Obesity and breast cancer: Role of inflammation and aromatase

Journal of Molecular Endocrinology

Volumn 51, Issue 3, 2013, Pages

  Simpson, Evan R ^a,b   Brown, Kristy A ^a,b  

^a HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b MONASH UNIVERSITY   (Australia)

Author keywords

Aromatase; Breast cancer; Inflammation; Obesity; PGE2

Indexed keywords

ACETYLSALICYLIC ACID; ANDROGEN; AROMATASE; AUTACOID; CD68 ANTIGEN; CELECOXIB; CYCLIC AMP; CYCLOOXYGENASE 2; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN; ESTROGEN RECEPTOR; FOLLITROPIN; HYDROXYSTEROID DEHYDROGENASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IBUPROFEN; INTERLEUKIN 11; INTERLEUKIN 6; JANUS KINASE 1; LIVER RECEPTOR HOMOLOG 1; ONCOSTATIN M; PHOSPHOLIPASE C; PROSTAGLANDIN E2; ROFECOXIB; SATURATED FATTY ACID; STAT3 PROTEIN; STEROID RECEPTOR; SULFATASE; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ADIPOCYTE; ADIPOSE TISSUE; AGING; ARTICLE; BIOSYNTHESIS; BODY MASS; BREAST; BREAST CANCER; BREAST CARCINOMA; CANCER PREVENTION; CANCER RISK; CANCER SIZE; CARDIOVASCULAR DISEASE; CHRONIC INFLAMMATION; COMORBIDITY; DISTANT METASTASIS FREE SURVIVAL; DRUG EFFICACY; ESTROGEN SYNTHESIS; FIBROBLAST; GENE EXPRESSION REGULATION; HORMONE SYNTHESIS; HUMAN; INFLAMMATION; INSULIN RESISTANCE; INTRADUCTAL CARCINOMA; INVASIVE CARCINOMA; KIDNEY FAILURE; MASTITIS; MESENCHYME CELL; META ANALYSIS (TOPIC); METABOLIC DISORDER; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PANDEMIC; POSTMENOPAUSE; PREMENOPAUSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; WAIST HIP RATIO;

AROMATASE; BREAST CANCER; INFLAMMATION; OBESITY; PGE2;

AROMATASE; BREAST NEOPLASMS; FEMALE; HUMANS; INFLAMMATION; OBESITY;

EID: 84888339266     PISSN: 09525041     EISSN: 14796813     Source Type: Journal    
DOI: 10.1530/JME-13-0217     Document Type: Article

References (44)

