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Volumn 12, Issue 5, 2015, Pages 566-571

Type 1 regulatory T cells: A new mechanism of peripheral immune tolerance

Author keywords

biomarkers; clinical trials; regulatory functions; type 1 regulatory T cells

Indexed keywords

ALPHA2 INTEGRIN; BIOLOGICAL MARKER; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 10; LENTIVIRUS VECTOR; MEMBRANE PROTEIN; PROTEIN LAG 3; STAT3 PROTEIN; STAT5 PROTEIN; UNCLASSIFIED DRUG;

EID: 84941106659     PISSN: 16727681     EISSN: None     Source Type: Journal    
DOI: 10.1038/cmi.2015.44     Document Type: Review
Times cited : (167)

References (66)
  • 2
    • 0028037782 scopus 로고
    • Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis
    • Chen Y, Kuchroo VK, Inobe J, Hafler DA, Weiner HL. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 1994; 265: 1237-1240.
    • (1994) Science , vol.265 , pp. 1237-1240
    • Chen, Y.1    Kuchroo, V.K.2    Inobe, J.3    Hafler, D.A.4    Weiner, H.L.5
  • 3
    • 0030704726 scopus 로고    scopus 로고
    • A CD41 T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
    • Groux H, OGarra A, Bigler M, Rouleau M, Antonenko S, de Vries JE et al. A CD41 T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 1997; 389: 737-742.
    • (1997) Nature , vol.389 , pp. 737-742
    • Groux, H.1    OGarra, A.2    Bigler, M.3    Rouleau, M.4    Antonenko, S.5    De Vries, J.E.6
  • 4
    • 84880275285 scopus 로고    scopus 로고
    • Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells
    • Gagliani N, Magnani CF, Huber S, Gianolini ME, Pala M, Licona-Limon P et al. Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells. Nat Med 2013; 19: 739-746.
    • (2013) Nat Med , vol.19 , pp. 739-746
    • Gagliani, N.1    Magnani, C.F.2    Huber, S.3    Gianolini, M.E.4    Pala, M.5    Licona-Limon, P.6
  • 5
    • 0036687184 scopus 로고    scopus 로고
    • Growth and expansion of human T regulatory type 1 cells are independent from TCR activation but require exogenous cytokines
    • Bacchetta R, Sartirana C, Levings MK, Bordignon C, Narula S, Roncarolo MG. Growth and expansion of human T regulatory type 1 cells are independent from TCR activation but require exogenous cytokines. Eur J Immunol 2002; 32: 2237-2245.
    • (2002) Eur J Immunol , vol.32 , pp. 2237-2245
    • Bacchetta, R.1    Sartirana, C.2    Levings, M.K.3    Bordignon, C.4    Narula, S.5    Roncarolo, M.G.6
  • 6
    • 0034114926 scopus 로고    scopus 로고
    • A soluble lymphocyte activation gene-3 molecule used as a vaccine adjuvant elicits greater humoral and cellular immune responses to both particulate and soluble antigens
    • El Mir S, Triebel F. A soluble lymphocyte activation gene-3 molecule used as a vaccine adjuvant elicits greater humoral and cellular immune responses to both particulate and soluble antigens. J Immunol 2000; 164: 5583-5589.
    • (2000) J Immunol , vol.164 , pp. 5583-5589
    • El Mir, S.1    Triebel, F.2
  • 7
    • 0344440962 scopus 로고    scopus 로고
    • LAG-3: A regulator of T-cell and DC responses and its use in therapeutic vaccination
    • Triebel F. LAG-3: a regulator of T-cell and DC responses and its use in therapeutic vaccination. Trends Immunol 2003; 24: 619-622.
    • (2003) Trends Immunol , vol.24 , pp. 619-622
    • Triebel, F.1
  • 8
    • 0025159429 scopus 로고
    • Alpha 2 beta 1 integrins from different cell types show different binding specificities
    • Kirchhofer D, Languino LR, Ruoslahti E, Pierschbacher MD. Alpha 2 beta 1 integrins from different cell types show different binding specificities. J Biol Chem 1990; 265: 615-618.
