Enhanced frequency of CD18- and CD49b-expressing T cells in peripheral blood of asthmatic patients correlates with disease severity

International Archives of Allergy and Immunology

Volumn 140, Issue 2, 2006, Pages 139-149

  Rahmoun, Massilva ^a   Foussat, Arnaud ^c   Groux, Hervé ^c   Pène, Jérôme ^a   Yssel, Hans ^a,b   Chanez, Pascal ^a,b  

^a INSERM   (France)

^b HÔPITAL ARNAUD DE VILLENEUVE   (France)

^c TxCell SA   (France)

Author keywords

Asthma; CD18; CD49b; Interleukin 10; T regulatory type 1 cells

Indexed keywords

ALPHA2 INTEGRIN; ANTIINFLAMMATORY AGENT; BECLOMETASONE; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CD18 ANTIGEN; CD4 ANTIGEN; DEXAMETHASONE; GLUCOCORTICOID; INTERLEUKIN 10; LONG ACTING DRUG; PREDNISOLONE; SALMETEROL; TRANSCRIPTOME;

ADULT; ANTIGEN EXPRESSION; ARTICLE; ASTHMA; CD4+ T LYMPHOCYTE; CELL CULTURE; CLINICAL ARTICLE; CONTROLLED STUDY; CORTICOSTEROID THERAPY; CYTOKINE PRODUCTION; DISEASE SEVERITY; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; EX VIVO STUDY; FEMALE; FLOW CYTOMETRY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LYMPHOCYTE COUNT; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PERIPHERAL CIRCULATION; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; REGULATORY T LYMPHOCYTE TYPE 1; SHORT COURSE THERAPY; T LYMPHOCYTE SUBPOPULATION;

ADULT; AGED; ANTIGENS, CD18; ASTHMA; DEXAMETHASONE; FEMALE; FLOW CYTOMETRY; FORCED EXPIRATORY VOLUME; GLUCOCORTICOIDS; HUMANS; IMMUNOPHENOTYPING; INTEGRIN ALPHA2; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; T-LYMPHOCYTES;

EID: 33646551167     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000092533     Document Type: Article

References (29)