1. Agarwal VR, Bulun SE, Leitch M, Rohrich R & Simpson ER 1996 Use of alternative promoters to express the aromatase cytochrome P450 (CYP19) gene in breast adipose tissues of cancer-free and breast cancer patients. Journal of Clinical Endocrinology and Metabolism 81 3843-3849. (doi:10.1210/jc.81.11.3843).
2. Amadou A, Ferrari P, Muwonge R, Moskal A, Biessy C, Romieu I& Hainaut P 2013 Overweight, obesity and risk of premenopausal breast cancer according to ethnicity: a systematic review and dose-response metaanalysis. Obesity Reviews 14 665-678. (doi:10.1111/obr.12028).
3. Arun B & Goss P 2004 The role of COX-2 inhibition in breast cancer treatment and prevention. Seminars in Oncology 31 22-29. (doi:10.1053/j.seminoncol.2004.03.042).
4. Berrino F, Muti P, Micheli A, Bolelli G, Krogh V, Sciajno R, Pisani P, Panico S & Secreto G 1996 Serum sex hormone levels after menopause and subsequent breast cancer. Journal of the National Cancer Institute 88 291-296. (doi:10.1093/jnci/88.5.291).
5. Biglia N, Peano E, Sgandurra P, Moggio G, Pecchio S, Maggiorotto F & Sismondi P 2012 Body mass index (BMI) and breast cancer: impact on tumour histopatologic features, cancer subtypes and recurrence rate in pre and postmenopausal women. Gynecological Endocrinology 29 263-267. (doi:10.3109/09513590.2012.736559).
6. Boyd NF, Lockwood GA, Byng JW, Little LE, Yaffe MJ & Tritchler DL 1998 The relationship of anthropometric measures to radiological features of the breast in premenopausal women. British Journal of Cancer 78 1233-1238. (doi:10.1038/bjc.1998.660).
7. Boyd NF, Martin LJ, Yaffe MJ &Minkin S 2011 Mammographic density and breast cancer risk: current understanding and future prospects. Breast Cancer Research 13 223. (doi:10.1186/bcr2942).
8. Brown KA & Simpson ER 2012 Obesity and breast cancer: mechanisms and therapeutic implications. Frontiers in Bioscience 4 2515-2524. (doi:10.2741/E562).
9. Bulun SE & Simpson ER 1994 Competitive reverse transcriptionpolymerase chain reaction analysis indicates that levels of aromatase cytochrome P450 transcripts in adipose tissue of buttocks, thighs, and abdomen of women increase with advancing age. Journal of Clinical Endocrinology and Metabolism 78 428-432. (doi:10.1210/jc.78.2.428).
10. Bulun SE, Price TM, Aitken J, Mahendroo MS & Simpson ER 1993 A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription. Journal of Clinical Endocrinology and Metabolism 77 1622-1628. (doi:10.1210/jc.77.6.1622).
11. Cheraghi Z, Poorolajal J, Hashem T, Esmailnasab N & Doosti Irani A 2012 Effect of body mass index on breast cancer during premenopausal and postmenopausal periods: a meta-analysis. PLoS ONE 7 e51446. (doi:10.1371/journal.pone.0051446).
12. Crichton MB, Nichols JE, Zhao Y, Bulun SE & Simpson ER 1996 Expression of transcriptsof interleukin-6andrelatedcytokines byhumanbreast tumors, breast cancer cells, and adipose stromal cells. Molecular and Cellular Endocrinology 118 215-220. (doi:10.1016/0303-7207(96)03761-6).
13. Dorgan JF, Klifa C, Shepherd JA, Egleston BL, Kwiterovich PO Jr, Himes JH, Gabriel KP, Horn LV, Snetselaar LG, Stevens VJ et al. 2012 Height, adiposity and body fat distribution and breast density in young women. Breast Cancer Research 14 R107. (doi:10.1186/bcr3228).
14. Fuhrman BJ, Brinton LA, Pfeiffer RM, Xu X, Veenstra TD, Teter BE, Byrne C, Dallal CM, Barba M, Muti PC et al. 2012 Estrogen metabolism and mammographic density in postmenopausal women: a cross-sectional study. Cancer Epidemiology, Biomarkers & Prevention 21 1582-1591. (doi:10.1158/1055-9965.EPI-12-0247).
15. Garrisi VM, Tufaro A, Trerotoli P, Bongarzone I, Quaranta M, Ventrella V, Tommasi S, Giannelli G & Paradiso A 2012 Body mass index and serum proteomic profile in breast cancer and healthy women: a prospective study. PLoS ONE 7 e49631. (doi:10.1371/journal.pone.0049631).