    • (1990) J Biol Chem , vol.265 , pp. 615-618
    • Kirchhofer, D.1    Languino, L.R.2    Ruoslahti, E.3    Pierschbacher, M.D.4
  • 9
    • 0024847956 scopus 로고
    • The human integrin VLA-2 is a collagen receptor on some cells and a collagen/laminin receptor on others
    • Elices MJ, Hemler ME. The human integrin VLA-2 is a collagen receptor on some cells and a collagen/laminin receptor on others. Proc Natl Acad Sci U S A 1989; 86: 9906-9910.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 9906-9910
    • Elices, M.J.1    Hemler, M.E.2
  • 11
    • 33745818581 scopus 로고    scopus 로고
    • Functional specialization of memory Th cells revealed by expression of integrin CD49b
    • Kassiotis G, Gray D, Kiafard Z, Zwirner J, Stockinger B. Functional specialization of memory Th cells revealed by expression of integrin CD49b. J Immunol 2006; 177: 968-975.
    • (2006) J Immunol , vol.177 , pp. 968-975
    • Kassiotis, G.1    Gray, D.2    Kiafard, Z.3    Zwirner, J.4    Stockinger, B.5
  • 12
    • 0036195161 scopus 로고    scopus 로고
    • CD4(1)CD25(1) immunoregulatory T cells: Gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor
    • McHugh RS, Whitters MJ, Piccirillo CA, Young DA, Shevach EM, Collins M, Byrne MC. CD4(1)CD25(1) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 2002; 16: 311-323.
    • (2002) Immunity , vol.16 , pp. 311-323
    • McHugh, R.S.1    Whitters, M.J.2    Piccirillo, C.A.3    Young, D.A.4    Shevach, E.M.5    Collins, M.6    Byrne, M.C.7
  • 13
    • 10744226541 scopus 로고    scopus 로고
    • Regulatory T cells and dendritic cells in transplantation tolerance: Molecular markers and mechanisms
    • Cobbold SP, Nolan KF, Graca L, Castejon R, Le Moine A, Frewin M et al. Regulatory T cells and dendritic cells in transplantation tolerance: molecular markers and mechanisms. Immunol Rev 2003; 196: 109-124.
    • (2003) Immunol Rev , vol.196 , pp. 109-124
    • Cobbold, S.P.1    Nolan, K.F.2    Graca, L.3    Castejon, R.4    Le Moine, A.5    Frewin, M.6
  • 14
  • 15
    • 33646551167 scopus 로고    scopus 로고
    • Enhanced frequency of CD18-and CD49b-expressing T cells in peripheral blood of asthmatic patients correlates with disease severity
    • Rahmoun M, Foussat A, Groux H, Pene J, Yssel H, Chanez P. Enhanced frequency of CD18-and CD49b-expressing T cells in peripheral blood of asthmatic patients correlates with disease severity. Int Arch Allergy Immunol 2006; 140: 139-149.
    • (2006) Int Arch Allergy Immunol , vol.140 , pp. 139-149
    • Rahmoun, M.1    Foussat, A.2    Groux, H.3    Pene, J.4    Yssel, H.5    Chanez, P.6
  • 16
    • 84903936227 scopus 로고    scopus 로고
    • Human CD41 CD391 regulatory T cells produce adenosine upon coexpression of surface CD73 or contact with CD731 exosomes or CD731 cells
    • Schuler PJ, Saze Z, Hong CS, Muller L, Gillespie DG, Cheng D et al. Human CD41 CD391 regulatory T cells produce adenosine upon coexpression of surface CD73 or contact with CD731 exosomes or CD731 cells. Clin Exp Immunol 2014; 177: 531-543.
