메뉴 건너뛰기




Volumn 40, Issue 1, 2013, Pages 28-44

Interleukin-6 induces the generation of IL-10-producing Tr1 cells and suppresses autoimmune tissue inflammation

Author keywords

Autoimmune disease; Immune regulatory; Inflammation; Interleukin 10; Interleukin 6; Tr1 cells

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 2 RECEPTOR BETA; INTERLEUKIN 21; INTERLEUKIN 27; INTERLEUKIN 6; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA;

EID: 84873742482     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2012.07.009     Document Type: Article
Times cited : (113)

References (43)
  • 1
    • 81155160952 scopus 로고    scopus 로고
    • Type 1 regulatory T cells (Tr1) in autoimmunity
    • Pot C., Apetoh L., Kuchroo V.K. Type 1 regulatory T cells (Tr1) in autoimmunity. Semin Immunol 2011, 23:202-208.
    • (2011) Semin Immunol , vol.23 , pp. 202-208
    • Pot, C.1    Apetoh, L.2    Kuchroo, V.K.3
  • 2
    • 77649184739 scopus 로고    scopus 로고
    • The regulation of IL-10 production by immune cells
    • Saraiva M., O'Garra A. The regulation of IL-10 production by immune cells. Nat Rev Immunol 2010, 10:170-181.
    • (2010) Nat Rev Immunol , vol.10 , pp. 170-181
    • Saraiva, M.1    O'Garra, A.2
  • 4
    • 79954620910 scopus 로고    scopus 로고
    • Th17 cells express interleukin-10 receptor and are controlled by Foxp3 and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner
    • Huber S., Gagliani N., Esplugues E., O'Connor W., Huber F.J., Chaudhry A., et al. Th17 cells express interleukin-10 receptor and are controlled by Foxp3 and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner. Immunity 2011, 34:554-565.
    • (2011) Immunity , vol.34 , pp. 554-565
    • Huber, S.1    Gagliani, N.2    Esplugues, E.3    O'Connor, W.4    Huber, F.J.5    Chaudhry, A.6
  • 5
    • 77649255586 scopus 로고    scopus 로고
    • IL-10 directly suppresses CD4 but not CD8 T cell effector and memory responses following acute viral infection
    • Brooks D.G., Walsh K.B., Elsaesser H., Oldstone M.B. IL-10 directly suppresses CD4 but not CD8 T cell effector and memory responses following acute viral infection. Proc Natl Acad Sci U S A 2010, 107:3018-3023.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 3018-3023
    • Brooks, D.G.1    Walsh, K.B.2    Elsaesser, H.3    Oldstone, M.B.4
  • 6
    • 0027521572 scopus 로고
    • Interleukin-10-deficient mice develop chronic enterocolitis
    • Kuhn R., Lohler J., Rennick D., Rajewsky K., Muller W. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 1993, 75:263-274.
    • (1993) Cell , vol.75 , pp. 263-274
    • Kuhn, R.1    Lohler, J.2    Rennick, D.3    Rajewsky, K.4    Muller, W.5
  • 7
    • 9244237038 scopus 로고    scopus 로고
    • T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation
    • Roers A., Siewe L., Strittmatter E., Deckert M., Schluter D., Stenzel W., et al. T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation. J Exp Med 2004, 200:1289-1297.
    • (2004) J Exp Med , vol.200 , pp. 1289-1297
    • Roers, A.1    Siewe, L.2    Strittmatter, E.3    Deckert, M.4    Schluter, D.5    Stenzel, W.6
  • 8
    • 55149111143 scopus 로고    scopus 로고
    • Diversity in the contribution of interleukin-10 to T-cell-mediated immune regulation
    • Maynard C.L., Weaver C.T. Diversity in the contribution of interleukin-10 to T-cell-mediated immune regulation. Immunol Rev 2008, 226:219-233.
    • (2008) Immunol Rev , vol.226 , pp. 219-233
    • Maynard, C.L.1    Weaver, C.T.2
  • 9
    • 62049085168 scopus 로고    scopus 로고
    • Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10
    • Sun J., Madan R., Karp C.L., Braciale T.J. Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10. Nat Med 2009, 15:277-284.
    • (2009) Nat Med , vol.15 , pp. 277-284
    • Sun, J.1    Madan, R.2    Karp, C.L.3    Braciale, T.J.4
  • 11