1. Fabbri L, Peters SP, Pavord I, Wenzel SE, Lazarus SC, Macnee W, Lemaire F, Abraham E: Allergic rhinitis, asthma, airway biology, and chronic obstructive pulmonary disease in AJRCCM in 2004. Am J Respir Crit Care Med 2005;171:686-698.
2. Cookson WO: The alliance of genes and environment in asthma and allergy. Nature 1999;402:B5-B11.
3. Panina-Bordignon P, Papi A, Mariani M, Di Lucia P, Casoni G, Bellettato C, Buonsanti C, Miotto D, Mapp C, Villa A, Arrigoni G, Fabbri LM, Sinigaglia F: The C-C chemokine receptors CCR4 and CCR8 identify airway T cells of allergen-challenged atopic asthmatics. J Clin Invest 2001;107:1357-1364.
4. Wills-Karp M: Immunologic basis of antigen-induced airway hyperresponsiveness. Annu Rev Immunol 1999;17:255-281.
5. Umetsu DT, McIntire JJ, Akbari O, Macaubas C, DeKruyff RH: Asthma: an epidemic of dysregulated immunity. Nat Immunol 2002;3:715-720.
6. Umetsu DT, Akbari O, Dekruyff RH: Regulatory T cells control the development of allergic disease and asthma. J Allergy Clin Immunol 2003;112:480-487.
7. Shevach EM: CD4+ CD25+ suppressor T cells: more questions than answers. Nat Rev Immunol 2002;2:389-400.
8. Groux H, O'Garra A, Bigler M, Rouleau M, Antonenko S, de Vries JE, Roncarolo MG: A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 1997;389:737-742.
9. Foussat A, Cottrez F, Brun V, Fournier N, Breittmayer JP, Groux H: A comparative study between T regulatory type 1 and CD4+CD25+ T cells in the control of inflammation. J Immunol 2003;171:5018-5026.
10. Akbari O, DeKruyff RH, Umetsu DT: Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen. Nat Immunol 2001;2:725-731.
11. Zuany-Amorim C, Sawicka E, Manlius C, Le Moine A, Brunet LR, Kemeny DM, Bowen G, Rook G, Walker C: Suppression of airway eosinophilia by killed Mycobacterium vaccae-induced allergen-specific regulatory T-cells. Nat Med 2002;8:625-629.
12. Van Oosterhouf AJ, Blocksma N: Regulatory T-lymphocytes in asthma. Eur Respir J 2005;26:918-932.
13. Global initiative for asthma 2003: global strategy for asthma management and prevention. NHLBI/WHO workshop report NIH02-3659. http://www.ginasthma.com.
14. Vachier I, Chiappara G, Vignola AM, Gagliardo R, Altieri E, Terouanne B, Vie P, Bousquet J, Godard P, Chanez P: Glucocorticoid receptors in bronchial epithelial cells in asthma. Am J Respir Crit Care Med 1998;158:963-970.
15. Juniper EF, O'Byrne PM, Guyatt GH, Ferrie PJ, King DR: Development and validation of a questionnaire to measure asthma control. Eur Respir J 1999;14:902-907
16. Yssel H, De Vries JE, Koken M, Van Blitterswijk W, Spits H: Serum-free medium for generation and propagation of functional human cytotoxic and helper T cell clones. J Immunol Methods 1984;72:219-227.
17. Scheffold A, Assenmacher M, Radbruch A: Phenotyping and separation of leucocyte populations based on affinity labeling; in Kaufman S, Kabelitz D (eds): Methods in Microbiology. London, Academic Press, 2002, vol 32, pp 707-749.
18. Pène J, Desroches A, Paradis L, Lebel B, Farce M, Nicodemus CF, Yssel H, Bousquet J: Immunotherapy with Fel d 1 peptides decreases IL-4 release by peripheral blood T cells of patients allergic to cats. J Allergy Clin Immunol 1998;102:571-578.
19. Lecart S, Boulay V, Raison-Peyron N, Bousquet J, Meunier L, Yssel H, Pène J: Phenotypic characterization of human CD4+ regulatory T cells obtained from cutaneous dinitrochlorobenzene-induced delayed type hypersensitivity reactions. J Invest Dermatol 2001;117:318-325.
20. Dustin ML, Springer TA: Role of lymphocyte adhesion receptors in transient interactions and cell locomotion. Annu Rev Immunol 1991;9:27-66.
21. Hemler ME, Jacobson JG: Cell matrix adhesion-related proteins VLA-1 and VLA-2: regulation of expression on T cells. J Immunol 1987;138:2941-2948.
22. Pitzalis C, Pipitone N, Bajocchi G, Hall M, Goulding N, Lee A, Kingsley G, Lanchbury J, Panayi G: Corticosteroids inhibit lymphocyte binding to endothelium and intercellular adhesion: an additional mechanism for their anti-inflammatory and immunosuppressive effect. J Immunol 1997;10:5007-5016.
23. Pantaleo G, Koenig S, Baseler M, Lane HC, Fauci AS: Defective clonogenic potential of CD8+ T lymphocytes in patients with AIDS. Expansion in vivo of a nonclonogenic CD3+CD8+DR+CD25- T cell population. J Immunol 1990;144:1696-1704.
24. Jinquan T, Quan S, Feili G, Larsen CG, Thestrup-Pedersen K: Eotaxin activates T cells to chemotaxis and adhesion only if induced to express CCR3 by IL-2 together with IL-4. J Immunol 1999;162:4285-4292.
25. Sallusto F, Mackay CR, Lanzavecchia A: Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells. Science 1997;277:2005-2007.
26. Barrat FJ, Cua DJ, Boonstra A, Richards DF, et al: In vitro generation of interleukin 10-producing regulatory CD4+ T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines. J Exp Med 2002;195:603-616.
27. Karagiannidis C, Akdis M, Holopainen P, et al: Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma. J Allergy Clin Immunol 2004;114:1425-1433.
28. 2-agonists. Am J Respir Cell Mol Biol 2005;33:105-111.
29. Matsumoto K, Inoue H, Fukuyama S, Tsuda M, Ikegami T, Kibe A, Yoshiura Y, Komori M, Hamasaki N, Aizawa H, Nakanishi Y: Decrease of interleukin-10- producing T cells in the peripheral blood of severe unstable atopic asthmatics. Int Arch Allergy Immunol 2004;134:295-302.