    • (2014) Clin Exp Immunol , vol.177 , pp. 531-543
    • Schuler, P.J.1    Saze, Z.2    Hong, C.S.3    Muller, L.4    Gillespie, D.G.5    Cheng, D.6
  • 17
    • 77956254094 scopus 로고    scopus 로고
    • Adenosine and prostaglandin E2 cooperate in the suppression of immune responses mediated by adaptive regulatory T cells
    • Mandapathil M, Szczepanski MJ, Szajnik M, Ren J, Jackson EK, Johnson JT et al. Adenosine and prostaglandin E2 cooperate in the suppression of immune responses mediated by adaptive regulatory T cells. J Biol Chem 2010; 285: 27571-27580.
    • (2010) J Biol Chem , vol.285 , pp. 27571-27580
    • Mandapathil, M.1    Szczepanski, M.J.2    Szajnik, M.3    Ren, J.4    Jackson, E.K.5    Johnson, J.T.6
  • 18
    • 34548804503 scopus 로고    scopus 로고
    • Expansion of human T regulatory type 1 cells in the microenvironment of cyclooxygenase 2 overexpressing head and neck squamous cell carcinoma
    • Bergmann C, Strauss L, Zeidler R, Lang S, Whiteside TL. Expansion of human T regulatory type 1 cells in the microenvironment of cyclooxygenase 2 overexpressing head and neck squamous cell carcinoma. Cancer Res 2007; 67: 8865-8873.
    • (2007) Cancer Res , vol.67 , pp. 8865-8873
    • Bergmann, C.1    Strauss, L.2    Zeidler, R.3    Lang, S.4    Whiteside, T.L.5
  • 19
    • 84939937375 scopus 로고    scopus 로고
    • Lack of the protein tyrosine phosphatase PTPN22 strengthens transplant tolerance to pancreatic islets in mice
    • Fousteri G, Jofra T, Di Fonte R, Gagliani N, Morsiani C, Stabilini A, Battaglia M. Lack of the protein tyrosine phosphatase PTPN22 strengthens transplant tolerance to pancreatic islets in mice. Diabetologia 2015; 58: 1319-1328.
    • (2015) Diabetologia , vol.58 , pp. 1319-1328
    • Fousteri, G.1    Jofra, T.2    Di Fonte, R.3    Gagliani, N.4    Morsiani, C.5    Stabilini, A.6    Battaglia, M.7
  • 20
    • 84873742482 scopus 로고    scopus 로고
    • Interleukin-6 induces the generation of IL-10-producing Tr1 cells and suppresses autoimmune tissue inflammation
    • Jin JO, Han X, Yu Q. Interleukin-6 induces the generation of IL-10-producing Tr1 cells and suppresses autoimmune tissue inflammation. J Autoimmun 2013; 40: 28-44.
    • (2013) J Autoimmun , vol.40 , pp. 28-44
    • Jin, J.O.1    Han, X.2    Yu, Q.3
  • 21
    • 84876437530 scopus 로고    scopus 로고
    • IL-27 paves different roads to Tr1
    • Vasanthakumar A, Kallies A. IL-27 paves different roads to Tr1. Eur J Immunol 2013; 43: 882-885.
    • (2013) Eur J Immunol , vol.43 , pp. 882-885
    • Vasanthakumar, A.1    Kallies, A.2
  • 22
    • 79955955899 scopus 로고    scopus 로고
    • Is ROG, repressor of GATA, a specific regulator of Th2-type immune response?
    • Kita H. Is ROG, repressor of GATA, a specific regulator of Th2-type immune response? Clin Immunol 2011; 139: 235-237.
    • (2011) Clin Immunol , vol.139 , pp. 235-237
    • Kita, H.1
  • 23
    • 56149095970 scopus 로고    scopus 로고
    • The production of IL-10 by human regulatory T cells is enhanced by IL-2 through a STAT5-responsive intronic enhancer in the IL-10 locus
    • Tsuji-Takayama K, Suzuki M, Yamamoto M, Harashima A, Okochi A, Otani T et al. The production of IL-10 by human regulatory T cells is enhanced by IL-2 through a STAT5-responsive intronic enhancer in the IL-10 locus. J Immunol 2008; 181: 3897-3905.