16. Harris RE, Beebe-Donk J & Alshafie GA 2006 Reduction in the risk of human breast cancer by selective cyclooxygenase-2 (COX-2) inhibitors. BMC Cancer 6 27. (doi:10.1186/1471-2407-6-27).
17. Irahara N, Miyoshi Y, Taguchi T, Tamaki Y & Noguchi S 2006 Quantitative analysis of aromatase mRNA expression derived from various promoters (I.4, I.3, PII and I.7) and its association with expression of TNF-a, IL-6 and COX-2 mRNAs in human breast cancer. International Journal of Cancer 118 1915-1921. (doi:10.1002/ijc.21562).
18. Kamineni A, Anderson ML, White E, Taplin SH, Porter P, Ballard-Barbash R, Malone K & Buist DS 2012 Body mass index, tumor characteristics, and prognosis following diagnosis of early-stage breast cancer in a mammographically screened population. Cancer Causes & Control 24 305-312. (doi:10.1007/s10552-012-0115-7).
19. Kumar P & Mendelson CR 2011 Estrogen-related receptor gamma (ERRgamma) mediates oxygen-dependent induction of aromatase (CYP19) gene expression during human trophoblast differentiation. Molecular Endocrinology 25 1513-1526. (doi:10.1210/me.2011-1012).
20. Kusano AS, Trichopoulos D, Terry KL, Chen WY, Willett WC & Michels KB 2006 A prospective study of breast size and premenopausal breast cancer incidence. International Journal of Cancer 118 2031-2034. (doi:10.1002/ijc.21588).
21. Leek RD, Landers R, Fox SB, Ng F, Harris AL & Lewis CE 1998 Association of tumour necrosis factor a and its receptors with thymidine phosphorylase expression in invasive breast carcinoma. British Journal of Cancer 77 2246-2251. (doi:10.1038/bjc.1998.373).
22. Ma X, Kundu N, Collin PD, Goloubeva O & Fulton AM 2012 Frondoside A inhibits breast cancer metastasis and antagonizes prostaglandin E receptors EP4 and EP2. Breast Cancer Research and Treatment 132 1001-1008. (doi:10.1007/s10549-011-1675-z).
23. MacDonald PC, Edman CD, Hemsell DL, Porter JC & Siiteri PK 1978 Effect of obesity on conversion of plasma androstenedione to estrone in postmenopausal women with and without endometrial cancer. American Journal of Obstetrics and Gynecology 130 448-455.
24. Markkula A, Bromee A, Henningson M, Hietala M, Ringberg A, Ingvar C, Rose C& JernstromH2012 Given breast cancer, does breast size matter? Data from a prospective breast cancer cohort Cancer Causes & Control 23 1307-1316. (doi:10.1007/s10552-012-0008-9).
25. van Nes JG, de Kruijf EM, Faratian D, van de Velde CJ, Putter H, Falconer C, Smit VT, Kay C, van de Vijver MJ, Kuppen PJ et al. 2011 COX2 expression in prognosis and in prediction to endocrine therapy in early breast cancer patients. Breast Cancer Research and Treatment 125 671-685. (doi:10.1007/s10549-010-0854-7).
26. O'Neill JS, Elton RA & Miller WR 1988 Aromatase activity in adipose tissue from breast quadrants: a link with tumour site. BMJ 296 741-743. (doi:10.1136/bmj.296.6624.741).
27. PierobonM&Frankenfeld CL 2013 Obesity as a risk factor for triple-negative breast cancers: a systematic review and meta-analysis. Breast Cancer Research and Treatment 137 307-314. (doi:10.1007/s10549-012-2339-3).
28. Prosperi JR & Robertson FM 2006 Cyclooxygenase-2 directly regulates gene expression of P450 Cyp19 aromatase promoter regions pII, pI.3 and pI.7 and estradiol production in human breast tumor cells. Prostaglandins & Other Lipid Mediators 81 55-70. (doi:10.1016/j.prostaglandins.2006. 07.003).
29. Simpson ER & Brown KA 2013 Minireview: obesity and breast cancer: a tale of inflammation and dysregulated metabolism. Molecular Endocrinology 27 715-725. (doi:10.1210/me.2013-1011).
30. Simpson ER, Clyne C, Rubin G, Boon WC, Robertson K, Britt K, Speed C & Jones M 2002 Aromatase-a brief overview. Annual Review of Physiology 64 93-127. (doi:10.1146/annurev.physiol.64.081601.142703).
