expression in nonsteroidogenic cells. Proc Natl Acad Sci USA 85:8948-8952
33. Shozu M, Murakami K, Segawa T, Kasai T, Ishikawa H, Shinohara K, Okada M, Inoue M 2004 Decreased expression of early growth response-1 and its role in uterine leiomyoma growth. Cancer Res 64:4677-4684
34. Klionsky DJ, Emr SD 2000 Autophagy as a regulated pathway of cellular degradation. Science 290:1717-1721
35. Young AR, Narita M, Ferreira M, Kirschner K, Sadaie M, Darot JF, Tavaré S, Arakawa S, Shimizu S, Watt FM, Narita M 2009 Autophagy mediates the mitotic senescence transition. Genes Dev 23: 798-803
36. Bulun SE, Sebastian S, Takayama K, Suzuki T, Sasano H, Shozu M 2003 The human CYP19 (aromatase P450) gene: update on physiologic roles and genomic organization of promoters. J Steroid Biochem Mol Biol 86:219-224
37. Shozu M, Sumitani H, Murakami K, Segawa T, Yang HJ, Inoue M 2001 Regulation of aromatase activity in bone-derived cells: possible role of mitogen-activated protein kinase. J Steroid Biochem Mol Biol 79:61-65
38. Chen S, Ye J, Kijima I, Kinoshita Y, Zhou D 2005 Positive and negative transcriptional regulation of aromatase expression in human breast cancer tissue. J Steroid Biochem Mol Biol 95:17-23
39. Catalano S, Barone I, Giordano C, Rizza P, Qi H, Gu G, Malivindi R, Bonofiglio D, Andò S 2009 Rapid estradiol/ERα signaling enhances aromatase enzymatic activity in breast cancer cells. Mol Endocrinol 23:1634-1645
40. Balthazart J, Baillien M, Charlier TD, Cornil CA, Ball GF 2003 Multiple mechanisms control brain aromatase activity at the genomic and non-genomic level. J Steroid Biochem Mol Biol 86: 367-379
41. Wang X, Chen S 2006 Aromatase destabilizer: novel action of exemestane, a food and drug administration-approved aromatase inhibitor. Cancer Res 66:10281-10286
42. Miller TW, Shin I, Kagawa N, Evans DB, Waterman MR, Arteaga CL2008 Aromatase is phosphorylated in situ at serine-118. J Steroid Biochem Mol Biol 112:95-101
43. Lanoux MJ, Cleland WH, Mendelson CR, Carr BR, Simpson ER 1985 Factors affecting the conversion of androstenedione to estrogens by human fetal hepatocytes in monolayer culture. Endocrinology 117:361-368
44. Singh A, Blench I, Morris HR, Savoy LA, Reed MJ 1992 Synergistic interaction of growth factors and albumin in regulating estradiol synthesis in breast cancer cells. Mol Cell Endocrinol 85:165-173
45. Etique N, Chardard D, Chesnel A, Merlin JL, Flament S, Grillier-Vuissoz I 2004 Ethanol stimulates proliferation, ERα and aromatase expression in MCF-7 human breast cancer cells. Int J Mol Med 13:149-155
46. Donohue Jr TM 2009 Autophagy and ethanol-induced liver injury. World J Gastroenterol 15:1178-1185
47. Todde V, Veenhuis M, van der Klei IJ 2009 Autophagy: principles and significance in health and disease. Biochim Biophys Acta 1792:3-13
48. Franch HA, Sooparb S, Du J, Brown NS 2001 A mechanism regulating proteolysis of specific proteins during renal tubular cell growth. J Biol Chem 276:19126-19131
49. Shen W, Brown NS, Finn PF, Dice JF, Franch HA 2006 Akt and Mammalian target of rapamycin regulate separate systems of proteolysis in renal tubular cells. J Am Soc Nephrol 17:2414-2423
50. Nixon RA, Wegiel J, Kumar A, Yu WH, Peterhoff C, Cataldo A, Cuervo AM 2005 Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study. J Neuropathol Exp Neurol 64:113-122
51. Singh R, Kaushik S, Wang Y, Xiang Y, Novak I, Komatsu M, Tanaka K, Cuervo AM, Czaja MJ 2009 Autophagy regulates lipid metabolism. Nature 458:1131-1135
52. Swerdlow S, McColl K, Rong Y, Lam M, Gupta A, Distelhorst CW 2008 Apoptosis inhibition by Bcl-2 gives way to autophagy in glucocorticoid- treated lymphocytes. Autophagy 4:612-620
53. Laane E, Tamm KP, Buentke E, Ito K, Kharaziha P, Khahariza P, Oscarsson J, Corcoran M, Björklund AC, Hultenby K, Lundin J, Heyman M, Söderhäll S, Mazur J, Porwit A, Pandolfi PP, Zhivotovsky B, Panaretakis T, Grandér D 2009 Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy. Cell Death Differ 16:1018-1029
54. Cornil CA, Ball GF, Balthazart J 2006 Functional significance of the rapid regulation of brain estrogen action: where do the estrogens come from? Brain Res 1126:2-26
55. Lephart ED, Simpson ER, McPhaul MJ 1992 Ovarian aromatase cytochrome P-450 mRNA levels correlate with enzyme activity and serum estradiol levels in anestrous, pregnant and lactating rats. Mol Cell Endocrinol 85:205-214