    • (2008) J Immunol , vol.181 , pp. 3897-3905
    • Tsuji-Takayama, K.1    Suzuki, M.2    Yamamoto, M.3    Harashima, A.4    Okochi, A.5    Otani, T.6
  • 26
    • 14044268797 scopus 로고    scopus 로고
    • IL-6 plays a unique role in initiating c-Maf expression during early stage of CD4 T cell activation
    • Yang Y, Ochando J, Yopp A, Bromberg JS, Ding Y. IL-6 plays a unique role in initiating c-Maf expression during early stage of CD4 T cell activation. J Immunol 2005; 174: 2720-2729.
    • (2005) J Immunol , vol.174 , pp. 2720-2729
    • Yang, Y.1    Ochando, J.2    Yopp, A.3    Bromberg, J.S.4    Ding, Y.5
  • 27
    • 84876436991 scopus 로고    scopus 로고
    • Egr-2 transcription factor is required for Blimp-1-mediated IL-10 production in IL-27-stimulated CD41 T cells
    • Iwasaki Y, Fujio K, Okamura T, Yanai A, Sumitomo S, Shoda H et al. Egr-2 transcription factor is required for Blimp-1-mediated IL-10 production in IL-27-stimulated CD41 T cells. Eur J Immunol 2013; 43: 1063-1073.
    • (2013) Eur J Immunol , vol.43 , pp. 1063-1073
    • Iwasaki, Y.1    Fujio, K.2    Okamura, T.3    Yanai, A.4    Sumitomo, S.5    Shoda, H.6
  • 29
    • 77955903212 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27
    • Apetoh L, Quintana FJ, Pot C, Joller N, Xiao S, Kumar D et al. The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27. Nat Immunol 2010; 11: 854-861.
    • (2010) Nat Immunol , vol.11 , pp. 854-861
    • Apetoh, L.1    Quintana, F.J.2    Pot, C.3    Joller, N.4    Xiao, S.5    Kumar, D.6
  • 30
    • 69249083836 scopus 로고    scopus 로고
    • Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells
    • Pot C, Jin H, Awasthi A, Liu SM, Lai CY, Madan R et al. Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells. J Immunol 2009; 183: 797-801.
    • (2009) J Immunol , vol.183 , pp. 797-801
    • Pot, C.1    Jin, H.2    Awasthi, A.3    Liu, S.M.4    Lai, C.Y.5    Madan, R.6
  • 31
    • 79952317431 scopus 로고    scopus 로고
    • IL-27 induces the differentiation of Tr1-like cells from human naive CD41 T cells via the phosphorylation of STAT1 and STAT3
    • Wang H, Meng R, Li Z, Yang B, Liu Y, Huang F et al. IL-27 induces the differentiation of Tr1-like cells from human naive CD41 T cells via the phosphorylation of STAT1 and STAT3. Immunol Lett 2011; 136: 21-28.
    • (2011) Immunol Lett , vol.136 , pp. 21-28
    • Wang, H.1    Meng, R.2    Li, Z.3    Yang, B.4    Liu, Y.5    Huang, F.6
  • 32
    • 0347895101 scopus 로고    scopus 로고
    • Activation of human CD41 cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype
    • Kemper C, Chan AC, Green JM, Brett KA, Murphy KM, Atkinson JP. Activation of human CD41 cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype. Nature 2003; 421: 388-392.
    • (2003) Nature , vol.421 , pp. 388-392
    • Kemper, C.1    Chan, A.C.2    Green, J.M.3    Brett, K.A.4    Murphy, K.M.5    Atkinson, J.P.6
  • 33
    • 0035885068 scopus 로고    scopus 로고
    • Differentiation of regulatory T cells 1 is induced by CD2 costimulation
    • Wakkach A, Cottrez F, Groux H. Differentiation of regulatory T cells 1 is induced by CD2 costimulation. J Immunol 2001; 167: 3107-3113.