31. Subbaramaiah K, Howe LR, Bhardwaj P, Du B, Gravaghi C, Yantiss RK, Zhou XK, Blaho VA, Hla T, Yang P et al. 2011 Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland. Cancer Prevention Research 4 329-346. (doi:10.1158/1940-6207.CAPR-10-0381).
32. Subbaramaiah K, Morris PG, Zhou XK, Morrow M, Du B, Giri D, Kopelovich L, Hudis CA & Dannenberg AJ 2012 Increased levels of COX-2 and prostaglandin E2 contribute to elevated aromatase expression in inflamed breast tissue of obese women. Cancer Discovery 2 356-365. (doi:10.1158/2159-8290.CD-11-0241).
33. Sugimoto Y & Narumiya S 2007 Prostaglandin E receptors. Journal of Biological Chemistry 282 11613-11617. (doi:10.1074/jbc.R600038200).
34. Thomas HV, Key TJ, Allen DS, Moore JW, Dowsett M, Fentiman IS & Wang DY 1997 A prospective study of endogenous serum hormone concentrations and breast cancer risk in post-menopausal women on the island of Guernsey. British Journal of Cancer 76 401-405. (doi:10.1038/bjc.1997.398).
35. To SQ, Knower KC & Clyne CD 2013 NFkB and MAPK signalling pathways mediate TNFa-induced early growth response gene transcription leading to aromatase expression. Biochemical and Biophysical Research Communications 433 96-101. (doi:10.1016/j.bbrc.2013.02.058).
36. Toniolo PG, LevitzM, Zeleniuch-Jacquotte A, Banerjee S, KoenigKL, ShoreRE, Strax P&PasternackBS 1995Aprospective study of endogenous estrogens and breast cancer in postmenopausal women. Journal of the National Cancer Institute 87 190-197. (doi:10.1093/jnci/87.3.190).
37. Vachon CM, Sasano H, Ghosh K, Brandt KR, Watson DA, Reynolds C, Lingle WL, Goss PE, Li R, Aiyar SE et al. 2010 Aromatase immunoreactivity is increased in mammographically dense regions of the breast. Breast Cancer Research and Treatment 125 243-252. (doi:10.1007/s10549-010-0944-6).
38. Xin X, Majumder M, Girish GV, Mohindra V, Maruyama T & Lala PK 2012 Targeting COX-2 and EP4 to control tumor growth, angiogenesis, lymphangiogenesis and metastasis to the lungs and lymph nodes in a breast cancer model. Laboratory Investigation 92 1115-1128. (doi:10.1038/labinvest.2012.90).
39. Zhang X, Smith-Warner SA, Collins LC, Rosner B, Willett WC & Hankinson SE 2012 Use of aspirin, other nonsteroidal anti-inflammatory drugs, and acetaminophen and postmenopausal breast cancer incidence. Journal of Clinical Oncology 30 3468-3477. (doi:10.1200/JCO.2012.42.2006).
40. Zhao Y, Mendelson CR & Simpson ER 1995a Characterization of the sequences of the humanCYP19 (aromatase) gene thatmediate regulation by glucocorticoids in adipose stromal cells and fetal hepatocytes. Molecular Endocrinology 9 340-349. (doi:10.1210/me.9.3.340).
41. Zhao Y, Nichols JE, Bulun SE, Mendelson CR & Simpson ER 1995b Aromatase P450 gene expression in human adipose tissue. Role of a Jak/STAT pathway in regulation of the adipose-specific promoter. Journal of Biological Chemistry 270 16449-16457. (doi:10.1074/jbc.270. 27.16449).
42. Zhao Y, Agarwal VR, Mendelson CR & Simpson ER 1996a Estrogen biosynthesis proximal to a breast tumor is stimulated by PGE2 via cyclic AMP, leading to activation of promoter II of the CYP19 (aromatase) gene. Endocrinology 137 5739-5742. (doi:10.1210/en.137.12.5739).
43. Zhao Y, Nichols JE, Valdez R, Mendelson CR & Simpson ER 1996b Tumor necrosis factor-a stimulates aromatase gene expression in human adipose stromal cells through use of an activating protein-1 binding site upstream of promoter 1.4. Molecular Endocrinology 10 1350-1357. (doi:10.1210/me.10.11.1350).
44. Zhou J, Suzuki T, Kovacic A, Saito R, Miki Y, Ishida T, Moriya T, Simpson ER, Sasano H & Clyne CD 2005 Interactions between prostaglandin E(2), liver receptor homologue-1, and aromatase in breast cancer. Cancer Research 65 657-663.