    • 79952994082 scopus 로고    scopus 로고
    • CD4+ T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs
    • Sun J., Dodd H., Moser E.K., Sharma R., Braciale T.J. CD4+ T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs. Nat Immunol 2011, 12:327-334.
    • (2011) Nat Immunol , vol.12 , pp. 327-334
    • Sun, J.1    Dodd, H.2    Moser, E.K.3    Sharma, R.4    Braciale, T.J.5
  • 12
    • 77955903212 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27
    • Apetoh L., Quintana F.J., Pot C., Joller N., Xiao S., Kumar D., et al. The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27. Nat Immunol 2010, 11:854-861.
    • (2010) Nat Immunol , vol.11 , pp. 854-861
    • Apetoh, L.1    Quintana, F.J.2    Pot, C.3    Joller, N.4    Xiao, S.5    Kumar, D.6
  • 13
    • 36248970701 scopus 로고    scopus 로고
    • A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells
    • Awasthi A., Carrier Y., Peron J.P., Bettelli E., Kamanaka M., Flavell R.A., et al. A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. Nat Immunol 2007, 8:1380-1389.
    • (2007) Nat Immunol , vol.8 , pp. 1380-1389
    • Awasthi, A.1    Carrier, Y.2    Peron, J.P.3    Bettelli, E.4    Kamanaka, M.5    Flavell, R.A.6
  • 14
    • 69249083836 scopus 로고    scopus 로고
    • Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells
    • Pot C., Jin H., Awasthi A., Liu S.M., Lai C.Y., Madan R., et al. Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells. J Immunol 2009, 183:797-801.
    • (2009) J Immunol , vol.183 , pp. 797-801
    • Pot, C.1    Jin, H.2    Awasthi, A.3    Liu, S.M.4    Lai, C.Y.5    Madan, R.6
  • 15
    • 64849083153 scopus 로고    scopus 로고
    • IL-21 mediates suppressive effects via its induction of IL-10
    • Spolski R., Kim H.P., Zhu W., Levy D.E., Leonard W.J. IL-21 mediates suppressive effects via its induction of IL-10. J Immunol 2009, 182:2859-2867.
    • (2009) J Immunol , vol.182 , pp. 2859-2867
    • Spolski, R.1    Kim, H.P.2    Zhu, W.3    Levy, D.E.4    Leonard, W.J.5
  • 17
    • 79957713226 scopus 로고    scopus 로고
    • The Th1 life cycle: molecular control of IFN-gamma to IL-10 switching
    • Cope A., Le Friec G., Cardone J., Kemper C. The Th1 life cycle: molecular control of IFN-gamma to IL-10 switching. Trends Immunol 2011, 32:278-286.
    • (2011) Trends Immunol , vol.32 , pp. 278-286
    • Cope, A.1    Le Friec, G.2    Cardone, J.3    Kemper, C.4
  • 18
    • 79957673711 scopus 로고    scopus 로고
    • IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer
    • Neurath M.F., Finotto S. IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer. Cytokine Growth Factor Rev 2011, 22:83-89.
    • (2011) Cytokine Growth Factor Rev , vol.22 , pp. 83-89
    • Neurath, M.F.1    Finotto, S.2
  • 19
    • 67349104400 scopus 로고    scopus 로고
    • Interleukin-6 as a key player in systemic inflammation and joint destruction
    • Fonseca J.E., Santos M.J., Canhao H., Choy E. Interleukin-6 as a key player in systemic inflammation and joint destruction. Autoimmun Rev 2009, 8:538-542.
    • (2009) Autoimmun Rev , vol.8 , pp. 538-542
    • Fonseca, J.E.1    Santos, M.J.2    Canhao, H.3    Choy, E.4
  • 21
    • 48249148236 scopus 로고    scopus 로고
    • IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis
    • Serada S., Fujimoto M., Mihara M., Koike N., Ohsugi Y., Nomura S., et al. IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A 2008, 105:9041-9046.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 9041-9046
    • Serada, S.1    Fujimoto, M.2    Mihara, M.3    Koike, N.4    Ohsugi, Y.5    Nomura, S.6
  • 22
    • 0035139890 scopus 로고    scopus 로고
    • Interleukin-6 deficiency increases inflammatory bone destruction
    • Balto K., Sasaki H., Stashenko P. Interleukin-6 deficiency increases inflammatory bone destruction. Infect Immun 2001, 69:744-750.