    • (2001) J Immunol , vol.167 , pp. 3107-3113
    • Wakkach, A.1    Cottrez, F.2    Groux, H.3
  • 34
    • 84890391485 scopus 로고    scopus 로고
    • CD55 costimulation induces differentiation of a discrete T regulatory type 1 cell population with a stable phenotype
    • Sutavani RV, Bradley RG, Ramage JM, Jackson AM, Durrant LG, Spendlove I. CD55 costimulation induces differentiation of a discrete T regulatory type 1 cell population with a stable phenotype. J Immunol 2013; 191: 5895-5903.
    • (2013) J Immunol , vol.191 , pp. 5895-5903
    • Sutavani, R.V.1    Bradley, R.G.2    Ramage, J.M.3    Jackson, A.M.4    Durrant, L.G.5    Spendlove, I.6
  • 35
    • 84862135028 scopus 로고    scopus 로고
    • Enhanced GITR/GITRL interactions augment IL-27 expression and induce IL-10-producing Tr-1 like cells
    • Carrier Y, Whitters MJ, Miyashiro JS, LaBranche TP, Ramon HE, Benoit SE et al. Enhanced GITR/GITRL interactions augment IL-27 expression and induce IL-10-producing Tr-1 like cells. Eur J Immunol 2012; 42: 1393-1404.
    • (2012) Eur J Immunol , vol.42 , pp. 1393-1404
    • Carrier, Y.1    Whitters, M.J.2    Miyashiro, J.S.3    LaBranche, T.P.4    Ramon, H.E.5    Benoit, S.E.6
  • 36
    • 84899749711 scopus 로고    scopus 로고
    • CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis
    • Zohar Y, Wildbaum G, Novak R, Salzman AL, Thelen M, Alon R et al. CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis. J Clin Invest 2014; 124: 2009-2022.
    • (2014) J Clin Invest , vol.124 , pp. 2009-2022
    • Zohar, Y.1    Wildbaum, G.2    Novak, R.3    Salzman, A.L.4    Thelen, M.5    Alon, R.6
  • 37
    • 84928898586 scopus 로고    scopus 로고
    • A B-1a cell subset induces Foxp3 T cells with regulatory activity through an IL-10-independent pathway
    • Hsu LH, Li KP, Chu KH, Chiang BL. A B-1a cell subset induces Foxp3 T cells with regulatory activity through an IL-10-independent pathway. Cell Mol Immunol 2014; 12: 354-365.
    • (2014) Cell Mol Immunol , vol.12 , pp. 354-365
    • Hsu, L.H.1    Li, K.P.2    Chu, K.H.3    Chiang, B.L.4
  • 38
    • 12844274909 scopus 로고    scopus 로고
    • Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD251CD41 Tr cells
    • Levings MK, Gregori S, Tresoldi E, Cazzaniga S, Bonini C, Roncarolo MG. Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD251CD41 Tr cells. Blood 2005; 105: 1162-1169.
    • (2005) Blood , vol.105 , pp. 1162-1169
    • Levings, M.K.1    Gregori, S.2    Tresoldi, E.3    Cazzaniga, S.4    Bonini, C.5    Roncarolo, M.G.6
  • 39
    • 84867039778 scopus 로고    scopus 로고
    • Enforced IL-10 expression confers type 1 regulatory T cell (Tr1) phenotype and function to human CD4(1) T cells
    • Andolfi G, Fousteri G, Rossetti M, Magnani CF, Jofra T, Locafaro G et al. Enforced IL-10 expression confers type 1 regulatory T cell (Tr1) phenotype and function to human CD4(1) T cells. Mol Ther 2012; 20: 1778-1790.
