The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease

Immunity

Volumn 43, Issue 2, 2015, Pages 264-276

  de Almeida, Lucia ^a   Khare, Sonal ^a   Misharin, Alexander V ^a   Patel, Rajul ^a   Ratsimandresy, Rojo A ^a   Wallin, Melissa C ^a   Perlman, Harris ^a   Greaves, David R ^b   Hoffman, Hal M ^c   Dorfleutner, Andrea ^a   Stehlik, Christian ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c LUDWIG INSTITUTE FOR CANCER RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS ASSOCIATED SPECK LIKE PROTEIN CONTAINING A CARD; DAMAGE ASSOCIATED MOLECULAR PATTERNS; INFLAMMASOME; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; PATHOGEN ASSOCIATED MOLECULAR PATTERNS; PROTEIN; PROTEIN NLRP; PYRIN DOMAIN ONLY PROTEIN 1; UNCLASSIFIED DRUG; CARRIER PROTEIN; CIAS1 PROTEIN, MOUSE; LIPOPOLYSACCHARIDE; POP1 PROTEIN, MOUSE; RIBONUCLEOPROTEIN; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; ENZYME ACTIVATION; FEEDBACK SYSTEM; FEMALE; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN TISSUE; INFLAMMATION; INFLAMMATORY DISEASE; MACROPHAGE; MALE; MOLECULAR BIOLOGY; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ANIMAL; APOPTOSIS; C57BL MOUSE; CELL LINE; CHEMICALLY INDUCED; CINCA SYNDROME; GENE EXPRESSION REGULATION; GENETICS; HOMEOSTASIS; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; PERITONEUM MACROPHAGE; PERITONITIS; PROTEIN MULTIMERIZATION; TRANSGENIC MOUSE;

ANIMALS; APOPTOSIS; CARRIER PROTEINS; CASPASE 1; CELL LINE; CRYOPYRIN-ASSOCIATED PERIODIC SYNDROMES; DENDRITIC CELLS; FEMALE; GENE EXPRESSION REGULATION; HOMEOSTASIS; HUMANS; INFLAMMASOMES; INTERLEUKIN-18; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MONOCYTES; PERITONITIS; PROTEIN MULTIMERIZATION; RIBONUCLEOPROTEINS; RNA, SMALL INTERFERING;

EID: 84940970623     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2015.07.018     Document Type: Article

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