    • (2001) Infect Immun , vol.69 , pp. 744-750
    • Balto, K.1    Sasaki, H.2    Stashenko, P.3
  • 23
    • 0028568369 scopus 로고
    • Local production of human IL-6 promotes insulitis but retards the onset of insulin-dependent diabetes mellitus in non-obese diabetic mice
    • DiCosmo B.F., Picarella D., Flavell R.A. Local production of human IL-6 promotes insulitis but retards the onset of insulin-dependent diabetes mellitus in non-obese diabetic mice. Int Immunol 1994, 6:1829-1837.
    • (1994) Int Immunol , vol.6 , pp. 1829-1837
    • DiCosmo, B.F.1    Picarella, D.2    Flavell, R.A.3
  • 24
    • 58649108302 scopus 로고    scopus 로고
    • IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
    • Grivennikov S., Karin E., Terzic J., Mucida D., Yu G.Y., Vallabhapurapu S., et al. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell 2009, 15:103-113.
    • (2009) Cancer Cell , vol.15 , pp. 103-113
    • Grivennikov, S.1    Karin, E.2    Terzic, J.3    Mucida, D.4    Yu, G.Y.5    Vallabhapurapu, S.6
  • 25
    • 2142764513 scopus 로고    scopus 로고
    • IL-6 prevents T cell-mediated hepatitis via inhibition of NKT cells in CD4+ T cell- and STAT3-dependent manners
    • Sun R., Tian Z., Kulkarni S., Gao B. IL-6 prevents T cell-mediated hepatitis via inhibition of NKT cells in CD4+ T cell- and STAT3-dependent manners. J Immunol 2004, 172:5648-5655.
    • (2004) J Immunol , vol.172 , pp. 5648-5655
    • Sun, R.1    Tian, Z.2    Kulkarni, S.3    Gao, B.4
  • 26
    • 36248965294 scopus 로고    scopus 로고
    • TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology
    • McGeachy M.J., Bak-Jensen K.S., Chen Y., Tato C.M., Blumenschein W., McClanahan T., et al. TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology. Nat Immunol 2007, 8:1390-1397.
    • (2007) Nat Immunol , vol.8 , pp. 1390-1397
    • McGeachy, M.J.1    Bak-Jensen, K.S.2    Chen, Y.3    Tato, C.M.4    Blumenschein, W.5    McClanahan, T.6
  • 27
    • 79952637807 scopus 로고    scopus 로고
    • IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation
    • Eto D., Lao C., DiToro D., Barnett B., Escobar T.C., Kageyama R., et al. IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation. PLoS One 2011, 6:e17739.
    • (2011) PLoS One , vol.6
    • Eto, D.1    Lao, C.2    DiToro, D.3    Barnett, B.4    Escobar, T.C.5    Kageyama, R.6
  • 28
    • 84866355862 scopus 로고    scopus 로고
    • IL-6 triggers IL-21 production by human CD4(+) T cells to drive STAT3-dependent plasma cell differentiation in B cells
    • Diehl S.A., Schmidlin H., Nagasawa M., Blom B., Spits H. IL-6 triggers IL-21 production by human CD4(+) T cells to drive STAT3-dependent plasma cell differentiation in B cells. Immunol Cell Biol 2012.
    • (2012) Immunol Cell Biol
    • Diehl, S.A.1    Schmidlin, H.2    Nagasawa, M.3    Blom, B.4    Spits, H.5
  • 29
    • 63849275584 scopus 로고    scopus 로고
    • Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities
    • Eddahri F., Denanglaire S., Bureau F., Spolski R., Leonard W.J., Leo O., et al. Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities. Blood 2009, 113:2426-2433.
    • (2009) Blood , vol.113 , pp. 2426-2433
    • Eddahri, F.1    Denanglaire, S.2    Bureau, F.3    Spolski, R.4    Leonard, W.J.5    Leo, O.6
  • 30
    • 33845453812 scopus 로고    scopus 로고
    • Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse
    • Kamanaka M., Kim S.T., Wan Y.Y., Sutterwala F.S., Lara-Tejero M., Galan J.E., et al. Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse. Immunity 2006, 25:941-952.
    • (2006) Immunity , vol.25 , pp. 941-952
    • Kamanaka, M.1    Kim, S.T.2    Wan, Y.Y.3    Sutterwala, F.S.4    Lara-Tejero, M.5    Galan, J.E.6
  • 31
    • 78650057188 scopus 로고    scopus 로고
    • IL-21 is an immune activator that also mediates suppression via IL-10