    • (2012) Mol Ther , vol.20 , pp. 1778-1790
    • Andolfi, G.1    Fousteri, G.2    Rossetti, M.3    Magnani, C.F.4    Jofra, T.5    Locafaro, G.6
  • 40
    • 0037018104 scopus 로고    scopus 로고
    • In vitro generation of interleukin 10-producing regulatory CD4(1) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)-and Th2-inducing cytokines
    • Barrat FJ, Cua DJ, Boonstra A, Richards DF, Crain C, Savelkoul HF et al. In vitro generation of interleukin 10-producing regulatory CD4(1) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)-and Th2-inducing cytokines. J Exp Med 2002; 195: 603-616.
    • (2002) J Exp Med , vol.195 , pp. 603-616
    • Barrat, F.J.1    Cua, D.J.2    Boonstra, A.3    Richards, D.F.4    Crain, C.5    Savelkoul, H.F.6
  • 41
    • 84941039573 scopus 로고    scopus 로고
    • Phenotype alterations in regulatory T-cell subsets in primary HIV infection and identification of Tr1-like cells as the main interleukin 10-producing CD41 T cells
    • Chevalier MF, Didier C, Petitjean G, Karmochkine M, Girard PM, Barre-Sinoussi F et al. Phenotype alterations in regulatory T-cell subsets in primary HIV infection and identification of Tr1-like cells as the main interleukin 10-producing CD41 T cells. J Infect Dis 2015; 211: 769-779.
    • (2015) J Infect Dis , vol.211 , pp. 769-779
    • Chevalier, M.F.1    Didier, C.2    Petitjean, G.3    Karmochkine, M.4    Girard, P.M.5    Barre-Sinoussi, F.6
  • 42
    • 0037450727 scopus 로고    scopus 로고
    • T cell regulation as a side effect of homeostasis and competition
    • Barthlott T, Kassiotis G, Stockinger B. T cell regulation as a side effect of homeostasis and competition. J Exp Med 2003; 197: 451-460.
    • (2003) J Exp Med , vol.197 , pp. 451-460
    • Barthlott, T.1    Kassiotis, G.2    Stockinger, B.3
  • 44
    • 84860259163 scopus 로고    scopus 로고
    • Regulatory Tcell therapy for inflammatory bowel disease: More questions than answers
    • Himmel ME, Yao Y, Orban PC, Steiner TS, Levings MK. Regulatory Tcell therapy for inflammatory bowel disease: more questions than answers. Immunology 2012; 136: 115-122.
    • (2012) Immunology , vol.136 , pp. 115-122
    • Himmel, M.E.1    Yao, Y.2    Orban, P.C.3    Steiner, T.S.4    Levings, M.K.5
  • 45
    • 84921519720 scopus 로고    scopus 로고
    • A novel upstream enhancer of FOXP3, sensitive to methylation-induced silencing, exhibits dysregulated methylation in rheumatoid arthritis Treg cells
    • Kennedy A, Schmidt EM, Cribbs AP, Penn H, Amjadi P, SyedK et al. A novel upstream enhancer of FOXP3, sensitive to methylation-induced silencing, exhibits dysregulated methylation in rheumatoid arthritis Treg cells. Eur J Immunol 2014; 44: 2968-2978.
    • (2014) Eur J Immunol , vol.44 , pp. 2968-2978
    • Kennedy, A.1    Schmidt, E.M.2    Cribbs, A.P.3    Penn, H.4    SyedK, A.P.5
  • 46
    • 76749133610 scopus 로고    scopus 로고
    • Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate
    • Zheng Y, Josefowicz S, Chaudhry A, Peng XP, Forbush K, Rudensky AY. Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature 2010; 463: 808-812.
    • (2010) Nature , vol.463 , pp. 808-812
    • Zheng, Y.1    Josefowicz, S.2    Chaudhry, A.3    Peng, X.P.4    Forbush, K.5    Rudensky, A.Y.6
  • 47
    • 34447265236 scopus 로고    scopus 로고
    • CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: A role for DNA methylation
    • Kim HP, Leonard WJ. CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: a role for DNA methylation. J Exp Med 2007; 204: 1543-1551.
