The production of IL-10 by human regulatory T cells is enhanced by IL-2 through a STAT5-responsive intronic enhancer in the IL-10 locus

Journal of Immunology

Volumn 181, Issue 6, 2008, Pages 3897-3905

  Tsuji Takayama, Kazue ^a   Suzuki, Motoyuki ^a   Yamamoto, Mayuko ^a   Harashima, Akira ^a   Okochi, Ayumi ^a   Otani, Takeshi ^a   Inoue, Toshiya ^a   Sugimoto, Akira ^a   Toraya, Terumasa ^a   Takeuchi, Makoto ^a   Yamasaki, Fumiyuki ^b   Nakamura, Shuji ^a   Kibata, Masayoshi ^a  

^a HAYASHIBARA BIOCHEMICAL LABORATORIES INC   (Japan)

^b University of Tokyo   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 2; STAT5 PROTEIN; IL10 PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CPG ISLAND; CYTOKINE PRODUCTION; DNA METHYLATION; ENHANCER REGION; GEL BLOT ANALYSIS; GENE CONTROL; GENE LOCUS; HUMAN; HUMAN CELL; INTRON; MOLECULAR MECHANICS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; UMBILICAL CORD; ANIMAL; BIOSYNTHESIS; CELL CULTURE; COCULTURE; COMPARATIVE STUDY; DNA RESPONSIVE ELEMENT; GENETIC EPIGENESIS; GENETICS; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; PROTEIN BINDING; TUMOR CELL LINE;

ANIMALS; BASE SEQUENCE; CELL LINE, TUMOR; CELLS, CULTURED; COCULTURE TECHNIQUES; CONSERVED SEQUENCE; ENHANCER ELEMENTS (GENETICS); EPIGENESIS, GENETIC; HUMANS; INTERLEUKIN-10; INTERLEUKIN-2; INTRONS; MICE; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; RESPONSE ELEMENTS; SIGNAL TRANSDUCTION; STAT5 TRANSCRIPTION FACTOR; T-LYMPHOCYTES, REGULATORY;

EID: 56149095970     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.181.6.3897     Document Type: Article

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