    • Spolski R., Leonard W.J. IL-21 is an immune activator that also mediates suppression via IL-10. Crit Rev Immunol 2010, 30:559-570.
    • (2010) Crit Rev Immunol , vol.30 , pp. 559-570
    • Spolski, R.1    Leonard, W.J.2
  • 33
    • 34250837518 scopus 로고    scopus 로고
    • A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA
    • Ivanov S., Dragoi A.M., Wang X., Dallacosta C., Louten J., Musco G., et al. A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA. Blood 2007, 110:1970-1981.
    • (2007) Blood , vol.110 , pp. 1970-1981
    • Ivanov, S.1    Dragoi, A.M.2    Wang, X.3    Dallacosta, C.4    Louten, J.5    Musco, G.6
  • 34
    • 73249149628 scopus 로고    scopus 로고
    • C-Maf regulates IL-10 expression during Th17 polarization
    • Xu J., Yang Y., Qiu G., Lal G., Wu Z., Levy D.E., et al. c-Maf regulates IL-10 expression during Th17 polarization. J Immunol 2009, 182:6226-6236.
    • (2009) J Immunol , vol.182 , pp. 6226-6236
    • Xu, J.1    Yang, Y.2    Qiu, G.3    Lal, G.4    Wu, Z.5    Levy, D.E.6
  • 35
    • 77955859470 scopus 로고    scopus 로고
    • Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells
    • Gandhi R., Kumar D., Burns E.J., Nadeau M., Dake B., Laroni A., et al. Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells. Nat Immunol 2010, 11:846-853.
    • (2010) Nat Immunol , vol.11 , pp. 846-853
    • Gandhi, R.1    Kumar, D.2    Burns, E.J.3    Nadeau, M.4    Dake, B.5    Laroni, A.6
  • 36
    • 79952955744 scopus 로고    scopus 로고
    • The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells
    • Cretney E., Xin A., Shi W., Minnich M., Masson F., Miasari M., et al. The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells. Nat Immunol 2011, 12:304-311.
    • (2011) Nat Immunol , vol.12 , pp. 304-311
    • Cretney, E.1    Xin, A.2    Shi, W.3    Minnich, M.4    Masson, F.5    Miasari, M.6
  • 37
    • 68149125188 scopus 로고    scopus 로고
    • IFN regulatory factor 4 regulates the expression of a subset of Th2 cytokines
    • Ahyi A.N., Chang H.C., Dent A.L., Nutt S.L., Kaplan M.H. IFN regulatory factor 4 regulates the expression of a subset of Th2 cytokines. J Immunol 2009, 183:1598-1606.
    • (2009) J Immunol , vol.183 , pp. 1598-1606
    • Ahyi, A.N.1    Chang, H.C.2    Dent, A.L.3    Nutt, S.L.4    Kaplan, M.H.5
  • 39
    • 42649095378 scopus 로고    scopus 로고
    • Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor
    • Quintana F.J., Basso A.S., Iglesias A.H., Korn T., Farez M.F., Bettelli E., et al. Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor. Nature 2008, 453:65-71.
    • (2008) Nature , vol.453 , pp. 65-71
    • Quintana, F.J.1    Basso, A.S.2    Iglesias, A.H.3    Korn, T.4    Farez, M.F.5    Bettelli, E.6
  • 40
    • 56149095970 scopus 로고    scopus 로고
    • The production of IL-10 by human regulatory T cells is enhanced by IL-2 through a STAT5-responsive intronic enhancer in the IL-10 locus
    • Tsuji-Takayama K., Suzuki M., Yamamoto M., Harashima A., Okochi A., Otani T., et al. The production of IL-10 by human regulatory T cells is enhanced by IL-2 through a STAT5-responsive intronic enhancer in the IL-10 locus. J Immunol 2008, 181:3897-3905.
    • (2008) J Immunol , vol.181 , pp. 3897-3905
    • Tsuji-Takayama, K.1    Suzuki, M.2    Yamamoto, M.3    Harashima, A.4    Okochi, A.5    Otani, T.6
  • 42
    • 14044268797 scopus 로고    scopus 로고
    • IL-6 plays a unique role in initiating c-Maf expression during early stage of CD4 T cell activation
    • Yang Y., Ochando J., Yopp A., Bromberg J.S., Ding Y. IL-6 plays a unique role in initiating c-Maf expression during early stage of CD4 T cell activation. J Immunol 2005, 174:2720-2729.
    • (2005) J Immunol , vol.174 , pp. 2720-2729
    • Yang, Y.1    Ochando, J.2    Yopp, A.3    Bromberg, J.S.4    Ding, Y.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.