    • (2007) J Exp Med , vol.204 , pp. 1543-1551
    • Kim, H.P.1    Leonard, W.J.2
  • 49
    • 82755187763 scopus 로고    scopus 로고
    • IFN-alpha and CD46 stimulation are associated with active lupus and skew natural T regulatory cell differentiation to type 1 regulatory T (Tr1) cells
    • Le Buanec H, Gougeon ML, Mathian A, Lebon P, Dupont JM, Peltre G et al. IFN-alpha and CD46 stimulation are associated with active lupus and skew natural T regulatory cell differentiation to type 1 regulatory T (Tr1) cells. Proc Natl Acad Sci U S A 2011; 108: 18995-19000.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 18995-19000
    • Le Buanec, H.1    Gougeon, M.L.2    Mathian, A.3    Lebon, P.4    Dupont, J.M.5    Peltre, G.6
  • 50
    • 84901421855 scopus 로고    scopus 로고
    • Regulatory T cells and their roles in immune dysregulation and allergy
    • Pellerin L, Jenks JA, Begin P, Bacchetta R, Nadeau KC. Regulatory T cells and their roles in immune dysregulation and allergy. Immunol Res 2014; 58: 358-368.
    • (2014) Immunol Res , vol.58 , pp. 358-368
    • Pellerin, L.1    Jenks, J.A.2    Begin, P.3    Bacchetta, R.4    Nadeau, K.C.5
  • 51
    • 0017119171 scopus 로고
    • Measuring method for the X-ray cine-densitometry of moving vessels (authors transl)
    • Decker D, Epple E, Becker J, Weller R. [Measuring method for the X-ray cine-densitometry of moving vessels (authors transl)]. Biomed Tech (Berl) 1976; 21: 179-185.
    • (1976) Biomed Tech (Berl) , vol.21 , pp. 179-185
    • Decker, D.1    Epple, E.2    Becker, J.3    Weller, R.4
  • 52
    • 77956538422 scopus 로고    scopus 로고
    • Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway
    • Gregori S, Tomasoni D, Pacciani V, Scirpoli M, Battaglia M, Magnani CF et al. Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway. Blood 2010; 116: 935-944.
    • (2010) Blood , vol.116 , pp. 935-944
    • Gregori, S.1    Tomasoni, D.2    Pacciani, V.3    Scirpoli, M.4    Battaglia, M.5    Magnani, C.F.6
  • 55
    • 79957576097 scopus 로고    scopus 로고
    • Killing of myeloid APCs via HLA class I, CD2 and CD226 defines a novel mechanism of suppression by human Tr1 cells
    • Magnani CF, Alberigo G, Bacchetta R, Serafini G, Andreani M, Roncarolo MG et al. Killing of myeloid APCs via HLA class I, CD2 and CD226 defines a novel mechanism of suppression by human Tr1 cells. Eur J Immunol 2011; 41: 1652-1662.
    • (2011) Eur J Immunol , vol.41 , pp. 1652-1662
    • Magnani, C.F.1    Alberigo, G.2    Bacchetta, R.3    Serafini, G.4    Andreani, M.5    Roncarolo, M.G.6
  • 56
    • 84874141619 scopus 로고    scopus 로고
    • The cellular and molecular mechanisms of immuno-suppression by human type 1 regulatory T cells
    • Gregori S, Goudy KS, Roncarolo MG. The cellular and molecular mechanisms of immuno-suppression by human type 1 regulatory T cells. Front Immunol 2012; 3: 30.
    • (2012) Front Immunol , vol.3 , pp. 30
    • Gregori, S.1    Goudy, K.S.2    Roncarolo, M.G.3
  • 58
    • 14944360112 scopus 로고    scopus 로고
    • Resting dendritic cells induce peripheral CD81 T cell tolerance through PD-1 and CTLA-4
    • Probst HC, McCoy K, Okazaki T, Honjo T, van den Broek M. Resting dendritic cells induce peripheral CD81 T cell tolerance through PD-1 and CTLA-4. Nat Immunol 2005; 6: 280-286.
    • (2005) Nat Immunol , vol.6 , pp. 280-286
    • Probst, H.C.1    McCoy, K.2    Okazaki, T.3    Honjo, T.4    Van Den Broek, M.5
  • 59
    • 77953747963 scopus 로고    scopus 로고
    • The PD-1 pathway in tolerance and autoimmunity
    • Francisco LM, Sage PT, Sharpe AH. The PD-1 pathway in tolerance and autoimmunity. Immunol Rev 2010; 236: 219-242.
    • (2010) Immunol Rev , vol.236 , pp. 219-242
    • Francisco, L.M.1    Sage, P.T.2    Sharpe, A.H.3
  • 60
    • 77449132554 scopus 로고    scopus 로고
    • Antigen-specific dependence of Tr1-cell therapy in preclinical models of islet transplant
    • Gagliani N, Jofra T, Stabilini A, Valle A, Atkinson M, Roncarolo MG et al. Antigen-specific dependence of Tr1-cell therapy in preclinical models of islet transplant. Diabetes 2010; 59: 433-439.
    • (2010) Diabetes , vol.59 , pp. 433-439
    • Gagliani, N.1    Jofra, T.2    Stabilini, A.3    Valle, A.4    Atkinson, M.5    Roncarolo, M.G.6
  • 61
    • 84863643114 scopus 로고    scopus 로고
    • Probiotic Bifidobacterium breve induces IL-10-producing Tr1 cells in the colon
    • Jeon SG, Kayama H, Ueda Y, Takahashi T, Asahara T, Tsuji H et al. Probiotic Bifidobacterium breve induces IL-10-producing Tr1 cells in the colon. PLoS Pathog 2012; 8: e1002714.
    • (2012) PLoS Pathog , vol.8 , pp. e1002714
    • Jeon, S.G.1    Kayama, H.2    Ueda, Y.3    Takahashi, T.4    Asahara, T.5    Tsuji, H.6
  • 64
    • 55749091291 scopus 로고    scopus 로고
    • A survey of fully haploidentical hematopoietic stem cell transplantation in adults with high-risk acute leukemia: A risk factor analysis of outcomes for patients in remission at transplantation
    • Ciceri F, Labopin M, Aversa F, Rowe JM, Bunjes D, Lewalle P et al. A survey of fully haploidentical hematopoietic stem cell transplantation in adults with high-risk acute leukemia: a risk factor analysis of outcomes for patients in remission at transplantation. Blood 2008; 112: 3574-3581.
    • (2008) Blood , vol.112 , pp. 3574-3581
    • Ciceri, F.1    Labopin, M.2    Aversa, F.3    Rowe, J.M.4    Bunjes, D.5    Lewalle, P.6
  • 65
    • 11144325816 scopus 로고    scopus 로고
    • Transplantation of haploidentically mismatched stem cells for the treatment of malignant diseases
    • Aversa F, Martelli MF. Transplantation of haploidentically mismatched stem cells for the treatment of malignant diseases. Springer Semin Immunopathol 2004; 26: 155-168.
    • (2004) Springer Semin Immunopathol , vol.26 , pp. 155-168
    • Aversa, F.1    Martelli, M.F.2
  • 66
    • 79953162067 scopus 로고    scopus 로고
    • Environmental influences on T regulatory cells in inflammatory bowel disease
    • Hardenberg G, Steiner TS, Levings MK. Environmental influences on T regulatory cells in inflammatory bowel disease. Semin Immunol 2011; 23: 130-138.
    • (2011) Semin Immunol , vol.23 , pp. 130-138
    • Hardenberg, G.1    Steiner, T.S.2    Levings, M.K.3


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